PE20010408A1 - COMPUESTOS DE ACIDO HIDROXAMICO DE O-AMINO-ß-SULFONILO COMO INHIBIDORES DE METALOPROTEASAS DE MATRIZ - Google Patents

COMPUESTOS DE ACIDO HIDROXAMICO DE O-AMINO-ß-SULFONILO COMO INHIBIDORES DE METALOPROTEASAS DE MATRIZ

Info

Publication number
PE20010408A1
PE20010408A1 PE2000000616A PE0006162000A PE20010408A1 PE 20010408 A1 PE20010408 A1 PE 20010408A1 PE 2000000616 A PE2000000616 A PE 2000000616A PE 0006162000 A PE0006162000 A PE 0006162000A PE 20010408 A1 PE20010408 A1 PE 20010408A1
Authority
PE
Peru
Prior art keywords
hydrocarbyl
defines
linked
sulfonil
inhibitors
Prior art date
Application number
PE2000000616A
Other languages
English (en)
Inventor
Thomas E Barta
Daniel P Becker
Louis J Bedell
Gary A Decrescenzo
John N Freskos
Clara I Villamil
Robert M Heintz
Susan L Hockerman
Madeleine Hui Li
Brent V Mischke
Daniel P Getman
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of PE20010408A1 publication Critical patent/PE20010408A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/65—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

SE REFIERE A COMPUESTOS DE ACIDO HIDROXAMICO DE O-AMINO-ß SULFONILO DE FORMULA A, DONDE: R2 ES HIDROCARBILO C1-C4, HIDROXI-HIDROCARBILO C1-C4, HIDROCARBILOXI C1-C4, HALOHIDROCARBILO C1-C4, ENTRE OTROS; R1 ES CARBOCICLO, HETEROCICLO, ARILO, HETEROARILO DE 5-6 MIEMBROS ENLAZADO AL GRUPO SO2, CON UNA LONGITUD MAYOR QUE LA DEL GRUPO PENTILO EXTENDIDO Y MENOR QUE LA DE UN GRUPO EICOSILO, EXTENDIDO DONDE R1 DEFINE UN VOLUMEN TRIDIMENSIONAL AL GIRAR AL REDEDOR DE UN EJE TRAZADO A TRAVES DE LA POSICION 1 Y LA POSICION 4 ENLAZADA A SO2 DE UN RADICAL DEL ANILLO DE 6 MIEMBROS O TRAZADO A TRAVES DE LA POSICION 1 ENLAZADO A SO2 Y EL CENTRO DE ENLACE 3,4 DE UN RADICAL DEL ANILLO DE 5 MIEMBROS, LA DIMENSION MAS ANCHA DEL VOLUMEN EN DIRECCION TRANSVERSAL AL EJE DE ROTACION QUE ES APROXIMADAMENTE LA DE UN ANILLO DE FURANILO A LA DE DOS ANILLOS DE FENILO; R6 Y R7 SON ALQUILCARBONILO, ARILCARBONILO, ALCOXICARBONILO, ENTRE OTROS; O JUNTO A N FORMAN UNA IMIDA CICLICA; R20 ES -O-R21, NR13-O-R22, NR13-O-R14; R21 ES ALQUILO C1-C6, ARILO, ARALQUILO C1-C6, ENTRE OTROS; R14 ES CWR15; W ES O, S; R15 ES ALQUILO C1-C6, ARILO, ALCOXI C1-C6, ENTRE OTROS. UN COMPUESTO PREFERIDO DE FORMULA II, ENTRE OTROS. LOS COMPUESTOS I SON INHIBIDORES DE LA ACTIVIDAD DE LA METALOPROTEASA MATRIZ (MMP) Y PUEDEN SER UTILES EN EL TRATAMIENTO DE CANCER
PE2000000616A 1999-05-20 2000-06-21 COMPUESTOS DE ACIDO HIDROXAMICO DE O-AMINO-ß-SULFONILO COMO INHIBIDORES DE METALOPROTEASAS DE MATRIZ PE20010408A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13499699P 1999-05-20 1999-05-20

Publications (1)

Publication Number Publication Date
PE20010408A1 true PE20010408A1 (es) 2001-04-05

Family

ID=22466022

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000616A PE20010408A1 (es) 1999-05-20 2000-06-21 COMPUESTOS DE ACIDO HIDROXAMICO DE O-AMINO-ß-SULFONILO COMO INHIBIDORES DE METALOPROTEASAS DE MATRIZ

Country Status (16)

