NO911020L - Fremgangsmaate og preparat for koiontoforese. - Google Patents
Fremgangsmaate og preparat for koiontoforese. Download PDFInfo
- Publication number
- NO911020L NO911020L NO91911020A NO911020A NO911020L NO 911020 L NO911020 L NO 911020L NO 91911020 A NO91911020 A NO 91911020A NO 911020 A NO911020 A NO 911020A NO 911020 L NO911020 L NO 911020L
- Authority
- NO
- Norway
- Prior art keywords
- active ingredient
- vasoactivator
- animal
- skin
- delivery
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 38
- 238000002360 preparation method Methods 0.000 title claims description 6
- 239000004480 active ingredient Substances 0.000 claims description 141
- 241001465754 Metazoa Species 0.000 claims description 61
- 230000017531 blood circulation Effects 0.000 claims description 49
- 229940124549 vasodilator Drugs 0.000 claims description 49
- 239000003071 vasodilator agent Substances 0.000 claims description 49
- 239000000203 mixture Substances 0.000 claims description 45
- 238000009472 formulation Methods 0.000 claims description 43
- 210000005166 vasculature Anatomy 0.000 claims description 39
- 239000005526 vasoconstrictor agent Substances 0.000 claims description 32
- 230000005684 electric field Effects 0.000 claims description 19
- 230000001965 increasing effect Effects 0.000 claims description 16
- 239000003814 drug Substances 0.000 claims description 13
- 150000002500 ions Chemical class 0.000 claims description 12
- 239000003085 diluting agent Substances 0.000 claims description 10
- 229940079593 drug Drugs 0.000 claims description 10
- 230000037317 transdermal delivery Effects 0.000 claims description 9
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims description 8
- XQYZDYMELSJDRZ-UHFFFAOYSA-N papaverine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 claims description 8
- 229960002312 tolazoline Drugs 0.000 claims description 7
- JIVZKJJQOZQXQB-UHFFFAOYSA-N tolazoline Chemical compound C=1C=CC=CC=1CC1=NCCN1 JIVZKJJQOZQXQB-UHFFFAOYSA-N 0.000 claims description 7
- 230000000694 effects Effects 0.000 claims description 6
- -1 mecolyl Chemical compound 0.000 claims description 6
- BMUKKTUHUDJSNZ-UHFFFAOYSA-N 4-[1-hydroxy-2-(1-phenoxypropan-2-ylamino)propyl]phenol Chemical compound C=1C=C(O)C=CC=1C(O)C(C)NC(C)COC1=CC=CC=C1 BMUKKTUHUDJSNZ-UHFFFAOYSA-N 0.000 claims description 4
- 229930008281 A03AD01 - Papaverine Natural products 0.000 claims description 4
- WZHCOOQXZCIUNC-UHFFFAOYSA-N cyclandelate Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C(O)C1=CC=CC=C1 WZHCOOQXZCIUNC-UHFFFAOYSA-N 0.000 claims description 4
- 229960000729 cyclandelate Drugs 0.000 claims description 4
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 claims description 4
- 229960002768 dipyridamole Drugs 0.000 claims description 4
- 229960001340 histamine Drugs 0.000 claims description 4
- 229960004819 isoxsuprine Drugs 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 150000002823 nitrates Chemical class 0.000 claims description 4
- 229960001789 papaverine Drugs 0.000 claims description 4
- 229960001999 phentolamine Drugs 0.000 claims description 4
- MRBDMNSDAVCSSF-UHFFFAOYSA-N phentolamine Chemical compound C1=CC(C)=CC=C1N(C=1C=C(O)C=CC=1)CC1=NCCN1 MRBDMNSDAVCSSF-UHFFFAOYSA-N 0.000 claims description 4
- 230000008859 change Effects 0.000 claims description 3
- 230000004913 activation Effects 0.000 claims 1
- 210000003491 skin Anatomy 0.000 description 64
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 22
- 229960004194 lidocaine Drugs 0.000 description 22
- 150000001875 compounds Chemical class 0.000 description 17
- 210000000434 stratum corneum Anatomy 0.000 description 11
- 239000008280 blood Substances 0.000 description 10
- 210000004369 blood Anatomy 0.000 description 10
- 210000004204 blood vessel Anatomy 0.000 description 8
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 6
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 6
- 230000004907 flux Effects 0.000 description 6
