PA8446901A1 - Atropisomeros de 3-heteroaril-4(3h)-quinazolinonas - Google Patents

Atropisomeros de 3-heteroaril-4(3h)-quinazolinonas

Info

Publication number
PA8446901A1
PA8446901A1 PA19988446901A PA8446901A PA8446901A1 PA 8446901 A1 PA8446901 A1 PA 8446901A1 PA 19988446901 A PA19988446901 A PA 19988446901A PA 8446901 A PA8446901 A PA 8446901A PA 8446901 A1 PA8446901 A1 PA 8446901A1
Authority
PA
Panama
Prior art keywords
heteroaril
quinazolinones
atropisomers
procedures
formula
Prior art date
Application number
PA19988446901A
Other languages
English (en)
Inventor
Bertrand Leo Chenard
Keith Michael Devries
Welch Jr Willard Mckowan
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PA8446901A1 publication Critical patent/PA8446901A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Abstract

LA PRESENTE INVENCION SE REFIERE A ATROPISOMEROS DE 3-HETEROARIL -4(3H)-QUINAZOLINONAS DE LA FORMULA IA; A SUS SALES FARMACEUTICAMENTE ACEPTABLES Y A COMPOSICIONES FARMACEUTICAS Y PROCEDIMIENTOS PARA EL TRATAMIENTO DE AFECCIONES NEURODEGENERATIVAS Y RELACIONADAS CON TRAUMAS DEL SNC.
PA19988446901A 1997-02-28 1998-02-17 Atropisomeros de 3-heteroaril-4(3h)-quinazolinonas PA8446901A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3854097P 1997-02-28 1997-02-28

Publications (1)

Publication Number Publication Date
PA8446901A1 true PA8446901A1 (es) 2000-05-24

Family

ID=21900535

Family Applications (1)

Application Number Title Priority Date Filing Date
PA19988446901A PA8446901A1 (es) 1997-02-28 1998-02-17 Atropisomeros de 3-heteroaril-4(3h)-quinazolinonas

Country Status (40)

Country Link
US (1) US6380204B1 (es)
EP (1) EP0964860B1 (es)
JP (1) JP3299990B2 (es)
KR (1) KR20000075812A (es)
CN (1) CN1248254A (es)
AP (1) AP9801202A0 (es)
AR (1) AR011886A1 (es)
AT (1) ATE264854T1 (es)
AU (1) AU732448B2 (es)
BG (1) BG103687A (es)
BR (1) BR9807807A (es)
CA (1) CA2282279C (es)
CO (1) CO4950615A1 (es)
DE (1) DE69823339T2 (es)
DK (1) DK0964860T3 (es)
DZ (1) DZ2438A1 (es)
EA (1) EA001961B1 (es)
ES (1) ES2218801T3 (es)
GT (1) GT199800039A (es)
HN (1) HN1998000028A (es)
HR (1) HRP980108B1 (es)
HU (1) HUP0000935A3 (es)
ID (1) ID23435A (es)
IL (1) IL130897A0 (es)
IS (1) IS5141A (es)
MA (1) MA24485A1 (es)
NO (1) NO994178L (es)
NZ (1) NZ336627A (es)
OA (1) OA11088A (es)
PA (1) PA8446901A1 (es)
PE (1) PE57999A1 (es)
PL (1) PL335307A1 (es)
PT (1) PT964860E (es)
SK (1) SK113199A3 (es)
TN (1) TNSN98034A1 (es)
TR (1) TR199902094T2 (es)
TW (1) TW530055B (es)
UA (1) UA58536C2 (es)
WO (1) WO1998038187A1 (es)
ZA (1) ZA981665B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323208B1 (en) * 1997-09-05 2001-11-27 Pfizer Inc Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones
JPH11279158A (ja) * 1998-02-09 1999-10-12 Pfizer Prod Inc キナゾリン―４―オン誘導体の製造方法
US6890930B1 (en) * 1999-09-28 2005-05-10 3-Dimensional Pharmaceuticals, Inc. Quinazolinones
JP2007501809A (ja) * 2003-08-08 2007-02-01 ユリシーズ・ファーマシューティカル・プロダクツ・インコーポレイテッド 抗菌剤としてのハロゲン化キナゾリニルニトロフラン
US20080146562A1 (en) * 2003-08-08 2008-06-19 Ulysses Pharmaceutical Products Inc., Halogenated quinazolinyl nitrofurans as antibacterial agents
GB0416730D0 (en) 2004-07-27 2004-09-01 Novartis Ag Organic compounds
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
JP2009514954A (ja) * 2005-11-04 2009-04-09 ハイドラ バイオサイエンシズ インコーポレイテッド Ｔｒｐｖ３機能を変調するための化合物
EP2079739A2 (en) * 2006-10-04 2009-07-22 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists
WO2008140750A1 (en) 2007-05-10 2008-11-20 Hydra Biosciences Inc. Compounds for modulating trpv3 function
BRPI1012333A2 (pt) * 2009-03-24 2016-03-29 Gilead Calistoga Llc atropisômeros de derivados de 2-purinil-3-tolil-quinazolinonas e métodos de uso
CA2763130C (en) 2009-05-29 2017-01-17 Merck Sharp & Dohme Corp. Radiolabeled pde10 inhibitors
US9216177B2 (en) 2011-02-28 2015-12-22 Drexel University Small molecular inhibitors of RAD51 recombinase and methods thereof
CA3168103A1 (en) 2020-01-29 2021-08-05 Kamari Pharma Ltd. Compounds and compositions for use in treating skin disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3748325A (en) 1970-04-06 1973-07-24 Karamchand Premchand Private Process for the preparation of quinazolinone derivatives
US4183931A (en) 1977-09-08 1980-01-15 Research Corporation 2-Ketoalkyl-4(3H)-quinazolinones
WO1992013535A1 (en) * 1991-02-06 1992-08-20 Research Corporation Technologies, Inc. Anticonvulsant substituted quinazolones
KR100375155B1 (ko) * 1996-05-15 2003-08-19 화이자 인코포레이티드 신규한2,3-이치환된-4(3에이치)-퀴나졸리논
DE69716810T2 (de) * 1996-05-15 2003-02-27 Pfizer 2,3-Disubstituierte-(5,6)-heteroarylkondensierte-pyrimidin-4-one

