PA8457001A1 - Derivados del 2-(4-aril o heteroaril-piperazin-i-ilmetil)-1h-indol - Google Patents
Derivados del 2-(4-aril o heteroaril-piperazin-i-ilmetil)-1h-indolInfo
- Publication number
- PA8457001A1 PA8457001A1 PA19988457001A PA8457001A PA8457001A1 PA 8457001 A1 PA8457001 A1 PA 8457001A1 PA 19988457001 A PA19988457001 A PA 19988457001A PA 8457001 A PA8457001 A PA 8457001A PA 8457001 A1 PA8457001 A1 PA 8457001A1
- Authority
- PA
- Panama
- Prior art keywords
- ilmetil
- heteroaril
- aril
- piperazin
- indol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
LA PRESENTE INVENCION SE REFIERE A LOS DERIVADOS 2-(4-ARIL O HETEROARIL-PIPERAZIN-1-ILMETIL)-1H-INDOL QUE POSEEN ACTIVIDAD DOPAMINERGICA CENTRAL. TALES COMPUESTOS SON UTILES EN EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL(SNC). ESTA INVENCION TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE USO DE DICHOS COMPUESTOS EN EL TRATAMIENTO DE LOS TRASTORNOS ANTERIORES EN MAMIFEROS, ESPECIALMENTE EN HUMANOS Y LAS COMPOSICIONES FARMACEUTICAS UTILES DE LAS MISMAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5576497P | 1997-08-15 | 1997-08-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
PA8457001A1 true PA8457001A1 (es) | 2000-09-29 |
Family
ID=22000003
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PA19988457001A PA8457001A1 (es) | 1997-08-15 | 1998-08-10 | Derivados del 2-(4-aril o heteroaril-piperazin-i-ilmetil)-1h-indol |
Country Status (30)
Country | Link |
---|---|
EP (1) | EP1003739A2 (es) |
JP (1) | JP2002536291A (es) |
KR (1) | KR20010022507A (es) |
CN (1) | CN1265660A (es) |
AP (1) | AP9801321A0 (es) |
AR (1) | AR017019A1 (es) |
AU (1) | AU8457298A (es) |
BG (1) | BG104069A (es) |
BR (1) | BR9811557A (es) |
CA (1) | CA2297486C (es) |
CO (1) | CO4960656A1 (es) |
DZ (1) | DZ2583A1 (es) |
EA (1) | EA200000023A1 (es) |
HR (1) | HRP980441A2 (es) |
HU (1) | HUP0003425A3 (es) |
ID (1) | ID23803A (es) |
IL (1) | IL133960A0 (es) |
IS (1) | IS5336A (es) |
MA (1) | MA24632A1 (es) |
NO (1) | NO20000722D0 (es) |
OA (1) | OA11286A (es) |
PA (1) | PA8457001A1 (es) |
PE (1) | PE106299A1 (es) |
PL (1) | PL338947A1 (es) |
SK (1) | SK1352000A3 (es) |
TN (1) | TNSN98151A1 (es) |
TR (1) | TR200000414T2 (es) |
UY (1) | UY25144A1 (es) |
WO (1) | WO1999009025A2 (es) |
ZA (1) | ZA987304B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2205179C2 (ru) * | 1997-10-27 | 2003-05-27 | НьюроСёрч А/С | Производное гомопиперазина и фармацевтическая композиция |
EP0953567A3 (en) | 1998-04-29 | 2003-04-02 | Pfizer Products Inc. | Bicyclic substituted piperazine-, piperidine- and tetrahydropyridine derivatives, their preparation and their use as agents with central dopaminergic (dopamine D4 receptor) activity |
DK1464641T3 (da) | 1999-12-30 | 2008-08-18 | Lundbeck & Co As H | 4-phenylpiperazinyl-, -piperidinyl- og -tetrahydropyridylderivater som dopamin-D4-antagonister |
GB0017952D0 (en) * | 2000-07-22 | 2000-09-13 | Univ Manchester | Treatment of dyskinesia |