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 6
- 229960002748 norepinephrine Drugs 0.000 description 6
- 230000002500 effect on skin Effects 0.000 description 5
- 230000004888 barrier function Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 230000035515 penetration Effects 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 3
- 229930182837 (R)-adrenaline Natural products 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 229960005139 epinephrine Drugs 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 238000013271 transdermal drug delivery Methods 0.000 description 3
- 230000032258 transport Effects 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- JHPHVAVFUYTVCL-UHFFFAOYSA-M methacholine chloride Chemical compound [Cl-].C[N+](C)(C)CC(C)OC(C)=O JHPHVAVFUYTVCL-UHFFFAOYSA-M 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241000282887 Suidae Species 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000037365 barrier function of the epidermis Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 150000001793 charged compounds Chemical class 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000010339 dilation Effects 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 150000008040 ionic compounds Chemical class 0.000 description 1
- 238000002690 local anesthesia Methods 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229960005015 local anesthetics Drugs 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000002550 vasoactive agent Substances 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Radiology & Medical Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Anesthesiology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49406290A | 1990-03-15 | 1990-03-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
NO911020D0 NO911020D0 (no) | 1991-03-14 |
NO911020L true NO911020L (no) | 1991-09-16 |
Family
ID=23962871
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO91911020A NO911020L (no) | 1990-03-15 | 1991-03-14 | Fremgangsmaate og preparat for koiontoforese. |
Country Status (10)
Country | Link |
---|---|
US (2) | US5334138A (ko) |
EP (1) | EP0448300A3 (ko) |
JP (1) | JPH07103046B2 (ko) |
KR (3) | KR930005320B1 (ko) |
AU (1) | AU7270091A (ko) |
CA (1) | CA2038097C (ko) |
FI (1) | FI911267A (ko) |
IE (1) | IE910714A1 (ko) |
NO (1) | NO911020L (ko) |
ZA (2) | ZA911876B (ko) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE64891B1 (en) * | 1990-03-15 | 1995-09-20 | Becton Dickinson Co | Composition for increased skin concentration of active agents by iontophoresis |
US5125894A (en) * | 1990-03-30 | 1992-06-30 | Alza Corporation | Method and apparatus for controlled environment electrotransport |
US6004309A (en) | 1990-03-30 | 1999-12-21 | Alza Corporation | Method and apparatus for controlled environment electrotransport |
US6287484B1 (en) | 1992-11-12 | 2001-09-11 | Robert Hausslein | Iontophoretic material |
US6060000A (en) * | 1992-11-12 | 2000-05-09 | Implemed, Inc. | Iontophoretic material containing carbon and metal granules |
AU681390B2 (en) * | 1993-04-08 | 1997-08-28 | University Of Queensland, The | Administration of vaso-active agent and therapeutic agent |
US5750141A (en) * | 1993-04-08 | 1998-05-12 | The University Of Queensland | Administration of vaso-active agent and therapeutic agent |
US7043297B2 (en) * | 1993-09-30 | 2006-05-09 | Vyteris, Inc. | Iontophoretic drug delivery device and reservoir and method of making same |
US6377847B1 (en) * | 1993-09-30 | 2002-04-23 | Vyteris, Inc. | Iontophoretic drug delivery device and reservoir and method of making same |
ATE165521T1 (de) * | 1994-03-30 | 1998-05-15 | Alza Corp | Verminderung der hautreizung während einer iontophoretischen abgabe von medikamenten |
US5990179A (en) * | 1995-04-28 | 1999-11-23 | Alza Corporation | Composition and method of enhancing electrotransport agent delivery |
