ES2063050T3 - Derivados de alcoxi-2-oxo-1,2-dihidroquinoxalina substituida en posicion 6. - Google Patents
Derivados de alcoxi-2-oxo-1,2-dihidroquinoxalina substituida en posicion 6.Info
- Publication number
- ES2063050T3 ES2063050T3 ES88309284T ES88309284T ES2063050T3 ES 2063050 T3 ES2063050 T3 ES 2063050T3 ES 88309284 T ES88309284 T ES 88309284T ES 88309284 T ES88309284 T ES 88309284T ES 2063050 T3 ES2063050 T3 ES 2063050T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- okyl
- substituted
- dihidroquinoxalina
- alcoxi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
Abstract
LA INVENCION SE REFIERE A UN COMPUESTO DE FORMULA(I), EN LA QUE Z ES N Y LA LINEA DE PUNTOS ES UN DOBLE ENLACE, O Z ES NH Y LINEA ES UN ENLACE SENCILLO, R1 ES H, ALQUILO DE 1 A 20 C O FENILO; A ES ALQUILENO DE CADENA CORTA Y R ES CARBOXILO, ALCOXICARBONILO, EL GRUPO(II) O 1 - CICLOALQUIL - TETRAZOILO - 5 (DONDE R2 ES ALQUILO, HIDROXI - ALQUILO O FENIL - ALQUILO Y R3 ES ALQUILO O CICLOALQUILO DE CADENA CORTA O R2 Y R3 JUNTOS AL NITROGENO AL QUE ESTAN UNIDOS FORMAN LOS GRPOS (III) O (IV), SIEN DO R5 Y R6 H O FENILO QUE PUEDE ESTAR SUSTITUIDO, O A UNA SAL SUYA, NO TOXICA Y FARMACOLOGICAMENTE ACEPTABLE.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP25126487 | 1987-10-05 | ||
JP63210346A JPH0276860A (ja) | 1987-10-05 | 1988-08-24 | 6−置換アルコキシ−2−オキソ−1,2−ジヒドロキノキサリン誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2063050T3 true ES2063050T3 (es) | 1995-01-01 |
Family
ID=26518000
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88309284T Expired - Lifetime ES2063050T3 (es) | 1987-10-05 | 1988-10-05 | Derivados de alcoxi-2-oxo-1,2-dihidroquinoxalina substituida en posicion 6. |
Country Status (5)
Country | Link |
---|---|
US (1) | US4870175A (es) |
EP (1) | EP0311378B1 (es) |
JP (1) | JPH0276860A (es) |
DE (1) | DE3889281T2 (es) |
ES (1) | ES2063050T3 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5214052A (en) * | 1987-07-28 | 1993-05-25 | Mitsubishi Kasei Corporation | Method for dissolving arginineamides and pharmaceutical compositions containing them |
US4997836A (en) * | 1988-11-11 | 1991-03-05 | Takeda Chemical Industries, Ltd. | Trisubstituted piperazine compounds, their production and use |
TW274550B (es) * | 1992-09-26 | 1996-04-21 | Hoechst Ag | |
JP2002509923A (ja) | 1998-03-31 | 2002-04-02 | ワーナー−ランバート・カンパニー | Xa因子およびトロンビンのようなセリンプロテアーゼ阻害剤としてのキノキサリノン |
DE10153345A1 (de) * | 2001-10-29 | 2003-05-08 | Gruenenthal Gmbh | Substituierte 1H-Chinoxalin-2-on-Verbindungen und substituierte 4-Aryl- und 4-Heteroarylcyclohexan-Verbindungen |
US20060058311A1 (en) | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
US20060035903A1 (en) * | 2004-08-14 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Storage stable perfusion solution for dihydropteridinones |
US7439358B2 (en) | 2006-02-08 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative |
US8329695B2 (en) * | 2007-08-03 | 2012-12-11 | Boehringer Ingelheim International Gmbh | Crystalline form of the free base N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7r)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide |
US8546566B2 (en) | 2010-10-12 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Process for manufacturing dihydropteridinones and intermediates thereof |
US9358233B2 (en) | 2010-11-29 | 2016-06-07 | Boehringer Ingelheim International Gmbh | Method for treating acute myeloid leukemia |
US9370535B2 (en) | 2011-05-17 | 2016-06-21 | Boehringer Ingelheim International Gmbh | Method for treatment of advanced solid tumors |
US20150031699A1 (en) | 2013-07-26 | 2015-01-29 | Boehringer Ingelheim International Gmbh | Treatment of myelodysplastic syndrome |
