SI2382215T1 - Derivati 2-piridin-2-il-pirazol-3(2H)-ona, njihova priprava in njihova terapevtska uporaba - Google Patents

Derivati 2-piridin-2-il-pirazol-3(2H)-ona, njihova priprava in njihova terapevtska uporaba

Info

Publication number: SI2382215T1
Authority: SI; Slovenia
Prior art keywords: pyrazol; pyridin; derivatives; preparation; therapeutic use
Prior art date: 2008-12-29

Application number

SI200931025T

Other languages

English (en)

Inventor

Jean-Michel Altenburger

Valerie Fossey

Stephane Illiano

Geraldine Manette

Original Assignee

Sanofi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-12-29

Filing date

2009-12-24

Publication date

2020-06-30

2008-12-29 Priority claimed from FR0807475A external-priority patent/FR2940652B1/fr

2009-08-28 Priority claimed from FR0904091A external-priority patent/FR2949468B1/fr

2009-12-24 Application filed by Sanofi filed Critical Sanofi

2020-06-30 Publication of SI2382215T1 publication Critical patent/SI2382215T1/sl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

SI200931025T 2008-12-29 2009-12-24 Derivati 2-piridin-2-il-pirazol-3(2H)-ona, njihova priprava in njihova terapevtska uporaba SI2382215T1 (sl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
FR0807475A FR2940652B1 (fr)	2008-12-29	2008-12-29	Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one,leur preparation et leur application en therapeutique
FR0904091A FR2949468B1 (fr)	2009-08-28	2009-08-28	Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur preparation et leur application en therapeutique
PCT/FR2009/052692 WO2010076525A1 (fr)	2008-12-29	2009-12-24	Dérivés de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur préparation et leur application en thérapeutique
EP09805790.4A EP2382215B1 (fr)	2008-12-29	2009-12-24	Dérivés de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur préparation et leur application en thérapeutique

Publications (1)

Publication Number	Publication Date
SI2382215T1 true SI2382215T1 (sl)	2020-06-30

Family

ID=41728182

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200931025T SI2382215T1 (sl)	2008-12-29	2009-12-24	Derivati 2-piridin-2-il-pirazol-3(2H)-ona, njihova priprava in njihova terapevtska uporaba

Country Status (34)

Country	Link
US (2)	US8697731B2 (sl)
EP (1)	EP2382215B1 (sl)
JP (1)	JP5865704B2 (sl)
KR (1)	KR101630475B1 (sl)
CN (1)	CN102333776B (sl)
AR (1)	AR074916A1 (sl)
AU (1)	AU2009334570B2 (sl)
BR (1)	BRPI0923875A2 (sl)
CA (1)	CA2748413A1 (sl)
CO (1)	CO6400145A2 (sl)
CR (1)	CR20110360A (sl)
CY (1)	CY1115635T1 (sl)
DK (1)	DK2382215T3 (sl)
EA (1)	EA019774B1 (sl)
EC (1)	ECSP11011164A (sl)
ES (1)	ES2511917T3 (sl)
HK (1)	HK1163679A1 (sl)
IL (1)	IL213790A (sl)
MA (1)	MA32978B1 (sl)
MX (1)	MX2011007061A (sl)
MY (1)	MY155244A (sl)
NI (1)	NI201100132A (sl)
NZ (1)	NZ593797A (sl)
PA (1)	PA8856101A1 (sl)
PE (1)	PE20120338A1 (sl)
PL (1)	PL2382215T3 (sl)
PT (1)	PT2382215E (sl)
SG (1)	SG172422A1 (sl)
SI (1)	SI2382215T1 (sl)
SM (1)	SMT201400157B (sl)
TN (1)	TN2011000308A1 (sl)
TW (1)	TWI441828B (sl)
WO (1)	WO2010076525A1 (sl)
ZA (1)	ZA201104785B (sl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2511917T3 (es)	2008-12-29	2014-10-23	Sanofi	Derivados de 2-piridin-2-il-pirazol-3(2H)-ona, su preparación y su aplicación en terapéutica
EP2361912A1 (en) *	2010-02-18	2011-08-31	GenKyoTex SA	Pyrazolo piperidine derivatives as NADPH oxidase inhibitors
EP2361911A1 (en) *	2010-02-18	2011-08-31	GenKyoTex SA	Pyrazolo piperidine derivatives as NADPH oxidase inhibitors
CN104321318A (zh)	2012-03-30	2015-01-28	第一三共株式会社	4-烷酰基氨基-3-吡唑啉酮衍生物
CN102731384B (zh) *	2012-07-10	2016-04-06	南开大学	一种6-甲基烟酸叔丁酯的合成方法
EP3336084B1 (en) *	2013-03-29	2021-03-17	Takeda Pharmaceutical Company Limited	6-(5-hydroxy-1h-pyrazol-1-yl)nicotinamide derivatives and their use as phd inhibitors
CN105061316B (zh) *	2015-07-17	2017-12-22	苏州大学	稠环类化合物、制备方法和用途
CN113072562B (zh) *	2021-04-06	2022-01-14	山东大学	一种GSK-3β抑制剂及其制备方法与应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3917469A1 (de) *	1989-05-30	1990-12-06	Bayer Ag	Heterocyclylpyridine
DE4023488A1 (de)	1990-07-24	1992-01-30	Bayer Ag	1-(pyri(mi)dyl-(2)) -5-hydroxy-pyrazol-mikrobizide
US5750088A (en) *	1993-03-30	1998-05-12	The Dupont Merck Pharmaceutical Company	Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals
GB9704762D0 (en)	1997-03-07	1997-04-23	Zeneca Ltd	Chemical process
WO2005030121A2 (en) *	2003-06-30	2005-04-07	Hif Bio, Inc.	Compounds, compositions and methods
CN1842332A (zh) *	2003-06-30	2006-10-04	Hif生物公司	化合物、组合物及方法
DE102005019712A1 (de)	2005-04-28	2006-11-09	Bayer Healthcare Ag	Dipyridyl-dihydropyrazolone und ihre Verwendung
AR059733A1 (es) *	2006-03-07	2008-04-23	Smithkline Beecham Corp	Compuesto derivado de glicina n- sustituida con heteroaromaticos bicicicos, composicion farmaceutica que lo comprende, uso para preparar un medicamento para tratar la anemia y proceso para su preparacion
JP5443988B2 (ja) *	2006-10-16	2014-03-19	メディシス・ファーマシューティカル・コーポレーション	治療用のピラゾリルチエノピリジン
DE102006050516A1 (de)	2006-10-26	2008-04-30	Bayer Healthcare Ag	Substituierte Dihydropyrazolone und ihre Verwendung
BRPI0812361A2 (pt) *	2007-05-18	2015-02-03	Bayer Schering Pharma Ag	Derivados de pirazol heteroaril-substituídos úteis parao tratamento de distúrbios e doenças hiperproliferativos associados à angiogênese
JP5734870B2 (ja)	2008-12-29	2015-06-17	サノフイ	２−ピリジン−２−イル−ピラゾール−３（２ｈ）−オンの誘導体、これらの調製およびｈｉｆ活性化剤としての治療用途
ES2511917T3 (es)	2008-12-29	2014-10-23	Sanofi	Derivados de 2-piridin-2-il-pirazol-3(2H)-ona, su preparación y su aplicación en terapéutica