Also Published As

Publication number Publication date
ES2218801T3 (es) 2004-11-16
ATE264854T1 (de) 2004-05-15
EA199900689A1 (ru) 2000-02-28
AU732448B2 (en) 2001-04-26
UA58536C2 (uk) 2003-08-15
MA24485A1 (fr) 1998-10-01
DE69823339D1 (de) 2004-05-27
PL335307A1 (en) 2000-04-10
HRP980108B1 (en) 2004-10-31
SK113199A3 (en) 2001-10-08
EP0964860B1 (en) 2004-04-21
AU5775998A (en) 1998-09-18
IS5141A (is) 1999-07-30
DK0964860T3 (da) 2004-07-26
BG103687A (en) 2000-06-30
HN1998000028A (es) 1999-02-09
CA2282279A1 (en) 1998-09-03
GT199800039A (es) 1999-08-13
DZ2438A1 (fr) 2003-01-11
NZ336627A (en) 2000-12-22
TNSN98034A1 (fr) 2005-03-15
AP9801202A0 (en) 1999-08-26
NO994178D0 (no) 1999-08-27
TR199902094T2 (xx) 1999-12-21
EP0964860A1 (en) 1999-12-22
PE57999A1 (es) 1999-06-21
ID23435A (id) 2000-04-20
TW530055B (en) 2003-05-01
PT964860E (pt) 2004-07-30
HUP0000935A2 (hu) 2001-04-28
IL130897A0 (en) 2001-01-28
HUP0000935A3 (en) 2002-04-29
CO4950615A1 (es) 2000-09-01
CN1248254A (zh) 2000-03-22
AR011886A1 (es) 2000-09-13
EA001961B1 (ru) 2001-10-22
HRP980108A2 (en) 1998-12-31
JP3299990B2 (ja) 2002-07-08
CA2282279C (en) 2004-11-02
US6380204B1 (en) 2002-04-30
OA11088A (en) 2002-03-15
WO1998038187A1 (en) 1998-09-03
NO994178L (no) 1999-08-27
BR9807807A (pt) 2000-02-22
JP2000509732A (ja) 2000-08-02
DE69823339T2 (de) 2005-05-12
ZA981665B (en) 1999-08-17
KR20000075812A (ko) 2000-12-26

Similar Documents

Publication Publication Date Title
GT199700049A (es) Nueva 4(3h)-quinazolinonas 2,3 disustituidas
PA8447001A1 (es) Atropisomeros de 3- aril-4(3h)- quinazolinonas
PA8446901A1 (es) Atropisomeros de 3-heteroaril-4(3h)-quinazolinonas
UY26782A1 (es) Derivados del benzotiazol
HN1999000045A (es) Derivados biciclicos del acido hidroxamico
TR200201505T2 (tr) Terapötik maddeler olarak pirazolopirimidinler
HN2001000224A (es) Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos.
HN2001000244A (es) Inhibidores de espiropirimidin - 2, 4, 6 - triona metaloproteinasas.
AR020727A1 (es) Uso de compuestos derivados 3-amino-4-aril-maleimidas para la preparacion de medicamentos para condiciones asociadas a una necesidad de inhibicion de lagsk-3, dichos compuestos, procedimiento para su preparacion y composiciones farmaceuticas que los comprenden
ES2139132T3 (es) Composiciones farmaceuticas activas en la terapia de desordenes del sueño.
PA8472301A1 (es) Derivados de isotiazol utiles como agentes anticancerosos
HN2001000037A (es) Derivados de eteres de pirazol como agentes antiinflamatorios/analgesicos
ES2169147T3 (es) Derivados de beta-carbolina agonistas de la melatonina, sus procedimientos de preparacion y su utilizacion a titulo de medicamento.
GT200000197A (es) 2-(3,5-bis-trifluorometil-fenil)-n-metil-n-(6- morfolin-4-il-4-o tolil-piridin-3-il)-isobutiramida.
HUP0101498A1 (hu) Dexmedetomidin alkalmazása nyugtató hatású gyógyszerkészítmények előállítására
SE9801494D0 (sv) Novel use
ATE360428T1 (de) Analgetisches arzneimittel
PA8559201A1 (es) Compuestos azapoliciclicos condensados con arilo
ECSP982408A (es) Atropisomeros de 3- heteroaril - 4(3h) - quinazolinonas
PA8545601A1 (es) Derivados de 4-aminopirimidina
HN2001000119A (es) S-metil-dihidro -ziprasidona para el tratamiento de trastornos psiquiatricos y oculares.
BR0112690A (pt) Medicamento contendo cilansetron para o tratamento de pacientes ibs masculinos não-obstipativos
ECSP982430A (es) Atropisomeros de 3-aril-4 (3h) quinazolinonas
AR026241A1 (es) Empleo de carbinoles 2-imidazolil substituidos para la preparacion de un medicamento para el tratamiento o profilaxis de enfermedades provocadas porestados isquemicos
EA200100876A3 (ru) Фармацевтическая композиция для предупреждения или лечения заболевания, связанного с избыточным продуцированием il-12