NO324206B1 - Antistoffer mot interferon alfa-/beta-reseptorer og fremgangsmater for fremstilling og anvendelse derav, samt DNA-molekyl, ekspresjonsvektor, vertscelle, farmasoytisk sammensetning, hybridom og sett. - Google Patents
Antistoffer mot interferon alfa-/beta-reseptorer og fremgangsmater for fremstilling og anvendelse derav, samt DNA-molekyl, ekspresjonsvektor, vertscelle, farmasoytisk sammensetning, hybridom og sett. Download PDFInfo
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- NO324206B1 NO324206B1 NO19985050A NO985050A NO324206B1 NO 324206 B1 NO324206 B1 NO 324206B1 NO 19985050 A NO19985050 A NO 19985050A NO 985050 A NO985050 A NO 985050A NO 324206 B1 NO324206 B1 NO 324206B1
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- 150000003335 secondary amines Chemical class 0.000 description 1
- 239000006152 selective media Substances 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
- 238000012868 site-directed mutagenesis technique Methods 0.000 description 1
- 238000003998 size exclusion chromatography high performance liquid chromatography Methods 0.000 description 1
- 201000010153 skin papilloma Diseases 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000563 toxic property Toxicity 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- 208000007089 vaccinia Diseases 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Mycology (AREA)
- Diabetes (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- Obesity (AREA)
- Plant Pathology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL11809696A IL118096A0 (en) | 1996-05-01 | 1996-05-01 | Antibodies against interferon alpha/beta receptor |
PCT/IL1997/000138 WO1997041229A1 (en) | 1996-05-01 | 1997-04-29 | Antibodies against interferon alpha/beta receptor |
Publications (3)
Publication Number | Publication Date |
---|---|
NO985050D0 NO985050D0 (no) | 1998-10-29 |
NO985050L NO985050L (no) | 1998-12-29 |
NO324206B1 true NO324206B1 (no) | 2007-09-10 |
Family
ID=11068814
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19985050A NO324206B1 (no) | 1996-05-01 | 1998-10-29 | Antistoffer mot interferon alfa-/beta-reseptorer og fremgangsmater for fremstilling og anvendelse derav, samt DNA-molekyl, ekspresjonsvektor, vertscelle, farmasoytisk sammensetning, hybridom og sett. |
Country Status (19)
Country | Link |
---|---|
US (1) | US6136309A (uk) |
EP (2) | EP1739177A1 (uk) |
JP (1) | JP4308322B2 (uk) |
KR (2) | KR100581798B1 (uk) |
CN (1) | CN1198929C (uk) |
AT (1) | ATE342981T1 (uk) |
AU (1) | AU719995B2 (uk) |
BR (1) | BR9709202A (uk) |
CA (1) | CA2253239C (uk) |
DE (1) | DE69736835T2 (uk) |
DK (1) | DK0927252T3 (uk) |
EA (1) | EA002543B1 (uk) |
ES (1) | ES2274542T3 (uk) |
HK (1) | HK1019339A1 (uk) |
IL (2) | IL118096A0 (uk) |
NO (1) | NO324206B1 (uk) |
PT (1) | PT927252E (uk) |
UA (1) | UA76396C2 (uk) |
WO (1) | WO1997041229A1 (uk) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0563487A1 (en) * | 1992-03-31 | 1993-10-06 | Laboratoire Europeen De Biotechnologie S.A. | Monoclonal antibodies against the interferon receptor, with neutralizing activity against type I interferon |
US6713609B1 (en) | 1996-07-16 | 2004-03-30 | Genentech, Inc. | Monoclonal antibodies to type I interferon receptor |
