NO782866L - Fremgangsmaate for fremstilling av cefalosporinderivater - Google Patents

Fremgangsmaate for fremstilling av cefalosporinderivater

Info

Publication number: NO782866L
Authority: NO; Norway
Prior art keywords: carboxy; methoxy; acid; cob; cephem
Prior art date: 1977-08-25

Application number

NO782866A

Other languages

English (en)

Norwegian (no)

Inventor

Masayuki Narisada

Wataru Nagata

Original Assignee

Shionogi & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-08-25

Filing date

1978-08-23

Publication date

1979-02-27

1978-08-23 Application filed by Shionogi & Co filed Critical Shionogi & Co

1979-02-27 Publication of NO782866L publication Critical patent/NO782866L/no

Links

238000000034 method Methods 0.000 title claims description 20
238000002360 preparation method Methods 0.000 title claims description 19
HOKIDJSKDBPKTQ-UHFFFAOYSA-N 3-(acetyloxymethyl)-7-[(5-amino-5-carboxypentanoyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical class S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)C(NC(=O)CCCC(N)C(O)=O)C12 HOKIDJSKDBPKTQ-UHFFFAOYSA-N 0.000 title 1
-1 p-hydroxyphenyl Chemical group 0.000 claims description 127
150000001875 compounds Chemical class 0.000 claims description 63
239000002253 acid Substances 0.000 claims description 39
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 26
150000001412 amines Chemical class 0.000 claims description 11
239000002904 solvent Substances 0.000 claims description 11
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 9
125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims description 8
125000000217 alkyl group Chemical group 0.000 claims description 8
229910052739 hydrogen Inorganic materials 0.000 claims description 8
239000001257 hydrogen Substances 0.000 claims description 8
125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims description 6
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 6
125000000524 functional group Chemical group 0.000 claims description 2
150000007942 carboxylates Chemical class 0.000 claims 2
241000472351 Echinopsis aurea Species 0.000 claims 1
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YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 39
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OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 23
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RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 17
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RDOXTESZEPMUJZ-UHFFFAOYSA-N anisole Chemical compound COC1=CC=CC=C1 RDOXTESZEPMUJZ-UHFFFAOYSA-N 0.000 description 14
125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 13
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UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 7
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238000003786 synthesis reaction Methods 0.000 description 5
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QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
XAKBSHICSHRJCL-UHFFFAOYSA-N [CH2]C(=O)C1=CC=CC=C1 Chemical group [CH2]C(=O)C1=CC=CC=C1 XAKBSHICSHRJCL-UHFFFAOYSA-N 0.000 description 4
150000008065 acid anhydrides Chemical class 0.000 description 4
239000000654 additive Substances 0.000 description 4
239000000010 aprotic solvent Substances 0.000 description 4
230000037396 body weight Effects 0.000 description 4
239000002775 capsule Substances 0.000 description 4
150000001732 carboxylic acid derivatives Chemical class 0.000 description 4
238000004587 chromatography analysis Methods 0.000 description 4
238000007796 conventional method Methods 0.000 description 4
125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 description 4
239000000284 extract Substances 0.000 description 4
239000008187 granular material Substances 0.000 description 4
150000002576 ketones Chemical class 0.000 description 4
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
238000002844 melting Methods 0.000 description 4
230000008018 melting Effects 0.000 description 4
239000012299 nitrogen atmosphere Substances 0.000 description 4
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
239000011541 reaction mixture Substances 0.000 description 4
235000017557 sodium bicarbonate Nutrition 0.000 description 4
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125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 4
ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
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125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 3
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239000011734 sodium Substances 0.000 description 3
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125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 3
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229920001223 polyethylene glycol Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
BDAWXSQJJCIFIK-UHFFFAOYSA-N potassium methoxide Chemical compound [K+].[O-]C BDAWXSQJJCIFIK-UHFFFAOYSA-N 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
229960004919 procaine Drugs 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000006239 protecting group Chemical group 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
206010039083 rhinitis Diseases 0.000 description 1
230000007017 scission Effects 0.000 description 1
208000013223 septicemia Diseases 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
229940115939 shigella sonnei Drugs 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
235000020374 simple syrup Nutrition 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
JVBXVOWTABLYPX-UHFFFAOYSA-L sodium dithionite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])=O JVBXVOWTABLYPX-UHFFFAOYSA-L 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
235000010339 sodium tetraborate Nutrition 0.000 description 1
VYPDUQYOLCLEGS-UHFFFAOYSA-M sodium;2-ethylhexanoate Chemical compound [Na+].CCCCC(CC)C([O-])=O VYPDUQYOLCLEGS-UHFFFAOYSA-M 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000011343 solid material Substances 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
239000001593 sorbitan monooleate Substances 0.000 description 1
235000011069 sorbitan monooleate Nutrition 0.000 description 1
229940035049 sorbitan monooleate Drugs 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
125000003638 stannyl group Chemical group [H][Sn]([H])([H])* 0.000 description 1
239000007858 starting material Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
238000003860 storage Methods 0.000 description 1
229940031000 streptococcus pneumoniae Drugs 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
125000004434 sulfur atom Chemical group 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
IXZDIALLLMRYOU-UHFFFAOYSA-N tert-butyl hypochlorite Chemical compound CC(C)(C)OCl IXZDIALLLMRYOU-UHFFFAOYSA-N 0.000 description 1
125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
150000003512 tertiary amines Chemical class 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
125000003396 thiol group Chemical group [H]S* 0.000 description 1
239000011135 tin Substances 0.000 description 1
125000005425 toluyl group Chemical group 0.000 description 1
206010044008 tonsillitis Diseases 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
125000004665 trialkylsilyl group Chemical group 0.000 description 1
125000005039 triarylmethyl group Chemical group 0.000 description 1
150000003852 triazoles Chemical class 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
230000036269 ulceration Effects 0.000 description 1
241001148471 unidentified anaerobic bacterium Species 0.000 description 1
125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
229920001567 vinyl ester resin Polymers 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000001993 wax Substances 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
125000005023 xylyl group Chemical group 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cephalosporin Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NO782866A 1977-08-25 1978-08-23 Fremgangsmaate for fremstilling av cefalosporinderivater NO782866L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP52102261A JPS609718B2 (ja)	1977-08-25	1977-08-25	チアジアゾリルチオセフアロスポリン類縁抗生物質

