NO973216L - Substituerte oksazolidin-calpain- og/eller cathepsin B-inhibitorer - Google Patents

Substituerte oksazolidin-calpain- og/eller cathepsin B-inhibitorer

Info

Publication number
NO973216L
NO973216L NO973216A NO973216A NO973216L NO 973216 L NO973216 L NO 973216L NO 973216 A NO973216 A NO 973216A NO 973216 A NO973216 A NO 973216A NO 973216 L NO973216 L NO 973216L
Authority
NO
Norway
Prior art keywords
calpain
cathepsin
inhibitors
substituted oxazolidine
oxazolidine
Prior art date
Application number
NO973216A
Other languages
English (en)
Other versions
NO309267B1 (no
NO973216D0 (no
Inventor
Norton Paul Peet
Shujaath Mehdi
Matthew D Linnik
Michael Richard Angelastro
Hwa-Ok Kim
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of NO973216D0 publication Critical patent/NO973216D0/no
Publication of NO973216L publication Critical patent/NO973216L/no
Publication of NO309267B1 publication Critical patent/NO309267B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO973216A 1995-01-11 1997-07-10 Substituerte oxazolidin-calpain- og/eller cathepsin B- inhibitorer og farmasöytisk preparat inneholdende disse NO309267B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37119295A 1995-01-11 1995-01-11
PCT/US1995/016565 WO1996021655A2 (en) 1995-01-11 1995-12-15 Substituted oxazolidine calpain and/or cathepsin b inhibitors

Publications (3)

Publication Number Publication Date
NO973216D0 NO973216D0 (no) 1997-07-10
NO973216L true NO973216L (no) 1997-09-09
NO309267B1 NO309267B1 (no) 2001-01-08

Family

ID=23462894

Family Applications (1)

Application Number Title Priority Date Filing Date
NO973216A NO309267B1 (no) 1995-01-11 1997-07-10 Substituerte oxazolidin-calpain- og/eller cathepsin B- inhibitorer og farmasöytisk preparat inneholdende disse

Country Status (23)

Country Link
US (1) US5691368A (no)
EP (1) EP0802909B1 (no)
JP (1) JP4157601B2 (no)
KR (1) KR100393701B1 (no)
CN (1) CN1088456C (no)
AR (1) AR001787A1 (no)
AT (1) ATE206413T1 (no)
AU (1) AU692044B2 (no)
CA (1) CA2210258C (no)
DE (1) DE69523072T2 (no)
DK (1) DK0802909T3 (no)
ES (1) ES2165441T3 (no)
FI (1) FI972935A (no)
HU (1) HUT77649A (no)
IL (1) IL116724A (no)
MX (1) MX9705235A (no)
NO (1) NO309267B1 (no)
NZ (1) NZ298999A (no)
PT (1) PT802909E (no)
SI (1) SI0802909T1 (no)
TW (1) TW454001B (no)
WO (1) WO1996021655A2 (no)
ZA (1) ZA96100B (no)

