OA10988A - Intermeditates for making hiv-protease inhibitors and methods of making hiv-protease inhibitors - Google Patents

Intermeditates for making hiv-protease inhibitors and methods of making hiv-protease inhibitors Download PDF

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Publication number
OA10988A
OA10988A OA9900049A OA9900049A OA10988A OA 10988 A OA10988 A OA 10988A OA 9900049 A OA9900049 A OA 9900049A OA 9900049 A OA9900049 A OA 9900049A OA 10988 A OA10988 A OA 10988A
Authority
OA
OAPI
Prior art keywords
group
formula
compound
aryl
alkyl
Prior art date
Application number
OA9900049A
Other languages
English (en)
Inventor
Katheen R Whitten
Michael E Deason
Original Assignee
Agouron Pharma
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma, Japan Tobacco Inc filed Critical Agouron Pharma
Publication of OA10988A publication Critical patent/OA10988A/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/08Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/28Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/287Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12Acetic acid esters
    • C07C69/14Acetic acid esters of monohydroxylic compounds
    • C07C69/145Acetic acid esters of monohydroxylic compounds of unsaturated alcohols
    • C07C69/157Acetic acid esters of monohydroxylic compounds of unsaturated alcohols containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62Halogen-containing esters
    • C07C69/63Halogen-containing esters of saturated acids
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
OA9900049A 1996-09-05 1999-03-03 Intermeditates for making hiv-protease inhibitors and methods of making hiv-protease inhibitors OA10988A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70841196A 1996-09-05 1996-09-05

Publications (1)

Publication Number Publication Date
OA10988A true OA10988A (en) 2001-11-01

Family

ID=24845703

Family Applications (1)

Application Number Title Priority Date Filing Date
OA9900049A OA10988A (en) 1996-09-05 1999-03-03 Intermeditates for making hiv-protease inhibitors and methods of making hiv-protease inhibitors

Country Status (33)

Country Link
EP (2) EP1361216B1 (es)
JP (3) JP4149000B2 (es)
KR (1) KR100563289B1 (es)
CN (2) CN1183117C (es)
AP (2) AP1322A (es)
AT (2) ATE254603T1 (es)
AU (2) AU740369B2 (es)
BG (2) BG64793B1 (es)
BR (1) BR9713192A (es)
CA (1) CA2264756A1 (es)
CZ (2) CZ298175B6 (es)
DE (2) DE69734689T2 (es)
DK (2) DK1361216T3 (es)
EA (1) EA002051B1 (es)
EE (1) EE04465B1 (es)
ES (2) ES2210573T3 (es)
GE (1) GEP20022799B (es)
HK (1) HK1062171A1 (es)
HU (1) HUP0000028A3 (es)
IL (1) IL128567A (es)
IS (1) IS2030B (es)
NO (1) NO313287B1 (es)
NZ (1) NZ334909A (es)
OA (1) OA10988A (es)
PL (2) PL198408B1 (es)
PT (1) PT927165E (es)
SG (1) SG94780A1 (es)
SI (2) SI0927165T1 (es)
SK (2) SK284899B6 (es)
TR (1) TR199900473T2 (es)
UA (1) UA67727C2 (es)
WO (1) WO1998009951A2 (es)
YU (1) YU11599A (es)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0641038A (ja) * 1992-07-17 1994-02-15 Mitsubishi Kasei Corp カルボン酸誘導体
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
JPH07248183A (ja) * 1994-03-11 1995-09-26 Osaka Gas Co Ltd 浴室兼用衣類乾燥室
JP3298293B2 (ja) * 1994-03-14 2002-07-02 松下電器産業株式会社 厨芥処理機
WO1996028423A1 (fr) * 1995-03-15 1996-09-19 Sankyo Company, Limited Composes dipeptidiques de structure ahpba
US5962704A (en) * 1995-09-26 1999-10-05 Japan Tobacco Inc. Production of amide derivatives and intermediate compounds therefor
EP0983999B8 (en) * 1995-09-26 2005-06-08 Japan Tobacco Inc. Process for producing amide derivatives and intermediates
US6121468A (en) * 1995-09-26 2000-09-19 Japan Tobacco Inc. Process for producing amide derivatives and intermediate compounds
TR199801648T2 (xx) * 1996-02-24 1998-11-23 Basf Aktiengesellschaft Herbisid olarak pirazol-4-il-hetaroil t�revleri

Also Published As

Publication number Publication date
AP9901497A0 (en) 1999-06-30
JP2008056693A (ja) 2008-03-13
SI1361216T1 (sl) 2006-02-28
EP0927165B1 (en) 2003-11-19
IL128567A (en) 2004-03-28
EE04465B1 (et) 2005-04-15
NO991072D0 (no) 1999-03-04
AU1473602A (en) 2002-03-14
PL201758B1 (pl) 2009-05-29
EA002051B1 (ru) 2001-12-24
ES2252586T3 (es) 2006-05-16
IS2030B (is) 2005-08-15
EP0927165A2 (en) 1999-07-07
CZ71699A3 (cs) 1999-06-16
PL198408B1 (pl) 2008-06-30
CN1232455A (zh) 1999-10-20
GEP20022799B (en) 2002-09-25
PL331801A1 (en) 1999-08-02
WO1998009951A3 (en) 1998-07-09
EP1361216B1 (en) 2005-11-16
JP4149000B2 (ja) 2008-09-10
BG65237B1 (bg) 2007-09-28
HUP0000028A2 (hu) 2000-05-28
DE69726298T2 (de) 2004-05-27
DK1361216T3 (da) 2006-01-23
DK0927165T3 (da) 2004-03-15
SG94780A1 (en) 2003-03-18
KR100563289B1 (ko) 2006-03-22
YU11599A (sh) 2000-03-21
IL128567A0 (en) 2000-01-31
HK1062171A1 (en) 2004-10-21
SK28299A3 (en) 1999-11-08
EP1361216A1 (en) 2003-11-12
NO313287B1 (no) 2002-09-09
CN1183117C (zh) 2005-01-05
EE9900109A (et) 1999-12-15
EA199900257A1 (ru) 1999-08-26
KR20010029489A (ko) 2001-04-06
JP2008088178A (ja) 2008-04-17
CZ298174B6 (cs) 2007-07-11
BR9713192A (pt) 1999-12-21
AU4331797A (en) 1998-03-26
SI0927165T1 (en) 2004-04-30
SK285278B6 (sk) 2006-10-05
CN1537846A (zh) 2004-10-20
SK284899B6 (sk) 2006-02-02
JP2001500495A (ja) 2001-01-16
AP2003002938A0 (en) 2003-12-31
ATE254603T1 (de) 2003-12-15
BG103305A (en) 2000-01-31
AU766155B2 (en) 2003-10-09
BG64793B1 (bg) 2006-04-28
DE69734689D1 (de) 2005-12-22
TR199900473T2 (xx) 1999-06-21
ES2210573T3 (es) 2004-07-01
IS4982A (is) 1999-02-19
NZ334909A (en) 2000-06-23
UA67727C2 (uk) 2004-07-15
WO1998009951A2 (en) 1998-03-12
HUP0000028A3 (en) 2003-05-28
NO991072L (no) 1999-03-04
DE69726298D1 (de) 2003-12-24
AU740369B2 (en) 2001-11-01
ATE309990T1 (de) 2005-12-15
CA2264756A1 (en) 1998-03-12
AP1322A (en) 2004-11-04
PT927165E (pt) 2004-04-30
DE69734689T2 (de) 2006-06-08
CN1305854C (zh) 2007-03-21
CZ298175B6 (cs) 2007-07-11

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