Publications (1)

Publication Number	Publication Date
NO782866L true NO782866L (no)	1979-02-27

Family

ID=14322642

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO782866A NO782866L (no)	1977-08-25	1978-08-23	Fremgangsmaate for fremstilling av cefalosporinderivater

Country Status (34)

Country	Link
US (1)	US4201782A (de)
JP (1)	JPS609718B2 (de)
AR (1)	AR220539A1 (de)
AT (1)	AT361121B (de)
AU (1)	AU517618B2 (de)
BE (1)	BE869955A (de)
BG (1)	BG34338A3 (de)
CA (1)	CA1101417A (de)
CH (1)	CH637396A5 (de)
CS (1)	CS203927B2 (de)
DD (1)	DD137230A5 (de)
DE (1)	DE2837264A1 (de)
DK (1)	DK372878A (de)
ES (1)	ES472817A1 (de)
FI (1)	FI65432C (de)
FR (1)	FR2401165A1 (de)
GB (1)	GB1576796A (de)
GR (1)	GR70260B (de)
HU (1)	HU177900B (de)
IE (1)	IE47630B1 (de)
IL (1)	IL55429A0 (de)
IT (1)	IT1118098B (de)
MX (1)	MX5328E (de)
NL (1)	NL190554C (de)
NO (1)	NO782866L (de)
NZ (1)	NZ188173A (de)
PH (1)	PH17508A (de)
PL (1)	PL110656B1 (de)
PT (1)	PT68434A (de)
RO (1)	RO75070A (de)
SE (1)	SE452010B (de)
SU (1)	SU812182A3 (de)
YU (1)	YU43999B (de)
ZA (1)	ZA784753B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4259485A (en) *	1979-04-24	1981-03-31	Eli Lilly And Company	Crystallization process
FR2494279A1 (fr) *	1980-11-20	1982-05-21	Rhone Poulenc Ind	Nouvelles oxacephalosporines, leur preparation et les medicaments qui les contiennent
DE3373475D1 (en) *	1982-12-14	1987-10-15	Beecham Group Plc	Process for the preparation of beta-lactam compounds
JPS60123490A (ja) *	1983-12-07	1985-07-02	Shionogi & Co Ltd	マロニルオキサセフェムカルボン酸誘導体
US6013835A (en) *	1995-06-07	2000-01-11	Hfm International, Inc.	Method and apparatus for preparing purified terephthalic acid
US6197794B1 (en)	1998-01-08	2001-03-06	Celltech Therapeutics Limited	Phenylalanine derivatives
US6329372B1 (en)	1998-01-27	2001-12-11	Celltech Therapeutics Limited	Phenylalanine derivatives
ATE273273T1 (de)	1998-02-26	2004-08-15	Celltech Therapeutics Ltd	Phenylalaninderivate als inhibitoren von alpha4 integrinen
GB9805655D0 (en)	1998-03-16	1998-05-13	Celltech Therapeutics Ltd	Chemical compounds
US6521626B1 (en)	1998-03-24	2003-02-18	Celltech R&D Limited	Thiocarboxamide derivatives
GB9811159D0 (en)	1998-05-22	1998-07-22	Celltech Therapeutics Ltd	Chemical compounds
GB9811969D0 (en)	1998-06-03	1998-07-29	Celltech Therapeutics Ltd	Chemical compounds
