EA200100876A3 - Фармацевтическая композиция для предупреждения или лечения заболевания, связанного с избыточным продуцированием il-12 - Google Patents
Фармацевтическая композиция для предупреждения или лечения заболевания, связанного с избыточным продуцированием il-12Info
- Publication number
- EA200100876A3 EA200100876A3 EA200100876A EA200100876A EA200100876A3 EA 200100876 A3 EA200100876 A3 EA 200100876A3 EA 200100876 A EA200100876 A EA 200100876A EA 200100876 A EA200100876 A EA 200100876A EA 200100876 A3 EA200100876 A3 EA 200100876A3
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- prevention
- treatment
- excessive
- production
- pharmaceutical composition
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title abstract 2
- 230000019734 interleukin-12 production Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 102000013462 Interleukin-12 Human genes 0.000 abstract 2
- 108010065805 Interleukin-12 Proteins 0.000 abstract 2
- MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 abstract 1
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 abstract 1
- 102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 abstract 1
- 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940117681 interleukin-12 Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- A—HUMAN NECESSITIES
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Данное изобретение относится к применению ингибитора PDE4 (фосфодиэстеразы 4) или его фармакологически приемлемой соли для производства лекарственного средства для предупреждения или лечения заболевания, связанного с избыточным продуцированном IL-12 (интерлейкина 12).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00402560A EP1188438A1 (en) | 2000-09-15 | 2000-09-15 | Pharmaceutical composition for preventing or treating a disease associated with an excess of Il-12 production |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200100876A2 EA200100876A2 (ru) | 2002-04-25 |
EA200100876A3 true EA200100876A3 (ru) | 2002-06-27 |
Family
ID=8173864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200100876A EA200100876A3 (ru) | 2000-09-15 | 2001-09-10 | Фармацевтическая композиция для предупреждения или лечения заболевания, связанного с избыточным продуцированием il-12 |
Country Status (20)
Country | Link |
---|---|
US (1) | US20020119967A1 (ru) |
EP (1) | EP1188438A1 (ru) |
JP (1) | JP2002316948A (ru) |
KR (1) | KR20020021606A (ru) |
CN (1) | CN1348763A (ru) |
AR (1) | AR030660A1 (ru) |
AU (1) | AU7033201A (ru) |
BR (1) | BR0104005A (ru) |
CA (1) | CA2357155A1 (ru) |
CZ (1) | CZ20013275A3 (ru) |
EA (1) | EA200100876A3 (ru) |
HU (1) | HUP0103686A2 (ru) |
IL (1) | IL145366A0 (ru) |
MX (1) | MXPA01009032A (ru) |
NO (1) | NO20014414L (ru) |
NZ (1) | NZ514107A (ru) |
PE (1) | PE20020465A1 (ru) |
PL (1) | PL349682A1 (ru) |
SK (1) | SK12932001A3 (ru) |
WO (1) | WO2002022112A2 (ru) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003535148A (ja) * | 2000-06-06 | 2003-11-25 | グラクソ グループ リミテッド | 癌の治療方法 |
US20050032725A1 (en) * | 2002-10-09 | 2005-02-10 | Toerrx, Inc. | Molecules preferentially associated with effector T cells or regulatory T cells and methods of their use |
AU2007303846B2 (en) | 2006-10-04 | 2011-03-10 | Pfizer Products Inc. | Pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as calcium receptor antagonists |
US7919518B2 (en) | 2008-03-07 | 2011-04-05 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40 |
BRPI0907974A2 (pt) | 2008-03-07 | 2015-08-04 | Acraf | Composto, composição farmacêutica, uso de um composto, e, método para tratar ou prevenir doenças |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ290266B6 (cs) * | 1993-07-02 | 2002-06-12 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Substituované benzamidy, způsob jejich výroby a farmaceutické prostředky s jejich obsahem |
