AR066617A1 - Derivados de pirazol sustituidos con heteroarilo utiles para tratar trastornos hiperproliferativos y emfermedades asociadas con angiogenesis - Google Patents

Derivados de pirazol sustituidos con heteroarilo utiles para tratar trastornos hiperproliferativos y emfermedades asociadas con angiogenesis

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Publication number
AR066617A1
AR066617A1 ARP080102099A ARP080102099A AR066617A1 AR 066617 A1 AR066617 A1 AR 066617A1 AR P080102099 A ARP080102099 A AR P080102099A AR P080102099 A ARP080102099 A AR P080102099A AR 066617 A1 AR066617 A1 AR 066617A1
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Argentina
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optionally substituted
halogen
alkyl
hydrogen
heterocyclyl
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ARP080102099A
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Bayer Healthcare Ag
Bayer Schering Pharma Ag
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Publication of AR066617A1 publication Critical patent/AR066617A1/es

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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

La presente se refiere a compuestos de pirazol sustituidos con heteroarilo, a composiciones farmacéuticas que contienen estos compuestos y al uso de estos compuestos o composiciones para tratar trastornos hiperproliferativos y/o angiogénesis, comoun unico agente o en combinacion con otros ingredientes activos o medidas terapéuticas. Reivindicacion 1: Un compuesto que tiene la formula (1), o una de sus sales, solvatos, hidratos o estereoisomeros fisiologicamente aceptables, en la que: A esheteroarilo opcionalmente sustituido con halogeno o fenilo o es heterociclilo; n es un numero entero de 0-3; R1 en cada aparicion es, de modo independiente, halogeno, -NR6C(O)R7, -C(O)R6, -C(O)OR6, -OC(O)R6, -OR6, -SR6, -S(O)R6, -SO2R6, ciano,nitro, -C(O)NR6R7, -SO2NR6R7 o -NR6R7, o R1 es, de modo independiente, arilo, heteroarilo, heterociclilo, alquilo o cicloalquilo, cada uno opcionalmente sustituido con uno o varios grupos halogeno, OR6 o NR6R7; R2 es arilo opcionalmente sustituidocon 1, 2 o 3 grupos R8 o heteroarilo opcionalmente sustituido con 1, 2 o 3 grupos R8, cuando A es heteroarilo mono- o bicíclico o heterociclilo mono- o bicíclico, o R2 es hidrogeno, halogeno, ciano, alquil opcionalmente sustituido con hasta 3 átomosde fluor, alquiloxi opcionalmente sustituido con hasta 3 átomos de fluor, cicloalquilo, ariloxi, aroílo, aralquilo opcionalmente sustituido con halogeno, o heterociclilo opcionalmente sustituido con alquilo, cuando A es heteroarilo bi- o tricíclicoo heterociclilo mono-, bi- o tricíclico; R3 y R4 son cada uno, de modo independiente, hidrogeno, halogeno, -OR6, -SR6, -NR6R7, alquilo opcionalmente sustituido con uno o varios grupos halogeno, R6, -OR6 o -NR6R7, o cicloalquilo opcionalmentesustituido con uno o varios grupos halogeno, R6, -OR6 o -NR6R7; R5 es hidrogeno, oxo o alquilo opcionalmente sustituido con uno o varios grupos halogeno, -OR6 o -NR6R7; cada aparicion de R6 o R7 puede ser igual o diferente y es, de modoindependiente, hidrogeno, o arilo, heteroarilo, heterociclilo, alquilo o cicloalquilo, cada uno de los cuales puede estar opcionalmente sustituido con uno o varios grupos hidrogeno, halogeno, -OR9 o -NR9R10; cada aparicion de R8 puede ser igual odiferente y es, de modo independiente, hidrogeno, halogeno, -NR9C(O)R10, -NR9C(O)OR10, -C(O)R9, -C(O)OR9, -OC(O)R9, -OR9, -SR9, -S(O)R9, -SO2R9, ciano, nitro, -C(O)NR9R10, -SO2NR9R10, -NR9R10 o arilo, heteroarilo, heterociclilo, alquilo ocicloalquilo, cada uno de los cuales puede estar opcionalmente sustituido con uno o varios grupos halogeno, R11, -OR9 o -NR9R10; cada aparicion de R9 y R10 puede ser igual o diferente y es, de modo independiente, hidrogeno, o arilo, heteroarilo,heterociclilo, alquilo, cicloalquilo, aralquilo o heterociclilalquilo, cada uno de los cuales puede estar opcionalmente sustituido con uno o varios grupos hidrogeno, halogeno, hidroxilo, alquiloxi, cicloalquiloxi, ariloxi, amino, alquilamino,cicloalquilamino, arilamino, alquilo, cicloalquilo, alquilcarbonilo o alcoxicarbonilo; cada aparicion de R11 puede ser igual o diferente y es, de modo independiente, hidrogeno, oxo, arilo, heteroarilo, heterociclilo, alquilo, cicloalquilo, -C(O)R9, -C(O)OR9, -NR12C(O)R13, -N[C(O)R13]2, -NR12C(O)OR13 o -N[C(O)OR13]2; R12 es hidrogeno o alquilo; y R13 es alquilo.
ARP080102099A 2007-05-18 2008-05-16 Derivados de pirazol sustituidos con heteroarilo utiles para tratar trastornos hiperproliferativos y emfermedades asociadas con angiogenesis AR066617A1 (es)

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US (1) US8796253B2 (es)
EP (1) EP2148877A2 (es)
JP (1) JP5702138B2 (es)
KR (1) KR20100016617A (es)
CN (1) CN101765596B (es)
AR (1) AR066617A1 (es)
AU (1) AU2008253311A1 (es)
BR (1) BRPI0812361A2 (es)
CA (1) CA2687306A1 (es)
CL (1) CL2008001372A1 (es)
IL (1) IL201537A0 (es)
MX (1) MX2009012000A (es)
PA (1) PA8780201A1 (es)
PE (1) PE20090297A1 (es)
RU (1) RU2009146851A (es)
TW (1) TW200909428A (es)
UY (1) UY31080A1 (es)
WO (1) WO2008141731A2 (es)
ZA (1) ZA200907999B (es)

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