NO781688L - Fremgangsmaate ved fremstilling av farmakologisk aktive midler - Google Patents

Fremgangsmaate ved fremstilling av farmakologisk aktive midler

Info

Publication number: NO781688L
Authority: NO; Norway
Prior art keywords: tinidazole; solution; nitroimidazole; drug; aqueous solution
Prior art date: 1977-05-14

Application number

NO78781688A

Other languages

English (en)

Norwegian (no)

Inventor

Mahdi Bakir Fawzi

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-05-14

Filing date

1978-05-12

Publication date

1978-11-15

1978-05-12 Application filed by Pfizer filed Critical Pfizer

1978-11-15 Publication of NO781688L publication Critical patent/NO781688L/no

Links

238000000034 method Methods 0.000 title claims description 17
239000013543 active substance Substances 0.000 title description 2
230000000144 pharmacologic effect Effects 0.000 title 1
WXTMDXOMEHJXQO-UHFFFAOYSA-N 2,5-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC(O)=CC=C1O WXTMDXOMEHJXQO-UHFFFAOYSA-N 0.000 claims description 30
HJLSLZFTEKNLFI-UHFFFAOYSA-N Tinidazole Chemical compound CCS(=O)(=O)CCN1C(C)=NC=C1[N+]([O-])=O HJLSLZFTEKNLFI-UHFFFAOYSA-N 0.000 claims description 28
229960005053 tinidazole Drugs 0.000 claims description 28
239000000243 solution Substances 0.000 claims description 22
YZEUHQHUFTYLPH-UHFFFAOYSA-N 2-nitroimidazole Chemical compound [O-][N+](=O)C1=NC=CN1 YZEUHQHUFTYLPH-UHFFFAOYSA-N 0.000 claims description 14
229960005219 gentisic acid Drugs 0.000 claims description 13
229940079593 drug Drugs 0.000 claims description 12
239000003814 drug Substances 0.000 claims description 12
239000007864 aqueous solution Substances 0.000 claims description 11
150000003839 salts Chemical class 0.000 claims description 10
PUZSUVGRVHEUQO-UHFFFAOYSA-N gentisyl alcohol Chemical compound OCC1=CC(O)=CC=C1O PUZSUVGRVHEUQO-UHFFFAOYSA-N 0.000 claims description 8
239000008194 pharmaceutical composition Substances 0.000 claims description 5
-1 dihydroxybenzyl alcohol Chemical compound 0.000 claims description 4
229960000282 metronidazole Drugs 0.000 claims description 4
VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims description 4
JOVXEDBYAWFQQX-UHFFFAOYSA-N 2-(2-methyl-5-nitroimidazol-1-yl)ethyl carbamate Chemical compound CC1=NC=C([N+]([O-])=O)N1CCOC(N)=O JOVXEDBYAWFQQX-UHFFFAOYSA-N 0.000 claims description 3
IPWKIXLWTCNBKN-UHFFFAOYSA-N Madelen Chemical compound CC1=NC=C([N+]([O-])=O)N1CC(O)CCl IPWKIXLWTCNBKN-UHFFFAOYSA-N 0.000 claims description 3
150000003863 ammonium salts Chemical class 0.000 claims description 3
229950005881 bamnidazole Drugs 0.000 claims description 3
229960004918 nimorazole Drugs 0.000 claims description 3
MDJFHRLTPRPZLY-UHFFFAOYSA-N nimorazole Chemical compound [O-][N+](=O)C1=CN=CN1CCN1CCOCC1 MDJFHRLTPRPZLY-UHFFFAOYSA-N 0.000 claims description 3
229960002313 ornidazole Drugs 0.000 claims description 3
238000004108 freeze drying Methods 0.000 claims description 2
230000001954 sterilising effect Effects 0.000 claims description 2
238000004659 sterilization and disinfection Methods 0.000 claims description 2
229940102223 injectable solution Drugs 0.000 claims 1
239000007972 injectable composition Substances 0.000 description 16
239000000203 mixture Substances 0.000 description 16
238000001990 intravenous administration Methods 0.000 description 13
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 8
CQRYARSYNCAZFO-UHFFFAOYSA-N o-hydroxybenzyl alcohol Natural products OCC1=CC=CC=C1O CQRYARSYNCAZFO-UHFFFAOYSA-N 0.000 description 6
238000009472 formulation Methods 0.000 description 5
BVJSUAQZOZWCKN-UHFFFAOYSA-N p-hydroxybenzyl alcohol Chemical compound OCC1=CC=C(O)C=C1 BVJSUAQZOZWCKN-UHFFFAOYSA-N 0.000 description 5
239000002253 acid Substances 0.000 description 3
239000007787 solid Substances 0.000 description 3
HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 description 2
GLDQAMYCGOIJDV-UHFFFAOYSA-N Pyrocatechuic acid Natural products OC(=O)C1=CC=CC(O)=C1O GLDQAMYCGOIJDV-UHFFFAOYSA-N 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
235000011114 ammonium hydroxide Nutrition 0.000 description 2
208000022506 anaerobic bacteria infectious disease Diseases 0.000 description 2
230000000845 anti-microbial effect Effects 0.000 description 2
239000004599 antimicrobial Substances 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
239000011521 glass Substances 0.000 description 2
238000007918 intramuscular administration Methods 0.000 description 2
239000000047 product Substances 0.000 description 2
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
229940090248 4-hydroxybenzoic acid Drugs 0.000 description 1
150000004958 5-nitroimidazoles Chemical class 0.000 description 1
208000004881 Amebiasis Diseases 0.000 description 1
206010001980 Amoebiasis Diseases 0.000 description 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
229930064664 L-arginine Natural products 0.000 description 1
235000014852 L-arginine Nutrition 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
208000010362 Protozoan Infections Diseases 0.000 description 1
VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 description 1
208000005448 Trichomonas Infections Diseases 0.000 description 1
206010044620 Trichomoniasis Diseases 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000000460 chlorine Substances 0.000 description 1
229910052801 chlorine Inorganic materials 0.000 description 1
OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
229960001231 choline Drugs 0.000 description 1
238000001816 cooling Methods 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
238000002845 discoloration Methods 0.000 description 1
238000001914 filtration Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000010255 intramuscular injection Methods 0.000 description 1
239000007927 intramuscular injection Substances 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
229960003194 meglumine Drugs 0.000 description 1
239000012528 membrane Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical class OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
229960004249 sodium acetate Drugs 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
229960002668 sodium chloride Drugs 0.000 description 1
239000001540 sodium lactate Substances 0.000 description 1
229940005581 sodium lactate Drugs 0.000 description 1
235000011088 sodium lactate Nutrition 0.000 description 1
229960004025 sodium salicylate Drugs 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
229940074404 sodium succinate Drugs 0.000 description 1
ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
239000008247 solid mixture Substances 0.000 description 1
239000012265 solid product Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
239000008215 water for injection Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

