OA13194A - Nicotinamide derivatives useful as PDE4 inhibitors. - Google Patents

Nicotinamide derivatives useful as PDE4 inhibitors. Download PDF

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Publication number: OA13194A
Authority: OA; OAPI
Prior art keywords: asthma; compound; disease; preparation; pathogenesis
Prior art date: 2003-07-25

Application number

OA1200600021A

Other languages

English (en)

Inventor

Christopher Gordon Barber

Mark Edward Bunnage

John Wilson Harvey

John Paul Mathias

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-25

Filing date

2004-07-13

Publication date

2006-12-13

2004-07-13 Application filed by Pfizer filed Critical Pfizer

2006-12-13 Publication of OA13194A publication Critical patent/OA13194A/en

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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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OA1200600021A 2003-07-25 2004-07-13 Nicotinamide derivatives useful as PDE4 inhibitors. OA13194A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0317498.4A GB0317498D0 (en)	2003-07-25	2003-07-25	Compounds

Publications (1)

Publication Number	Publication Date
OA13194A true OA13194A (en)	2006-12-13

Family

ID=27772727

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Application Number	Title	Priority Date	Filing Date
OA1200600020A OA13193A (en)	2003-07-25	2004-07-13	Nicotinamide derivatives useful as PDE4 inhibitors.
OA1200600021A OA13194A (en)	2003-07-25	2004-07-13	Nicotinamide derivatives useful as PDE4 inhibitors.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
OA1200600020A OA13193A (en)	2003-07-25	2004-07-13	Nicotinamide derivatives useful as PDE4 inhibitors.

Country Status (39)

Country	Link
US (4)	US20090035313A1 (ja)
EP (2)	EP1651640B1 (ja)
JP (2)	JP4016059B2 (ja)
KR (2)	KR20060034300A (ja)
CN (2)	CN1860113A (ja)
AP (2)	AP2006003484A0 (ja)
AR (2)	AR045090A1 (ja)
AT (2)	ATE353893T1 (ja)
AU (2)	AU2004259133A1 (ja)
BR (2)	BRPI0412834A (ja)
CA (2)	CA2532249A1 (ja)
CR (1)	CR8205A (ja)
CY (1)	CY1106343T1 (ja)
DE (2)	DE602004004794T2 (ja)
DK (2)	DK1651641T3 (ja)
EA (2)	EA200600100A1 (ja)
EC (2)	ECSP066304A (ja)
ES (2)	ES2286650T3 (ja)
GB (1)	GB0317498D0 (ja)
GT (2)	GT200400143A (ja)
HR (2)	HRP20051021A2 (ja)
IL (2)	IL172793A0 (ja)
IS (2)	IS8201A (ja)
MA (2)	MA27930A1 (ja)
MX (2)	MXPA06000936A (ja)
NL (2)	NL1026717C2 (ja)
NO (2)	NO20060314L (ja)
OA (2)	OA13193A (ja)
PA (2)	PA8607801A1 (ja)
PE (2)	PE20050329A1 (ja)
PL (2)	PL1651641T3 (ja)
PT (2)	PT1651641E (ja)
RS (1)	RS20060051A (ja)
SI (2)	SI1651641T1 (ja)
TN (2)	TNSN06026A1 (ja)
TW (2)	TW200524916A (ja)
UY (2)	UY28434A1 (ja)
WO (2)	WO2005009995A1 (ja)
ZA (2)	ZA200510421B (ja)

