HRP931109A2 - Remineralizing tooth-care agent - Google Patents
Remineralizing tooth-care agent Download PDFInfo
- Publication number
- HRP931109A2 HRP931109A2 HR931109A HRP931109A HRP931109A2 HR P931109 A2 HRP931109 A2 HR P931109A2 HR 931109 A HR931109 A HR 931109A HR P931109 A HRP931109 A HR P931109A HR P931109 A2 HRP931109 A2 HR P931109A2
- Authority
- HR
- Croatia
- Prior art keywords
- toothpaste
- pct
- polishing
- acids
- magnesium
- Prior art date
Links
- 230000000395 remineralizing effect Effects 0.000 title description 3
- 239000000606 toothpaste Substances 0.000 claims abstract description 35
- 229940034610 toothpaste Drugs 0.000 claims abstract description 28
- 238000005498 polishing Methods 0.000 claims abstract description 21
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 claims abstract description 16
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 claims abstract description 4
- 235000012239 silicon dioxide Nutrition 0.000 claims description 26
- 239000003795 chemical substances by application Substances 0.000 claims description 23
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims description 17
- 125000005624 silicic acid group Chemical class 0.000 claims description 9
- 150000002222 fluorine compounds Chemical class 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000011230 binding agent Substances 0.000 claims description 4
- 239000011777 magnesium Substances 0.000 claims description 3
- 159000000003 magnesium salts Chemical class 0.000 claims description 3
- QJLVYSQIYAHNJO-UHFFFAOYSA-L magnesium;fluoro-dioxido-oxo-$l^{5}-phosphane Chemical compound [Mg+2].[O-]P([O-])(F)=O QJLVYSQIYAHNJO-UHFFFAOYSA-L 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 229910052749 magnesium Inorganic materials 0.000 claims description 2
- 229940074371 monofluorophosphate Drugs 0.000 claims description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- -1 fluorophosphate ions Chemical class 0.000 abstract description 7
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 abstract description 3
- 229910001425 magnesium ion Inorganic materials 0.000 abstract description 3
- 210000004268 dentin Anatomy 0.000 description 10
- 239000000126 substance Substances 0.000 description 10
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- 229910052588 hydroxylapatite Inorganic materials 0.000 description 6
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 6
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- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000001622 pimenta officinalis fruit oil Substances 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- CMDGQTVYVAKDNA-UHFFFAOYSA-N propane-1,2,3-triol;hydrate Chemical compound O.OCC(O)CO CMDGQTVYVAKDNA-UHFFFAOYSA-N 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 229960001462 sodium cyclamate Drugs 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- LROWVYNUWKVTCU-STWYSWDKSA-M sodium sorbate Chemical compound [Na+].C\C=C\C=C\C([O-])=O LROWVYNUWKVTCU-STWYSWDKSA-M 0.000 description 1
- 235000019250 sodium sorbate Nutrition 0.000 description 1
- RPACBEVZENYWOL-XFULWGLBSA-M sodium;(2r)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate Chemical compound [Na+].C=1C=C(Cl)C=CC=1OCCCCCC[C@]1(C(=O)[O-])CO1 RPACBEVZENYWOL-XFULWGLBSA-M 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- AGGIJOLULBJGTQ-UHFFFAOYSA-N sulfoacetic acid Chemical compound OC(=O)CS(O)(=O)=O AGGIJOLULBJGTQ-UHFFFAOYSA-N 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 230000004222 uncontrolled growth Effects 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 229940117960 vanillin Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Dental Preparations (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Detergent Compositions (AREA)
Description
Izum se odnosi na sredstvo za njegu zuba sa obnavljajućim djelovanjem površine zuba kao i na postupak za obnavljanje površine zuba. Sredstva za njegu zuba služe u prvom redu za čišćenje površine zuba od ostataka hrane, promjena boja i bakterijskih zubnih naslaga koje čvrsto prianjaju.
Dalje se pokušava specijaliziranim dodacima, npr. pomoću fluor spojeva ili antimikrobijalnih materija spriječiti oboljenje zuba kao karijes ili paradontoza.
Kao jedan od prvih stadija zubnog karijesa zapažene su lezije u zubnoj caklini i otvorenim kanalićima dentilne (tzv. Tomes Pits), koje nastaju procesima razgradnje pod utjecajem bakterije koje stvaraju kiselinu.
Ova kvarenja supstance dentina mogu se zapaziti na npr. osjetljivošću zubnog vrata prema temperaturnim promjenama.