EP1177792A3 (en) | 2000-07-27 | 2002-10-23 | Pfizer Products Inc. | Dopamine D4 Ligands for the treatment of novelty-seeking disorders |
WO2002072548A2 (en) * | 2001-03-09 | 2002-09-19 | Ortho-Mcneil Pharmaceutical, Inc. | Heterocyclic compounds and their use as histamine h4 ligands. |
RU2005106274A (ru) | 2002-09-06 | 2005-11-10 | Янссен Фармацевтика, Н.В. (Be) | Гетероциклические соединения |
WO2004108671A1 (en) * | 2003-06-06 | 2004-12-16 | Suven Life Sciences Limited | Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them |
EP2253315A1 (en) | 2004-03-30 | 2010-11-24 | Takeda Pharmaceutical Company Limited | Alkoxyphenylpropanoic acid derivatives |
US7618980B2 (en) | 2004-07-14 | 2009-11-17 | Bristol-Myers Squibb Company | Pyrrolo(oxo)quinolines as 5HT ligands |
US7572805B2 (en) | 2004-07-14 | 2009-08-11 | Bristol-Myers Squibb Company | Pyrrolo(oxo)isoquinolines as 5HT ligands |
JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
JO2642B1 (en) | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
JO2849B1 (en) * | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
US8906921B2 (en) | 2007-04-23 | 2014-12-09 | Janssen Pharmaceutica Nv | 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists |
ES2400710T3 (es) | 2007-04-23 | 2013-04-11 | Janssen Pharmaceutica, N.V. | Tia(dia)zoles como antagonistas del receptor de dopamina 2 de disociación rápida |
WO2010000456A1 (en) | 2008-07-03 | 2010-01-07 | Janssen Pharmaceutica Nv | Substituted 6- (1-piperazinyl) -pyridazines as 5-ht6 receptor antagonists |
EA019048B1 (ru) | 2008-07-31 | 2013-12-30 | Янссен Фармацевтика Нв | Пиперазин-1-илтрифторметилзамещенные пиридины в качестве быстро диссоциирующихся антагонистов d-рецепторов дофамина |
CN109843872B (zh) * | 2017-09-20 | 2022-08-30 | 杭州英创医药科技有限公司 | 作为ido抑制剂和/或ido-hdac双重抑制剂的多环化合物 |
CA3171950A1 (en) * | 2020-04-22 | 2021-10-28 | David William Sheppard | Collagen 1 translation inhibitors and methods of use thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB944443A (es) * | 1959-09-25 | 1900-01-01 | ||
WO1993001181A1 (en) * | 1991-07-03 | 1993-01-21 | The Upjohn Company | Substituted indoles as anti-aids pharmaceuticals |
JPH05255089A (ja) * | 1991-12-18 | 1993-10-05 | Sanwa Kagaku Kenkyusho Co Ltd | 抗ウイルス剤 |
CA2146018A1 (en) * | 1992-10-23 | 1994-05-11 | Paul David Leeson | Dopamine receptor subtype ligands |
GB9305644D0 (en) * | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
US5576336A (en) * | 1993-03-18 | 1996-11-19 | Merck Sharp & Dohme Limited | Indole derivatives as dopamine D4 antagonists |
US5814644A (en) * | 1993-04-15 | 1998-09-29 | Merck Sharp & Dohme, Ltd. | Indole derivatives as dopamine D4 antagonists |
DE4414113A1 (de) * | 1994-04-22 | 1995-10-26 | Merck Patent Gmbh | 3-Indolylpiperidine |
TW406075B (en) * | 1994-12-13 | 2000-09-21 | Upjohn Co | Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds |
ZA968661B (en) * | 1995-11-17 | 1998-04-14 | Upjohn Co | Oxazolidinone antibacterial agent with tricyclic substituents. |