US9867831B2 (en) | 2014-10-01 | 2018-01-16 | Boehringer Ingelheim International Gmbh | Combination treatment of acute myeloid leukemia and myelodysplastic syndrome |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4167512A (en) * | 1977-09-21 | 1979-09-11 | The B. F. Goodrich Company | Synthesis of 2-keto-1,4-diazacycloalkanes |
EP0008864A1 (en) * | 1978-08-15 | 1980-03-19 | FISONS plc | Pyridopyrazine and quinoxaline derivatives, processes for their preparation, and pharmaceutical compositions containing them |
DE2922084A1 (de) * | 1979-05-31 | 1980-12-11 | Boehringer Mannheim Gmbh | Neue aminopropanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
US4466916A (en) * | 1979-10-26 | 1984-08-21 | The B. F. Goodrich Company | Substituted 2-keto-1,4-diazacycloalkanes |
DE3119077A1 (de) * | 1981-05-14 | 1982-12-02 | Basf Ag, 6700 Ludwigshafen | Heterocyclische dihalogenacetmide, verfahren zu ihrer herstellung und herbizide mittel, die acetanilide als herbizide wirkstoffe und diese dihalogenacetamine als antagonistische mittel enthalten |
-
1988
- 1988-08-24 JP JP63210346A patent/JPH0276860A/ja active Pending
- 1988-10-05 US US07/253,546 patent/US4870175A/en not_active Expired - Fee Related
- 1988-10-05 DE DE3889281T patent/DE3889281T2/de not_active Expired - Fee Related
- 1988-10-05 EP EP88309284A patent/EP0311378B1/en not_active Expired - Lifetime
- 1988-10-05 ES ES88309284T patent/ES2063050T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE3889281D1 (de) | 1994-06-01 |
EP0311378B1 (en) | 1994-04-27 |
EP0311378A3 (en) | 1989-12-13 |
DE3889281T2 (de) | 1994-10-13 |
US4870175A (en) | 1989-09-26 |
EP0311378A2 (en) | 1989-04-12 |
JPH0276860A (ja) | 1990-03-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2063050T3 (es) | Derivados de alcoxi-2-oxo-1,2-dihidroquinoxalina substituida en posicion 6. | |
ES2053609T3 (es) | Derivados de urea inhibidores de lipoxigenasa. | |
AR248138A1 (es) | Un procedimiento de preparacion de acilamino-2-tiazoles. | |
EA200100755A1 (ru) | 4-оксо-1,4-дигидро-3-хинолинкарбоксамиды как антивирусные агенты | |
BRPI0014526B8 (pt) | compostos cíclicos de seis elementos contendo nitrogênio aromático, composição farmacêutica e uso do mesmo | |
ES2100187T3 (es) | Derivados de carboestirilos y composiciones farmaceuticas que los contienen. | |
ES2058809T3 (es) | Derivados heterociclicos. | |
DK0471236T3 (da) | Imidazopyridinderivater og deres anvendelse | |
UY24625A1 (es) | Derivados de la 4-hidroxi-piperidina | |
CO4290355A1 (es) | Derivados de indol | |
ES2043863T3 (es) | Procedimiento para preparar derivados de la 1,2,5,6-tetrahidropiridina. | |
DE69614833T2 (de) | Entzündungshemmende benzoesäurederivate | |
ES2119874T3 (es) | Nuevos derivados de elipticina, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. | |
ES2107027T3 (es) | Oxazalinas y tiazolinas artropodicas. | |
CO5080785A1 (es) | Derivados heterociclicos | |
DK415789A (da) | Tetracykliske antidepressive midler | |
ATE139772T1 (de) | Aromatische amine derivate von 2,5-dimercapto- 1,3,4-thiadiazolen. | |
ES2053755T3 (es) | Un procedimiento para preparar compuestos heterociclicos. | |
ATE69605T1 (de) | Azolylpropenyl- und azolylmethyloxiran-derivate und diese enthaltende fungizide. | |
MX9301721A (es) | Derivados, composiciones de carbinol de bis-arilo sin puente, y metodos de uso. | |
DK0478173T3 (da) | 4,5-polymethylen-4-isothiazolin-3-onderivater og anvendelse heraf som biocider | |
ES2053257T3 (es) | Derivados de pradimicina. | |
ES2032838T3 (es) | Un procedimiento para preparar derivados tetrahidropirido (1,2-a)indol. | |
DE68909025D1 (de) | Mittel zur Verhinderung von Zahnbelagbildung. | |
ATE155774T1 (de) | Nitroxyalkylamid-derivate |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 311378 Country of ref document: ES |