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PE20060272A1 (es)	2004-05-24	2006-05-22	Glaxo Group Ltd	(2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
WO2006077497A1 (en) *	2005-01-21	2006-07-27	Pfizer Limited	Crystalline forms cis-5-fluoro-n-[4-(2-hydroxy-4-methylbenzamido) cyclohexyl]-2-(tetrahydrothiopyran-a-yloxy) nicotinamide
EP1683795A1 (en) *	2005-01-21	2006-07-26	Pfizer Limited	Crystalline forms of cis-5-fluoro-N-¬4-(2-hydroxy-4-methylbenzamido)cyclohexyl\|-2-(tetrahydrothiopyran-4-yloxy)nicotinamide
PT2366393E (pt) *	2005-04-19	2013-10-04	Takeda Gmbh	Roflumilaste para o tratamento da hipertensão pulmonar
GB0514809D0 (en)	2005-07-19	2005-08-24	Glaxo Group Ltd	Compounds
US7926591B2 (en) *	2006-02-10	2011-04-19	Halliburton Energy Services, Inc.	Aqueous-based emulsified consolidating agents suitable for use in drill-in applications
EP1996218A4 (en) *	2006-02-24	2012-07-11	Ironwood Pharmaceuticals Inc	METHODS AND COMPOSITIONS FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS
KR20240024285A (ko) *	2008-03-18	2024-02-23	아레나 파마슈티칼스, 인크.	프로스타시클린 （ｐｇｉ２） 수용체와 관련된 장애의 치료에 유용한 상기 수용체의 조절제
CN103880757B (zh) *	2014-04-15	2016-02-24	上海毕得医药科技有限公司	一种5-羟基嘧啶-2-羧酸的合成方法
ES2965069T3 (es)	2017-03-01	2024-04-11	Arena Pharm Inc	Composiciones que comprenden agonistas del receptor de PGI2 y procesos para la preparación de las mismas
CN115151550A (zh) *	2019-12-23	2022-10-04	桑福德·伯纳姆·普雷比医学发现研究所	外核苷酸焦磷酸酶/磷酸二酯酶1(enpp1)调节剂及其用途
CN115038777A (zh) *	2020-01-31	2022-09-09	路博润公司	用于生产烷基水杨酸的方法和由其衍生的高碱性洗涤剂
CN111302945B (zh) *	2020-02-21	2023-06-13	上海再启生物技术有限公司	3-羟基-4-甲氧基-2-硝基苯甲酸的制备方法
DE102020107795A1 (de)	2020-03-20	2021-09-23	Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein	Elektronen emittierende Keramik

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YU49899A (sh) *	1997-04-04	2002-09-19	Pfizer Products Inc.	Nikotinamidni derivati
US20020111495A1 (en) *	1997-04-04	2002-08-15	Pfizer Inc.	Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
IL150486A0 (en) *	2000-01-31	2002-12-01	Pfizer Prod Inc	Pyrimidine carboxamides useful as inhibitors of pde4 isozymes
KR20020072299A (ko) *	2000-01-31	2002-09-14	화이자 프로덕츠 인코포레이티드	Ｐｄｅ4 이소자임의 선택적 억제제로서 유용한니코틴아미드 벤조접합된-헤테로사이클릴 유도체
JP2004520386A (ja) *	2001-01-31	2004-07-08	ファイザー・プロダクツ・インク	Ｐｄｅ４アイソザイムの阻害剤として有用なニコチンアミドビアリール誘導体
HUP0401305A2 (hu) *	2001-01-31	2004-10-28	Pfizer Products Inc.	Tiazolil-, oxazolil-, pirrolil- és imidazolil-savamid-származékok, mint PDE4 izozimek inhibitorai és az ezeket tartalmazó gyógyszerkészítmények