TW504510B (en) * | 1996-05-10 | 2002-10-01 | Janssen Pharmaceutica Nv | 2,4-diaminopyrimidine derivatives |
-
1998
- 1998-08-05 AU AU84572/98A patent/AU8457298A/en not_active Abandoned
- 1998-08-05 IL IL13396098A patent/IL133960A0/xx unknown
- 1998-08-05 CA CA002297486A patent/CA2297486C/en not_active Expired - Fee Related
- 1998-08-05 AP APAP/P/1998/001321A patent/AP9801321A0/en unknown
- 1998-08-05 JP JP2000509706A patent/JP2002536291A/ja active Pending
- 1998-08-05 BR BR9811557-0A patent/BR9811557A/pt not_active IP Right Cessation
- 1998-08-05 PL PL98338947A patent/PL338947A1/xx unknown
- 1998-08-05 TR TR2000/00414T patent/TR200000414T2/xx unknown
- 1998-08-05 WO PCT/IB1998/001198 patent/WO1999009025A2/en not_active Application Discontinuation
- 1998-08-05 ID IDW20000197A patent/ID23803A/id unknown
- 1998-08-05 KR KR1020007001093A patent/KR20010022507A/ko not_active Application Discontinuation
- 1998-08-05 SK SK135-2000A patent/SK1352000A3/sk unknown
- 1998-08-05 EP EP98935229A patent/EP1003739A2/en not_active Withdrawn
- 1998-08-05 EA EA200000023A patent/EA200000023A1/ru unknown
- 1998-08-05 CN CN98807831A patent/CN1265660A/zh active Pending
- 1998-08-05 HU HU0003425A patent/HUP0003425A3/hu unknown
- 1998-08-10 PA PA19988457001A patent/PA8457001A1/es unknown
- 1998-08-10 PE PE1998000717A patent/PE106299A1/es not_active Application Discontinuation
- 1998-08-12 TN TNTNSN98151A patent/TNSN98151A1/fr unknown
- 1998-08-12 MA MA25210A patent/MA24632A1/fr unknown
- 1998-08-12 DZ DZ980193A patent/DZ2583A1/xx active
- 1998-08-13 AR ARP980104021A patent/AR017019A1/es unknown
- 1998-08-14 CO CO98046788A patent/CO4960656A1/es unknown
- 1998-08-14 HR HR60/055,764A patent/HRP980441A2/hr not_active Application Discontinuation
- 1998-08-14 ZA ZA9807304A patent/ZA987304B/xx unknown
- 1998-08-17 UY UY25144A patent/UY25144A1/es not_active Application Discontinuation
-
2000
- 2000-01-10 BG BG104069A patent/BG104069A/xx unknown
- 2000-01-11 IS IS5336A patent/IS5336A/is unknown
- 2000-02-08 OA OA1200000030A patent/OA11286A/en unknown
- 2000-02-14 NO NO20000722A patent/NO20000722D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MA24632A1 (fr) | 1999-04-01 |
PL338947A1 (en) | 2000-12-04 |
EA200000023A1 (ru) | 2000-08-28 |
ZA987304B (en) | 2000-02-14 |
ID23803A (id) | 2000-05-11 |
CA2297486A1 (en) | 1999-02-25 |
NO20000722L (no) | 2000-02-14 |
OA11286A (en) | 2003-10-22 |
KR20010022507A (ko) | 2001-03-15 |
SK1352000A3 (en) | 2000-08-14 |
NO20000722D0 (no) | 2000-02-14 |
BG104069A (en) | 2001-05-31 |
HUP0003425A3 (en) | 2002-02-28 |
AP9801321A0 (en) | 2000-02-14 |
WO1999009025A3 (en) | 1999-04-15 |
EP1003739A2 (en) | 2000-05-31 |
PE106299A1 (es) | 1999-11-02 |
HRP980441A2 (en) | 1999-04-30 |
IS5336A (is) | 2000-01-11 |
AU8457298A (en) | 1999-03-08 |
TR200000414T2 (tr) | 2000-08-21 |
JP2002536291A (ja) | 2002-10-29 |
CN1265660A (zh) | 2000-09-06 |
UY25144A1 (es) | 2000-12-29 |