US6376067B1 (en) * | 1998-12-21 | 2002-04-23 | Mitsubishi Polyester Film, Llc | Silicone coated film with back side slip control coating and method of controlling slip of such film |
RU2181297C2 (ru) | 2000-06-20 | 2002-04-20 | Эпштейн Олег Ильич | Способ лечения патологического синдрома и лекарственное средство |
ATE502648T1 (de) * | 2001-01-09 | 2011-04-15 | Baylor Res Inst | Verfahren zur behandlung von autoimmunerkrankungen bei einem probanden und diagnostische in-vitro-assays |
AU2007202840B2 (en) * | 2001-01-09 | 2011-07-28 | Baylor Research Institute | Methods for treating autoimmune diseases in a subject and in vitro diagnostic assays |
US7087726B2 (en) | 2001-02-22 | 2006-08-08 | Genentech, Inc. | Anti-interferon-α antibodies |
UA76640C2 (uk) * | 2002-08-02 | 2006-08-15 | Олєг Ільіч Епштєйн | Спосіб корекції патологічних імунних реакцій та гомеопатичний лікарський засіб |
UA76638C2 (en) * | 2002-08-02 | 2006-08-15 | Oleh Illich Epshtein | Homeopathic medication based on anti-interferon antibodies and method for treating a pathological syndrome associated with interferon |
UA76639C2 (uk) * | 2002-08-02 | 2006-08-15 | Олєг Ільіч Епштєйн | Гомеопатичний лікарський засіб та спосіб лікування еректильних дисфункцій |
WO2004093908A2 (en) * | 2003-04-23 | 2004-11-04 | Medarex, Inc. | Compositions and methods for the therapy of inflammatory bowel disease |
AU2007203559B2 (en) * | 2003-04-23 | 2010-09-02 | E. R. Squibb & Sons, L.L.C. | Compositions and methods for the therapy of inflammatory bowel disease |
LT2418220T (lt) | 2003-12-10 | 2017-10-10 | E. R. Squibb & Sons, L.L.C. | Interferono-alfa antikūnai ir jų panaudojimas |
EP1781705B1 (en) * | 2004-06-21 | 2014-10-08 | Medarex, L.L.C. | Interferon alpha receptor i antibodies and their uses |
JP5837730B2 (ja) | 2005-02-10 | 2015-12-24 | ベイラー リサーチ インスティテュートBaylor Research Institute | 抗インターフェロンアルファモノクローナル抗体及び使用方法 |
US7888481B2 (en) * | 2005-02-10 | 2011-02-15 | Baylor Research Institute | Anti-interferon alpha monoclonal antibodies and methods for use |
JP2008543335A (ja) * | 2005-06-22 | 2008-12-04 | ジェネンテック・インコーポレーテッド | Ifnar2を標的とするための方法と組成物 |
AU2009245792B2 (en) * | 2008-05-07 | 2012-11-01 | Coimmune, Inc. | Humanized antibodies against human interferon-alpha |
FR2962651A1 (fr) | 2010-07-15 | 2012-01-20 | Oleg Iliich Epshtein | Composition pharmaceutique d'association et son utilisation dans des procedes pour traiter les maladies ou affections fonctionnelles du tractus gastro-intestinal |
FR2962656A1 (fr) | 2010-07-15 | 2012-01-20 | Oleg Iliich Epshtein | Procede pour augmenter l'effet d'une forme activee-potentialisee d'un anticorps |
WO2018010140A1 (zh) * | 2016-07-14 | 2018-01-18 | 中国科学院生物物理研究所 | I型干扰素受体抗体及其用途 |
CN115558027B (zh) * | 2022-12-05 | 2023-02-28 | 北京万泰生物药业股份有限公司 | 一种核酸酶的单克隆抗体及其应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0563487A1 (en) * | 1992-03-31 | 1993-10-06 | Laboratoire Europeen De Biotechnologie S.A. | Monoclonal antibodies against the interferon receptor, with neutralizing activity against type I interferon |
IL108584A (en) * | 1994-02-07 | 2008-03-20 | Yeda Res & Dev | Cloning of the interferon-binding protein ALPHA / BETA |
