NO310992B1 - Diagnostisk metode for detektering av ruptur av fotale membraner og testkit som anvender denne - Google Patents

Diagnostisk metode for detektering av ruptur av fotale membraner og testkit som anvender denne Download PDF

Info

Publication number: NO310992B1
Authority: NO; Norway
Prior art keywords: igfbp; sample; test; concentration; antibody
Prior art date: 1990-12-31

Application number

NO19932363A

Other languages

English (en)

Norwegian (no)

Other versions

NO932363L (no

NO932363D0 (no

Inventor

Eeva-Marja Rutanen

Original Assignee

Medix Biochemica Ab Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-31

Filing date

1993-06-28

Publication date

2001-09-24

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8531673&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO310992(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1993-06-28 Application filed by Medix Biochemica Ab Oy filed Critical Medix Biochemica Ab Oy

1993-06-28 Publication of NO932363D0 publication Critical patent/NO932363D0/no

1993-08-23 Publication of NO932363L publication Critical patent/NO932363L/no

2001-09-24 Publication of NO310992B1 publication Critical patent/NO310992B1/no

Links

238000002405 diagnostic procedure Methods 0.000 title claims description 7
239000012528 membrane Substances 0.000 title description 42
238000003149 assay kit Methods 0.000 title description 4
102000004375 Insulin-like growth factor-binding protein 1 Human genes 0.000 claims description 106
108090000957 Insulin-like growth factor-binding protein 1 Proteins 0.000 claims description 106
238000012360 testing method Methods 0.000 claims description 71
210000004381 amniotic fluid Anatomy 0.000 claims description 42
150000001875 compounds Chemical class 0.000 claims description 42
238000000034 method Methods 0.000 claims description 29
239000000243 solution Substances 0.000 claims description 23
238000009739 binding Methods 0.000 claims description 20
239000003550 marker Substances 0.000 claims description 20
230000009870 specific binding Effects 0.000 claims description 18
210000002219 extraembryonic membrane Anatomy 0.000 claims description 17
102000004169 proteins and genes Human genes 0.000 claims description 16
108090000623 proteins and genes Proteins 0.000 claims description 16
230000027455 binding Effects 0.000 claims description 14
239000003153 chemical reaction reagent Substances 0.000 claims description 12
210000003756 cervix mucus Anatomy 0.000 claims description 10
238000010790 dilution Methods 0.000 claims description 9
239000012895 dilution Substances 0.000 claims description 9
239000002245 particle Substances 0.000 claims description 8
210000001215 vagina Anatomy 0.000 claims description 8
230000035945 sensitivity Effects 0.000 claims description 2
239000007790 solid phase Substances 0.000 claims description 2
239000000523 sample Substances 0.000 description 45
210000004379 membrane Anatomy 0.000 description 40
108090000790 Enzymes Proteins 0.000 description 16
102000004190 Enzymes Human genes 0.000 description 16
210000002966 serum Anatomy 0.000 description 13
239000000427 antigen Substances 0.000 description 12
102000036639 antigens Human genes 0.000 description 12
108091007433 antigens Proteins 0.000 description 12
210000004369 blood Anatomy 0.000 description 12
239000008280 blood Substances 0.000 description 12
101001081567 Homo sapiens Insulin-like growth factor-binding protein 1 Proteins 0.000 description 8
102100027636 Insulin-like growth factor-binding protein 1 Human genes 0.000 description 8
238000006243 chemical reaction Methods 0.000 description 8
230000008774 maternal effect Effects 0.000 description 8
239000000758 substrate Substances 0.000 description 8
108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 7
108010057464 Prolactin Proteins 0.000 description 7
102000003946 Prolactin Human genes 0.000 description 7
239000004816 latex Substances 0.000 description 7
