AR015514A1 - Compuesto de amida, proceso para su preparacion y composicion farmaceutica que lo contiene - Google Patents

Compuesto de amida, proceso para su preparacion y composicion farmaceutica que lo contiene

Info

Publication number
AR015514A1
AR015514A1 ARP990100525A ARP990100525A AR015514A1 AR 015514 A1 AR015514 A1 AR 015514A1 AR P990100525 A ARP990100525 A AR P990100525A AR P990100525 A ARP990100525 A AR P990100525A AR 015514 A1 AR015514 A1 AR 015514A1
Authority
AR
Argentina
Prior art keywords
alkyl
halogen
nr7r8
alkoxy
formula
Prior art date
Application number
ARP990100525A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9802842.6A external-priority patent/GB9802842D0/en
Priority claimed from GBGB9810688.3A external-priority patent/GB9810688D0/en
Priority claimed from GBGB9826553.1A external-priority patent/GB9826553D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR015514A1 publication Critical patent/AR015514A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Abstract

Un compuesto de amida inhibidor de células B que tiene la formula (A). En donde cualquiera de: 1) Z es O; n es 0 o 1; T es un residuo de formula (I), endonde R6 es H; alquilo C1-6 opcionalmente sustituido en la posicion terminal por halogeno, OH, NR7R8, COOH, CO-O-alquilo C1-4, o CO-NR7R8; alquilo C1-6interrumpido por uno o más heteroátomos seleccionados a partir de N, O o S, y sustituido en la posicion terminal por halogeno, OH, NR7R8, COOH, CO-O-alquiloC1-4, o CO-NR7R8; OR9; NHR10; ciano; o formilo; cada uno de R7 y R8 es independientemente H, alquilo C1-4, omega-HO-alquilo C1-4, CHO o heterocicloalquiloC1-4, o R7 y R8 forman junto con el átomo de nitrogeno con el que están enlazados, un anillo heterocíclico; R9 es alquilo C1-6 sustituidoen la posicionterminal por OH o NR7R8; R10 es alquilo C1-6 sustituido en la posicion terminal por OH o NR7R8; y W es un residuo de formula (II) en donde: i) X es -CR1=, endonde R1 es H, F, CF3, alquilo C1-4, o NH2; y R2 es H, F, OH, alcoxi C1-4, CN,NO2, CF3 o NHCO-alquilo C1-4; R3 es H, halogeno, CN, NO2, CF3, NH2 u OH; R4 esH, halogeno, CF3, o alcoxi C1-4; y R5 es H, halogeno, alcoxi C1-4, tioalquilo C1-4, CF3, NH2, alquilo C1-4, o un grupo heterocíclico; o ii) X es -N=; y R3 esH, halogeno, NH2, alcoxi C1-4, OH, -O(CH2)3-NH2, piperidino, o CF3; R4 es H, F, CF3, CN o NO2; y cada uno de R2 y R5 es H; 2) Z es O o S; n es 0 o 1; T es unresiduo de formula (III), en donde: R11 es H, CH3 o C2H5; R12 es H, halogeno, alquilo C1-4, o cicloalquiloC3-6; R13 es H, halogeno, hidroxi, alcoxi C1-2,fenilalcoxi C1-2, o alquilo C1-2 sustituido por NH2, NH(alquilo C1-5), NH-SO2-alquilo C1-2, o NH-CO-alcoxi C1-4; y W es un residuo de formula (IV) en donde:uno de R14, R15 y R16 es F, CF3, OCF3, CN, alquilo C2-4, di-(alquilo C1-2)amino o carbamoílo, y los otros dos símbolos son H; o uno de R14, R15 y R16 es H, ylos otros 2 símbolos son cada uno CF3, cada uno de R14, R15 y R16 es H; o cada uno de R14, R15 y R16 es halogeno; el grupo fenil-amida o tiamida está unido acualquiera de los átomos de C libres del anillo de indol; en el entendido de que, cuando R13 es H, cuando menos uno de R14, R15 y R16 sea diferente de H, en
ARP990100525A 1998-02-10 1999-02-08 Compuesto de amida, proceso para su preparacion y composicion farmaceutica que lo contiene AR015514A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9802842.6A GB9802842D0 (en) 1998-02-10 1998-02-10 Organic compounds
GBGB9810688.3A GB9810688D0 (en) 1998-05-19 1998-05-19 Organic compounds
GBGB9826553.1A GB9826553D0 (en) 1998-12-02 1998-12-02 Organic compounds