FR2725719B1 (fr) * | 1994-10-14 | 1996-12-06 | Jouveinal Inst Rech | Diazepino-indoles inhibiteurs de phosphodiesterases iv |
CA2221351A1 (en) * | 1995-05-18 | 1996-11-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Cyclohexyl dihydrobenzofuranes |
FR2746800B1 (fr) * | 1996-03-29 | 1998-06-05 | Jouveinal Inst Rech | Diazepino-indoles inhibiteurs de phosphodiesterases 4 |
DK0936923T3 (da) * | 1996-11-15 | 2004-04-26 | Kennedy Inst Of Rheumatology | Undertrykkelse af TNFalpha og IL-12 ved terapi |
EP0998300A1 (en) * | 1997-03-18 | 2000-05-10 | Basf Aktiengesellschaft | Methods and compositions for modulating responsiveness to corticosteroids |
FR2762841B1 (fr) * | 1997-04-30 | 1999-07-02 | Jouveinal Inst Rech | Diazepino-indolones inhibitrices de phosphodiesterases iv |
FR2776660B1 (fr) * | 1998-03-27 | 2000-05-12 | Parke Davis | Diazepino-indoles de phosphodiesterases iv |
DE19843793C2 (de) * | 1998-09-24 | 2000-08-03 | Gruenenthal Gmbh | Substituierte Benzamide |
PT1161239E (pt) * | 1999-03-10 | 2005-02-28 | Altana Pharma Ag | 3-ciclopropilmetoxi-4-difluorometoxi-n-(3,5-dicloropirid-4-il)-benzamida para o tratamento da esclerose multipla |
FR2792938B1 (fr) * | 1999-04-28 | 2001-07-06 | Warner Lambert Co | NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV |
FR2803299B1 (fr) * | 2000-01-05 | 2004-09-17 | Warner Lambert Co | NOUVELLES PYRAZOLO [4,3-e] DIAZEPINES SUBSTITUEES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION |
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2000
- 2000-09-15 EP EP00402560A patent/EP1188438A1/en not_active Withdrawn
-
2001
- 2001-09-06 MX MXPA01009032A patent/MXPA01009032A/es unknown
- 2001-09-10 IL IL14536601A patent/IL145366A0/xx unknown
- 2001-09-10 EA EA200100876A patent/EA200100876A3/ru unknown
- 2001-09-11 NO NO20014414A patent/NO20014414L/no unknown
- 2001-09-11 CZ CZ20013275A patent/CZ20013275A3/cs unknown
- 2001-09-11 NZ NZ514107A patent/NZ514107A/xx not_active Application Discontinuation
- 2001-09-11 CA CA002357155A patent/CA2357155A1/en not_active Abandoned
- 2001-09-11 KR KR1020010055998A patent/KR20020021606A/ko not_active Application Discontinuation
- 2001-09-11 SK SK1293-2001A patent/SK12932001A3/sk unknown
- 2001-09-11 PE PE2001000914A patent/PE20020465A1/es not_active Application Discontinuation
- 2001-09-12 AU AU70332/01A patent/AU7033201A/en not_active Abandoned
- 2001-09-12 JP JP2001277234A patent/JP2002316948A/ja active Pending
- 2001-09-12 BR BR0104005-7A patent/BR0104005A/pt not_active Application Discontinuation
- 2001-09-12 CN CN01138457A patent/CN1348763A/zh active Pending
- 2001-09-12 HU HU0103686A patent/HUP0103686A2/hu unknown
- 2001-09-12 AR ARP010104308A patent/AR030660A1/es unknown
- 2001-09-13 WO PCT/EP2001/010590 patent/WO2002022112A2/en active Search and Examination
- 2001-09-14 PL PL01349682A patent/PL349682A1/xx not_active Application Discontinuation
- 2001-09-15 US US09/953,822 patent/US20020119967A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20020021606A (ko) | 2002-03-21 |
PL349682A1 (en) | 2002-03-25 |
SK12932001A3 (sk) | 2002-04-04 |
NO20014414L (no) | 2002-03-18 |
AU7033201A (en) | 2002-03-21 |
HU0103686D0 (en) | 2001-11-28 |
AR030660A1 (es) | 2003-08-27 |
NZ514107A (en) | 2001-09-28 |
US20020119967A1 (en) | 2002-08-29 |
WO2002022112A2 (en) | 2002-03-21 |
EP1188438A1 (en) | 2002-03-20 |
MXPA01009032A (es) | 2004-11-10 |
PE20020465A1 (es) | 2002-06-06 |
BR0104005A (pt) | 2002-07-09 |
EA200100876A2 (ru) | 2002-04-25 |
CZ20013275A3 (cs) | 2002-04-17 |
NO20014414D0 (no) | 2001-09-11 |
JP2002316948A (ja) | 2002-10-31 |
IL145366A0 (en) | 2002-06-30 |
HUP0103686A2 (en) | 2002-06-29 |
WO2002022112A3 (en) | 2004-02-26 |
CA2357155A1 (en) | 2002-03-15 |
CN1348763A (zh) | 2002-05-15 |
WO2002022112A9 (en) | 2002-06-06 |
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