GB9812088D0 (en)	1998-06-05	1998-08-05	Celltech Therapeutics Ltd	Chemical compounds
GB9814414D0 (en)	1998-07-03	1998-09-02	Celltech Therapeutics Ltd	Chemical compounds
GB9821061D0 (en)	1998-09-28	1998-11-18	Celltech Therapeutics Ltd	Chemical compounds
GB9821222D0 (en)	1998-09-30	1998-11-25	Celltech Therapeutics Ltd	Chemical compounds
GB9821406D0 (en) *	1998-10-01	1998-11-25	Celltech Therapeutics Ltd	Chemical compounds
GB9825652D0 (en)	1998-11-23	1999-01-13	Celltech Therapeutics Ltd	Chemical compounds
US6518283B1 (en)	1999-05-28	2003-02-11	Celltech R&D Limited	Squaric acid derivatives
US6534513B1 (en)	1999-09-29	2003-03-18	Celltech R&D Limited	Phenylalkanoic acid derivatives
US6455539B2 (en)	1999-12-23	2002-09-24	Celltech R&D Limited	Squaric acid derivates
EP1332132B1 (de)	2000-04-17	2007-10-10	UCB Pharma, S.A.	Enamin-derivate als zell-adhäsionsmoleküle
US6545013B2 (en)	2000-05-30	2003-04-08	Celltech R&D Limited	2,7-naphthyridine derivatives
US6403608B1 (en)	2000-05-30	2002-06-11	Celltech R&D, Ltd.	3-Substituted isoquinolin-1-yl derivatives
AU2001267753A1 (en)	2000-07-07	2002-01-21	Celltech R And D Limited	Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists
US6649756B2 (en) *	2000-07-13	2003-11-18	Wyeth, Five Giralda Farms	Process improvement in the preparation of (4r, 5s, 6s)-3-[[(2r,3r)-2-[[[(s)-2-amino-3-methyl-1-oxobutyl]amino]methyl]tetrahydro-3-furanyl]thio]-6-[(r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
AU2001275724A1 (en)	2000-08-02	2002-02-13	Celltech R&D Limited	3-substituted isoquinolin-1-yl derivatives
CN102827191B (zh) *	2012-09-24	2015-03-11	浙江东邦药业有限公司	一种氧头孢类化合物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL178005C (nl) *	1972-11-06	1986-01-02	Merck & Co Inc	Werkwijze voor het bereiden van een farmaceutisch preparaat met antibacteriele werking, alsmede werkwijze ter bereiding van een cefalosporine-antibioticum.
US4045438A (en) *	1975-10-24	1977-08-30	Yeda Research And Development Co. Ltd.	Cephalosporin antibiotics
US4031083A (en) *	1975-10-24	1977-06-21	Yeda Research And Development Co., Ltd.	Cephalosporin antibiotics
CA1070688A (en) *	1975-11-12	1980-01-29	Mitsuru Yoshioka	Cephalosporin analogues
CA1085392A (en) *	1976-03-25	1980-09-09	Masayuki Narisada	Arylmalonamido-1-oxadethiacephalosporins

