DK1464641T3 - 4-phenylpiperazinyl-, -piperidinyl- og -tetrahydropyridylderivater som dopamin-D4-antagonister - Google Patents

4-phenylpiperazinyl-, -piperidinyl- og -tetrahydropyridylderivater som dopamin-D4-antagonister

Info

Publication number: DK1464641T3
Authority: DK; Denmark
Prior art keywords: phenylpiperazinyl; dopamine; piperidinyl; antagonists; tetrahydropyridyl
Prior art date: 1999-12-30

Application number

DK04007739T

Other languages

English (en)

Inventor

Benny Bang-Andersen

Jan Kehler

Jakob Felding

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-30

Filing date

2000-12-22

Publication date

2008-08-18

2000-12-22 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

2008-08-18 Application granted granted Critical

2008-08-18 Publication of DK1464641T3 publication Critical patent/DK1464641T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings

DK04007739T 1999-12-30 2000-12-22 4-phenylpiperazinyl-, -piperidinyl- og -tetrahydropyridylderivater som dopamin-D4-antagonister DK1464641T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DKPA199901887		1999-12-30
PCT/DK2000/000728 WO2001049679A1 (en)	1999-12-30	2000-12-22	4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives

Publications (1)

Publication Number	Publication Date
DK1464641T3 true DK1464641T3 (da)	2008-08-18

Family

ID=8108820

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK00984931T DK1246817T3 (da)	1999-12-30	2000-12-22	4-Phenyl-1-piperazinyl, -piperidinyl og - tetrahydropyridyl derivater
DK04007739T DK1464641T3 (da)	1999-12-30	2000-12-22	4-phenylpiperazinyl-, -piperidinyl- og -tetrahydropyridylderivater som dopamin-D4-antagonister

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK00984931T DK1246817T3 (da)	1999-12-30	2000-12-22	4-Phenyl-1-piperazinyl, -piperidinyl og - tetrahydropyridyl derivater

Country Status (32)