229920000126 latex Polymers 0.000 description 7
229940097325 prolactin Drugs 0.000 description 7
102100023635 Alpha-fetoprotein Human genes 0.000 description 6
102000013275 Somatomedins Human genes 0.000 description 6
108010026331 alpha-Fetoproteins Proteins 0.000 description 6
239000011324 bead Substances 0.000 description 6
239000000975 dye Substances 0.000 description 6
239000012530 fluid Substances 0.000 description 6
238000005259 measurement Methods 0.000 description 6
230000028327 secretion Effects 0.000 description 6
238000004458 analytical method Methods 0.000 description 5
239000000872 buffer Substances 0.000 description 5
102000028416 insulin-like growth factor binding Human genes 0.000 description 5
108091022911 insulin-like growth factor binding Proteins 0.000 description 5
239000004033 plastic Substances 0.000 description 5
108010001336 Horseradish Peroxidase Proteins 0.000 description 4
238000003556 assay Methods 0.000 description 4
238000001514 detection method Methods 0.000 description 4
238000003745 diagnosis Methods 0.000 description 4
238000007865 diluting Methods 0.000 description 4
230000002028 premature Effects 0.000 description 4
230000004520 agglutination Effects 0.000 description 3
239000012131 assay buffer Substances 0.000 description 3
230000000694 effects Effects 0.000 description 3
230000001900 immune effect Effects 0.000 description 3
238000011534 incubation Methods 0.000 description 3
208000015181 infectious disease Diseases 0.000 description 3
239000007788 liquid Substances 0.000 description 3
239000000203 mixture Substances 0.000 description 3
239000008363 phosphate buffer Substances 0.000 description 3
230000001681 protective effect Effects 0.000 description 3
238000010998 test method Methods 0.000 description 3
235000011330 Armoracia rusticana Nutrition 0.000 description 2
240000003291 Armoracia rusticana Species 0.000 description 2
108091003079 Bovine Serum Albumin Proteins 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 2
208000003107 Premature Rupture Fetal Membranes Diseases 0.000 description 2
239000002250 absorbent Substances 0.000 description 2
230000002745 absorbent Effects 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
229940098773 bovine serum albumin Drugs 0.000 description 2
230000008859 change Effects 0.000 description 2
238000011161 development Methods 0.000 description 2
206010073071 hepatocellular carcinoma Diseases 0.000 description 2
238000002372 labelling Methods 0.000 description 2
239000000463 material Substances 0.000 description 2
230000001376 precipitating effect Effects 0.000 description 2
230000002285 radioactive effect Effects 0.000 description 2
238000003127 radioimmunoassay Methods 0.000 description 2
230000009467 reduction Effects 0.000 description 2
238000011160 research Methods 0.000 description 2
238000003786 synthesis reaction Methods 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
ZPLCXHWYPWVJDL-UHFFFAOYSA-N 4-[(4-hydroxyphenyl)methyl]-1,3-oxazolidin-2-one Chemical compound C1=CC(O)=CC=C1CC1NC(=O)OC1 ZPLCXHWYPWVJDL-UHFFFAOYSA-N 0.000 description 1
102000014914 Carrier Proteins Human genes 0.000 description 1
108060003951 Immunoglobulin Proteins 0.000 description 1
102000004218 Insulin-Like Growth Factor I Human genes 0.000 description 1
206010056254 Intrauterine infection Diseases 0.000 description 1
239000000020 Nitrocellulose Substances 0.000 description 1
239000004677 Nylon Substances 0.000 description 1
208000001300 Perinatal Death Diseases 0.000 description 1
102000008217 Pregnancy Proteins Human genes 0.000 description 1
108010035746 Pregnancy Proteins Proteins 0.000 description 1
BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
208000034713 Spontaneous Rupture Diseases 0.000 description 1
206010046914 Vaginal infection Diseases 0.000 description 1
238000002835 absorbance Methods 0.000 description 1
DPKHZNPWBDQZCN-UHFFFAOYSA-N acridine orange free base Chemical compound C1=CC(N(C)C)=CC2=NC3=CC(N(C)C)=CC=C3C=C21 DPKHZNPWBDQZCN-UHFFFAOYSA-N 0.000 description 1