2009
- 2009-12-24 ES ES09805790.4T patent/ES2511917T3/es active Active
- 2009-12-24 JP JP2011542887A patent/JP5865704B2/ja not_active Expired - Fee Related
- 2009-12-24 DK DK09805790.4T patent/DK2382215T3/da active
- 2009-12-24 MA MA34029A patent/MA32978B1/fr unknown
- 2009-12-24 AU AU2009334570A patent/AU2009334570B2/en not_active Ceased
- 2009-12-24 EP EP09805790.4A patent/EP2382215B1/fr active Active
- 2009-12-24 MY MYPI2011003011A patent/MY155244A/en unknown
- 2009-12-24 CA CA2748413A patent/CA2748413A1/fr not_active Abandoned
- 2009-12-24 WO PCT/FR2009/052692 patent/WO2010076525A1/fr active Application Filing
- 2009-12-24 CN CN200980157589.3A patent/CN102333776B/zh not_active Expired - Fee Related
- 2009-12-24 MX MX2011007061A patent/MX2011007061A/es active IP Right Grant
- 2009-12-24 BR BRPI0923875-1A patent/BRPI0923875A2/pt not_active IP Right Cessation
- 2009-12-24 NZ NZ593797A patent/NZ593797A/xx not_active IP Right Cessation
- 2009-12-24 PL PL09805790T patent/PL2382215T3/pl unknown
- 2009-12-24 EA EA201170900A patent/EA019774B1/ru not_active IP Right Cessation
- 2009-12-24 SG SG2011047529A patent/SG172422A1/en unknown
- 2009-12-24 PT PT98057904T patent/PT2382215E/pt unknown
- 2009-12-24 PE PE2011001291A patent/PE20120338A1/es not_active Application Discontinuation
- 2009-12-24 SI SI200931025T patent/SI2382215T1/sl unknown
- 2009-12-24 KR KR1020117017677A patent/KR101630475B1/ko active IP Right Grant
- 2009-12-28 AR ARP090105127A patent/AR074916A1/es unknown
- 2009-12-28 PA PA20098856101A patent/PA8856101A1/es unknown
- 2009-12-28 TW TW098145333A patent/TWI441828B/zh not_active IP Right Cessation
2011
- 2011-06-17 TN TN2011000308A patent/TN2011000308A1/fr unknown
- 2011-06-23 CR CR20110360A patent/CR20110360A/es unknown
- 2011-06-27 IL IL213790A patent/IL213790A/en not_active IP Right Cessation
- 2011-06-27 EC EC2011011164A patent/ECSP11011164A/es unknown
- 2011-06-28 NI NI201100132A patent/NI201100132A/es unknown
- 2011-06-28 ZA ZA2011/04785A patent/ZA201104785B/en unknown
- 2011-06-29 CO CO11081313A patent/CO6400145A2/es active IP Right Grant
- 2011-06-29 US US13/172,321 patent/US8697731B2/en not_active Expired - Fee Related
2012
- 2012-05-02 HK HK12104300.3A patent/HK1163679A1/xx not_active IP Right Cessation
2014
- 2014-03-07 US US14/200,698 patent/US9359329B2/en not_active Expired - Fee Related
- 2014-10-16 CY CY20141100849T patent/CY1115635T1/el unknown
- 2014-10-29 SM SM201400157T patent/SMT201400157B/xx unknown