Country	Link
US (2)	US7074796B2 (da)
EP (2)	EP1246817B1 (da)
JP (1)	JP2003519225A (da)
KR (2)	KR100729536B1 (da)
CN (2)	CN1244577C (da)
AR (1)	AR029461A1 (da)
AT (2)	ATE395333T1 (da)
AU (2)	AU783786B2 (da)
BG (1)	BG106960A (da)
BR (1)	BR0016953A (da)
CA (1)	CA2395869C (da)
CZ (1)	CZ20022603A3 (da)
DE (2)	DE60038911D1 (da)
DK (2)	DK1246817T3 (da)
EA (2)	EA008627B1 (da)
ES (2)	ES2223628T3 (da)
HK (1)	HK1055960A1 (da)
HR (1)	HRP20020567A2 (da)
HU (1)	HUP0203839A3 (da)
IL (3)	IL150366A0 (da)
IS (1)	IS6432A (da)
MX (1)	MXPA02006590A (da)
NO (2)	NO323401B1 (da)
NZ (2)	NZ530137A (da)
PL (1)	PL355502A1 (da)
PT (2)	PT1464641E (da)
SG (1)	SG152900A1 (da)
SK (1)	SK11072002A3 (da)
TR (2)	TR200402408T4 (da)
UA (1)	UA73756C2 (da)
WO (1)	WO2001049679A1 (da)
ZA (1)	ZA200205019B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2001250404A1 (en) *	2000-03-27	2001-10-08	Basf Aktiengesellschaft	Use of dopamine-d3 receptor ligands for the treatment of diseases of the central nervous system
GB0117577D0 (en) *	2001-02-16	2001-09-12	Aventis Pharm Prod Inc	Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands
FR2831166B1 (fr)	2001-10-18	2004-02-27	Sanofi Synthelabo	Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant
ES2251624T3 (es)	2001-12-28	2006-05-01	Acadia Pharmaceuticals Inc.	Analogos de la tetrahidroquinolina como los agonistas muscarinicos.
US7550459B2 (en)	2001-12-28	2009-06-23	Acadia Pharmaceuticals, Inc.	Tetrahydroquinoline analogues as muscarinic agonists
PL1701940T3 (pl)	2003-12-23	2008-11-28	H Lundbeck As	Pochodne 2-(1H-indolilosulfanylo)benzyloaminy jako SSRI
DE102004027358A1 (de) *	2004-06-04	2005-12-29	Abbott Gmbh & Co. Kg	Pyrimidinverbindungen und ihre Verwendung
AR052308A1 (es)	2004-07-16	2007-03-14	Lundbeck & Co As H	Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto
FR2878524B1 (fr) *	2004-12-01	2007-01-19	Bioprojet Soc Civ Ile	Nouveaux derives d'arylpiperazine
US7629473B2 (en)	2005-06-17	2009-12-08	H. Lundbeck A/S	2-(1H-indolylsulfanyl)-aryl amine derivatives
AR054393A1 (es)	2005-06-17	2007-06-20	Lundbeck & Co As H	Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos.
EP1870405A1 (en) *	2006-06-22	2007-12-26	Bioprojet	Carbonylated (Aza)cyclohexanes as dopamine D3 receptor ligands
US9598401B2 (en)	2013-07-29	2017-03-21	Sunshine Lake Pharma Co., Ltd.	Substituted heteroaryl compounds and methods of use thereof
US9714232B2 (en)	2013-12-20	2017-07-25	Sunshine Lake Pharma Co., Ltd.	Substituted piperazine compounds and methods of use thereof
WO2016192657A1 (en)	2015-06-03	2016-12-08	Sunshine Lake Pharma Co., Ltd.	Substituted piperazine compounds and methods of use and use thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB944443A (da) *	1959-09-25	1900-01-01
US3468882A (en) *	1966-10-07	1969-09-23	Sterling Drug Inc	Phenylhydrazone derivatives as intermediates for preparing indoles
DE2138865A1 (de) *	1970-08-15	1973-02-22	Sumitomo Chemical Co	3-indolylpiperazine, verfahren zu ihrer herstellung und arzneimittel
FR2635104B1 (fr) *	1988-08-03	1992-04-30	Synthelabo	Derives d'indolone, leur preparation et leur application en therapeutique
US4950664A (en) *	1988-09-16	1990-08-21	Rugby-Darby Group Companies, Inc.	Nasal administration of benzodiazepine hypnotics
DE4101686A1 (de) *	1991-01-22	1992-07-23	Merck Patent Gmbh	Indolderivate
US5556857A (en) *	1991-05-08	1996-09-17	Otsuka Pharmaceutical Co., Ltd.	Disturbance-of-consciousness improving agent
IT1255178B (it) *	1992-06-26	1995-10-20	Pierrel Spa	N(eter0)-aril-n(etero)-tetralinalchil piperazine aventi attivita' serotoninergica,dopaminergica e adrenergica
WO1994024105A1 (en) *	1993-04-15	1994-10-27	Merck Sharp & Dohme Limited	Indole derivatives as dopamine d4 antagonists
DK0639374T3 (da) *	1993-06-28	2002-05-06	American Home Prod	Nye behandlingsmetoder ved anvendelse af phenethylderivater
EP0796251B1 (de) *	1994-12-07	2001-10-17	Byk Gulden Lomberg Chemische Fabrik GmbH	Uracilderivate
WO1998008816A1 (fr) *	1996-08-26	1998-03-05	Meiji Seika Kaisha, Ltd.	Derives d'indoxyle et psychotropes
WO1999009025A2 (en) *	1997-08-15	1999-02-25	Pfizer Products Inc.	2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1h-indole derivatives interacting with the dopamine d4 receptor
US6355644B1 (en) *	1999-06-14	2002-03-12	Neurogen Corporation	Benzylpiperazinyl-indolinylethanones
US6376514B1 (en) *	2000-10-17	2002-04-23	The Procter & Gamble Co.	Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
TW580446B (en) *	2003-05-15	2004-03-21	Benq Corp	Color electrode array printer