Dok se pomoću dodataka desenzibilizirajućih aktivnih tvari suzbijaju jedino bolni simptomi, već se pokušalo pomoću dodataka koji smanjuju razgradljivost apatiteta, da se spriječi stvaranje takvih lezija površine zuba.
U novije vrijeme činjeni su već također i prijedlozi da se prisutna kvarenja smanje pomoću remineralizirajućih sredstava za njegu zuba.
Tako je predloženo od strane Chow i Brown-a (u J.Dent. Res., 54 (1975) 65 - 70), da se za remineraliziranje dentina stavi dikalcij fosfat dihidrat. Iz US 4,097,588 je bila poznata vodica za usta sa remineralizirajućim djelovanjem, koja je bila zasićena sa CaHP04 . 2H20.
Do sada poznati pokušaji da se na ovaj način obnovi površina zuba vodili su pak do nekontroliranog rasta hidroksiapatit kristala na površini zuba, koji je daljnjem napadu na površinu zuba pružao malo otpora.
Stoga je cilj ovog izuma, da razvije zubnu pastu, koja uzrokuje kontroliranu remineralizaciju, naročito u brazdama ogrebotina i kanalima dentina i ova u velikoj mjeri izravnava, tako da se stvara zatvorena, glatka površina zuba.
Otkriveno je da se ovaj cilj u velikoj mjeri postiže pomoću kombinacija sredstava za poliranje prema izumu.
Predmet izuma je zubna pasta za obnavljanje površine zuba sa sadržajem sredstava za poliranje, fluor spojeva, sredstava za održavanje vlažnosti, veziva i vode, koja kao sredstvo za poliranje sadrži kombinaciju silicijeve kiseline i dikalcij fosfat dihidrata (Brushit) u odnosu mase od 10:1 do 1:1.
Zapaženo je da se pravilnom obradom zuba pomoću paste za zube prema izumu postiže zatvaranje kanala dentina uz izravnavanje u velikoj mjeri površine zuba.
Kao silicij kiselinska sredstva za poliranje pogodne su sve galsilicijeve kiseline, hidrogalsilicijeve kiseline i taložne silicijeve kiseline koje su poznate kao tijela za čišćenja.
Galsilicijeve kiseline se izrađuju reakcijom natrij silikatnih otopina sa jakim, vodenim mineralnim kiselinama uz stvaranje hidrosola, stvaranjem u hidro-gel, ispiranjem i sušenjem.
Ako se sušenje obavlja pod blagim uvjetima na sadržaj vode od 15 do 35 mas. -%, tada se dobivaju takozvane hidrogelsilicijeve kiseline, kako su one poznate npr. iz US 4,153,680. Sušenjem na sadržaje vode ispod 15 mas.% obavlja se ireverzibilno smežuravanje prethodno rastresite strukture hidrogala u gustu strukturu tzv. kserogela.
Takve kserogel silicijeve kiseline su npr. opisane u Us 3,538,230. Druga, podobna grupa silicij kiselinskih sredstava za poliranje koja se pretpostavlja su taložene silicijeve kiseline.
Ove se dobivaju taloženjem silicijeve kiseline iz razblaženih otopina alkalnog silikata dodavanjem jakih kiselina pod uvjetima pri kojima ne može na-stupiti agregacija u sol i gel.
Pogodni postupci za izradu taloženih silicijevih kiselina su npr. opisani u DE-OS 25 22 486 i u DE-OS 31 14 493.
Pogodno se pretpostavlja prema DE-OS 31 14 493 izrađena taložna silicijeva kiselina sa BET površinom od 15 - 110 m2/g, veličinom čestica od 0,5-20 u, pri čemu treba biti najmanje 80 mas. - % primarnih čestica ispod 5 u, i viskozitetom u 30%tnoj disperziji glicerin-voda (1:1) od 30 - 60 Pa.s (20 °C) u količini od 10 -20 mas. - % zubne paste.
Pogodne taložne silicijeve kiseline koje se pretpostavljaju osim toga imaju zaobljene kutove i rubove i mogu se dobiti pod trgovačkom oznakom Side-nt R12 (DS) (DEGUSSA).
Da bi se dobio dovoljno visok udio silicijeve kiseline sa srednjom veličinom čestice od manje od 5 u i naročito za udio od najmanje 3 mas. - %, rač-nato na cjelokupnu zubnu pastu, silicijeve kiseline sa primarnom veličinom čestice od 1 - 3 u, stavlja se pogodno pored navedene taložne silicijeve kiseline još jedna finijeg tipa sa BET površinom od 150-250.
Pogodan tip silicijeve kiseline je npr. Sipernat (R)22LS (DEGUSSA), koji se u zubnoj pasti stavlja u količini od 1 - 5 mas. - %.