1977
- 1977-08-25 JP JP52102261A patent/JPS609718B2/ja not_active Expired
1978
- 1978-04-28 GB GB17007/78A patent/GB1576796A/en not_active Expired
- 1978-08-17 NZ NZ188173A patent/NZ188173A/xx unknown
- 1978-08-17 PT PT68434A patent/PT68434A/pt unknown
- 1978-08-21 ZA ZA00784753A patent/ZA784753B/xx unknown
- 1978-08-21 CA CA309,705A patent/CA1101417A/en not_active Expired
- 1978-08-22 CS CS785485A patent/CS203927B2/cs unknown
- 1978-08-23 NO NO782866A patent/NO782866L/no unknown
- 1978-08-23 AR AR273406A patent/AR220539A1/es active
- 1978-08-23 MX MX787347U patent/MX5328E/es unknown
- 1978-08-23 IE IE1703/78A patent/IE47630B1/en not_active IP Right Cessation
- 1978-08-23 DD DD78207438A patent/DD137230A5/de unknown
- 1978-08-24 DK DK372878A patent/DK372878A/da not_active Application Discontinuation
- 1978-08-24 AU AU39238/78A patent/AU517618B2/en not_active Expired
- 1978-08-24 IT IT68975/78A patent/IT1118098B/it active
- 1978-08-24 FI FI782586A patent/FI65432C/fi not_active IP Right Cessation
- 1978-08-24 ES ES472817A patent/ES472817A1/es not_active Expired
- 1978-08-24 US US05/936,506 patent/US4201782A/en not_active Expired - Lifetime
- 1978-08-24 SE SE7808950A patent/SE452010B/sv not_active IP Right Cessation
- 1978-08-24 FR FR7824595A patent/FR2401165A1/fr active Granted
- 1978-08-24 IL IL7855429A patent/IL55429A0/xx not_active IP Right Cessation
- 1978-08-24 BE BE190057A patent/BE869955A/xx not_active IP Right Cessation
- 1978-08-25 HU HU78SI1644A patent/HU177900B/hu not_active IP Right Cessation
- 1978-08-25 DE DE19782837264 patent/DE2837264A1/de active Granted
- 1978-08-25 BG BG7840749A patent/BG34338A3/xx unknown
- 1978-08-25 GR GR57086A patent/GR70260B/el unknown
- 1978-08-25 PL PL1978209215A patent/PL110656B1/pl unknown
- 1978-08-25 RO RO7895037A patent/RO75070A/ro unknown
- 1978-08-25 YU YU2028/78A patent/YU43999B/xx unknown
- 1978-08-25 CH CH899678A patent/CH637396A5/de not_active IP Right Cessation
- 1978-08-25 NL NLAANVRAGE7808802,A patent/NL190554C/xx not_active IP Right Cessation
- 1978-08-25 PH PH21699A patent/PH17508A/en unknown
- 1978-08-25 SU SU782652750A patent/SU812182A3/ru active
- 1978-08-25 AT AT620378A patent/AT361121B/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
NZ188173A (en)	1981-05-15
GB1576796A (en)	1980-10-15
AR220539A1 (es)	1980-11-14
ZA784753B (en)	1979-08-29
MX5328E (es)	1983-06-22
AT361121B (de)	1981-02-25
AU517618B2 (en)	1981-08-13
ES472817A1 (es)	1979-02-16
ATA620378A (de)	1980-07-15
NL190554B (nl)	1993-11-16
NL190554C (nl)	1994-04-18
NL7808802A (nl)	1979-02-27
DK372878A (da)	1979-02-26
YU43999B (en)	1990-02-28
RO75070A (ro)	1980-10-30
DD137230A5 (de)	1979-08-22
IL55429A0 (en)	1978-10-31
FR2401165A1 (fr)	1979-03-23
PH17508A (en)	1984-09-07
DE2837264A1 (de)	1979-03-01
AU3923878A (en)	1980-02-28
PT68434A (en)	1978-09-01
IE47630B1 (en)	1984-05-16
FI65432B (fi)	1984-01-31
CS203927B2 (en)	1981-03-31
US4201782A (en)	1980-05-06
GR70260B (de)	1982-09-02
DE2837264C2 (de)	1991-06-13
PL209215A1 (pl)	1979-06-04
PL110656B1 (en)	1980-07-31
BG34338A3 (en)	1983-08-15
IT1118098B (it)	1986-02-24
FI65432C (fi)	1984-05-10
IT7868975A0 (it)	1978-08-24
FR2401165B1 (de)	1982-06-25
CH637396A5 (de)	1983-07-29
JPS609718B2 (ja)	1985-03-12
YU202878A (en)	1982-10-31
SU812182A3 (ru)	1981-03-07
BE869955A (fr)	1978-12-18
CA1101417A (en)	1981-05-19
IE781703L (en)	1979-02-25
JPS5436288A (en)	1979-03-16
SE7808950L (sv)	1979-02-26
HU177900B (en)	1982-01-28
SE452010B (sv)	1987-11-09
FI782586A (fi)	1979-02-26