2000
- 2000-12-22 CN CNB00819145XA patent/CN1244577C/zh not_active Expired - Fee Related
- 2000-12-22 DK DK00984931T patent/DK1246817T3/da active
- 2000-12-22 JP JP2001550219A patent/JP2003519225A/ja active Pending
- 2000-12-22 ES ES00984931T patent/ES2223628T3/es not_active Expired - Lifetime
- 2000-12-22 HU HU0203839A patent/HUP0203839A3/hu unknown
- 2000-12-22 NZ NZ530137A patent/NZ530137A/en unknown
- 2000-12-22 ES ES04007739T patent/ES2302992T3/es not_active Expired - Lifetime
- 2000-12-22 EA EA200400641A patent/EA008627B1/ru not_active IP Right Cessation
- 2000-12-22 UA UA2002065264A patent/UA73756C2/uk unknown
- 2000-12-22 CZ CZ20022603A patent/CZ20022603A3/cs unknown
- 2000-12-22 NZ NZ519740A patent/NZ519740A/en unknown
- 2000-12-22 DK DK04007739T patent/DK1464641T3/da active
- 2000-12-22 PT PT04007739T patent/PT1464641E/pt unknown
- 2000-12-22 SG SG200405552-1A patent/SG152900A1/en unknown
- 2000-12-22 PL PL00355502A patent/PL355502A1/xx not_active IP Right Cessation
- 2000-12-22 EA EA200200729A patent/EA005013B1/ru not_active IP Right Cessation
- 2000-12-22 CN CNA2005101310970A patent/CN1803784A/zh active Pending
- 2000-12-22 EP EP00984931A patent/EP1246817B1/en not_active Expired - Lifetime
- 2000-12-22 PT PT00984931T patent/PT1246817E/pt unknown
- 2000-12-22 AU AU21527/01A patent/AU783786B2/en not_active Ceased
- 2000-12-22 MX MXPA02006590A patent/MXPA02006590A/es active IP Right Grant
- 2000-12-22 AT AT04007739T patent/ATE395333T1/de not_active IP Right Cessation
- 2000-12-22 KR KR1020027008576A patent/KR100729536B1/ko not_active IP Right Cessation
- 2000-12-22 BR BR0016953-6A patent/BR0016953A/pt not_active Application Discontinuation
- 2000-12-22 KR KR1020077000879A patent/KR100792186B1/ko not_active IP Right Cessation
- 2000-12-22 TR TR2004/02408T patent/TR200402408T4/xx unknown
- 2000-12-22 IL IL15036600A patent/IL150366A0/xx active IP Right Grant
- 2000-12-22 CA CA002395869A patent/CA2395869C/en not_active Expired - Fee Related
- 2000-12-22 TR TR2002/01690T patent/TR200201690T2/xx unknown
- 2000-12-22 AT AT00984931T patent/ATE269857T1/de not_active IP Right Cessation
- 2000-12-22 DE DE60038911T patent/DE60038911D1/de not_active Expired - Fee Related
- 2000-12-22 SK SK1107-2002A patent/SK11072002A3/sk unknown
- 2000-12-22 DE DE60011817T patent/DE60011817T2/de not_active Expired - Fee Related
- 2000-12-22 EP EP04007739A patent/EP1464641B1/en not_active Expired - Lifetime
- 2000-12-22 WO PCT/DK2000/000728 patent/WO2001049679A1/en active Application Filing
- 2000-12-28 AR ARP000106991A patent/AR029461A1/es not_active Application Discontinuation
2002
- 2002-06-19 IS IS6432A patent/IS6432A/is unknown
- 2002-06-21 ZA ZA200205019A patent/ZA200205019B/en unknown
- 2002-06-23 IL IL150366A patent/IL150366A/en not_active IP Right Cessation
- 2002-06-27 US US10/186,339 patent/US7074796B2/en not_active Expired - Fee Related
- 2002-06-28 NO NO20023151A patent/NO323401B1/no unknown
- 2002-07-03 HR HR20020567A patent/HRP20020567A2/hr not_active Application Discontinuation
- 2002-07-26 BG BG106960A patent/BG106960A/bg unknown
2003
- 2003-11-13 HK HK03108252A patent/HK1055960A1/xx unknown
2006
- 2006-03-08 AU AU2006201000A patent/AU2006201000A1/en not_active Abandoned
- 2006-03-15 US US11/377,772 patent/US7223765B2/en not_active Expired - Fee Related
- 2006-12-14 NO NO20065681A patent/NO20065681L/no not_active Application Discontinuation
2007
- 2007-10-25 IL IL186954A patent/IL186954A0/en unknown

