PA8764301A1 - Derivados de n-(amino-heteroaril)-1h-pirrolopiridin-2-carboxamidas, su preparacion y su aplicacion en terapeutica - Google Patents

Derivados de n-(amino-heteroaril)-1h-pirrolopiridin-2-carboxamidas, su preparacion y su aplicacion en terapeutica

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Publication number
PA8764301A1
PA8764301A1 PA20078764301A PA8764301A PA8764301A1 PA 8764301 A1 PA8764301 A1 PA 8764301A1 PA 20078764301 A PA20078764301 A PA 20078764301A PA 8764301 A PA8764301 A PA 8764301A PA 8764301 A1 PA8764301 A1 PA 8764301A1
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Panama
Prior art keywords
rent
nitrogen atom
renting
group
therapeutics
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PA20078764301A
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English (en)
Inventor
Laurent Dubois
Yannick Evanno
Catherine Gille
David Machnik
Andre Malanda
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Sanofi Aventis
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Publication of PA8764301A1 publication Critical patent/PA8764301A1/es

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    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA GENERAL (I): EN LA QUE EL NUCLEO DE PIRROLOPIRIDINA ESTÁ EVENTUALMENTE SUUSTITUIDO EN LOS CARBONOS DE POSICION 4,5,6 Y/O 7 CON UNO O VARIOS SUSTITUYENTES X, IDÉNTICOS O DIFERENTES UNO DE OTRO, ELEGIDOS ENTRE UN ÁTOMO DE HIDRÓGENO O UN GRUPO ALQUILO C1-C6, CICLOALQUILO C3-C7, CICLOALQUIL C3-C7-ALQUILENO C1-CE, FLUOROALQUILO C1-C6, ALCOXILO C1-C6, CICLOALCOXILO C3-C7, CICLOALQUIL C3-C7-ALQUILENO(C1-C6)-O-, FLUOROALCOXILO C1-C6, CIANO, TIOALQUILO C1-C6, -S(O)-ALQUILO C1-C6, -S(O)2-ALQUILO C1-C6, SF5 C(O)NR1R2, SO2NR1R2, NITRO, NR1R2, OCONR1R2, NR3COR4, NR3CONR1R2, NR3SO2R5, NR3SO2NR1R2, ARIL-ALQUILENO C1-C6, HETEROARIL-ALQUILENO C1-C6, ARILO O HETEROARILO, ESTANDO EL ARILO Y EL HETEROARILO EVENTUALMENTE SUSTITUIDOS; N ES IGUAL A 0, 1, 2 Ó 3; Y REPRESENTA UN ARILO O UN HETEROARILO, ESTANDO EL ARILO O EL HETEROARILO EVENTUALMENTE SUSTITUIDOS; Z1, Z2, Z3, Z4 REPRESENTAN, INDEPENDIENTEMENTE UNO DE OTRO,UN ATOMO DE NITROGENO O UN GRUPO C(R6), CORRESPONDIENDO UNO AL MENOS A UN ATOMO DE NITROGENO Y CORRESPONDIENDO UNO AL MENOS A UN GRUPO C(R6); Z REPRESENTA O BIEN UNA AMINA CICLICA UNIDA POR EL ATOMO DE NITROGENO, O BIEN UNA AMINA ACILICA, UNIDA POR EL ATOMO DE NITROGENO, DE LA FORMULA NRARB; EN EL ESTADO DE BASE O DE SAL DE ADICION A UN ACIDO, ASI COMO EN EL ESTADO DE HIDRATO O DE SOLVATO. PROCEDIMIENTO PREPARACION Y APLICACION EN TERAPEUTICA.
PA20078764301A 2006-12-26 2007-12-26 Derivados de n-(amino-heteroaril)-1h-pirrolopiridin-2-carboxamidas, su preparacion y su aplicacion en terapeutica PA8764301A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0611353A FR2910473B1 (fr) 2006-12-26 2006-12-26 Derives de n-(amino-heteroaryl)-1h-pyrrolopyridine-2- carboxamides, leur preparation et leur application en therapeutique.

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US (3) US8153650B2 (es)
EP (1) EP2125811B1 (es)
JP (1) JP5284274B2 (es)
AR (1) AR064524A1 (es)
CL (1) CL2007003826A1 (es)
FR (1) FR2910473B1 (es)
PA (1) PA8764301A1 (es)
PE (1) PE20081549A1 (es)
TW (1) TW200835486A (es)
UY (1) UY30842A1 (es)
WO (1) WO2008093024A2 (es)

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Publication number Publication date
UY30842A1 (es) 2008-07-31
JP2010514742A (ja) 2010-05-06
US8716272B2 (en) 2014-05-06
FR2910473A1 (fr) 2008-06-27
WO2008093024A2 (fr) 2008-08-07
US20100041634A1 (en) 2010-02-18
TW200835486A (en) 2008-09-01
EP2125811A2 (fr) 2009-12-02
US8716273B2 (en) 2014-05-06
AR064524A1 (es) 2009-04-08
EP2125811B1 (fr) 2013-05-29
US20120142669A1 (en) 2012-06-07
PE20081549A1 (es) 2008-12-14
JP5284274B2 (ja) 2013-09-11
WO2008093024A3 (fr) 2008-10-02
FR2910473B1 (fr) 2009-02-13
US20120142670A1 (en) 2012-06-07
US8153650B2 (en) 2012-04-10
CL2007003826A1 (es) 2009-01-23

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