US5620416A (en) * | 1995-06-07 | 1997-04-15 | North Carolina State University | Methods of using topical agents with systemically administered active agents |
US5840056A (en) * | 1995-06-15 | 1998-11-24 | Empi, Inc. | Iontophoresis electrode |
US5788666A (en) * | 1995-06-15 | 1998-08-04 | Empi, Inc. | Iontophoresis electrode |
US5833647A (en) * | 1995-10-10 | 1998-11-10 | The Penn State Research Foundation | Hydrogels or lipogels with enhanced mass transfer for transdermal drug delivery |
US5759564A (en) * | 1996-04-16 | 1998-06-02 | Implemed, Inc. | Iontophoretic material |
EP0898467B1 (en) * | 1996-04-16 | 2004-07-28 | PATHAGON, Inc. | Iontophoretic structure |
WO1997048444A1 (en) * | 1996-06-19 | 1997-12-24 | Becton Dickinson And Company | Iontophoretic delivery of cell adhesion inhibitors |
US7033598B2 (en) * | 1996-11-19 | 2006-04-25 | Intrabrain International N.V. | Methods and apparatus for enhanced and controlled delivery of a biologically active agent into the central nervous system of a mammal |
US6650934B2 (en) | 1996-12-17 | 2003-11-18 | Alza Corp | Polymeric foam reservoirs for an electrotransport delivery device |
US6246904B1 (en) | 1996-12-17 | 2001-06-12 | Alza Corporation | Electrotransport drug delivery reservoirs containing inert fillers |
US6119036A (en) * | 1997-03-26 | 2000-09-12 | The Board Of Regents Of The University Of Oklahoma | Iontophoretic transdermal delivery device |
US5954675A (en) * | 1997-07-07 | 1999-09-21 | Dellagatta; Enrico Michael | Method of ultrasonic therapy |
ATE373957T1 (de) | 1997-10-09 | 2007-10-15 | Univ Emory | Verfahren und vorrichtung zur transdermalen verabreichung von lithium |
US6295469B1 (en) | 1997-11-14 | 2001-09-25 | Alza Corporation | Formulation for electrically assisted delivery of lidocaine and epinephrine |
US6319901B1 (en) * | 1998-10-15 | 2001-11-20 | Ichor Medical Systems, Inc. | Methods for prolonging cell membrane permeability |
US6730691B1 (en) | 2000-02-10 | 2004-05-04 | Miles A. Galin | Uses of alpha adrenergic blocking agents |
US6560483B1 (en) * | 2000-10-18 | 2003-05-06 | Minnesota High-Tech Resources, Llc | Iontophoretic delivery patch |
US6553255B1 (en) | 2000-10-27 | 2003-04-22 | Aciont Inc. | Use of background electrolytes to minimize flux variability during iontophoresis |
US20030065285A1 (en) * | 2001-07-23 | 2003-04-03 | Higuchi William I. | Method and apparatus for increasing flux during reverse iontophoresis |
US20030092774A1 (en) * | 2001-10-17 | 2003-05-15 | Parkinson Thomas M. | Methods for treating neoplastic, angiogenic, vascular, fibroblastic, and/or immunosuppressive iregularities of the eye and/or joint via administration of combretastatin based medicaments, and iontophoretic devices for delivering combretastatin based medicaments |
US7099713B2 (en) | 2002-06-28 | 2006-08-29 | Battelle Memorial Institute | Skin conduction and transport systems |
US7666914B2 (en) * | 2004-06-03 | 2010-02-23 | Richlin David M | Topical preparation and method for transdermal delivery and localization of therapeutic agents |
US20060013866A1 (en) * | 2004-07-16 | 2006-01-19 | Carter Stephen G | Transdermal drug delivery formulations with optimal amounts of vasodilators therein |
US20060013769A1 (en) * | 2004-07-16 | 2006-01-19 | Stephen Carter | Transdermal drug delivery formulations and method of determining optimal amounts of vasodilators therein |
US20060062836A1 (en) * | 2004-09-21 | 2006-03-23 | Carter Stephen G | Methods of device-assisted drug delivery |
US8246949B2 (en) * | 2004-10-27 | 2012-08-21 | Aciont, Inc. | Methods and devices for sustained in-vivo release of an active agent |
US20060135906A1 (en) * | 2004-11-16 | 2006-06-22 | Akihiko Matsumura | Iontophoretic device and method for administering immune response-enhancing agents and compositions |
JP2006296511A (ja) * | 2005-04-15 | 2006-11-02 | Transcutaneous Technologies Inc | 外用剤、外用剤の塗布方法、イオントフォレーシス装置及び経皮パッチ |
US20070135754A1 (en) * | 2005-09-30 | 2007-06-14 | Hidero Akiyama | Electrode assembly for iontophoresis for administering active agent enclosed in nanoparticle and iontophoresis device using the same |