CA2297486C (en) | 2005-05-03 |
AR017019A1 (es) | 2001-08-22 |
TNSN98151A1 (fr) | 2005-03-15 |
IL133960A0 (en) | 2001-04-30 |
DZ2583A1 (fr) | 2003-02-22 |
CO4960656A1 (es) | 2000-09-25 |
WO1999009025A2 (en) | 1999-02-25 |
HUP0003425A2 (hu) | 2001-10-28 |
BR9811557A (pt) | 2000-08-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PA8457001A1 (es) | Derivados del 2-(4-aril o heteroaril-piperazin-i-ilmetil)-1h-indol | |
SV1998000029A (es) | Compuestos de pirazina ref. pg3186 | |
ES2145774T3 (es) | Derivados de adenosina que tienen actividad agonista en a2. | |
CO4930259A1 (es) | Derivados 6,6-heterobiciclicos sustituidos y composiciones farmaceuticas que los contienen | |
ES2071486T3 (es) | Derivado de la 5h-pirrolo(3,4-b)pirazina opticamente activa, su preparacion y las composiciones farmaceuticas que le contienen. | |
AR002705A1 (es) | Un nuevo compuesto de indolina, un proceso para su preparacion y composiciones farmaceuticas que lo contienen. | |
PT960107E (pt) | Compostos de paclitaxel 6-tio-substituidos | |
GT199700095A (es) | Derivados 6,5-heterobiciclicos sustituidos. | |
CR20110095A (es) | Derivados biciclicos [3.1.0] como inhibidores del transportador de glicina (divisional solicitud 8333) | |
GT199900070A (es) | Derivados de isotiazol, utiles como agentes anticancerosos. | |
CO4560552A1 (es) | Antagonistas de receptores de taquicininas no peptidicos | |
CR20120009A (es) | 2-indolinonas sustituidas con pirrolos inhibidores de proteinquinasas (divisional exp. 6728) | |
PA8442201A1 (es) | Derivados de 6-fenilpiridil-2-amina | |
PT639577E (pt) | Eteres fosfono-oximetilicos ou metiltiometilicos de derivados do taxano como agentes anti-tumor | |
PA8462401A1 (es) | Derivados de la tienopirimidina y de la tienopiridina utiles como agentes anticancerigenos | |
DK0556332T3 (da) | Substituerede tetrahydropyridiner og hydroxypiperidiner som midler til behandling af centralnervesystemet | |
ES2121949T3 (es) | Derivados de benceno 1,2,4-trioxigenados utiles como antagonistas de leucotrienos. | |
DK1032556T3 (da) | Farmaceutisk aktive forbindelser og anvendelsesfremgangsmåder | |
ES2067874T3 (es) | Derivados de acetamida. | |
ES2189956T3 (es) | Derivados de quinolina, procedimientos para su preparacion y su uso como medicamentos. | |
MX9305510A (es) | Compuestos para el tratamiento o profilaxis de desordenes gastrointestinales, cardiovasculares y del sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. | |
ES2149504T3 (es) | Imidazo(1,2-a)quinoxalin-4-aminas activas como antagonistas de la adenosina, procedimiento para su preparacion y composiciones farmaceuticas de las mismas. | |
HUP0100611A2 (hu) | Triazin vegyületek, és ilyeneket tartalmazó gyógyszerkészítmények a központi idegrendszer elváltozásainak kezelésére | |
ES2140672T3 (es) | Compuestos biciclicos sustituidos, fusionados y puentes utilizados como agentes terapeuticos. | |
GT199900078A (es) | 2-aminopiridinas que contienen sustituyentes de anillos condensados. |