230000009471 action Effects 0.000 description 1
125000003275 alpha amino acid group Chemical group 0.000 description 1
OHDRQQURAXLVGJ-HLVWOLMTSA-N azane;(2e)-3-ethyl-2-[(e)-(3-ethyl-6-sulfo-1,3-benzothiazol-2-ylidene)hydrazinylidene]-1,3-benzothiazole-6-sulfonic acid Chemical compound [NH4+].[NH4+].S/1C2=CC(S([O-])(=O)=O)=CC=C2N(CC)C\1=N/N=C1/SC2=CC(S([O-])(=O)=O)=CC=C2N1CC OHDRQQURAXLVGJ-HLVWOLMTSA-N 0.000 description 1
230000008901 benefit Effects 0.000 description 1
DZBUGLKDJFMEHC-UHFFFAOYSA-N benzoquinolinylidene Natural products C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 1
108091008324 binding proteins Proteins 0.000 description 1
210000001124 body fluid Anatomy 0.000 description 1
239000010839 body fluid Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
239000000084 colloidal system Substances 0.000 description 1
238000004040 coloring Methods 0.000 description 1
239000002299 complementary DNA Substances 0.000 description 1
238000011109 contamination Methods 0.000 description 1
230000037029 cross reaction Effects 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
210000003785 decidua Anatomy 0.000 description 1
239000003599 detergent Substances 0.000 description 1
239000012470 diluted sample Substances 0.000 description 1
239000013024 dilution buffer Substances 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000000986 disperse dye Substances 0.000 description 1
210000004696 endometrium Anatomy 0.000 description 1
210000004700 fetal blood Anatomy 0.000 description 1
210000003754 fetus Anatomy 0.000 description 1
239000007850 fluorescent dye Substances 0.000 description 1
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
239000010931 gold Substances 0.000 description 1
229910052737 gold Inorganic materials 0.000 description 1
230000036541 health Effects 0.000 description 1
230000008105 immune reaction Effects 0.000 description 1
102000018358 immunoglobulin Human genes 0.000 description 1
229940072221 immunoglobulins Drugs 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
230000002452 interceptive effect Effects 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
210000004877 mucosa Anatomy 0.000 description 1
XJCPMUIIBDVFDM-UHFFFAOYSA-M nile blue A Chemical compound [Cl-].C1=CC=C2C3=NC4=CC=C(N(CC)CC)C=C4[O+]=C3C=C(N)C2=C1 XJCPMUIIBDVFDM-UHFFFAOYSA-M 0.000 description 1
IHRSXGONVFFQQF-SDXDJHTJSA-N nitrazine Chemical compound OS(=O)(=O)C1=CC2=CC(S(O)(=O)=O)=CC=C2C(=O)\C1=N/NC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O IHRSXGONVFFQQF-SDXDJHTJSA-N 0.000 description 1
229920001220 nitrocellulos Polymers 0.000 description 1
229920001778 nylon Polymers 0.000 description 1
210000001672 ovary Anatomy 0.000 description 1
230000009984 peri-natal effect Effects 0.000 description 1
239000012071 phase Substances 0.000 description 1
230000003169 placental effect Effects 0.000 description 1
210000005152 placental membrane Anatomy 0.000 description 1
230000035935 pregnancy Effects 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
238000000746 purification Methods 0.000 description 1
238000005070 sampling Methods 0.000 description 1
229910052711 selenium Inorganic materials 0.000 description 1
239000011669 selenium Substances 0.000 description 1
210000000582 semen Anatomy 0.000 description 1
239000007787 solid Substances 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
239000000126 substance Substances 0.000 description 1
BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
230000001573 trophoblastic effect Effects 0.000 description 1
239000013026 undiluted sample Substances 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
238000012795 verification Methods 0.000 description 1
230000000007 visual effect Effects 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/36—Gynecology or obstetrics
- G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
- Y10S436/814—Pregnancy