WO2007041158A1 (en) * | 2005-09-30 | 2007-04-12 | Vyteris, Inc. | Iontophoresis drug delivery device providing acceptable depth and duration of dermal anesthesia |
US20070083185A1 (en) * | 2005-09-30 | 2007-04-12 | Darrick Carter | Iontophoretic device and method of delivery of active agents to biological interface |
JP2009509682A (ja) * | 2005-09-30 | 2009-03-12 | バイテリス,インコーポレイテッド | 予め充填された結合電気搬送パッチからの性腺刺激ホルモン放出ホルモンのパルス状搬送 |
US20070078434A1 (en) * | 2005-09-30 | 2007-04-05 | Vyteris, Inc. | Indications For Local Transport of Anaesthetic Agents By Electrotransport Devices |
WO2007041323A1 (en) * | 2005-09-30 | 2007-04-12 | Tti Ellebeau, Inc. | Iontophoretic delivery of vesicle-encapsulated active agents |
US20070078375A1 (en) * | 2005-09-30 | 2007-04-05 | Transcutaneous Technologies Inc. | Iontophoretic delivery of active agents conjugated to nanoparticles |
US20070083186A1 (en) * | 2005-09-30 | 2007-04-12 | Darrick Carter | Transdermal drug delivery systems, devices, and methods employing novel pharmaceutical vehicles |
US20070078372A1 (en) * | 2005-09-30 | 2007-04-05 | Vyteris, Inc. | Iontophoresis Drug Delivery Formulation Providing Acceptable Sensation and Dermal Anesthesia |
US20090221985A1 (en) * | 2005-10-19 | 2009-09-03 | Shmuel Bukshpan | System for iontophoretic transdermal delivery of polymeric agents and methods of use thereof |
EP1965856A2 (en) | 2005-12-30 | 2008-09-10 | Tti Ellebeau, Inc. | Iontophoretic systems, devices, and methods of delivery of active agents to biological interface |
US20080193514A1 (en) * | 2006-11-02 | 2008-08-14 | Transcu Ltd. | Compostions and methods for iontophoresis delivery of active ingredients through hair follicles |
WO2008087803A1 (ja) * | 2007-01-16 | 2008-07-24 | Hokkaido University | 抗酸化成分を封入したイオントフォレーシス用リポソーム製剤 |
EP2157970A1 (en) * | 2007-05-18 | 2010-03-03 | Tti Ellebeau, Inc. | Transdermal delivery devices assuring an improved release of an active principle through a biological interface |
JP2010187707A (ja) * | 2007-06-12 | 2010-09-02 | Hokkaido Univ | インスリンを封入したイオントフォレーシス用リポソーム製剤 |
WO2009003173A1 (en) | 2007-06-27 | 2008-12-31 | The General Hospital Corporation | Method and apparatus for optical inhibition of photodymanic therapy |
AR073575A1 (es) * | 2008-09-10 | 2010-11-17 | Transcu Ltd | Aparato y metodo para dispensar basados en hpc liquidos viscosos en sustratos porosos por ejemplo proceso continuo basado en bandas |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3991755A (en) * | 1973-07-27 | 1976-11-16 | Medicon, Inc. | Iontophoresis apparatus for applying local anesthetics |
US4406658A (en) * | 1981-03-06 | 1983-09-27 | Medtronic, Inc. | Iontophoretic device with reversible polarity |
US4820263A (en) * | 1981-03-06 | 1989-04-11 | Medtronic, Inc. | Apparatus and method for iontophoretic drug delivery |
JPS5810066A (ja) * | 1981-07-10 | 1983-01-20 | 株式会社アドバンス | イオントフオレ−ゼ用プラスタ−構造体 |
US4702732A (en) * | 1984-12-24 | 1987-10-27 | Trustees Of Boston University | Electrodes, electrode assemblies, methods, and systems for tissue stimulation and transdermal delivery of pharmacologically active ligands |
US4752285B1 (en) * | 1986-03-19 | 1995-08-22 | Univ Utah Res Found | Methods and apparatus for iontophoresis application of medicaments |
IE60941B1 (en) * | 1986-07-10 | 1994-09-07 | Elan Transdermal Ltd | Transdermal drug delivery device |
CA1317522C (en) * | 1987-03-20 | 1993-05-11 | Dan Sibalis | Transdermal drug delivery system |
AU615188B2 (en) * | 1987-05-28 | 1991-09-26 | Drug Delivery Systems Inc. | Pulsating transdermal drug delivery system |
FR2616333A1 (fr) * | 1987-06-12 | 1988-12-16 | Cird | Procede d'ionophorese pour administrer une substance dissoute ou partiellement dissoute, par voie percutanee ou perungueale et dispositif correspondant |
US4845233A (en) * | 1987-09-11 | 1989-07-04 | Iprx, Inc. | Imidazolin-2-ones |