NO78781688A 1977-05-14 1978-05-12 Fremgangsmaate ved fremstilling av farmakologisk aktive midler NO781688L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB2037977		1977-05-14

Publications (1)

Publication Number	Publication Date
NO781688L true NO781688L (no)	1978-11-15

Family

ID=10144988

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO78781688A NO781688L (no)	1977-05-14	1978-05-12	Fremgangsmaate ved fremstilling av farmakologisk aktive midler

Country Status (16)

Country	Link
JP (1)	JPS542315A (fr)
AU (1)	AU504551B1 (fr)
BE (1)	BE867040A (fr)
DE (1)	DE2820992A1 (fr)
DK (1)	DK212678A (fr)
ES (1)	ES469749A1 (fr)
FI (1)	FI781507A (fr)
FR (1)	FR2390162A1 (fr)
IL (1)	IL54687A0 (fr)
IT (1)	IT1115599B (fr)
LU (1)	LU79655A1 (fr)
NL (1)	NL7805158A (fr)
NO (1)	NO781688L (fr)
PT (1)	PT68034B (fr)
SE (1)	SE7805471L (fr)
ZA (1)	ZA782736B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3070778D1 (en) *	1979-08-11	1985-07-25	Bayer Ag	Antimycotic agents with enhanced release of the active ingredients
FR2624736B1 (fr) *	1987-12-16	1991-03-22	Dietlin Francois	Nouvelles compositions pharmaceutiques dispersibles dans l'eau a base d'ornidazole
CN104127379A (zh) *	2014-08-14	2014-11-05	珠海亿邦制药股份有限公司	一种奥硝唑注射液及其制备方法
CN110538144A (zh) *	2019-06-13	2019-12-06	南京瓦尔生物医药有限公司	一种奥硝唑注射液和s-奥硝唑注射液

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4032645A (en) *	1975-06-19	1977-06-28	G. D. Searle & Co.	Injectable metronidazole composition

1978
- 1978-05-10 IL IL54687A patent/IL54687A0/xx unknown
- 1978-05-11 ES ES469749A patent/ES469749A1/es not_active Expired
- 1978-05-12 NL NL7805158A patent/NL7805158A/xx not_active Application Discontinuation
- 1978-05-12 FR FR7814291A patent/FR2390162A1/fr not_active Withdrawn
- 1978-05-12 AU AU36078/78A patent/AU504551B1/en not_active Expired
- 1978-05-12 DK DK212678A patent/DK212678A/da not_active Application Discontinuation
- 1978-05-12 DE DE19782820992 patent/DE2820992A1/de active Pending
- 1978-05-12 BE BE187664A patent/BE867040A/fr unknown
- 1978-05-12 ZA ZA00782736A patent/ZA782736B/xx unknown
- 1978-05-12 LU LU79655A patent/LU79655A1/fr unknown
- 1978-05-12 SE SE7805471A patent/SE7805471L/xx unknown
- 1978-05-12 PT PT68034A patent/PT68034B/pt unknown
- 1978-05-12 IT IT23351/78A patent/IT1115599B/it active
- 1978-05-12 NO NO78781688A patent/NO781688L/no unknown
- 1978-05-12 FI FI781507A patent/FI781507A/fi not_active Application Discontinuation
- 1978-05-13 JP JP5706378A patent/JPS542315A/ja active Pending

Also Published As

Publication number	Publication date
BE867040A (fr)	1978-11-13
AU504551B1 (en)	1979-10-18
FR2390162A1 (fr)	1978-12-08
DK212678A (da)	1978-11-15
ES469749A1 (es)	1978-12-16
ZA782736B (en)	1979-05-30
DE2820992A1 (de)	1978-12-07
IL54687A0 (en)	1978-07-31
FI781507A (fi)	1978-11-15
JPS542315A (en)	1979-01-09
IT1115599B (it)	1986-02-03
IT7823351A0 (it)	1978-05-12
PT68034B (en)	1979-10-24
SE7805471L (sv)	1978-11-15
NL7805158A (nl)	1978-11-16
PT68034A (en)	1978-06-01
LU79655A1 (fr)	1979-12-06

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