NO308902B1 - Nye kinoksalindionderivater og anvendelse i legemidler - Google Patents

Nye kinoksalindionderivater og anvendelse i legemidler

Info

Publication number
NO308902B1
NO308902B1 NO954315A NO954315A NO308902B1 NO 308902 B1 NO308902 B1 NO 308902B1 NO 954315 A NO954315 A NO 954315A NO 954315 A NO954315 A NO 954315A NO 308902 B1 NO308902 B1 NO 308902B1
Authority
NO
Norway
Prior art keywords
substd
opt
halo
phenyl
new
Prior art date
Application number
NO954315A
Other languages
English (en)
Norwegian (no)
Other versions
NO954315D0 (no
NO954315L (no
Inventor
Andreas Huth
Lechoslaw Turski
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4314591A external-priority patent/DE4314591A1/de
Priority claimed from DE19934344486 external-priority patent/DE4344486A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO954315D0 publication Critical patent/NO954315D0/no
Publication of NO954315L publication Critical patent/NO954315L/no
Publication of NO308902B1 publication Critical patent/NO308902B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40Benzopyrazines
    • C07D241/44Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509Six-membered rings
    • C07F9/650952Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • C07F9/650994Six-membered rings having the nitrogen atoms in the positions 1 and 4 condensed with carbocyclic rings or carbocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO954315A 1993-04-28 1995-10-27 Nye kinoksalindionderivater og anvendelse i legemidler NO308902B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4314591A DE4314591A1 (de) 1993-04-28 1993-04-28 Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
DE19934344486 DE4344486A1 (de) 1993-12-21 1993-12-21 Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
PCT/DE1994/000493 WO1994025469A1 (de) 1993-04-28 1994-04-28 Neue chinoxalindionderivative, deren herstellung und verwendung in arzneimitteln

Publications (3)

Publication Number Publication Date
NO954315D0 NO954315D0 (no) 1995-10-27
NO954315L NO954315L (no) 1995-12-28
NO308902B1 true NO308902B1 (no) 2000-11-13

Family

ID=25925529

Family Applications (2)

Application Number Title Priority Date Filing Date
NO954315A NO308902B1 (no) 1993-04-28 1995-10-27 Nye kinoksalindionderivater og anvendelse i legemidler
NO20001604A NO311428B1 (no) 1993-04-28 2000-03-28 Nye kinoksalindionderivater og legemidler inneholdende disse

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20001604A NO311428B1 (no) 1993-04-28 2000-03-28 Nye kinoksalindionderivater og legemidler inneholdende disse

Country Status (23)