US5068226A (en) * | 1987-12-07 | 1991-11-26 | Cyclex, Inc. | Pharmaceutical preparations containing cyclodextrins and their use in iontophoretic therapies |
US5057072A (en) * | 1988-10-28 | 1991-10-15 | Medtronic, Inc. | Iontophoresis electrode |
US5088977A (en) * | 1988-12-21 | 1992-02-18 | Drug Delivery Systems Inc. | Electrical transdermal drug applicator with counteractor and method of drug delivery |
US4950229A (en) * | 1989-09-25 | 1990-08-21 | Becton, Dickinson And Company | Apparatus for an electrode used for iontophoresis |
US5023085A (en) * | 1989-11-29 | 1991-06-11 | Pfizer Inc. | Transdermal flux enhancers in combination with iontophoresis in topical administration of pharmaceuticals |
US5047007A (en) * | 1989-12-22 | 1991-09-10 | Medtronic, Inc. | Method and apparatus for pulsed iontophoretic drug delivery |
US5084008A (en) * | 1989-12-22 | 1992-01-28 | Medtronic, Inc. | Iontophoresis electrode |
US5084006A (en) * | 1990-03-30 | 1992-01-28 | Alza Corporation | Iontopheretic delivery device |
US5087620A (en) * | 1990-05-17 | 1992-02-11 | Bristol-Myers Squibb Co. | Controlled dermal penetration enhancement using imidazoles |
-
1991
- 1991-02-08 US US07/653,204 patent/US5334138A/en not_active Expired - Fee Related
- 1991-02-08 US US07/653,202 patent/US5302172A/en not_active Expired - Lifetime
- 1991-03-04 IE IE071491A patent/IE910714A1/en unknown
- 1991-03-07 AU AU72700/91A patent/AU7270091A/en not_active Abandoned
- 1991-03-12 CA CA002038097A patent/CA2038097C/en not_active Expired - Fee Related
- 1991-03-14 ZA ZA911876A patent/ZA911876B/xx unknown
- 1991-03-14 FI FI911267A patent/FI911267A/fi unknown
- 1991-03-14 ZA ZA911875A patent/ZA911875B/xx unknown
- 1991-03-14 NO NO91911020A patent/NO911020L/no unknown
- 1991-03-15 JP JP3051725A patent/JPH07103046B2/ja not_active Expired - Lifetime
- 1991-03-15 KR KR1019910004167A patent/KR930005320B1/ko not_active IP Right Cessation
- 1991-03-15 KR KR1019910004165A patent/KR910016316A/ko not_active Application Discontinuation
- 1991-03-15 EP EP19910302221 patent/EP0448300A3/en not_active Withdrawn
- 1991-03-15 KR KR1019910004166A patent/KR930005319B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO911020D0 (no) | 1991-03-14 |
JPH06183999A (ja) | 1994-07-05 |
ZA911876B (en) | 1992-03-25 |
FI911267A (fi) | 1991-09-16 |
AU7270091A (en) | 1991-09-19 |
ZA911875B (en) | 1992-03-25 |
CA2038097C (en) | 1997-01-07 |
IE910714A1 (en) | 1991-09-25 |
US5302172A (en) | 1994-04-12 |
JPH07103046B2 (ja) | 1995-11-08 |
KR910016316A (ko) | 1991-11-05 |
EP0448300A2 (en) | 1991-09-25 |
US5334138A (en) | 1994-08-02 |
EP0448300A3 (en) | 1991-12-27 |
KR930005320B1 (ko) | 1993-06-17 |
CA2038097A1 (en) | 1991-09-16 |
FI911267A0 (fi) | 1991-03-14 |
KR930005319B1 (ko) | 1993-06-17 |
KR910016317A (ko) | 1991-11-05 |
KR910016318A (ko) | 1991-11-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO911020L (no) | Fremgangsmaate og preparat for koiontoforese. | |
KR100856693B1 (ko) | 항미생물제 양립가능성 저장소 조성물을 포함하는 경피전기수송 전달 장치 | |
DK175043B1 (da) | Indretning til iontophoretisk medikamenttilförsel | |
Kari | Control of blood glucose levels in alloxan-diabetic rabbits by iontophoresis of insulin | |
JP4049389B2 (ja) | 電気的移送式作用剤投与のための組成物、デバイス及び方法 | |
US5203768A (en) | Transdermal delivery device | |
US5667491A (en) | Method for rapid temporal control of molecular transport across tissue | |
Jue-Chen et al. | Blood glucose control in diabetic rats by transdermal iontophoretic delivery of insulin | |
EP1080731A2 (en) | Composition and device structure for iontophoresis | |
AU2002303239A1 (en) | Transdermal electrotransport delivery device including an antimicrobial compatible reservoir composition | |
US5861439A (en) | Method for enhanced electrotransport agent delivery | |
EP0448299B1 (en) | Composition for increased skin concentration of active agents by iontophoresis | |
DE69105322T2 (de) | Iontophoreseverfahren und -zusammensetzung. | |
JP2002065868A (ja) | フッ化水素酸化学熱傷治療用具 |