Also Published As

Publication number	Publication date
KR20070014234A (ko)	2007-01-31
MXPA02006590A (es)	2002-12-13
CZ20022603A3 (cs)	2002-10-16
EA005013B1 (ru)	2004-10-28
AR029461A1 (es)	2003-07-02
US20030027832A1 (en)	2003-02-06
DE60011817D1 (de)	2004-07-29
IL150366A0 (en)	2002-12-01
ES2302992T3 (es)	2008-08-01
CN1244577C (zh)	2006-03-08
NZ519740A (en)	2004-03-26
US7223765B2 (en)	2007-05-29
KR100792186B1 (ko)	2008-01-08
WO2001049679A1 (en)	2001-07-12
AU2152701A (en)	2001-07-16
ATE395333T1 (de)	2008-05-15
PT1464641E (pt)	2008-07-01
IL150366A (en)	2008-06-05
AU2006201000A1 (en)	2006-04-06
EP1464641B1 (en)	2008-05-14
ES2223628T3 (es)	2005-03-01
US20060148815A1 (en)	2006-07-06
CN1803784A (zh)	2006-07-19
EP1246817A1 (en)	2002-10-09
PT1246817E (pt)	2004-11-30
NO323401B1 (no)	2007-04-23
ZA200205019B (en)	2003-09-22
CA2395869C (en)	2006-07-25
ATE269857T1 (de)	2004-07-15
NZ530137A (en)	2005-09-30
NO20023151D0 (no)	2002-06-28
HRP20020567A2 (en)	2005-04-30
EP1464641A1 (en)	2004-10-06
NO20065681L (no)	2002-08-02
TR200402408T4 (tr)	2004-12-21
IS6432A (is)	2002-06-19
EA008627B1 (ru)	2007-06-29
SG152900A1 (en)	2009-06-29
CA2395869A1 (en)	2001-07-12
HUP0203839A3 (en)	2004-07-28
CN1434819A (zh)	2003-08-06
EA200400641A1 (ru)	2004-10-28
KR20020063285A (ko)	2002-08-01
PL355502A1 (en)	2004-05-04
IL186954A0 (en)	2009-02-11
HUP0203839A2 (hu)	2003-02-28
EA200200729A1 (ru)	2002-12-26
DK1246817T3 (da)	2004-10-18
JP2003519225A (ja)	2003-06-17
EP1246817B1 (en)	2004-06-23
AU783786B2 (en)	2005-12-08
BG106960A (bg)	2003-04-30
TR200201690T2 (tr)	2002-11-21
BR0016953A (pt)	2003-02-25
NO20023151L (no)	2002-08-02
DE60038911D1 (de)	2008-06-26
DE60011817T2 (de)	2005-07-14
UA73756C2 (en)	2005-09-15
SK11072002A3 (sk)	2003-03-04
US7074796B2 (en)	2006-07-11
HK1055960A1 (en)	2004-01-30
KR100729536B1 (ko)	2007-06-18

Publication	Publication Date	Title
FR18C1024I2 (fr)	2019-05-17	Derives d'heterocyclocarboxamide
NO20013809L (no)	2001-10-02	Indolderivater og anvendelse derav som MCP-1 antagonister
IS7667A (is)	2005-01-27	Nýjar bensimídazólafleiður
NO20015366L (no)	2002-01-03	Piperazinderivater som er anvendbare som CCR5-antagonister
NO20025978L (no)	2002-12-12	Benzotiazol-derivater
EE200100492A (et)	2002-12-16	Ensüümi IMPDH inhibiitorid
NO20034439L (no)	2003-12-02	Benzamidinderivater
NO20013666L (no)	2001-09-26	Heterocykliske peptidylketoner med anvendelse som tryptase- inhibitorer
DK1272468T3 (da)	2005-03-29	Indolin-2-on-derivater og deres anvendelse som ligander for oxytocinreceptorerne
NO20021459D0 (no)	2002-03-22	Piperazin-derivater som 5-HT1B-antagonister
NO20041235L (no)	2004-03-24	Kinolinderivater som neuropeptid Y antagonister
ATE386518T1 (de)	2008-03-15	Benzimidazolderivate
DK1464641T3 (da)	2008-08-18	4-phenylpiperazinyl-, -piperidinyl- og -tetrahydropyridylderivater som dopamin-D4-antagonister
PT1237857E (pt)	2004-10-29	Novos derivados fenalquiloxi-fenilo
NO20015897L (no)	2001-12-03	Indolylpiperidinderivater som antihistaminiske og antiallergiske midler
DK1216250T3 (da)	2004-02-23	Thienoisoxazolyl- og thienylpyrazolyl-phenoxy- substituerede propylderivater som D4-antagonister
DK1231211T3 (da)	2003-10-27	Thiazolidindion-derivater som antidiabetika
IS6434A (is)	2002-06-19	Nýjar indól afleiður
DK1173436T3 (da)	2004-09-27	Thiazolidindionderivat og anvendelse deraf som antidiabetikum
SE514398E (sv)	2001-02-19	Förfarande vid spetsdragning
DE50001813D1 (de)	2003-05-22	Substituierte benzoxazole
IS2431B (is)	2008-10-15	Nýjar indólafleiður
DE60118970D1 (de)	2006-05-24	Indol- und dihydroindolderivate
NO20021249L (no)	2002-05-10	Tienoisoksazolfenoksyusubstituerte etyl- og propylderivater anvendbare som D4antagonister
DE29908682U1 (de)	1999-08-05	Bohrständer