Country Link
US (1) US6583299B1 (es)
EP (1) EP1178959A1 (es)
JP (1) JP2003500389A (es)
KR (1) KR20020003881A (es)
CN (1) CN1373751A (es)
AR (1) AR035318A1 (es)
AU (1) AU776171C (es)
BR (1) BR0010810A (es)
CA (1) CA2373577A1 (es)
CO (1) CO5170408A1 (es)
MX (1) MXPA01011865A (es)
NZ (1) NZ515307A (es)
PE (1) PE20010408A1 (es)
UY (1) UY26158A1 (es)
WO (1) WO2000071514A1 (es)
ZA (1) ZA200109228B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1252143A1 (en) * 2000-01-27 2002-10-30 American Cyanamid Company Method for preparing alpha-sulfonyl hydroxamic acid derivatives
CA2471814C (en) 2001-12-27 2011-03-15 Sumitomo Pharmaceuticals Co., Ltd. Hydroxamic acid derivative and mmp inhibitor containing the same as active ingredient
GB0206711D0 (en) 2002-03-21 2002-05-01 Isis Innovation HIF Inhibitor
ATE457716T1 (de) 2002-12-30 2010-03-15 Angiotech Int Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
ES2537514T3 (es) 2003-04-04 2015-06-09 Incyte Corporation Composiciones, métodos y kits relacionados con la escisión de HER-2
KR20160061439A (ko) * 2007-03-28 2016-05-31 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
ES2903079T3 (es) * 2016-04-18 2022-03-31 Vivoryon Therapeutics N V Novedosos inhibidores de meprina alfa y beta
BR112021006407A8 (pt) 2018-10-04 2022-12-06 Inst Nat Sante Rech Med uso de inibidores do egfr para ceratodermas

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4595700A (en) 1984-12-21 1986-06-17 G. D. Searle & Co. Thiol based collagenase inhibitors
JPS62221675A (ja) * 1986-03-19 1987-09-29 Mitsubishi Chem Ind Ltd β−テトラゾ−ル置換アラニン誘導体
CA2108670A1 (en) * 1991-04-18 1992-10-19 Robert S. Phillips Inhibitors of kynureninase
EP0634998B1 (en) 1992-04-07 1997-03-19 British Biotech Pharmaceuticals Limited Hydroxamic acid based collagenase and cytokine inhibitors
US5376664A (en) 1992-07-27 1994-12-27 The Du Pont Merck Pharmaceutical Company Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents
GB9307956D0 (en) 1993-04-17 1993-06-02 Walls Alan J Hydroxamic acid derivatives
GB9320660D0 (en) 1993-10-07 1993-11-24 British Bio Technology Inhibition of cytokine production
PT726763E (pt) 1993-11-04 2000-09-29 Liposome Co Inc Metodos de tratamento utilizando formulacoes lipossomicas unilamelares de metabolitos de acido araquidonico
US5480887A (en) * 1994-02-02 1996-01-02 Eli Lilly And Company Protease inhibitors
GB9416897D0 (en) 1994-08-20 1994-10-12 British Biotech Pharm Metalloproteinase inhibitors
MX9702487A (es) 1994-10-05 1998-04-30 Darwin Discovery Ltd Compuestos peptidilo y su uso terapeutico como inhibidores de las metaloproteasas.
ES2195034T3 (es) 1995-12-08 2003-12-01 Agouron Pharma Inhibidor de metaloproteinasas, composicion farmaceutica que contiene este inhibidor y su utilizacion farmaceutica, y procedimientos que sirven para su preparacion.
ATE225343T1 (de) 1995-12-20 2002-10-15 Hoffmann La Roche Matrix-metalloprotease inhibitoren
AU1529897A (en) 1996-01-02 1997-07-28 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted (aryl, heteroaryl, arylmethyl or heteroarylmethyl) hydroxamic acid compounds
EP0994104A4 (en) * 1996-06-27 2001-09-12 Ono Pharmaceutical Co ARYL SULFIDE, SULFOXIDE AND SULPHONE DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THEM AS AN ACTIVE INGREDIENT
CN1230884A (zh) * 1996-07-22 1999-10-06 孟山都公司 硫羟砜金属蛋白酶抑制剂
EP0997147B1 (en) * 1997-07-08 2006-03-15 Ono Pharmaceutical Co., Ltd. Amino acid derivatives

Also Published As

Publication number Publication date
AU776171C (en) 2005-05-12
BR0010810A (pt) 2002-02-19
CO5170408A1 (es) 2002-06-27
JP2003500389A (ja) 2003-01-07
MXPA01011865A (es) 2002-06-04
WO2000071514A1 (en) 2000-11-30
AU776171B2 (en) 2004-09-02
CN1373751A (zh) 2002-10-09
NZ515307A (en) 2004-08-27
WO2000071514A8 (en) 2001-02-22
UY26158A1 (es) 2000-12-29
US6583299B1 (en) 2003-06-24
AU4973500A (en) 2000-12-12
CA2373577A1 (en) 2000-11-30
ZA200109228B (en) 2002-11-15
AR035318A1 (es) 2004-05-12
EP1178959A1 (en) 2002-02-13
KR20020003881A (ko) 2002-01-15

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