Pokazalo se kao naročito pogodno za tvorbu glatke površine zuba, ako zubna pasta sadrži prema izumu male količine svježe taložene, tj. in situ pri izradi paste izrađena silicijeva kiselina.
Ova se postiže npr. time, što se pri izradi zubne paste npr. dodavanjem limunske kiseline održava pH vrijednost od 3 - 5 i potom se dodatkom malih količina vodene otopine natrij silikata pH vrijednost povisi na 7-7,5.
Na ovaj način in situ stvorena silicijeva kiselina je izvanredno finočestičasta i iznosi manje od 0,1 mas. - % zubne paste.
Pored silicij kiselinskih sredstava za poliranje mogu se u manjem obujmu sadržavati i druge poznate tvari za poliranje, npr. aluminij oksid u obliku slabo kalcinirane gline sa sadržajem γ- i α-aluminij oksida.
Takav aluminij oksid može se dobiti pod trgovačkom oznakom Poliertoner-de PLO feinst (Giulini- Chemie). Odnos se takvih tvari u datom slučaju dodatnih komponenata sredstava za poliranje u silicij kiselinskom sredstvu za poliranje ne bi ipak trebao biti viši od (1-15) : 100.
Druga, obvezna komponenta sredstva za poliranje je dikalcij fosfat dihidrat (CaHPO4 . 2H2O) koji se u prirodi nalazi kao brshit. Dikalcij fosfat dihidrat se odavno primjenjuje kao sredstvo za poliranje u zubnim pastama i može isto tako da se dobije u pogodnim veličinama zrna u trgovini od 1-50 u. Količine stavljanja koja se pretpostavlja iznosi 1 - 5 mas. - % zubne paste.
Zubna pasta prema izumu po mogućnosti ne bi trebale sadržavati daljnje komponente za poliranje koje grade kalcij ione kao na pr. kredu ili druge kalcij fosfate.
Zapaženo je naprotiv da magnezijevi ioni imaju povoljan utjecaj na kontroliran rast hidroksiapatita koji raste u zubnim lezijama, potpomažu ubrzano otvrdnjavanje zubne cakline, i otuda stvaraju daljnji doprinos za rješenje zadatka prema izumu.
Daljnji predmet izuma je otuda zubna pasta prema izumu, koja sadrži u vodi topljivu magnezijevu sol u količini koja odgovara 0,1 - 0,5 mas. - % Mg.
Kao soli magnezija pogodne su sve soli; koje su u vodi na 20° C bar do 0,5 mas. - % (računato kao Mg) topljive, npr. MgSO4, MgCl2 i magnezij-monofluorfosfat (MgPO3F).
Dalje je utvrđeno, da fluorfosfatni ioni imaju povoljan utjecaj na kontrolirani rast kristala hidroksiapatita. Otuda se pretpostavljaju zubne pa-ste prema izumu, koje kao fluor spojevi sadrže monofluorfosfat u količini koja odgovara 0,2 - 2,0 mas. - % (PO3F). Za ovo su pogodne npr. alkalne soli, npr. u trgovini uobičajeni natrij monofluorfosfat.
Sadržaj magnezij iona i fluorfosfat iona koji se pretpostavlja, može se posebno prigodno postići tako, što se kao fluor spoj sadrži magnezij monofluorfosfat.
Kao nosač za zubne paste prema izumu, koji omogućuje podešavanje pogodne konzistencije za doziranje iz tube, posuda za raspodjelu ili savitljivih boca na osnovi kombinacije sredstava za poliranje prema izumu, pogodna je kombinacija od sredstava za održavanje vlažnosti mogu se staviti na pr. glicerin, sorbit, ksilit, propilen glikol, polietilen glikol, polietilen glikoli, naročito takva sa srednjim molekularnim masama od 200 - 800.
Kao regulatori konzistencije (odn. veziva) služe prirodni i/ili sintetski polimeri topljivi u vodi kao alginati, karagenati, tragant, škrob i škrobni eteri, celulozni eteri kao npr. karboksimetil celuloza (Na so), hidroksietil celuloza, metilhidroksipropil celuloza, guar, guma akcija, agar-agar, ksantan guma, brašno rogača, pektini, u vodi topljivi karboksivinil polimeri (npr. Carbopol (R) tipovi), polivinil alkohol, polivinilpirolidon, polietilen glikoli, naročito takvi sa molekularnim masama, od 1 500 - 1 000 000.