Publications (1)

Publication Number Publication Date
AR015514A1 true AR015514A1 (es) 2001-05-02

Family

ID=27269204

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990100525A AR015514A1 (es) 1998-02-10 1999-02-08 Compuesto de amida, proceso para su preparacion y composicion farmaceutica que lo contiene

Country Status (5)

Country Link
AR (1) AR015514A1 (es)
AU (1) AU2832399A (es)
CO (1) CO4980854A1 (es)
PE (1) PE20000281A1 (es)
WO (1) WO1999041239A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001277731A1 (en) 2000-08-09 2002-02-18 Welfide Corporation Fused bicyclic amide compounds and medicinal use thereof
CA2430951A1 (en) * 2000-12-07 2002-06-13 Cv Therapeutics, Inc. Substituted 1, 3, 5-triazines and pyrimidines as abca-1 elevating compounds against coronary artery disease or atherosclerosis
WO2002072549A1 (en) * 2001-03-12 2002-09-19 Millennium Pharmaceuticals, Inc. Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor
EP1417204B1 (en) 2001-08-15 2006-01-18 E. I. du Pont de Nemours and Company Ortho-heterocyclic substituted aryl amides for controlling invertebrate pests
EP1503986B1 (en) 2001-12-21 2015-09-30 Cytokinetics, Inc. Compositions and methods for treating heart failure
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
US8686048B2 (en) 2010-05-06 2014-04-01 Rhizen Pharmaceuticals Sa Immunomodulator and anti-inflammatory compounds
EP2594555B1 (en) * 2010-07-02 2018-03-07 ASKA Pharmaceutical Co., Ltd. HETEROCYCLIC COMPOUND, AND p27 KIP1 DEGRADATION INHIBITOR
US20140031383A1 (en) 2011-02-08 2014-01-30 Dana-Farber Cancer Institute, Inc. Methods for treatment of melanoma
EP2847165A2 (en) * 2012-04-02 2015-03-18 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Indole, indoline derivatives, compositions comprising them and uses thereof
SG11201602183QA (en) 2013-10-25 2016-05-30 Novartis Ag Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors
EP3200786B1 (en) 2014-10-03 2019-08-28 Novartis AG Use of ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors
US9802917B2 (en) 2015-03-25 2017-10-31 Novartis Ag Particles of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide
US10730839B2 (en) * 2016-11-27 2020-08-04 Russell Dahl Quinolines as cytoprotective agents
CN111164075A (zh) * 2017-09-20 2020-05-15 北京加科思新药研发有限公司 用作fgfr4抑制剂的稠环衍生物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1305458A (es) * 1969-02-26 1973-01-31
US3699123A (en) * 1970-03-24 1972-10-17 Sandoz Ltd 4-(3-amino-2-hydroxy-propoxy) indole derivatives
FR2121394A1 (fr) * 1971-01-08 1972-08-25 Anvar Procédé d'obtention de dérivés d'acides indole carboxyliques et produits préparables par ce procédé.
US5484944A (en) * 1993-10-27 1996-01-16 Neurogen Corporation Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands

Also Published As

Publication number Publication date
CO4980854A1 (es) 2000-11-27
AU2832399A (en) 1999-08-30
WO1999041239A1 (en) 1999-08-19
PE20000281A1 (es) 2000-05-15

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