Publication	Publication Date	Title
NO782866L (no)	1979-02-27	Fremgangsmaate for fremstilling av cefalosporinderivater
US4748170A (en)	1988-05-31	Carboxyalkenamidocephalosporins
US4254119A (en)	1981-03-03	3-Unsubstituted-3-cephem compounds
US4731362A (en)	1988-03-15	Alkylcarbamoyloxymethylcephem compounds
US4731361A (en)	1988-03-15	Alkeneamidocephalosporin esters
EP0107928B1 (de)	1988-01-07	Vinylthioacetamido Oxacephalosporin-Derivate und Zwischenprodukte, ihre Herstellung, sie enthaltende Zusammensetzungen und ihre antibakterielle Verwendung
US5134138A (en)	1992-07-28	Phenacylpyridiniothiocephalosporins
EP0128536B1 (de)	1989-09-13	Fluormethylthiooxacephalosporin-Derivate
EP0287734A1 (de)	1988-10-26	2-Beta-substituiertes-methyl-penamderivate
JP3238209B2 (ja)	2001-12-10	チオメチルチオカルバセファロスポリン誘導体
US4705852A (en)	1987-11-10	1-oxadethia cephalosporin hydroxamic acid derivatives
US4629726A (en)	1986-12-16	Penem carboxylic acids
JPS6016989A (ja)	1985-01-28	オキソ飽和異項環カルボンアミドセフエム化合物
KR870000611B1 (ko)	1987-03-25	세팔로스포린의 제조방법
CA1100962A (en)	1981-05-12	Haloarylmalonamidooxacephalosporins
US4569993A (en)	1986-02-11	Malonyloxacephemcarboxylic acid derivatives
EP0114751B1 (de)	1987-12-09	Beta-Lactam antibakterielle Mittel
IE47929B1 (en)	1984-07-25	Substituted imidazolidinyl-3-chloro-3-cephem-4-carboxylic acids
JPS60197689A (ja)	1985-10-07	オキサセフアロスポリンのビニルチオ誘導体
JPS60130590A (ja)	1985-07-12	置換メチルチオメチルセフアロスポリン類