NO308933B1 - Remineraliserende tannpleiemiddel - Google Patents

Remineraliserende tannpleiemiddel Download PDF

Info

Publication number: NO308933B1
Authority: NO; Norway
Prior art keywords: toothpaste; tooth; polishing; pct; silicic acid
Prior art date: 1992-11-06

Application number

NO950229A

Other languages

English (en)

Norwegian (no)

Other versions

NO950229L (no

NO950229D0 (no

Inventor

Klaus Schumann

Franz Foerg

Hans Laska

Original Assignee

Henkel Kgaa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-11-06

Filing date

1995-01-20

Publication date

2000-11-20

1995-01-20 Application filed by Henkel Kgaa filed Critical Henkel Kgaa

1995-01-20 Publication of NO950229L publication Critical patent/NO950229L/no

1995-01-20 Publication of NO950229D0 publication Critical patent/NO950229D0/no

2000-11-20 Publication of NO308933B1 publication Critical patent/NO308933B1/no

Links

230000000395 remineralizing effect Effects 0.000 title description 2
238000005498 polishing Methods 0.000 claims abstract description 22
RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 claims abstract description 16
XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 claims abstract description 5
235000012239 silicon dioxide Nutrition 0.000 claims description 33
239000003795 chemical substances by application Substances 0.000 claims description 32
RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims description 19
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
150000002222 fluorine compounds Chemical class 0.000 claims description 7
239000011230 binding agent Substances 0.000 claims description 5
230000014759 maintenance of location Effects 0.000 claims description 4
239000011777 magnesium Substances 0.000 claims description 3
159000000003 magnesium salts Chemical class 0.000 claims description 3
QJLVYSQIYAHNJO-UHFFFAOYSA-L magnesium;fluoro-dioxido-oxo-$l^{5}-phosphane Chemical compound [Mg+2].[O-]P([O-])(F)=O QJLVYSQIYAHNJO-UHFFFAOYSA-L 0.000 claims description 3
239000002245 particle Substances 0.000 claims description 3
229940074371 monofluorophosphate Drugs 0.000 claims description 2
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
229910052749 magnesium Inorganic materials 0.000 claims 1
239000000606 toothpaste Substances 0.000 abstract description 27
229940034610 toothpaste Drugs 0.000 abstract description 20
-1 fluorophosphate ions Chemical class 0.000 abstract description 10
JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 abstract description 3
230000000694 effects Effects 0.000 abstract description 3
229910001425 magnesium ion Inorganic materials 0.000 abstract description 3
125000005624 silicic acid group Chemical class 0.000 description 14
239000000126 substance Substances 0.000 description 8
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
210000004268 dentin Anatomy 0.000 description 6
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 5
239000000654 additive Substances 0.000 description 5
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
235000014113 dietary fatty acids Nutrition 0.000 description 4
239000000194 fatty acid Substances 0.000 description 4
229930195729 fatty acid Natural products 0.000 description 4
150000004665 fatty acids Chemical class 0.000 description 4
239000000017 hydrogel Substances 0.000 description 4
MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 4
239000002253 acid Substances 0.000 description 3
125000002252 acyl group Chemical group 0.000 description 3
125000000217 alkyl group Chemical class 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
239000013078 crystal Substances 0.000 description 3
238000001035 drying Methods 0.000 description 3
150000002148 esters Chemical class 0.000 description 3
239000000499 gel Substances 0.000 description 3
235000011187 glycerol Nutrition 0.000 description 3
229910052588 hydroxylapatite Inorganic materials 0.000 description 3
230000003902 lesion Effects 0.000 description 3
239000000203 mixture Substances 0.000 description 3
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 3
229920001223 polyethylene glycol Polymers 0.000 description 3
239000000243 solution Substances 0.000 description 3
239000004094 surface-active agent Substances 0.000 description 3
XHXUANMFYXWVNG-ADEWGFFLSA-N (-)-Menthyl acetate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(C)=O XHXUANMFYXWVNG-ADEWGFFLSA-N 0.000 description 2
208000002064 Dental Plaque Diseases 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
239000004115 Sodium Silicate Substances 0.000 description 2
229920002125 Sokalan® Polymers 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
239000005844 Thymol Substances 0.000 description 2
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
239000008186 active pharmaceutical agent Substances 0.000 description 2
150000001447 alkali salts Chemical class 0.000 description 2
POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
230000009286 beneficial effect Effects 0.000 description 2
125000004432 carbon atom Chemical group C* 0.000 description 2
208000002925 dental caries Diseases 0.000 description 2
210000003298 dental enamel Anatomy 0.000 description 2
239000006185 dispersion Substances 0.000 description 2
XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 2
238000011065 in-situ storage Methods 0.000 description 2
230000002401 inhibitory effect Effects 0.000 description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
229910052943 magnesium sulfate Inorganic materials 0.000 description 2
235000019341 magnesium sulphate Nutrition 0.000 description 2
239000000155 melt Substances 0.000 description 2
238000000034 method Methods 0.000 description 2
TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 2
239000006072 paste Substances 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
239000011164 primary particle Substances 0.000 description 2
NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 2
229910052911 sodium silicate Inorganic materials 0.000 description 2
239000008107 starch Substances 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
229960000790 thymol Drugs 0.000 description 2
RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
239000000230 xanthan gum Substances 0.000 description 2
235000010493 xanthan gum Nutrition 0.000 description 2
229920001285 xanthan gum Polymers 0.000 description 2
229940082509 xanthan gum Drugs 0.000 description 2
239000001605 (5-methyl-2-propan-2-ylcyclohexyl) acetate Substances 0.000 description 1
KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 description 1
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