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AU6134498A (en) * 1997-03-07 1998-09-22 Hoechst Marion Roussel, Inc. Method of treating trauma associated with brain, spinal cord or peripheral nerveinjury using carbobenzyloxy n-protected di- and tripeptide phenylalaninals
WO2000021550A2 (en) * 1998-10-13 2000-04-20 President And Fellows Of Harvard College Methods and compositions for treating neurodegenerative diseases
EP1131082A2 (en) * 1998-11-12 2001-09-12 Research Corporation Technologies, Inc A method for treating tissue damaged from ischemia
US6395897B1 (en) 1999-03-02 2002-05-28 Boehringer Ingelheim Pharmaceuticals, Inc. Nitrile compounds useful as reversible inhibitors of #9 cathepsin 5
TW200404789A (en) 1999-03-15 2004-04-01 Axys Pharm Inc Novel compounds and compositions as protease inhibitors
AU779177B2 (en) 1999-03-15 2005-01-13 Axys Pharmaceuticals, Inc. Novel compounds and compositions as protease inhibitors
EP1516877A1 (en) * 1999-03-15 2005-03-23 Axys Pharmaceuticals, Inc. Amine derivatives as protease inhibitors
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
CA2389685C (fr) * 1999-11-05 2011-07-12 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R) Nouveaux composes heterocycliques et leur application a titre de medicaments
FR2800737B1 (fr) * 1999-11-05 2006-06-30 Sod Conseils Rech Applic Nouveaux composes heterocycliques et leur application a titre de medicaments
AU2001278084A1 (en) * 2000-07-31 2002-02-13 The Regents Of The University Of California Model for alzheimer's disease and other neurodegenerative diseases
JP2004523506A (ja) 2000-12-22 2004-08-05 アクシス・ファーマシューティカルズ・インコーポレイテッド カテプシン阻害剤としての新規な化合物と組成物
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
CA2460125A1 (en) 2001-09-14 2003-03-27 Aventis Pharmaceuticals Inc. Novel compounds and compositions as cathepsin inhibitors
RU2004117877A (ru) 2001-11-14 2006-01-10 Авентис Фармасьютикалз Инк. (Us) Олигопептиды и композиции, содержащие их, в качестве ингибиторов катепсина s
WO2004084830A2 (en) * 2003-03-21 2004-10-07 Buck Institute Method for treating alzheimer’s dementia
US7384970B2 (en) * 2003-03-24 2008-06-10 Irm Llc Inhibitors of cathepsin S
US7109243B2 (en) * 2003-03-24 2006-09-19 Irm Llc Inhibitors of cathepsin S
WO2004089395A2 (en) * 2003-04-01 2004-10-21 Aventis Pharmaceuticals Inc. Use of an inhibitor of cathepsin-s or -b to treat or prevent chronic obstructive pulmonary disease
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
US7173051B2 (en) * 2003-06-13 2007-02-06 Irm, Llc Inhibitors of cathepsin S
US7256207B2 (en) * 2003-08-20 2007-08-14 Irm Llc Inhibitors of cathepsin S
FR2863268B1 (fr) * 2003-12-09 2006-02-24 Sod Conseils Rech Applic Nouveaux derives du 2-hydroxytetrahydrofuranne et leur application a titre de medicaments
JP5379692B2 (ja) 2006-11-09 2013-12-25 プロビオドルグ エージー 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
JP5523107B2 (ja) 2006-11-30 2014-06-18 プロビオドルグ エージー グルタミニルシクラーゼの新規阻害剤
ZA200905537B (en) 2007-03-01 2010-10-27 Probiodrug Ag New use of glutaminyl cyclase inhibitors
ES2533484T3 (es) 2007-04-18 2015-04-10 Probiodrug Ag Derivados de tiourea como inhibidores de la glutaminil ciclasa
WO2010003092A1 (en) * 2008-07-03 2010-01-07 University Of Massachusetts Methods and compositions for reducing inflammation and treating inflammatory disorders
EA022007B1 (ru) 2009-09-11 2015-10-30 Пробиодруг Аг Гетероциклические производные в качестве ингибиторов глутаминилциклазы
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
KR101790806B1 (ko) 2010-03-10 2017-11-20 프로비오드룩 아게 글루타미닐 사이클라제(ｑｃ, ｅｃ 2.3.2.5)의 헤테로사이클릭 억제제
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
WO2012123563A1 (en) 2011-03-16 2012-09-20 Probiodrug Ag Benz imidazole derivatives as inhibitors of glutaminyl cyclase
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
WO2024018245A1 (en) 2022-07-22 2024-01-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of calpain inhibitors for the treatment of the diabetic kidney disease

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Also Published As

Publication number Publication date
ATE206413T1 (de) 2001-10-15
SI0802909T1 (en) 2002-02-28
AU692044B2 (en) 1998-05-28
EP0802909B1 (en) 2001-10-04
ES2165441T3 (es) 2002-03-16
NZ298999A (en) 1999-01-28
CN1173174A (zh) 1998-02-11
EP0802909A2 (en) 1997-10-29
KR100393701B1 (ko) 2003-11-28
DE69523072T2 (de) 2002-06-20
DE69523072D1 (en) 2001-11-08
AR001787A1 (es) 1997-12-10
DK0802909T3 (da) 2002-01-28
US5691368A (en) 1997-11-25
FI972935A0 (fi) 1997-07-10
IL116724A0 (en) 1996-05-14
FI972935A (fi) 1997-07-10
CA2210258C (en) 2002-10-01
TW454001B (en) 2001-09-11
HUT77649A (hu) 1998-07-28
PT802909E (pt) 2002-03-28
JPH10512257A (ja) 1998-11-24
AU4473196A (en) 1996-07-31
IL116724A (en) 2000-08-31
MX9705235A (es) 1997-10-31
WO1996021655A2 (en) 1996-07-18
CN1088456C (zh) 2002-07-31
CA2210258A1 (en) 1996-07-18
NO309267B1 (no) 2001-01-08
WO1996021655A3 (en) 1996-09-06
JP4157601B2 (ja) 2008-10-01
NO973216D0 (no) 1997-07-10
ZA96100B (en) 1996-07-24

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