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Physics & Mathematics (AREA)
General Physics & Mathematics (AREA)
Cell Biology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Biotechnology (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Pathology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Reproductive Health (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring And Recording Apparatus For Diagnosis (AREA)
Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Peptides Or Proteins (AREA)

NO19932363A 1990-12-31 1993-06-28 Diagnostisk metode for detektering av ruptur av fotale membraner og testkit som anvender denne NO310992B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FI906469A FI86777C (fi)	1990-12-31	1990-12-31	Foerfarande foer diagnosticering av bristningen av fosterhinnorna samt reagensfoerpackning foer anvaendning daervid
PCT/FI1991/000413 WO1992012426A1 (en)	1990-12-31	1991-12-30	Diagnostic method for detecting the rupture of fetal membranes and test kit employing the method

Publications (3)

Publication Number	Publication Date
NO932363D0 NO932363D0 (no)	1993-06-28
NO932363L NO932363L (no)	1993-08-23
NO310992B1 true NO310992B1 (no)	2001-09-24

Family

ID=8531673

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19932363A NO310992B1 (no)	1990-12-31	1993-06-28	Diagnostisk metode for detektering av ruptur av fotale membraner og testkit som anvender denne

Country Status (12)

Country	Link
US (1)	US5554504A (ja)
EP (1)	EP0565541B1 (ja)
JP (1)	JP2592386B2 (ja)
KR (1)	KR0162504B1 (ja)
AU (1)	AU652598B2 (ja)
CA (1)	CA2099374C (ja)
DE (1)	DE69128428T2 (ja)
DK (1)	DK0565541T3 (ja)
ES (1)	ES2110487T3 (ja)
FI (1)	FI86777C (ja)
NO (1)	NO310992B1 (ja)
WO (1)	WO1992012426A1 (ja)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI94181C (fi) *	1992-06-29	1995-07-25	Medix Biochemica Ab Oy	Diagnostinen menetelmä synnytysajankohdan ennustamiseksi sekä siihen käytettävä reagenssipakkaus
WO1994017405A1 (en) *	1993-01-22	1994-08-04	Adeza Biomedical Corporation	Assay method to rule out rupture of membranes in women at risk for imminent delivery
US5783396A (en) *	1993-03-23	1998-07-21	Voroteliak; Victor	Method of detecting rupture of the amniotic membranes in pregnant mammals
US5597700A (en) *	1994-04-28	1997-01-28	California Research, Llc	Method for detecting free insulin-like growth-factor-binding protein 1 and a test device for detecting the ruptures of fetal membranes using the above method
US5712103A (en) *	1995-02-13	1998-01-27	Regents Of The University Of California	Diagnostic assay for the prediction of preeclampsia
DE29514562U1 (de) *	1995-09-04	1995-11-16	Rühl, Britta, 23623 Ahrensbök	Fruchtwasserindikator zur Selbstkontrolle über Fruchtwasserverlust
US5747273A (en) *	1996-05-07	1998-05-05	Diagnostic Systems Laboratories, Inc.	Immunoassay of total insulin-like growth factor binding protein-1
DE19719001C2 (de) *	1997-05-06	2001-05-10	Schuetzdeller Angelika	Verfahren zum immunologisch-funktionalen Nachweis biologisch aktiver Insulin-Like Growth Factor Binding Proteine oder löslicher Insulin-Like Growth Factor - Rezeptoren im Immunoassay
FI981049A (fi) *	1998-05-12	1999-11-13	Medix Biochemica Ab Oy	Menetelmä ja koeväline kohdunkaulan kypsyyden arvioimiseksi IGFBP-1:n fosforyloiduilla isomuodoilla
US6126597A (en) *	1998-07-22	2000-10-03	Smith; Ramada S.	System for identifying premature rupture of membrane during pregnancy
US7790690B2 (en)	2000-10-11	2010-09-07	U.S. Department Of Veterans Affairs	Glucose sensitive regulator of insulin transcription
ES2401036T3 (es)	2002-08-13	2013-04-16	N-Dia, Inc.	Uso de dispositivos y métodos para detectar líquido amniótico en secreciones vaginales
US20050131287A1 (en) *	2003-12-16	2005-06-16	Kimberly-Clark Worldwide, Inc.	Detection of premature rupture of the amniotic membrane
WO2006017004A1 (en)	2004-07-07	2006-02-16	Obstecare Inc.	Method for monitoring a childbirth process
US20060024724A1 (en)	2004-07-30	2006-02-02	Robert Hussa	Oncofetal fibronectin as a marker for health and disease
JP5374682B2 (ja) *	2008-03-24	2013-12-25	静岡県公立大学法人	ストレス状態の評価方法及びストレス状態の評価試薬キット
FR2960974B1 (fr)	2010-06-03	2016-12-30	Biosynex	Procede de detection de rupture de membranes
US10338065B2 (en) *	2010-09-01	2019-07-02	Clinical Innovations, Llc	Detection of amniotic fluid in vaginal secretions of pregnant women due to premature rupture of fetal membranes
US8765487B2 (en)	2010-09-01	2014-07-01	Clinical Innovations	Detection of amniotic fluid in vaginal secretions of pregnant women due to premature rupture of fetal membranes
US11555816B2 (en)	2010-09-01	2023-01-17	Clinical Innovations, Llc	Detection of amniotic fluid in vaginal secretions of pregnant women due to premature rupture of fetal membranes
DE102010040687A1 (de) *	2010-09-14	2012-03-15	Hamilton Bonaduz Ag	Verfahren zum Herstellen von Wirkstoff-Beads
CN103175968A (zh) *	2011-12-20	2013-06-26	安徽深蓝医疗科技有限公司	一种胎膜早破检测试剂盒及制备方法
EP2941644B1 (en)	2013-01-02	2019-09-11	Qiagen Sciences, LLC	Methods for predicting time-to-delivery in pregnant women
US10935555B2 (en)	2016-12-22	2021-03-02	Qiagen Sciences, Llc	Determining candidate for induction of labor
US10656164B2 (en)	2016-12-22	2020-05-19	Qiagen Sciences, Llc	Screening asymptomatic pregnant woman for preterm birth