TYBHZVUFOINFDV-UHFFFAOYSA-N 2-bromo-6-[(3-bromo-5-chloro-2-hydroxyphenyl)methyl]-4-chlorophenol Chemical compound OC1=C(Br)C=C(Cl)C=C1CC1=CC(Cl)=CC(Br)=C1O TYBHZVUFOINFDV-UHFFFAOYSA-N 0.000 description 1
PKRSYEPBQPFNRB-UHFFFAOYSA-N 2-phenoxybenzoic acid Chemical compound OC(=O)C1=CC=CC=C1OC1=CC=CC=C1 PKRSYEPBQPFNRB-UHFFFAOYSA-N 0.000 description 1
XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical class CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
241000416162 Astragalus gummifer Species 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
229940123208 Biguanide Drugs 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
235000013912 Ceratonia siliqua Nutrition 0.000 description 1
240000008886 Ceratonia siliqua Species 0.000 description 1
235000007866 Chamaemelum nobile Nutrition 0.000 description 1
244000303965 Cyamopsis psoralioides Species 0.000 description 1
UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
XHXUANMFYXWVNG-UHFFFAOYSA-N D-menthyl acetate Natural products CC(C)C1CCC(C)CC1OC(C)=O XHXUANMFYXWVNG-UHFFFAOYSA-N 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
229930091371 Fructose Natural products 0.000 description 1
239000005715 Fructose Substances 0.000 description 1
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
241000206672 Gelidium Species 0.000 description 1
229920000084 Gum arabic Polymers 0.000 description 1
239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
244000042664 Matricaria chamomilla Species 0.000 description 1
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229910019142 PO4 Inorganic materials 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
QOSMNYMQXIVWKY-UHFFFAOYSA-N Propyl levulinate Chemical compound CCCOC(=O)CCC(C)=O QOSMNYMQXIVWKY-UHFFFAOYSA-N 0.000 description 1
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical class CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 1
WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 description 1
239000004283 Sodium sorbate Substances 0.000 description 1
208000014151 Stomatognathic disease Diseases 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
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235000010489 acacia gum Nutrition 0.000 description 1
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239000004480 active ingredient Substances 0.000 description 1
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235000010419 agar Nutrition 0.000 description 1
238000004220 aggregation Methods 0.000 description 1
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230000032683 aging Effects 0.000 description 1
235000010443 alginic acid Nutrition 0.000 description 1
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150000001335 aliphatic alkanes Chemical class 0.000 description 1
239000003513 alkali Substances 0.000 description 1
229910052910 alkali metal silicate Inorganic materials 0.000 description 1
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PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
229940011037 anethole Drugs 0.000 description 1
239000010617 anise oil Substances 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
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229910052586 apatite Inorganic materials 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
230000037358 bacterial metabolism Effects 0.000 description 1
GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
150000004283 biguanides Chemical class 0.000 description 1
230000001680 brushing effect Effects 0.000 description 1
239000000872 buffer Substances 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
239000001110 calcium chloride Substances 0.000 description 1
235000011148 calcium chloride Nutrition 0.000 description 1
229910001628 calcium chloride Inorganic materials 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
235000011010 calcium phosphates Nutrition 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
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235000013339 cereals Nutrition 0.000 description 1
229940117916 cinnamic aldehyde Drugs 0.000 description 1
KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 description 1
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238000004140 cleaning Methods 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 1
GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 description 1
CGMRCMMOCQYHAD-UHFFFAOYSA-J dicalcium hydroxide phosphate Chemical compound [OH-].[Ca++].[Ca++].[O-]P([O-])([O-])=O CGMRCMMOCQYHAD-UHFFFAOYSA-J 0.000 description 1
MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical group OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 1
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125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
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239000001525 mentha piperita l. herb oil Substances 0.000 description 1
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LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical group COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
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VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
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WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
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235000019250 sodium sorbate Nutrition 0.000 description 1
RPACBEVZENYWOL-XFULWGLBSA-M sodium;(2r)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate Chemical compound [Na+].C=1C=C(Cl)C=CC=1OCCCCCC[C@]1(C(=O)[O-])CO1 RPACBEVZENYWOL-XFULWGLBSA-M 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
235000019721 spearmint oil Nutrition 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
230000008719 thickening Effects 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
230000004222 uncontrolled growth Effects 0.000 description 1
MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
235000012141 vanillin Nutrition 0.000 description 1
229940117960 vanillin Drugs 0.000 description 1
238000005406 washing Methods 0.000 description 1
229920003169 water-soluble polymer Polymers 0.000 description 1
230000029663 wound healing Effects 0.000 description 1
239000002888 zwitterionic surfactant Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Inorganic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Birds (AREA)
Oral & Maxillofacial Surgery (AREA)
Cosmetics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Dental Preparations (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Detergent Compositions (AREA)

NO950229A 1992-11-06 1995-01-20 Remineraliserende tannpleiemiddel NO308933B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4237500A DE4237500A1 (de)	1992-11-06	1992-11-06	Remineralisierendes Zahnpflegemittel
PCT/EP1993/002991 WO1994010969A1 (de)	1992-11-06	1993-10-28	Remineralisierendes zahnpflegemittel

Publications (3)

Publication Number	Publication Date
NO950229L NO950229L (no)	1995-01-20
NO950229D0 NO950229D0 (no)	1995-01-20
NO308933B1 true NO308933B1 (no)	2000-11-20

Family

ID=6472268

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO950229A NO308933B1 (no)	1992-11-06	1995-01-20	Remineraliserende tannpleiemiddel

Country Status (22)

Country	Link
US (1)	US5605677A (ja)
EP (1)	EP0666730B1 (ja)
JP (1)	JPH08502988A (ja)
KR (1)	KR100295937B1 (ja)
CN (1)	CN1047304C (ja)
AT (1)	ATE166225T1 (ja)
BG (1)	BG99417A (ja)
CA (1)	CA2148909C (ja)
CZ (1)	CZ287746B6 (ja)
DE (2)	DE4237500A1 (ja)
DK (1)	DK0666730T3 (ja)
ES (1)	ES2117153T3 (ja)
FI (1)	FI952110A (ja)
HR (1)	HRP931109A2 (ja)
HU (1)	HU218972B (ja)
LT (1)	LT3075B (ja)
LV (1)	LV11427A (ja)
NO (1)	NO308933B1 (ja)
PL (1)	PL172151B1 (ja)
SI (1)	SI9300478A (ja)
SK (1)	SK280006B6 (ja)
WO (1)	WO1994010969A1 (ja)

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US5658553A (en) *	1995-05-02	1997-08-19	The Procter & Gamble Company	Dentifrice compositions
US5651958A (en) *	1995-05-02	1997-07-29	The Procter & Gamble Company	Dentifrice compositions
US5589160A (en) *	1995-05-02	1996-12-31	The Procter & Gamble Company	Dentifrice compositions
US6036944A (en) *	1995-08-08	2000-03-14	Enamelon, Inc.	Processes for the remineralization and mineralization of teeth
US6159449A (en) *	1997-04-03	2000-12-12	Enamelon, Inc.	Dentifrice products and methods for remineralizing and/or mineralizing teeth
EP0870493A1 (en) *	1997-04-11	1998-10-14	Carter-Wallace, Inc.	Oral gel composition comprising hydrated silica
CN1189153C (zh) *	1997-05-19	2005-02-16	科尔加特·帕尔莫利弗公司	用于牙齿再矿化的口用组合物和再矿化方法
DE19740453A1 (de) *	1997-09-15	1999-03-18	Henkel Kgaa	Zahnreinigungsmittel
US6294155B1 (en) *	1998-04-08	2001-09-25	W. R. Grace & Co. -Conn.	Abrasive silica compositions and dentifrice compositions prepared therefrom
DE19831547A1 (de) *	1998-07-14	2000-01-20	Henkel Kgaa	Flüssige Zahnreinigungsmittel
AUPP494798A0 (en)	1998-07-29	1998-08-20	Pacific Biolink Pty Limited	Protective protein formulation
US7625855B2 (en) *	1999-08-11	2009-12-01	Gonzalez Gustavo M	Cleaning compositions for removing organic deposits in hard to reach surfaces
US6303104B1 (en)	1999-02-12	2001-10-16	Enamelon, Inc.	Remineralizing/mineralizing oral products having improved whitening and stain removal properties
US6485708B1 (en)	1999-05-13	2002-11-26	Church & Dwight Co. Inc.	Products and methods for the remineralization and prevention of demineralization of teeth
US6685920B2 (en) *	1999-11-12	2004-02-03	The Procter & Gamble Company	Method of protecting teeth against erosion
US6174515B1 (en)	2000-06-05	2001-01-16	Amway Corporation	Toothpaste composition
US6652611B1 (en) *	2000-08-18	2003-11-25	J. M. Huber Corporation	Method for making abrasive compositions and products thereof
US6372198B1 (en)	2000-09-14	2002-04-16	Joseph M. Abbate	Dentifrice for the mineralization and remineralization of teeth
KR20030017797A (ko) *	2001-08-22	2003-03-04	(주) 시온텍	치아우식증(충치)예방을 위한 불소이온 용출 필터소재 및그 응용방법
DE10223157C1 (de)	2002-05-24	2003-10-23	Max Planck Gesellschaft	Induzierte Remineralisation von humanem Zahnschmelz
BRPI0413535A (pt)	2003-09-09	2006-10-10	Dsm Ip Assets Bv	agente tópico essencialmente anidro com atividade oral compreendendo uma ou mais substáncias sensìveis à oxidação
US20050084461A1 (en) *	2003-10-16	2005-04-21	Winston Anthony E.	Tooth enamel rejuvenating toothpaste
US20070258916A1 (en) *	2006-04-14	2007-11-08	Oregon Health & Science University	Oral compositions for treating tooth hypersensitivity
US20090186090A1 (en) *	2007-04-30	2009-07-23	Colgate-Palmolive	Oral Care Composition to Reduce or Eliminate Dental Sensitivity
US20080267891A1 (en) *	2007-04-30	2008-10-30	Colgate-Palmolive Company	Oral Care Composition To Reduce Or Eliminate Dental Sensitivity
US7850453B2 (en) *	2007-08-08	2010-12-14	Coll Partners Ltd.	Reshapable device for fixation at a dental site
CA2760130C (en)	2009-05-18	2016-11-08	Colgate-Palmolive Company	Oral compositions containing polyguanidinium compounds and methods of manufacture and use thereof
US8741268B2 (en) *	2009-09-10	2014-06-03	Preventive Technologies, Inc.	Dental prophylactic paste
TWI499430B (zh)	2009-12-17	2015-09-11	Colgate Palmolive Co	抗侵蝕的牙膏組成物
MX341431B (es)	2010-01-29	2016-08-18	Colgate-Palmolive Company *	Producto de cuidado oral para el cuidado de esmalte sensible.
GB201016970D0 (en) *	2010-10-08	2010-11-24	Univ Leeds	Composition
US20150150973A1 (en) *	2012-03-30	2015-06-04	The Royal Institution For The Advancement Of Learning/Mcgill University	Magnesium phosphate gels
DE102013109846A1 (de)	2013-09-09	2015-03-12	Heraeus Kulzer Gmbh	Formulierungen und Kit zur biomimetischen Abscheidung von Apatit auf Zähnen
DE102013109847A1 (de)	2013-09-09	2015-03-12	Heraeus Kulzer Gmbh	Formulierungen und Kit zur biomimetischen Abscheidung von Apatit auf Zähnen
DE102013109848A1 (de)	2013-09-09	2015-03-12	Heraeus Kulzer Gmbh	Applikationssystem zur einfachen, 3-dimensionalen Anwendung von medizinischen, kosmetischen oder Arzneimittel enthaltenden Zahnpflegeprodukten
US9668844B2 (en)	2013-11-06	2017-06-06	Colldent Y.A Ltd	Device for fixation at a dental site
ES2929118T3 (es) *	2015-12-10	2022-11-24	Invicare Inc	Hidrogeles de fosfato de magnesio
JP7135092B2 (ja)	2018-01-17	2022-09-12	ザプロクターアンドギャンブルカンパニー	エナメル質の硬度及び耐性を増加させる方法及び組成物
CN111658561B (zh) *	2019-03-08	2023-04-11	湖北中部医疗科技有限公司	一种抗牙齿敏感牙膏及其制备方法
CN115339121B (zh) *	2021-05-12	2024-06-07	华侨大学	一种柔性溶胶凝胶抛光块体的制备方法

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US3538230A (en) *	1966-12-05	1970-11-03	Lever Brothers Ltd	Oral compositions containing silica xerogels as cleaning and polishing agents
AU497891B2 (en) *	1974-05-22	1979-01-18	J.M. Huber Corp.	Siliceous pigments & their production
US4097588A (en) *	1975-03-11	1978-06-27	National Research Development Corporation	Mineralizing dental mouthrinse
DE2526808A1 (de) *	1975-06-16	1977-01-20	Henkel & Cie Gmbh	Fluorhaltige zahnpasta fuer druckgasverpackung
US4024239A (en) *	1975-07-03	1977-05-17	Lever Brothers Company	Toothpaste composition
AU514418B2 (en) *	1976-02-05	1981-02-12	W.R. Grace & Co.	Dentifrice
US4412983A (en) *	1977-02-22	1983-11-01	Colgate-Palmolive Company	Dentifrices containing amorphous silica
US4183914A (en) *	1977-12-19	1980-01-15	Abdul Gaffar	Magnesium polycarboxylate complexes and anticalculus agents
EP0040938A3 (en) *	1980-05-19	1981-12-16	Monsanto Company	Prophylactic dental paste comprising dicalcium phosphate and method of using it for cleaning, polishing and remineralizing teeth
US4348382A (en) *	1980-12-05	1982-09-07	Colgate-Palmolive Company	Dentifrice composition
DE3114492A1 (de) *	1981-04-10	1982-10-28	Degussa Ag, 6000 Frankfurt	Zahnpflegemittel
DE3114493A1 (de) *	1981-04-10	1982-10-28	Degussa Ag, 6000 Frankfurt	"faellungskieselsaeuren und verfahren zu ihrer herstellung"
US4425324A (en) *	1981-05-11	1984-01-10	Colgate-Palmolive Company	Hazed toothpaste
US4472365A (en) *	1981-06-15	1984-09-18	Stauffer Chemical Company	Dicalcium phosphate dihydrate having improved monofluorophosphate compatibility and process for the preparation thereof
US4411876A (en) *	1982-12-30	1983-10-25	Stauffer Chemical Company	Process for the manufacture of trimagnesium phosphate octahydrate of high purity
US4565692A (en) *	1983-12-23	1986-01-21	Colgate-Palmolive Company	Extrudable dentifrice
US5037636A (en) *	1989-10-23	1991-08-06	Monsanto Chemical Company	Fluoride stability in dicalcium phosphate dihydrate composition

1992
- 1992-11-06 DE DE4237500A patent/DE4237500A1/de not_active Withdrawn
1993
- 1993-08-09 HR HR931109A patent/HRP931109A2/hr not_active Application Discontinuation
- 1993-09-16 SI SI9300478A patent/SI9300478A/sl unknown
- 1993-10-28 CZ CZ19951172A patent/CZ287746B6/cs not_active IP Right Cessation
- 1993-10-28 WO PCT/EP1993/002991 patent/WO1994010969A1/de active IP Right Grant
- 1993-10-28 CA CA002148909A patent/CA2148909C/en not_active Expired - Lifetime
- 1993-10-28 DK DK93923565T patent/DK0666730T3/da active
- 1993-10-28 PL PL93308767A patent/PL172151B1/pl not_active IP Right Cessation
- 1993-10-28 JP JP6511652A patent/JPH08502988A/ja active Pending
- 1993-10-28 ES ES93923565T patent/ES2117153T3/es not_active Expired - Lifetime
- 1993-10-28 KR KR1019950700803A patent/KR100295937B1/ko not_active IP Right Cessation
- 1993-10-28 DE DE59308590T patent/DE59308590D1/de not_active Expired - Lifetime
- 1993-10-28 EP EP93923565A patent/EP0666730B1/de not_active Expired - Lifetime
- 1993-10-28 HU HU9501325A patent/HU218972B/hu not_active IP Right Cessation
- 1993-10-28 SK SK565-95A patent/SK280006B6/sk unknown
- 1993-10-28 US US08/433,391 patent/US5605677A/en not_active Expired - Fee Related
- 1993-10-28 AT AT93923565T patent/ATE166225T1/de not_active IP Right Cessation
- 1993-11-05 LT LTIP1437A patent/LT3075B/lt not_active IP Right Cessation
- 1993-11-05 CN CN93114226A patent/CN1047304C/zh not_active Expired - Fee Related
1995
- 1995-01-20 NO NO950229A patent/NO308933B1/no not_active IP Right Cessation
- 1995-02-13 BG BG99417A patent/BG99417A/bg unknown
- 1995-05-03 FI FI952110A patent/FI952110A/fi unknown
- 1995-05-05 LV LV950124A patent/LV11427A/xx unknown

Also Published As

Publication number	Publication date
PL308767A1 (en)	1995-08-21
DE4237500A1 (de)	1994-05-11
FI952110A0 (fi)	1995-05-03
NO950229L (no)	1995-01-20
CN1090751A (zh)	1994-08-17
EP0666730B1 (de)	1998-05-20
NO950229D0 (no)	1995-01-20
LT3075B (en)	1994-11-25
CZ117295A3 (en)	1995-11-15
FI952110A (fi)	1995-05-03
HRP931109A2 (en)	1995-06-30
CN1047304C (zh)	1999-12-15
SK56595A3 (en)	1997-01-08
EP0666730A1 (de)	1995-08-16
LV11427A (lv)	1996-08-20
KR100295937B1 (ko)	2001-11-14
DK0666730T3 (da)	1999-03-08
ATE166225T1 (de)	1998-06-15
HUT70078A (en)	1995-09-28
CA2148909C (en)	2003-06-10
HU218972B (hu)	2001-01-29
SK280006B6 (sk)	1999-07-12
SI9300478A (en)	1994-06-30
ES2117153T3 (es)	1998-08-01
PL172151B1 (pl)	1997-08-29
CA2148909A1 (en)	1994-05-26
HU9501325D0 (en)	1995-06-28
DE59308590D1 (de)	1998-06-25
CZ287746B6 (en)	2001-01-17
LTIP1437A (en)	1994-05-15
JPH08502988A (ja)	1996-04-02
BG99417A (bg)	1995-06-30
WO1994010969A1 (de)	1994-05-26
US5605677A (en)	1997-02-25

Legal Events

Date	Code	Title	Description
2002-06-10	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN APRIL 2002

Publication	Publication Date	Title
NO308933B1 (no)	2000-11-20	Remineraliserende tannpleiemiddel
FI79940B (fi)	1989-12-29	Tandpasta.
US4816245A (en)	1989-03-28	Antiplaque/antigingivitis method using certain polyphosphonic acids
GB2100983A (en)	1983-01-12	Dentifrices containing xanthan gum
SK3682000A3 (en)	2000-09-12	CLEANING AGENT FOR DENTAL USE COMPRISING A COMBINATION OFì (54) POLISHING AGENTS BASED ON A SILICIC ACID AND ALUMINIUM OXID
US4702904A (en)	1987-10-27	Oral composition containing zirconium-bonded synthetic amorphous silicate
US5456903A (en)	1995-10-10	Method of making a tartar control baking soda dentifrice
AU740042B2 (en)	2001-10-25	Oral and dental hygiene products for sensitive teeth
CN110769801B (zh)	2022-10-14	口腔护理组合物
JPS60169423A (ja)	1985-09-02	歯垢防止及び歯肉炎防止組成物
NO155527B (no)	1987-01-05	Munnpleiemiddel.
EP3192497B1 (en)	2020-05-20	Oral care composition comprising an enzyme and a natural gum
US4562063A (en)	1985-12-31	Astringent gel dentifrice
WO1996021420A1 (en)	1996-07-18	Oral compositions
NZ213162A (en)	1988-04-29	Abrasive dentifrice
JPS63141920A (ja)	1988-06-14	歯磨組成物
CA1187806A (en)	1985-05-28	Visually clear dentifrice
BR112021012994A2 (pt)	2021-09-14	Composição para cuidados orais e uso de uma composição para cuidados orais
JP2003518025A (ja)	2003-06-03	歯磨き剤
JPS635015A (ja)	1988-01-11	歯磨組成物
JP2003518031A (ja)	2003-06-03	歯磨き剤
CZ2000164A3 (cs)	2000-08-16	Prostředek pro ústní hygienu
JPH0259802B2 (ja)	1990-12-13
NZ212431A (en)	1986-01-24	Dentifrice containing siliceous polishing material and resinous poly(ethylene oxide)
JP2000026258A (ja)	2000-01-25	口腔用組成物