CA2297486A1 - 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1h-indole derivatives interacting with the dopamine d4 receptor - Google Patents
2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1h-indole derivatives interacting with the dopamine d4 receptor Download PDFInfo
- Publication number
- CA2297486A1 CA2297486A1 CA002297486A CA2297486A CA2297486A1 CA 2297486 A1 CA2297486 A1 CA 2297486A1 CA 002297486 A CA002297486 A CA 002297486A CA 2297486 A CA2297486 A CA 2297486A CA 2297486 A1 CA2297486 A1 CA 2297486A1
- Authority
- CA
- Canada
- Prior art keywords
- piperazin
- ylmethyl
- heteroaryl
- receptor
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000003962 Dopamine D4 receptors Human genes 0.000 title 1
- 108090000357 Dopamine D4 receptors Proteins 0.000 title 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Ophthalmology & Optometry (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
2(4-Aryl or Heteroaryl-piperazin-1-ylmethyl)-1H-Indole derivatives of formula (I) wherein a, T, V, X, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined above, their pharmaceutically acceptable salts and pharmaceutical compositions containing such compounds or their salts interacting with the dopamin D4 receptor.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5576497P | 1997-08-15 | 1997-08-15 | |
US60/055,764 | 1997-08-15 | ||
PCT/IB1998/001198 WO1999009025A2 (en) | 1997-08-15 | 1998-08-05 | 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1h-indole derivatives interacting with the dopamine d4 receptor |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2297486A1 true CA2297486A1 (en) | 1999-02-25 |
CA2297486C CA2297486C (en) | 2005-05-03 |
Family
ID=22000003
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002297486A Expired - Fee Related CA2297486C (en) | 1997-08-15 | 1998-08-05 | 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1h-indole derivatives interacting with the dopamine d4 receptor |
Country Status (30)
Country | Link |
---|---|
EP (1) | EP1003739A2 (en) |
JP (1) | JP2002536291A (en) |
KR (1) | KR20010022507A (en) |
CN (1) | CN1265660A (en) |
AP (1) | AP9801321A0 (en) |
AR (1) | AR017019A1 (en) |
AU (1) | AU8457298A (en) |
BG (1) | BG104069A (en) |
BR (1) | BR9811557A (en) |
CA (1) | CA2297486C (en) |
CO (1) | CO4960656A1 (en) |
DZ (1) | DZ2583A1 (en) |
EA (1) | EA200000023A1 (en) |
HR (1) | HRP980441A2 (en) |
HU (1) | HUP0003425A3 (en) |
ID (1) | ID23803A (en) |
IL (1) | IL133960A0 (en) |
IS (1) | IS5336A (en) |
MA (1) | MA24632A1 (en) |
NO (1) | NO20000722D0 (en) |
OA (1) | OA11286A (en) |
PA (1) | PA8457001A1 (en) |
PE (1) | PE106299A1 (en) |
PL (1) | PL338947A1 (en) |
SK (1) | SK1352000A3 (en) |
TN (1) | TNSN98151A1 (en) |
TR (1) | TR200000414T2 (en) |
UY (1) | UY25144A1 (en) |
WO (1) | WO1999009025A2 (en) |
ZA (1) | ZA987304B (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69826883T2 (en) * | 1997-10-27 | 2005-02-03 | Neurosearch A/S | HETEROARYL DIAZACYCLOALKANE AS CHOLINERGIC LIGAND FOR NICOTIN ACETYLCHOLINE RECEPTORS |
EP0953567A3 (en) * | 1998-04-29 | 2003-04-02 | Pfizer Products Inc. | Bicyclic substituted piperazine-, piperidine- and tetrahydropyridine derivatives, their preparation and their use as agents with central dopaminergic (dopamine D4 receptor) activity |
DK1246817T3 (en) | 1999-12-30 | 2004-10-18 | Lundbeck & Co As H | 4-Phenyl-1-piperazinyl, -piperidinyl and - tetrahydropyridyl derivatives |
GB0017952D0 (en) * | 2000-07-22 | 2000-09-13 | Univ Manchester | Treatment of dyskinesia |
EP1177792A3 (en) | 2000-07-27 | 2002-10-23 | Pfizer Products Inc. | Dopamine D4 Ligands for the treatment of novelty-seeking disorders |
AU2002336273A1 (en) | 2001-03-09 | 2002-09-24 | Ortho-Mcneil Pharmaceutical, Inc. | Heterocyclic compounds and their use as histamine h4 ligands. |
CN1694704A (en) | 2002-09-06 | 2005-11-09 | 詹森药业有限公司 | Use of (1H-benzimidazole-2-yl)-(piperazineyl)- ketaderavitive and correlative compound used as histamine H4 receptor antagonist for the treatment of allergy and asthma |
