ES2169147T3 - Derivados de beta-carbolina agonistas de la melatonina, sus procedimientos de preparacion y su utilizacion a titulo de medicamento. - Google Patents
Derivados de beta-carbolina agonistas de la melatonina, sus procedimientos de preparacion y su utilizacion a titulo de medicamento.Info
- Publication number
- ES2169147T3 ES2169147T3 ES95931243T ES95931243T ES2169147T3 ES 2169147 T3 ES2169147 T3 ES 2169147T3 ES 95931243 T ES95931243 T ES 95931243T ES 95931243 T ES95931243 T ES 95931243T ES 2169147 T3 ES2169147 T3 ES 2169147T3
- Authority
- ES
- Spain
- Prior art keywords
- derivatives
- melatonina
- carbolina
- agonistas
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
LA PRESENTE INVENCION SE REFIERE A DERIVADOS DE CARBOLINAS DE FORMULA GENERAL (I). SE REFIERE TAMBIEN A LOS DERIVADOS ANTERIORES, COMO MEDICAMENTOS, LAS COMPOSICIONES FARMACEUTICAS O COSMETICAS QUE LOS COMPRENDES, Y SU PROCEDIMIENTO DE PREPARACION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9410964A FR2724384B1 (fr) | 1994-09-14 | 1994-09-14 | Nouveaux derives de la 3,4-dihydro beta-carboline agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2169147T3 true ES2169147T3 (es) | 2002-07-01 |
Family
ID=9466929
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95931243T Expired - Lifetime ES2169147T3 (es) | 1994-09-14 | 1995-09-14 | Derivados de beta-carbolina agonistas de la melatonina, sus procedimientos de preparacion y su utilizacion a titulo de medicamento. |
Country Status (13)
Country | Link |
---|---|
US (1) | US6048868A (es) |
EP (1) | EP0781281B1 (es) |
JP (1) | JP4051712B2 (es) |
CN (1) | CN1046514C (es) |
AT (1) | ATE211138T1 (es) |
AU (1) | AU3475595A (es) |
DE (1) | DE69524774T2 (es) |
DK (1) | DK0781281T3 (es) |
ES (1) | ES2169147T3 (es) |
FR (1) | FR2724384B1 (es) |
PT (1) | PT781281E (es) |
WO (1) | WO1996008490A1 (es) |
ZA (1) | ZA961898B (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2724384B1 (fr) * | 1994-09-14 | 1999-04-16 | Cemaf | Nouveaux derives de la 3,4-dihydro beta-carboline agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament |
FR2754262B1 (fr) * | 1996-10-08 | 1998-10-30 | Synthelabo | Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique |
FR2765582B1 (fr) * | 1997-07-03 | 1999-08-06 | Synthelabo | Derives de 3-alkyl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one leur preparation et leur application en therapeutique |
FR2765581B1 (fr) * | 1997-07-03 | 1999-08-06 | Synthelabo | Derives de 3-aryl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one, leur preparation et leur application en therapeutique |
DK1064284T3 (da) * | 1998-03-17 | 2002-07-22 | Besins Int Lab | Hypnotiske beta-carbolinderivater, fremgangsmåde til fremstilling deraf og deres anvendelse som medicinske produkter |
FR2792937B1 (fr) * | 1999-04-27 | 2001-08-10 | Cemaf | NOUVEAUX DERIVES DE PYRROLO-(3,4-b) QUINOLEINE, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION A TITRE DE MEDICAMENT |
UA74826C2 (en) | 2000-05-17 | 2006-02-15 | Ortho Mcneil Pharm Inc | ?-carboline derivatives as phosphodiesterase inhibitors |
FR2824829B1 (fr) * | 2001-05-16 | 2005-06-03 | Macef | Nouveaux derives de dihydroimidazo [5,1-a]-beta-carboline, leur procede de preparation et leur application a titre de medicament |
AU2003220222A1 (en) | 2002-03-13 | 2003-09-29 | Signum Biosciences, Inc. | Modulation of protein methylation and phosphoprotein phosphate |
ES2427166T3 (es) * | 2003-06-23 | 2013-10-29 | Ono Pharmaceutical Co., Ltd. | Compuesto heterocíclico tricíclico novedoso |
US8076353B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
MXPA06010543A (es) | 2004-03-15 | 2007-03-26 | Ptc Therapeutics Inc | Derivados de carbolina utiles en la inhibicion de la angiogenesis. |
US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
US7767689B2 (en) | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
US7964726B2 (en) * | 2004-12-22 | 2011-06-21 | Ono Pharmaceutical Co., Ltd. | Tricyclic compound and use thereof |
US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
US8221804B2 (en) * | 2005-02-03 | 2012-07-17 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
FR2898358B1 (fr) * | 2006-03-08 | 2008-05-30 | Macef Sa | Association d'un antagoniste du recepteur 5ht2 et d'activateur du recepteur 5ht2 par modulation allosterique et leurs utilisations comme produits medicaux |
FR2908768A1 (fr) * | 2006-06-19 | 2008-05-23 | Fourtillan Snc | DERIVES DE 3H,11H-OXAZOLO (3',4':1,2)PYRIDO(3,4-b)INDOLE ET LEUR UTILISATION EN THERAPEUTIQUE |
FR2904973A1 (fr) * | 2006-08-18 | 2008-02-22 | Fourtillan Snc | Derives de 1-methylidene-pyrido[3,4-b]indole et leur utilisation en therapeutique. |
FR2912405A1 (fr) * | 2007-02-08 | 2008-08-15 | Fourtillan Snc | Derives des imidazo[1',5':1,6]pyrido[3,4-b]indoles et leur utilisation en therapeutique |
FR2912747A1 (fr) * | 2007-02-19 | 2008-08-22 | Fourtillan Snc | Derives des 1-(1-hydoxy-3-oxo-propen-1-yl)-1,2,3,3a,8,8a-hexahydro- pyrrolo[2,3-b)indoles et leur utilisation en therapeutique |
WO2008103470A2 (en) | 2007-02-21 | 2008-08-28 | Trustees Of Columbia University In The City Of New York | Oncogenic-ras-signal dependent lethal compounds |
FR2916200A1 (fr) * | 2007-05-18 | 2008-11-21 | Fourtillan Snc | Nouveaux derives des 1,2,3,4,6,7,12,12a-octahydro pyrazino[1',2':1,6]pyrido[3,4-b]indoles, leur preparation et leur utilisation en therapeutique |
US9486441B2 (en) | 2008-04-21 | 2016-11-08 | Signum Biosciences, Inc. | Compounds, compositions and methods for making the same |
EP3253378B1 (fr) * | 2015-02-04 | 2019-05-08 | Soeur Josefa Menendez | Système thérapeutique transdermique contenant de la valentonine et son utilisation comme médicament |
FI130627B (en) * | 2021-03-31 | 2023-12-18 | Equinorm Ltd | NEW HETEROCYCLIC COMPOUNDS AND THEIR USE |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3395E (fr) * | 1904-03-23 | 1904-10-27 | Georges Felix Coffignon | Cordon métallique |
ES273769A1 (es) * | 1961-01-18 | 1962-06-01 | Geigy Ag J R | Procedimiento para la preparaciën de nuevos derivados de amidas de acido beta-carbolin-carboxilico |
FR1524953A (fr) * | 1962-03-26 | 1968-05-17 | Konink Pharmaceutische Fabrike | Procédé de préparation des dérivés de la quinolizine |
FR3395M (fr) * | 1963-07-30 | 1965-06-28 | Roussel Uclaf | Nouveau médicament notamment pour le traitement des états neurodépressifs et des psychoses d'anxiété. |
GB1055203A (en) * | 1964-09-16 | 1967-01-18 | Ici Ltd | -ß-carboline derivatives, a process for their manufacture, and compositions containing them |
US3718657A (en) * | 1970-12-03 | 1973-02-27 | Abbott Lab | Certain-2-substituted-1,2,3,4-tetrahydro-beta or gamma carbolines |
US4336260A (en) * | 1977-12-08 | 1982-06-22 | The Dow Chemical Company | Method and compositions using 1-aryl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid for treating depression |
DK72180A (da) * | 1979-04-10 | 1980-10-11 | Ciba Geigy Ag | Fremgangsmaade til fremstilling af diazatricycler samt salte deraf |
FR2455044A1 (fr) * | 1979-04-26 | 1980-11-21 | Synthelabo | Pyrido-indoles et leur application en therapeutique |
DE3621413A1 (de) * | 1986-06-26 | 1988-01-07 | Boehringer Ingelheim Kg | Verwendung carbocyclisch und heterocyclisch annelierter dihydropyridine als cardioprotektive mittel sowie neue heterocyclisch und carbocyclisch anellierte dihydropyridine, verfahren zu deren herstellung und zwischenstufen fuer deren herstellung |
US5093352A (en) * | 1988-11-14 | 1992-03-03 | Whitby Research, Inc. | Antidepressant agents |
US5283343A (en) * | 1987-08-17 | 1994-02-01 | Whitby Research, Inc. | 2-aryl substituted N-acetyltryptamines and process of preparing such |
FR2663935A1 (fr) * | 1990-06-27 | 1992-01-03 | Adir | Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
DE4104257A1 (de) * | 1991-02-13 | 1992-08-20 | Boehringer Ingelheim Kg | Verwendung von anellierten tetrahydropyridinessigsaeurederivaten fuer die behandlung neurologischer erkrankungen |
US5206377A (en) * | 1991-12-05 | 1993-04-27 | Whitby Research, Inc. | Compounds useful as antiproliferative agents |
FR2724384B1 (fr) * | 1994-09-14 | 1999-04-16 | Cemaf | Nouveaux derives de la 3,4-dihydro beta-carboline agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament |
-
1994
- 1994-09-14 FR FR9410964A patent/FR2724384B1/fr not_active Expired - Fee Related
-
1995
- 1995-09-14 DK DK95931243T patent/DK0781281T3/da active
- 1995-09-14 WO PCT/FR1995/001179 patent/WO1996008490A1/fr active IP Right Grant
- 1995-09-14 AT AT95931243T patent/ATE211138T1/de not_active IP Right Cessation
- 1995-09-14 CN CN95195692A patent/CN1046514C/zh not_active Expired - Fee Related
- 1995-09-14 PT PT95931243T patent/PT781281E/pt unknown
- 1995-09-14 JP JP50996096A patent/JP4051712B2/ja not_active Expired - Fee Related
- 1995-09-14 EP EP95931243A patent/EP0781281B1/fr not_active Expired - Lifetime
- 1995-09-14 DE DE69524774T patent/DE69524774T2/de not_active Expired - Lifetime
- 1995-09-14 ES ES95931243T patent/ES2169147T3/es not_active Expired - Lifetime
- 1995-09-14 AU AU34755/95A patent/AU3475595A/en not_active Abandoned
-
1996
- 1996-03-08 ZA ZA961898A patent/ZA961898B/xx unknown
-
1998
- 1998-03-17 US US09/042,990 patent/US6048868A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69524774D1 (de) | 2002-01-31 |
EP0781281B1 (fr) | 2001-12-19 |
DE69524774T2 (de) | 2002-09-19 |
DK0781281T3 (da) | 2002-04-15 |
JPH10505606A (ja) | 1998-06-02 |
WO1996008490A1 (fr) | 1996-03-21 |
CN1161039A (zh) | 1997-10-01 |
CN1046514C (zh) | 1999-11-17 |
JP4051712B2 (ja) | 2008-02-27 |
US6048868A (en) | 2000-04-11 |
FR2724384A1 (fr) | 1996-03-15 |
ATE211138T1 (de) | 2002-01-15 |
AU3475595A (en) | 1996-03-29 |
FR2724384B1 (fr) | 1999-04-16 |
PT781281E (pt) | 2002-08-30 |
EP0781281A1 (fr) | 1997-07-02 |
ZA961898B (en) | 1996-09-17 |
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