IL106591A (en) * | 1992-09-03 | 2008-03-20 | Yeda Res & Dev | Interferon alpha/beta binding protein, its preparation and pharmaceutical compositions containing it |
JPH11501283A (ja) * | 1993-09-17 | 1999-02-02 | ラボラトワール ウーロペアン ドゥ バイオテクノロジ ソシエテ アノニム | I型インターフェロンに対する中和活性を有する、インターフェロンレセプターに対するモノクローナル抗体を含んでなる医薬組成物 |
-
1996
- 1996-05-01 IL IL11809696A patent/IL118096A0/xx unknown
-
1997
- 1997-04-29 JP JP53837897A patent/JP4308322B2/ja not_active Expired - Lifetime
- 1997-04-29 BR BR9709202A patent/BR9709202A/pt active Search and Examination
- 1997-04-29 EP EP06014510A patent/EP1739177A1/en not_active Withdrawn
- 1997-04-29 DE DE69736835T patent/DE69736835T2/de not_active Expired - Lifetime
- 1997-04-29 WO PCT/IL1997/000138 patent/WO1997041229A1/en active IP Right Grant
- 1997-04-29 PT PT97919622T patent/PT927252E/pt unknown
- 1997-04-29 KR KR1020047011388A patent/KR100581798B1/ko not_active IP Right Cessation
- 1997-04-29 AU AU24027/97A patent/AU719995B2/en not_active Expired
- 1997-04-29 EA EA199800968A patent/EA002543B1/ru not_active IP Right Cessation
- 1997-04-29 DK DK97919622T patent/DK0927252T3/da active
- 1997-04-29 CN CNB971951861A patent/CN1198929C/zh not_active Expired - Lifetime
- 1997-04-29 EP EP97919622A patent/EP0927252B1/en not_active Expired - Lifetime
- 1997-04-29 IL IL126835A patent/IL126835A/en not_active IP Right Cessation
- 1997-04-29 CA CA2253239A patent/CA2253239C/en not_active Expired - Lifetime
- 1997-04-29 ES ES97919622T patent/ES2274542T3/es not_active Expired - Lifetime
- 1997-04-29 UA UA98116315A patent/UA76396C2/uk unknown
- 1997-04-29 AT AT97919622T patent/ATE342981T1/de active
- 1997-04-29 KR KR1019980708393A patent/KR20000064953A/ko active Search and Examination
-
1998
- 1998-04-29 US US09/171,979 patent/US6136309A/en not_active Expired - Lifetime
- 1998-10-29 NO NO19985050A patent/NO324206B1/no not_active IP Right Cessation
-
1999
- 1999-09-30 HK HK99104252A patent/HK1019339A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
BR9709202A (pt) | 1999-08-10 |
DE69736835T2 (de) | 2007-11-22 |
EA199800968A1 (ru) | 1999-04-29 |
IL126835A (en) | 2007-07-24 |
IL118096A0 (en) | 1996-09-12 |
DK0927252T3 (da) | 2007-02-05 |
EA002543B1 (ru) | 2002-06-27 |
CN1198929C (zh) | 2005-04-27 |
KR20000064953A (ko) | 2000-11-06 |
JP4308322B2 (ja) | 2009-08-05 |
ATE342981T1 (de) | 2006-11-15 |
EP0927252B1 (en) | 2006-10-18 |
DE69736835D1 (de) | 2006-11-30 |
US6136309A (en) | 2000-10-24 |
AU719995B2 (en) | 2000-05-18 |
CA2253239A1 (en) | 1997-11-06 |
HK1019339A1 (en) | 2000-02-03 |
PT927252E (pt) | 2007-01-31 |
KR100581798B1 (ko) | 2006-05-25 |
WO1997041229A1 (en) | 1997-11-06 |
ES2274542T3 (es) | 2007-05-16 |
EP1739177A1 (en) | 2007-01-03 |
KR20040075105A (ko) | 2004-08-26 |
AU2402797A (en) | 1997-11-19 |
JP2000509276A (ja) | 2000-07-25 |
CA2253239C (en) | 2010-08-10 |
EP0927252A1 (en) | 1999-07-07 |
NO985050D0 (no) | 1998-10-29 |
UA76396C2 (en) | 2006-08-15 |
NO985050L (no) | 1998-12-29 |
CN1220699A (zh) | 1999-06-23 |
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Legal Events
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MK1K | Patent expired |