2003
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2004
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- 2004-07-13 AT AT04744038T patent/ATE362930T1/de not_active IP Right Cessation
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2005
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2006
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2007
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Publication number	Publication date
AP2006003483A0 (en)	2006-02-28
MA27931A1 (fr)	2006-06-01
EP1651641A1 (en)	2006-05-03
ECSP066317A (es)	2006-07-28
TNSN06027A1 (fr)	2007-10-03
EA200600100A1 (ru)	2006-08-25
CR8205A (es)	2006-07-14
PA8607801A1 (es)	2005-02-04
DK1651640T3 (da)	2007-05-14
CA2533624A1 (en)	2005-02-03
PA8607701A1 (es)	2005-02-04
MA27930A1 (fr)	2006-06-01
SI1651641T1 (sl)	2007-10-31
UY28434A1 (es)	2005-02-28
CN1860113A (zh)	2006-11-08
DE602004006627T2 (de)	2008-01-24
AP2006003484A0 (en)	2006-02-28
HRP20051021A2 (en)	2006-05-31
JP2006528657A (ja)	2006-12-21
NL1026717C2 (nl)	2005-11-01
IL172793A0 (en)	2006-06-11
PE20050329A1 (es)	2005-05-16
ES2286650T3 (es)	2007-12-01
OA13193A (en)	2006-12-13
JP4012935B2 (ja)	2007-11-28
DE602004004794T2 (de)	2007-12-06
GT200400143A (es)	2005-03-03
TW200521127A (en)	2005-07-01
NO20060963L (no)	2006-02-27
EA200600018A1 (ru)	2006-08-25
NL1026716A1 (nl)	2005-01-26
GT200400142A (es)	2005-03-03
MXPA06000986A (es)	2006-04-11
CN1829712A (zh)	2006-09-06
AR045090A1 (es)	2005-10-12
AU2004259133A1 (en)	2005-02-03
CY1106343T1 (el)	2011-10-12
DK1651641T3 (da)	2007-09-03
DE602004004794D1 (de)	2007-03-29
AR045091A1 (es)	2005-10-12
EP1651640A1 (en)	2006-05-03
BRPI0412910A (pt)	2006-09-26
TW200524916A (en)	2005-08-01
EP1651640B1 (en)	2007-02-14
PT1651641E (pt)	2007-07-13
US20050020611A1 (en)	2005-01-27
DE602004006627D1 (de)	2007-07-05
NL1026717A1 (nl)	2005-01-26
US20050043326A1 (en)	2005-02-24
NO20060314L (no)	2006-04-06
PL1651641T3 (pl)	2007-09-28
EP1651641B1 (en)	2007-05-23
GB0317498D0 (en)	2003-08-27
UY28433A1 (es)	2005-02-28
RS20060051A (en)	2008-06-05
BRPI0412834A (pt)	2006-09-26
PE20050713A1 (es)	2005-09-14
NL1026716C2 (nl)	2005-10-05
MXPA06000936A (es)	2006-03-30
TNSN06026A1 (fr)	2007-10-03
ATE353893T1 (de)	2007-03-15
HRP20060017A2 (en)	2006-06-30
KR20060034300A (ko)	2006-04-21
US20060178408A1 (en)	2006-08-10
JP4016059B2 (ja)	2007-12-05
AU2004259526A1 (en)	2005-02-03
ECSP066304A (es)	2006-07-28
JP2006528625A (ja)	2006-12-21
CA2532249A1 (en)	2005-02-03
PL1651640T3 (pl)	2007-06-29
ZA200510421B (en)	2007-01-31
ZA200600695B (en)	2007-05-30
WO2005009994A1 (en)	2005-02-03
PT1651640E (pt)	2007-04-30
IL173001A0 (en)	2006-06-11
ATE362930T1 (de)	2007-06-15
IS8242A (is)	2006-01-19
KR20060039012A (ko)	2006-05-04
ES2280980T3 (es)	2007-09-16
US20090035313A1 (en)	2009-02-05
WO2005009995A1 (en)	2005-02-03
IS8201A (is)	2005-12-27
SI1651640T1 (sl)	2007-06-30

Publication	Publication Date	Title
ZA200510421B (en)	2007-01-31	Nicotinamide derivatives useful as pde4 inhibitors
US20070066645A1 (en)	2007-03-22	Novel compounds
US7056934B2 (en)	2006-06-06	Nicotinamide derivatives useful as PDE4 inhibitors
US20050026952A1 (en)	2005-02-03	Nicotinamide derivatives useful as PDE4 inhibitors
US7153870B2 (en)	2006-12-26	Nicotinamide derivatives useful as PDE4 inhibitors
US20050020587A1 (en)	2005-01-27	Nicotinamide derivatives useful as PDE4 inhibitors
WO2005009438A1 (en)	2005-02-03	Nicotinamide compounds useful as pde4 inhibitors
EP1651647A1 (en)	2006-05-03	Nicotinamide derivatives useful as pdea4 inhibitors