Also Published As

Publication number	Publication date
TN2011000308A1 (fr)	2012-12-17
EP2382215B1 (fr)	2014-07-16
NZ593797A (en)	2013-01-25
AR074916A1 (es)	2011-02-23
EA201170900A1 (ru)	2012-02-28
EP2382215A1 (fr)	2011-11-02
TW201028424A (en)	2010-08-01
PE20120338A1 (es)	2012-04-30
SMT201400157B (it)	2015-01-15
AU2009334570B2 (en)	2016-06-09
CN102333776A (zh)	2012-01-25
ZA201104785B (en)	2012-09-26
KR101630475B1 (ko)	2016-06-14
AU2009334570A1 (en)	2011-07-21
EA019774B1 (ru)	2014-06-30
MX2011007061A (es)	2011-12-16
DK2382215T3 (da)	2014-10-27
HK1163679A1 (en)	2012-09-14
SG172422A1 (en)	2011-07-28
PL2382215T3 (pl)	2015-01-30
CY1115635T1 (el)	2017-01-04
BRPI0923875A2 (pt)	2015-07-21
CA2748413A1 (fr)	2010-07-08
WO2010076525A1 (fr)	2010-07-08
MA32978B1 (fr)	2012-01-02
CO6400145A2 (es)	2012-03-15
CR20110360A (es)	2011-10-13
JP5865704B2 (ja)	2016-02-17
US20110301148A1 (en)	2011-12-08
CN102333776B (zh)	2014-05-21
NI201100132A (es)	2011-11-01
PT2382215E (pt)	2014-10-16
US8697731B2 (en)	2014-04-15
IL213790A0 (en)	2011-07-31
PA8856101A1 (es)	2010-07-27
MY155244A (en)	2015-09-30
ES2511917T3 (es)	2014-10-23
TWI441828B (zh)	2014-06-21
US20140194470A1 (en)	2014-07-10
US9359329B2 (en)	2016-06-07
IL213790A (en)	2015-09-24
JP2012513977A (ja)	2012-06-21
ECSP11011164A (es)	2011-07-29
US20160137627A9 (en)	2016-05-19
KR20110111437A (ko)	2011-10-11

Publication	Publication Date	Title
HK1159108A1 (en)	2012-07-27	Pyridino-pyridinone derivatives, preparation thereof, and therapeutic use thereof
HK1163679A1 (en)	2012-09-14	Derivatives of 2-pyridin-2-yl-pyrazol-3(2h)-one, preparation and therapeutic use thereof 2--2---3(2h)-
PL2262803T3 (pl)	2013-03-29	Wielopodstawione pochodne 2-arylo-6-fenyloimidazo[1,2-A]pirydyn, ich wytwarzanie i ich zastosowanie w lecznictwie
IL214390A0 (en)	2011-09-27	Derivatives of azapiranyl-alkylcarbamates of 5-member heterocyclic compounds, preparation thereof and therapeutic use thereof
IL219888A0 (en)	2012-07-31	Pyridine-pyridinone derivatives, preparation and therapeutic use thereof
IL209840A0 (en)	2011-02-28	Azacarboline derivatives, preparation thereof, and therapeutic use thereof as kinase inhibitors
ZA201103516B (en)	2012-07-25	Carbamate derivatives of alkyl-heterocycles, preparation thereof and therapeutic use thereof
ZA201107363B (en)	2012-12-27	Quinazolinedione derivatives,preparation thereof and various therapeutic uses thereof
HK1158632A1 (en)	2012-07-20	Derivatives of 2-oxo-alkyl-1-piperazin-2-one, preparation method thereof and therapeutic use of same 2--1--2-
IL215103A0 (en)	2011-12-29	N-[(6-AZA-bicyclo[3.2.1]OCT-5-YL]-ARYL-METHYL]-HETEROBENZAMIDE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE OF SAME
ZA201004643B (en)	2011-09-28	Derivatives of n-heterocyclic-imidazo[1,2-a]pyridine-2-carboxamides,preparation thereof and therapeutic application thereof
ZA201104783B (en)	2012-09-26	Derivatives of 2-pyridin-2-yl-pyrazol-3(2h)-one,preparation and therapeutic use thereof as hif activators
ZA201000745B (en)	2011-04-28	Tricyclic n-heteroaryl-carboxamide derivatives,preparation thereof and therapeutic use of same
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