WO2004108671A1 (en) * | 2003-06-06 | 2004-12-16 | Suven Life Sciences Limited | Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them |
EP2253315A1 (en) | 2004-03-30 | 2010-11-24 | Takeda Pharmaceutical Company Limited | Alkoxyphenylpropanoic acid derivatives |
US7618980B2 (en) | 2004-07-14 | 2009-11-17 | Bristol-Myers Squibb Company | Pyrrolo(oxo)quinolines as 5HT ligands |
US7572805B2 (en) | 2004-07-14 | 2009-08-11 | Bristol-Myers Squibb Company | Pyrrolo(oxo)isoquinolines as 5HT ligands |
JO2769B1 (en) * | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Fast Dissociting Dopamine 2 Receptor Antagonists |
JO2642B1 (en) * | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Fast Dissociating Dopamine 2 Receptor Antagonists |
JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Fast -Dissociating Dopamine 2 Receptor Antagonists |
DK2148873T3 (en) | 2007-04-23 | 2012-11-26 | Janssen Pharmaceutica Nv | 4-ALKOXYPYRIDAZINE DERIVATIVES AS QUICK DISSOCATING DOPAMINE 2- RECEPTOR ANTAGONISTS |
EP2148879B1 (en) | 2007-04-23 | 2012-11-28 | Janssen Pharmaceutica, N.V. | Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists |
CN102159554B (en) | 2008-07-03 | 2014-09-24 | 詹森药业有限公司 | Substituted 6- (1-piperazinyl) -pyridazines as 5-ht6 receptor antagonists |
EA019048B1 (en) | 2008-07-31 | 2013-12-30 | Янссен Фармацевтика Нв | Piperazin-1-yl-trifluoromethyl-substituted pyridines as fast dissociating dopamine 2 receptor antagonists |
US11266640B2 (en) * | 2017-09-20 | 2022-03-08 | Hangzhou Innogate Pharma Co., Ltd. | Polycyclic compound acting as IDO inhibitor and/or IDO-HDAC dual inhibitor |
JP2023523176A (en) * | 2020-04-22 | 2023-06-02 | アニマ バイオテック インコーポレイテッド | COLLAGEN 1 TRANSLATION INHIBITOR AND METHOD OF USE THEREOF |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB944443A (en) * | 1959-09-25 | 1900-01-01 | ||
JP3119485B2 (en) * | 1991-07-03 | 2000-12-18 | ファルマシア・アンド・アップジョン・カンパニー | Substituted indoles as anti-AIDS drugs |
JPH05255089A (en) * | 1991-12-18 | 1993-10-05 | Sanwa Kagaku Kenkyusho Co Ltd | Antiviral agent |
WO1994010162A1 (en) * | 1992-10-23 | 1994-05-11 | Merck Sharp & Dohme Limited | Dopamine receptor subtype ligands |
AU6215594A (en) * | 1993-03-18 | 1994-10-11 | Merck Sharp & Dohme Limited | Indole derivatives as dopamine d4 antagonists |
GB9305644D0 (en) * | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
AU6435594A (en) * | 1993-04-15 | 1994-11-08 | Merck Sharp & Dohme Limited | Indole derivatives as dopamine d4 antagonists |
DE4414113A1 (en) * | 1994-04-22 | 1995-10-26 | Merck Patent Gmbh | 3-indolylpiperidines |
TW406075B (en) * | 1994-12-13 | 2000-09-21 | Upjohn Co | Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds |
ZA968661B (en) * | 1995-11-17 | 1998-04-14 | Upjohn Co | Oxazolidinone antibacterial agent with tricyclic substituents. |
TW504510B (en) * | 1996-05-10 | 2002-10-01 | Janssen Pharmaceutica Nv | 2,4-diaminopyrimidine derivatives |
-
1998
- 1998-08-05 BR BR9811557-0A patent/BR9811557A/en not_active IP Right Cessation
- 1998-08-05 HU HU0003425A patent/HUP0003425A3/en unknown
- 1998-08-05 EP EP98935229A patent/EP1003739A2/en not_active Withdrawn
- 1998-08-05 AP APAP/P/1998/001321A patent/AP9801321A0/en unknown
- 1998-08-05 SK SK135-2000A patent/SK1352000A3/en unknown
- 1998-08-05 WO PCT/IB1998/001198 patent/WO1999009025A2/en not_active Application Discontinuation
- 1998-08-05 PL PL98338947A patent/PL338947A1/en unknown
- 1998-08-05 CA CA002297486A patent/CA2297486C/en not_active Expired - Fee Related
- 1998-08-05 KR KR1020007001093A patent/KR20010022507A/en not_active Application Discontinuation
- 1998-08-05 JP JP2000509706A patent/JP2002536291A/en active Pending
- 1998-08-05 ID IDW20000197A patent/ID23803A/en unknown
- 1998-08-05 AU AU84572/98A patent/AU8457298A/en not_active Abandoned
- 1998-08-05 EA EA200000023A patent/EA200000023A1/en unknown
- 1998-08-05 CN CN98807831A patent/CN1265660A/en active Pending
- 1998-08-05 IL IL13396098A patent/IL133960A0/en unknown
- 1998-08-05 TR TR2000/00414T patent/TR200000414T2/en unknown