Daljnje tvari, koje su pogodne za kontrolu viskoziteta, su npr. slojeviti silikati kao npr. monmorilonitne gline, koloidne silicijeve kiseline za zgušnjavanje kao npr. aerogel-silicijeve kiseline, pirogene silicijeve kiseline ili najfinije samljevene taložene silicijeve kiseline.
Za izradu zubnih pasta sa kombinacijom sredstava za poliranje prema izu-mu naročito dobar pogodan nosač sadrži
15 - 25 mas. -% glicerina
10 - 20 mas. -% sorbita
1 - 5 mas. -% polietilen glikola MM : 400
1 - 5 mas. -% silicijeve kiseline za zgušnjavanje
0,1 - 1 mas. -% ksantan gume i 35-45 mas. -% vode.
Zubne paste mogu u njihovom viskozitetu isto tako nisko biti podešene, da se mogu dozirati kao tekuće sredstvo za čišćenje zuba sa viskozitetom od 2 000 - 10 000 m.Pa.s (25°C) iz savitljive posude od plastične mase na zubnu četkicu, tamo prodrijeti između čekinja, ali da ne otkaplju sa četkice za zube.
Za ovu svrhu pogodno je kao vezivo kombinacija koja se pretpostavlja od 0,1 - 1 mas. -% ksantan gume i 0,01 - 5 mas. -% dodatka koji stabilizira viskozitet iz grupe
- hidroksipropil supstituiranih hidro koloida ili
- kopolimera polietilenglikol/polipropilenglikola sa srednjom molekulamom masom od 1 000 do 5 000.
Daljnji uobičajeni dodaci zubnim pastama, koji se ukupno mogu iznositi čak do 5 mas. -% sastava zubne paste, su npr. tenzidi za potpomaganje djelovanja čišćenja i u danom slučaju za razvijanje pjene pri četkanju zuba i za stabiliziranje disperzije komponenata sredstava za poliranje u nosaču.
Pogodni tenzidi su npr. linearni natrij alkil sulfati sa 12 do 18 C-atoma u alkil grupi.
Ove tvari imaju dodatno djelovanje koje koči enzim bakterijske izmjene tvari zubne naslage. Daljnji pogodni tenzidi su alkalne soli, pretpostavljaju se natrijeve soli alkilpoliglikoletersulfata sa 12 do 16 C-atoma u linearnoj alkil grupi i 2 - 6 glikoleterskih grupa u molekuli, linearnog alkan (C12-C18)-sulfonata, monoalkil (C12-C18) estera sulfojanitame kiseline, sulfatiranih monoglicerida masnih kiselina, sulfatiranih alkanolamida masnih kiselina, alkil (C12-C16)-estera sulfooctene kiseline, acilsarkozina, aciltaurida i acil-izetionata sa uvijek 8-18 C-atoma u acil grupi.
Isto tako su pogodni amfotemi, amfolitički i neionski tenzidi, npr. okse-tilati mono- i digliceridi masnih kiselina, sorbitam estera masnih kiselina i alkil (oligo)-glukozidi.
Daljnji uobičajeni dodaci zubnih pasta su
- konzervansi i antimikrobijalne tvari, kao npr. metil, etil ili propil esteri p-hidroksibenzove kiseline, natrij sorbat, natrij benzoat, bromklorofen, ester fenil-solicilne kiseline, bigvanidi, timol itd.
- sredstva za zaslađivanje kao npr. saharin natrij, natrij ciklamat, sukroza, laktoza, maltoza, fruktoza,
- aroma kao npr. ulja od nane, ulje obične nane, ulje eukaliptusa, ulje anisa, ulje divlje mirodije, ulje kima, mentil acetat, cimetni aldehid, anetol, vanilin, timol kao i smjesa ovih i drugih prirodnih i sintetskih aroma,
- pigmenti kao npr. titan dioksid ,
- boje
- puferne supstance kao npr. primarni, sekundarni ili tercijarni alkalni fosfati ili limunska kiselina/natrij citrat,
- tvari koje liječe rane i koje koče upalu kao npr. alantoin, karbamid kao i azulen, aktivne tvari kamilice, derivati acetil salicilnne kiseline.
Sljedeći Primjeri trebaju predmet izuma objasniti pobliže.
Primjeri
Izrađene su zubne paste prema izumu (Primjer 1, 2 i 3) i jedna usporedna zubna pasta (Primjer V) (uspor. Tabelu 1).
Tabela 1
[image]
Primjenjeni su sljedeći trgovački proizvodi :
Sident 12 DS: Taložna silicijeva kiselina firme
DEGUSSA AG Frankfurt a.M., BET površina : 80 m2/g
Nabijena gustoća: 220g/1
Siparnat 22 LS: Taložena silicijeva kiselina firme
DEGUSSA AG Frankfurt a. M., BET površina: 190 m2/g
Nabijena gustoća: 80g/1
Kieselsaure FK 320 DS: Taložnasilicijeva kiselina firme
DEGUSSA AG Frankfurtt a.M.,BET površina : 170 m2/g
Nabijena gustoća: 80g/1
Keltrol F: Ksantan guma Firme KELCO, Brisel
Texapon K L296-granulat: Na-laurilsulfat HENKEL KGaA Dusseldorf
Dokaz djelovanja
Sa zubnom pastom prema izumu (Primjer I) i usporednom zubnom pastom (Primjer V, bez dikalcij fosfat dihidrata i bez magnezij sulfata) izvedeni su sljedeći oglede:
Iz ljudskog zuba pilom su isječeni 4x5mm veliki komadi (tzv. slabs) iz krune (za oglede sa caklinom) 1 iz područja korijena (za oglede sa dentinom) i površina se izravna pomoću papira za mokro brušenje i glatko ispolira sa polir pastom.
Slabs cakline se dodatno nagrizaju pomoću 0,1 molarne vodene mliječne kiseline, koja je sadržavala 500 mg/1 hidroksiapatita, pri pH = 4,6 i T = 37 °C preko 6 sati.
Tako pripremljeni uzorci se potom dva puta dnevno čiste 5 minuta sa oglednom zubnom pastom (koja je razblažena 1:1).
U preostalom vremenu se uzorci na 37°C drže u CaHPO4 . 2H2O suspenziji, koja svježe izrađivala dva puta dnevno ( ujutro i uvečer ) taloženjem (CaCl2 + Na2HPO4 --- CaHPO4 + 2NaCl). Ova obrada zuba se uvijek izvodila 20 dana dugo.
Prije obrade (tj. poslije poliranja slabs) i poslije završetka obrade obavljena su snimanja površine uzoraka rasterelektromikroskopsi (REM).
Na Slikama 1 - 6 su ovi dani u srazmjeru 5000 : 1.
Sl. 1 Ljudska caklina, neobrađena
Sl. 2 Ljudski dentin, neobrađen
Sl. 3 Ljudska caklina, obrađena pomoću usporedne zubne paste V
Sl. 4 Ljudski dentin, obrađen pomoću usporedne zubne paste V
Sl. 5 Ljudska caklina, obrađena pomoću zubne paste Primjera 1. Zapaža se da se u žljebovima strukture površine izdvojio hidroksiapatit,
Sl. 6 Ljudski dentin, obrađen pomoću zubne paste Primjera 1. Jasno se zapaža u velikoj mjeri zatvaranje kanala dentina uslijed izdvojenog hidroksiapatita.
Claims (5)
1. Zubna pasta za obnavljanje zubne površine sa sadržajem sredstava za poliranje, fluornih spojeva, sredstava za održavanje vlažnosti, veziva i vode, naznačena time, što kao sredstvo za poliranje sadrži kombinaciju silicijevih kiselina i dikalcij fosfat dihidrata (brushit) u odnosu mase 10 : 1 do 1: 1.
2. Zubna pasta prema zahtjevu 1, naznačena time, što se sadrži magnezijeva sol topljiva u vodi u količini koja odgovara 0,1 - 0,5 mas. -% magnezija.
3. Zubna pasta prema zahtjevu 1 ili 2, naznačena time, što se kao fluorni spoj sadrži monofluorfosfat u količini koja odgovara 0,2 - 2,0 mas. - % ( PO3F-).
4. Zubna pasta prema zahtjevu 1 do 2, naznačena time, što se kao fluorni spoj sadrži magnezij-monofluorfosfat.
5. Zubna pasta prema zahtjevu 1 do 4, naznačena time, što se kao sredstvo za poliranje sadrži taložena silicijeva kiselina sa srednjom veličinom dijelova od 0,5 - 30 mikrona ( u) u količini od 10 - 20 mas. - % i dikalcij fosfat dihidrat (brushit) u količini od 1 - 5 mas. - %.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4237500A DE4237500A1 (de) | 1992-11-06 | 1992-11-06 | Remineralisierendes Zahnpflegemittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP931109A2 true HRP931109A2 (en) | 1995-06-30 |
Family
ID=6472268
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR931109A HRP931109A2 (en) | 1992-11-06 | 1993-08-09 | Remineralizing tooth-care agent |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5605677A (hr) |
| EP (1) | EP0666730B1 (hr) |
| JP (1) | JPH08502988A (hr) |
| KR (1) | KR100295937B1 (hr) |
| CN (1) | CN1047304C (hr) |
| AT (1) | ATE166225T1 (hr) |
| BG (1) | BG99417A (hr) |
| CA (1) | CA2148909C (hr) |
| CZ (1) | CZ287746B6 (hr) |
| DE (2) | DE4237500A1 (hr) |
| DK (1) | DK0666730T3 (hr) |
| ES (1) | ES2117153T3 (hr) |
| FI (1) | FI952110A (hr) |
| HR (1) | HRP931109A2 (hr) |
| HU (1) | HU218972B (hr) |
| LT (1) | LT3075B (hr) |
| LV (1) | LV11427A (hr) |
| NO (1) | NO308933B1 (hr) |
| PL (1) | PL172151B1 (hr) |
| SI (1) | SI9300478A (hr) |
| SK (1) | SK280006B6 (hr) |
| WO (1) | WO1994010969A1 (hr) |
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| US5658553A (en) * | 1995-05-02 | 1997-08-19 | The Procter & Gamble Company | Dentifrice compositions |
| US5651958A (en) * | 1995-05-02 | 1997-07-29 | The Procter & Gamble Company | Dentifrice compositions |
| US5589160A (en) * | 1995-05-02 | 1996-12-31 | The Procter & Gamble Company | Dentifrice compositions |
| US6036944A (en) * | 1995-08-08 | 2000-03-14 | Enamelon, Inc. | Processes for the remineralization and mineralization of teeth |
| US6159449A (en) * | 1997-04-03 | 2000-12-12 | Enamelon, Inc. | Dentifrice products and methods for remineralizing and/or mineralizing teeth |
| EP0870493A1 (en) * | 1997-04-11 | 1998-10-14 | Carter-Wallace, Inc. | Oral gel composition comprising hydrated silica |
| CN1189153C (zh) * | 1997-05-19 | 2005-02-16 | 科尔加特·帕尔莫利弗公司 | 用于牙齿再矿化的口用组合物和再矿化方法 |
| DE19740453A1 (de) * | 1997-09-15 | 1999-03-18 | Henkel Kgaa | Zahnreinigungsmittel |
| US6294155B1 (en) * | 1998-04-08 | 2001-09-25 | W. R. Grace & Co. -Conn. | Abrasive silica compositions and dentifrice compositions prepared therefrom |
| DE19831547A1 (de) * | 1998-07-14 | 2000-01-20 | Henkel Kgaa | Flüssige Zahnreinigungsmittel |
| AUPP494798A0 (en) | 1998-07-29 | 1998-08-20 | Pacific Biolink Pty Limited | Protective protein formulation |
| US7625855B2 (en) * | 1999-08-11 | 2009-12-01 | Gonzalez Gustavo M | Cleaning compositions for removing organic deposits in hard to reach surfaces |
| US6303104B1 (en) | 1999-02-12 | 2001-10-16 | Enamelon, Inc. | Remineralizing/mineralizing oral products having improved whitening and stain removal properties |
| US6485708B1 (en) | 1999-05-13 | 2002-11-26 | Church & Dwight Co. Inc. | Products and methods for the remineralization and prevention of demineralization of teeth |
| US6685920B2 (en) * | 1999-11-12 | 2004-02-03 | The Procter & Gamble Company | Method of protecting teeth against erosion |
| US6174515B1 (en) | 2000-06-05 | 2001-01-16 | Amway Corporation | Toothpaste composition |
| US6652611B1 (en) * | 2000-08-18 | 2003-11-25 | J. M. Huber Corporation | Method for making abrasive compositions and products thereof |