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5096830A (en) *	1987-11-17	1992-03-17	Adeza Biomedical Corporation	Preterm labor and membrane rupture test
CA1337394C (en) *	1987-11-17	1995-10-24	Nelson N. H. Teng	Vaginal sample test and reagents
US4952517A (en) *	1988-02-08	1990-08-28	Hygeia Sciences, Inc.	Positive step immunoassay
US5258287A (en) *	1988-03-22	1993-11-02	Genentech, Inc.	DNA encoding and methods of production of insulin-like growth factor binding protein BP53
US5037735A (en) *	1988-06-24	1991-08-06	Microgenics Corporation	Visual discrimination qualitative enzyme complementation assay
EP0424416B1 (en) *	1988-07-15	1995-07-19	Central Sydney Area Health Service	Acid-labile subunit (als) of insulin-like-growth factor (igf) binding protein complex
US5252459A (en) *	1988-09-23	1993-10-12	Abbott Laboratories	Indicator reagents, diagnostic assays and test kits employing organic polymer latex particles

1990
- 1990-12-31 FI FI906469A patent/FI86777C/fi active IP Right Grant
1991
- 1991-12-30 KR KR1019930701750A patent/KR0162504B1/ko not_active IP Right Cessation
- 1991-12-30 US US08/081,286 patent/US5554504A/en not_active Expired - Lifetime
- 1991-12-30 ES ES92901167T patent/ES2110487T3/es not_active Expired - Lifetime
- 1991-12-30 DE DE69128428T patent/DE69128428T2/de not_active Ceased
- 1991-12-30 WO PCT/FI1991/000413 patent/WO1992012426A1/en active IP Right Grant
- 1991-12-30 EP EP92901167A patent/EP0565541B1/en not_active Expired - Lifetime
- 1991-12-30 DK DK92901167.4T patent/DK0565541T3/da active
- 1991-12-30 AU AU90880/91A patent/AU652598B2/en not_active Expired
- 1991-12-30 JP JP4501180A patent/JP2592386B2/ja not_active Expired - Fee Related
- 1991-12-30 CA CA002099374A patent/CA2099374C/en not_active Expired - Lifetime
1993
- 1993-06-28 NO NO19932363A patent/NO310992B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP2592386B2 (ja)	1997-03-19
NO932363L (no)	1993-08-23
FI906469A (fi)	1992-06-30
AU652598B2 (en)	1994-09-01
KR0162504B1 (ko)	1999-05-01
JPH06504841A (ja)	1994-06-02
EP0565541A1 (en)	1993-10-20
FI86777B (fi)	1992-06-30
ES2110487T3 (es)	1998-02-16
AU9088091A (en)	1992-08-17
NO932363D0 (no)	1993-06-28
DE69128428D1 (de)	1998-01-22
EP0565541B1 (en)	1997-12-10
KR930703611A (ko)	1993-11-30
US5554504A (en)	1996-09-10
CA2099374C (en)	2003-09-16
DK0565541T3 (da)	1998-04-14
FI86777C (fi)	1992-10-12
CA2099374A1 (en)	1992-07-01
FI906469A0 (fi)	1990-12-31
WO1992012426A1 (en)	1992-07-23
DE69128428T2 (de)	1998-07-09

Legal Events

Date	Code	Title	Description
2012-01-09	MK1K	Patent expired

Publication	Publication Date	Title
NO310992B1 (no)	2001-09-24	Diagnostisk metode for detektering av ruptur av fotale membraner og testkit som anvender denne
US7892774B2 (en)	2011-02-22	Diagnostic method for determining the susceptibility to delivery and reagent kit for use therefor
EP0755515B1 (en)	1999-11-03	Method and device for detecting free igfbp-1
FI60935B (fi)	1981-12-31	Foerfarande foer koncentrering och rening av ett urin- och serumprov foer bestaemning av hcg eller dess beta-underenhet immunologiskt och i foerfarandet anvaendbar anordning
US5514598A (en)	1996-05-07	Prenatal detection of meconium
Khaliq et al.	1999	Thyroid functions in pre-eclampsia and its correlation with maternal age, parity, severity of blood pressure and serum albumin
Kishida et al.	1995	Diagnosis of premature rupture of membranes with an improved alpha-fetoprotein monoclonal antibody kit
KR102079738B1 (ko)	2020-02-20	베타 코어 단편 hCG를 표지자로 포함하는 신규 임신 진단 장치
WO2009050711A2 (en)	2009-04-23	A diagnostic device for identifying rupture of membrane during pregnancy
Kishida et al.	1995	Diagnosis of preterm premature rupture of the membranes using a newly developed AFP monoclonal antibody test kit
Yamada et al.	1995	Rapid diagnosis of premature rupture of membranes using a new kit employing anti-AFP monoclonal antibody
WO1998059245A1 (en)	1998-12-30	Diagnostic method and kits for detecting the rupture of foetal membranes
JPH10239311A (ja)	1998-09-11	異常分娩の検出方法及び検出試薬