Country Link
US (2) US5750525A (cs)
EP (2) EP0696288B1 (cs)
JP (1) JP3530190B2 (cs)
KR (1) KR100293880B1 (cs)
CN (1) CN1053190C (cs)
AT (1) ATE196474T1 (cs)
AU (1) AU690550B2 (cs)
CA (1) CA2161425A1 (cs)
CZ (1) CZ290295B6 (cs)
DE (1) DE59409534D1 (cs)
DK (1) DK0696288T3 (cs)
ES (1) ES2150989T3 (cs)
FI (1) FI955140A (cs)
GR (1) GR3035053T3 (cs)
HU (1) HUT73676A (cs)
IL (1) IL109397A0 (cs)
NO (2) NO308902B1 (cs)
NZ (1) NZ265599A (cs)
PL (1) PL180332B1 (cs)
PT (1) PT696288E (cs)
RU (1) RU2140420C1 (cs)
SK (1) SK282851B6 (cs)
WO (1) WO1994025469A1 (cs)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057304A (en) * 1992-10-26 2000-05-02 Schering Aktiengesellschaft Quinoxaline-phosphonic acid derivatives
PT647137E (pt) * 1992-06-22 2008-11-24 Univ California Antagonistas dos receptores da glicina e a sua utilização
HU217837B (hu) * 1994-05-18 2000-04-28 EGIS Gyógyszergyár Rt. Savamidok, ezeket tartalmazó gyógyászati készítmények és eljárás a hatóanyagok előállítására
GB9419318D0 (en) * 1994-09-24 1994-11-09 Pfizer Ltd Therapeutic agents
ATE209644T1 (de) * 1994-09-27 2001-12-15 Yamanouchi Pharma Co Ltd 1,2,3,4-tetrahydroquinoxalindion derivate und ihre verwendung als glutamat rezeptor antagonisten
DE4439493A1 (de) * 1994-10-25 1996-05-02 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
DE4439492A1 (de) * 1994-10-25 1996-05-02 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
DE19519979A1 (de) * 1995-05-24 1996-11-28 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
CA2224718A1 (en) * 1995-07-10 1997-01-30 Novartis Ag Novel quinoxaline- and quinoxalinylalkane-phosphonic acids
DE19545251A1 (de) * 1995-11-24 1997-05-28 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
TW448171B (en) * 1996-06-06 2001-08-01 Yamanouchi Pharma Co Ltd Imidazole-substituted quinoxalinedione derivatives
AU733896B2 (en) * 1996-10-23 2001-05-31 Warner-Lambert Company Substituted gamma aminobutyric acids as pharmaceutical agents
RU2181362C2 (ru) * 1996-10-24 2002-04-20 Новартис Аг Производные аминофосфоновых и -фосфиновых кислот, способ их получения и фармацевтические составы на их основе
DE19728326A1 (de) * 1997-06-27 1999-01-07 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
DE19737446A1 (de) * 1997-08-22 1999-02-25 Schering Ag Verfahren zur Herstellung von Phosphonsäurederivaten
KR100588247B1 (ko) * 1997-09-01 2006-06-13 교린 세이야꾸 가부시키 가이샤 6,7-비대칭 이치환된 퀴녹살린카복실산 유도체와 이의부가염 및 이들의 제조방법
US6015800A (en) * 1997-09-03 2000-01-18 Warner-Lambert Company Substituted quinoxaline-2-ones as glutamate receptor antagonists
EP1100504A2 (en) * 1998-07-02 2001-05-23 Eisai Co., Ltd. Pharmaceutical compositions and their uses for treatment of demyelinating disorders
DE60027546T2 (de) 1999-02-15 2007-04-26 Eisai Co., Ltd. Heterodiazinon-derivate
FR2791982B1 (fr) * 1999-04-06 2002-12-27 Inst Nat Sante Rech Med Inhibiteurs de lta4 hydrolase et leurs applications therapeutiques.
EP2177520A1 (en) 2000-06-12 2010-04-21 Eisai R&D Management Co., Ltd. 1,5-Di(aryl or heteroaryl)-3-halo-2(1H)-pyridones as intermediates for the preparation of AMPA receptor inhibitors
GB0129260D0 (en) 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
MY148809A (en) 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
CN100490835C (zh) * 2004-12-14 2009-05-27 朱木林 一种治疗骨折的药物
EP2338492A1 (en) 2009-12-24 2011-06-29 Universidad del Pais Vasco Methods and compositions for the treatment of alzheimer
MX2021006317A (es) 2018-12-14 2021-08-11 Eisai R&D Man Co Ltd Formulaciones farmaceuticas de base acuosa de compuestos de 1,2-dihidropiridina.
CN112142797B (zh) * 2020-09-11 2023-07-14 江西师范大学 含磷的喹喔啉类化合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO179551C (no) * 1987-11-10 1996-10-30 Novo Nordisk As Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser
IL90315A0 (en) * 1988-06-01 1989-12-15 Ferrosan As Imidazoquinoxaline compounds,their preparation and pharmaceutical compositions containing them
DK69790D0 (da) * 1990-03-16 1990-03-16 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling af anvendelse
ATE194985T1 (de) * 1990-11-06 2000-08-15 Yamanouchi Pharma Co Ltd Kondensiertes pyrazinderivat
PT101004B (pt) * 1991-10-26 1999-10-29 Schering Ag Derivados da quinoxalina, processo para a sua preparacao e composicoes farmaceuticas que os contem
PT647137E (pt) * 1992-06-22 2008-11-24 Univ California Antagonistas dos receptores da glicina e a sua utilização

Also Published As

Publication number Publication date
US5750525A (en) 1998-05-12
HU9503078D0 (en) 1995-12-28
DE59409534D1 (de) 2000-10-26
CZ290295B6 (cs) 2002-07-17
ES2150989T3 (es) 2000-12-16
FI955140A0 (fi) 1995-10-27
NO20001604D0 (no) 2000-03-28
CA2161425A1 (en) 1994-11-10
EP0696288B1 (de) 2000-09-20
FI955140A (fi) 1995-10-27
EP1002796A3 (de) 2001-09-12
CZ282895A3 (en) 1996-02-14
GR3035053T3 (en) 2001-03-30
JP3530190B2 (ja) 2004-05-24
EP1002796A2 (de) 2000-05-24
SK282851B6 (sk) 2002-12-03
PL317075A1 (en) 1997-03-03
WO1994025469A1 (de) 1994-11-10
SK131895A3 (en) 1996-07-03
NO954315D0 (no) 1995-10-27
PT696288E (pt) 2001-01-31
KR100293880B1 (ko) 2001-09-17
DK0696288T3 (da) 2000-11-13
PL180332B1 (pl) 2001-01-31
AU690550B2 (en) 1998-04-30
CN1153517A (zh) 1997-07-02
CN1053190C (zh) 2000-06-07
IL109397A0 (en) 1994-07-31
US5955461A (en) 1999-09-21
NO954315L (no) 1995-12-28
EP0696288A1 (de) 1996-02-14
NZ265599A (en) 1997-10-24
HUT73676A (en) 1996-09-30
RU2140420C1 (ru) 1999-10-27
NO20001604L (no) 1995-12-28
JPH08508037A (ja) 1996-08-27
AU6675594A (en) 1994-11-21
ATE196474T1 (de) 2000-10-15
NO311428B1 (no) 2001-11-26

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