| US6372198B1 (en) | 2000-09-14 | 2002-04-16 | Joseph M. Abbate | Dentifrice for the mineralization and remineralization of teeth |
| KR20030017797A (ko) * | 2001-08-22 | 2003-03-04 | (주) 시온텍 | 치아우식증(충치)예방을 위한 불소이온 용출 필터소재 및그 응용방법 |
| DE10223157C1 (de) | 2002-05-24 | 2003-10-23 | Max Planck Gesellschaft | Induzierte Remineralisation von humanem Zahnschmelz |
| BRPI0413535A (pt) | 2003-09-09 | 2006-10-10 | Dsm Ip Assets Bv | agente tópico essencialmente anidro com atividade oral compreendendo uma ou mais substáncias sensìveis à oxidação |
| US20050084461A1 (en) * | 2003-10-16 | 2005-04-21 | Winston Anthony E. | Tooth enamel rejuvenating toothpaste |
| US20070258916A1 (en) * | 2006-04-14 | 2007-11-08 | Oregon Health & Science University | Oral compositions for treating tooth hypersensitivity |
| US20090186090A1 (en) * | 2007-04-30 | 2009-07-23 | Colgate-Palmolive | Oral Care Composition to Reduce or Eliminate Dental Sensitivity |
| US20080267891A1 (en) * | 2007-04-30 | 2008-10-30 | Colgate-Palmolive Company | Oral Care Composition To Reduce Or Eliminate Dental Sensitivity |
| US7850453B2 (en) * | 2007-08-08 | 2010-12-14 | Coll Partners Ltd. | Reshapable device for fixation at a dental site |
| CA2760130C (en) | 2009-05-18 | 2016-11-08 | Colgate-Palmolive Company | Oral compositions containing polyguanidinium compounds and methods of manufacture and use thereof |
| US8741268B2 (en) * | 2009-09-10 | 2014-06-03 | Preventive Technologies, Inc. | Dental prophylactic paste |
| TWI499430B (zh) | 2009-12-17 | 2015-09-11 | Colgate Palmolive Co | 抗侵蝕的牙膏組成物 |
| MX341431B (es) | 2010-01-29 | 2016-08-18 | Colgate-Palmolive Company * | Producto de cuidado oral para el cuidado de esmalte sensible. |
| GB201016970D0 (en) * | 2010-10-08 | 2010-11-24 | Univ Leeds | Composition |
| US20150150973A1 (en) * | 2012-03-30 | 2015-06-04 | The Royal Institution For The Advancement Of Learning/Mcgill University | Magnesium phosphate gels |
| DE102013109846A1 (de) | 2013-09-09 | 2015-03-12 | Heraeus Kulzer Gmbh | Formulierungen und Kit zur biomimetischen Abscheidung von Apatit auf Zähnen |
| DE102013109847A1 (de) | 2013-09-09 | 2015-03-12 | Heraeus Kulzer Gmbh | Formulierungen und Kit zur biomimetischen Abscheidung von Apatit auf Zähnen |
| DE102013109848A1 (de) | 2013-09-09 | 2015-03-12 | Heraeus Kulzer Gmbh | Applikationssystem zur einfachen, 3-dimensionalen Anwendung von medizinischen, kosmetischen oder Arzneimittel enthaltenden Zahnpflegeprodukten |
| US9668844B2 (en) | 2013-11-06 | 2017-06-06 | Colldent Y.A Ltd | Device for fixation at a dental site |
| ES2929118T3 (es) * | 2015-12-10 | 2022-11-24 | Invicare Inc | Hidrogeles de fosfato de magnesio |
| JP7135092B2 (ja) | 2018-01-17 | 2022-09-12 | ザ プロクター アンド ギャンブル カンパニー | エナメル質の硬度及び耐性を増加させる方法及び組成物 |
| CN111658561B (zh) * | 2019-03-08 | 2023-04-11 | 湖北中部医疗科技有限公司 | 一种抗牙齿敏感牙膏及其制备方法 |
| CN115339121B (zh) * | 2021-05-12 | 2024-06-07 | 华侨大学 | 一种柔性溶胶凝胶抛光块体的制备方法 |
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| AU497891B2 (en) * | 1974-05-22 | 1979-01-18 | J.M. Huber Corp. | Siliceous pigments & their production |
| US4097588A (en) * | 1975-03-11 | 1978-06-27 | National Research Development Corporation | Mineralizing dental mouthrinse |
| DE2526808A1 (de) * | 1975-06-16 | 1977-01-20 | Henkel & Cie Gmbh | Fluorhaltige zahnpasta fuer druckgasverpackung |
| US4024239A (en) * | 1975-07-03 | 1977-05-17 | Lever Brothers Company | Toothpaste composition |
| AU514418B2 (en) * | 1976-02-05 | 1981-02-12 | W.R. Grace & Co. | Dentifrice |
| US4412983A (en) * | 1977-02-22 | 1983-11-01 | Colgate-Palmolive Company | Dentifrices containing amorphous silica |
| US4183914A (en) * | 1977-12-19 | 1980-01-15 | Abdul Gaffar | Magnesium polycarboxylate complexes and anticalculus agents |
| EP0040938A3 (en) * | 1980-05-19 | 1981-12-16 | Monsanto Company | Prophylactic dental paste comprising dicalcium phosphate and method of using it for cleaning, polishing and remineralizing teeth |
| US4348382A (en) * | 1980-12-05 | 1982-09-07 | Colgate-Palmolive Company | Dentifrice composition |
| DE3114492A1 (de) * | 1981-04-10 | 1982-10-28 | Degussa Ag, 6000 Frankfurt | Zahnpflegemittel |
| DE3114493A1 (de) * | 1981-04-10 | 1982-10-28 | Degussa Ag, 6000 Frankfurt | "faellungskieselsaeuren und verfahren zu ihrer herstellung" |
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| US5037636A (en) * | 1989-10-23 | 1991-08-06 | Monsanto Chemical Company | Fluoride stability in dicalcium phosphate dihydrate composition |
-
1992
- 1992-11-06 DE DE4237500A patent/DE4237500A1/de not_active Withdrawn
-
1993
- 1993-08-09 HR HR931109A patent/HRP931109A2/hr not_active Application Discontinuation
- 1993-09-16 SI SI9300478A patent/SI9300478A/sl unknown
- 1993-10-28 CZ CZ19951172A patent/CZ287746B6/cs not_active IP Right Cessation
- 1993-10-28 WO PCT/EP1993/002991 patent/WO1994010969A1/de active IP Right Grant
- 1993-10-28 CA CA002148909A patent/CA2148909C/en not_active Expired - Lifetime
- 1993-10-28 DK DK93923565T patent/DK0666730T3/da active
- 1993-10-28 PL PL93308767A patent/PL172151B1/pl not_active IP Right Cessation
- 1993-10-28 JP JP6511652A patent/JPH08502988A/ja active Pending
- 1993-10-28 ES ES93923565T patent/ES2117153T3/es not_active Expired - Lifetime
- 1993-10-28 KR KR1019950700803A patent/KR100295937B1/ko not_active IP Right Cessation
- 1993-10-28 DE DE59308590T patent/DE59308590D1/de not_active Expired - Lifetime
- 1993-10-28 EP EP93923565A patent/EP0666730B1/de not_active Expired - Lifetime
- 1993-10-28 HU HU9501325A patent/HU218972B/hu not_active IP Right Cessation
- 1993-10-28 SK SK565-95A patent/SK280006B6/sk unknown
- 1993-10-28 US US08/433,391 patent/US5605677A/en not_active Expired - Fee Related
- 1993-10-28 AT AT93923565T patent/ATE166225T1/de not_active IP Right Cessation
- 1993-11-05 LT LTIP1437A patent/LT3075B/lt not_active IP Right Cessation
- 1993-11-05 CN CN93114226A patent/CN1047304C/zh not_active Expired - Fee Related
-
1995
- 1995-01-20 NO NO950229A patent/NO308933B1/no not_active IP Right Cessation
- 1995-02-13 BG BG99417A patent/BG99417A/bg unknown
- 1995-05-03 FI FI952110A patent/FI952110A/fi unknown
- 1995-05-05 LV LV950124A patent/LV11427A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL308767A1 (en) | 1995-08-21 |
| DE4237500A1 (de) | 1994-05-11 |
| FI952110A0 (fi) | 1995-05-03 |
| NO950229L (no) | 1995-01-20 |
| CN1090751A (zh) | 1994-08-17 |
| EP0666730B1 (de) | 1998-05-20 |
| NO950229D0 (no) | 1995-01-20 |
| LT3075B (en) | 1994-11-25 |
| CZ117295A3 (en) | 1995-11-15 |
| FI952110A (fi) | 1995-05-03 |
| CN1047304C (zh) | 1999-12-15 |
| SK56595A3 (en) | 1997-01-08 |
| EP0666730A1 (de) | 1995-08-16 |
| LV11427A (lv) | 1996-08-20 |
| KR100295937B1 (ko) | 2001-11-14 |
| DK0666730T3 (da) | 1999-03-08 |
| ATE166225T1 (de) | 1998-06-15 |
| HUT70078A (en) | 1995-09-28 |
| CA2148909C (en) | 2003-06-10 |
| HU218972B (hu) | 2001-01-29 |
| SK280006B6 (sk) | 1999-07-12 |
| SI9300478A (en) | 1994-06-30 |
| ES2117153T3 (es) | 1998-08-01 |
| PL172151B1 (pl) | 1997-08-29 |
| CA2148909A1 (en) | 1994-05-26 |
| HU9501325D0 (en) | 1995-06-28 |
| DE59308590D1 (de) | 1998-06-25 |
| CZ287746B6 (en) | 2001-01-17 |
| LTIP1437A (en) | 1994-05-15 |
| JPH08502988A (ja) | 1996-04-02 |
| BG99417A (bg) | 1995-06-30 |
| WO1994010969A1 (de) | 1994-05-26 |
| NO308933B1 (no) | 2000-11-20 |
| US5605677A (en) | 1997-02-25 |
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