- 1998-08-10 PE PE1998000717A patent/PE106299A1/en not_active Application Discontinuation
- 1998-08-10 PA PA19988457001A patent/PA8457001A1/en unknown
- 1998-08-12 MA MA25210A patent/MA24632A1/en unknown
- 1998-08-12 DZ DZ980193A patent/DZ2583A1/en active
- 1998-08-12 TN TNTNSN98151A patent/TNSN98151A1/en unknown
- 1998-08-13 AR ARP980104021A patent/AR017019A1/en unknown
- 1998-08-14 HR HR60/055,764A patent/HRP980441A2/en not_active Application Discontinuation
- 1998-08-14 CO CO98046788A patent/CO4960656A1/en unknown
- 1998-08-14 ZA ZA9807304A patent/ZA987304B/en unknown
- 1998-08-17 UY UY25144A patent/UY25144A1/en not_active Application Discontinuation
-
2000
- 2000-01-10 BG BG104069A patent/BG104069A/en unknown
- 2000-01-11 IS IS5336A patent/IS5336A/en unknown
- 2000-02-08 OA OA1200000030A patent/OA11286A/en unknown
- 2000-02-14 NO NO20000722A patent/NO20000722D0/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CO4960656A1 (en) | 2000-09-25 |
HUP0003425A2 (en) | 2001-10-28 |
OA11286A (en) | 2003-10-22 |
IL133960A0 (en) | 2001-04-30 |
JP2002536291A (en) | 2002-10-29 |
SK1352000A3 (en) | 2000-08-14 |
HRP980441A2 (en) | 1999-04-30 |
HUP0003425A3 (en) | 2002-02-28 |
KR20010022507A (en) | 2001-03-15 |
UY25144A1 (en) | 2000-12-29 |
PA8457001A1 (en) | 2000-09-29 |
TNSN98151A1 (en) | 2005-03-15 |
NO20000722L (en) | 2000-02-14 |
MA24632A1 (en) | 1999-04-01 |
BR9811557A (en) | 2000-08-22 |
WO1999009025A3 (en) | 1999-04-15 |
PE106299A1 (en) | 1999-11-02 |
AP9801321A0 (en) | 2000-02-14 |
WO1999009025A2 (en) | 1999-02-25 |
EA200000023A1 (en) | 2000-08-28 |
TR200000414T2 (en) | 2000-08-21 |
PL338947A1 (en) | 2000-12-04 |
DZ2583A1 (en) | 2003-02-22 |
BG104069A (en) | 2001-05-31 |
CN1265660A (en) | 2000-09-06 |
ID23803A (en) | 2000-05-11 |
CA2297486C (en) | 2005-05-03 |
NO20000722D0 (en) | 2000-02-14 |
EP1003739A2 (en) | 2000-05-31 |
AR017019A1 (en) | 2001-08-22 |
AU8457298A (en) | 1999-03-08 |
IS5336A (en) | 2000-01-11 |
ZA987304B (en) | 2000-02-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2297486A1 (en) | 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1h-indole derivatives interacting with the dopamine d4 receptor | |
CA2105114A1 (en) | Monohydrate of 5-(2-(4-(1,2 Benzisothiazol-3-Yl)-1- Piperazinyl)-Ethyl)-6-Chloro-1,3-Dihydro-2H-Indol-2-One Hydrochloride | |
IL124537A0 (en) | Naphthyl-substituted benzimidazole derivatives and pharmaceutical compositions containing the same | |
CA2274669A1 (en) | 1,5-benzodiazepine derivatives | |
MX9602837A (en) | Cosmetic or pharmaceutical compositions containing mangiferin or derivatives thereof. | |
CA2317462A1 (en) | 4-(2-keto-1-benzimidazolinyl)piperidine compounds as orl1-receptor agonists | |
AU2420897A (en) | Meta-substituted phenylene sulphonamide derivatives | |
GEP20053474B (en) | Glucocorticoid Receptor Modulators | |
CA2166800A1 (en) | 4-substituted piperidine derivatives useful as neurokinin antagonists | |
AU1200695A (en) | 4,5-diaryloxazole derivatives | |
CA2373117A1 (en) | 13-methyl-erythromycin derivatives | |
GB9322643D0 (en) | Lactam derivatives | |
NO996108L (en) | 9 oksinerytromycinderivater | |
AU1247195A (en) | Cyclic amide derivatives as neurokinin a antagonists | |
CA2296637A1 (en) | Thermodynamically stable modification of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole, process for its preparation and pharmaceutical compositions containingit | |
CA2286511A1 (en) | Novel macrolide derivatives | |
CA2120028A1 (en) | Indol Derivatives for the Treatment of Migrane | |
IL117093A0 (en) | Heterocyclic derivatives | |
NZ240575A (en) | N-benzoylproline derivatives and pharmaceutical compositions | |
IL125982A0 (en) | 2-(arylphenyl) amino-imidazoline derivatives | |
CA2307581A1 (en) | Heterocyclic compounds having nos inhibiting action | |
EP0816366A4 (en) | Imidazothiazole compounds | |
WO2001004112A3 (en) | Benzofurane derivatives | |
CA2389156A1 (en) | Benzamidine derivatives | |
CA2245484A1 (en) | Novel urea derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |