NO307299B1 - Mellomprodukt for fremstilling av terapeutisk aktive forbindelser - Google Patents
Mellomprodukt for fremstilling av terapeutisk aktive forbindelserInfo
- Publication number
- NO307299B1 NO307299B1 NO983900A NO983900A NO307299B1 NO 307299 B1 NO307299 B1 NO 307299B1 NO 983900 A NO983900 A NO 983900A NO 983900 A NO983900 A NO 983900A NO 307299 B1 NO307299 B1 NO 307299B1
- Authority
- NO
- Norway
- Prior art keywords
- group
- formula
- carboxylic acyl
- atom
- xiv
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heat Sensitive Colour Forming Recording (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7208394 | 1994-04-11 |
Publications (3)
Publication Number | Publication Date |
---|---|
NO983900L NO983900L (no) | 1995-10-12 |
NO983900D0 NO983900D0 (no) | 1998-08-25 |
NO307299B1 true NO307299B1 (no) | 2000-03-13 |
Family
ID=13479165
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO951398A NO305987B1 (no) | 1994-04-11 | 1995-04-10 | Heterosykliske forbindelser med antidiabetisk aktivitet, deres anvendelse og farmasoeytisk preparat inneholdende disse |
NO983900A NO307299B1 (no) | 1994-04-11 | 1998-08-25 | Mellomprodukt for fremstilling av terapeutisk aktive forbindelser |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO951398A NO305987B1 (no) | 1994-04-11 | 1995-04-10 | Heterosykliske forbindelser med antidiabetisk aktivitet, deres anvendelse og farmasoeytisk preparat inneholdende disse |
Country Status (22)
Country | Link |
---|---|
US (6) | US5624935A (no) |
EP (2) | EP1022274B1 (no) |
KR (1) | KR950032188A (no) |
CN (1) | CN1060173C (no) |
AT (2) | ATE207488T1 (no) |
AU (1) | AU683348B2 (no) |
CA (1) | CA2146701A1 (no) |
CZ (1) | CZ289317B6 (no) |
DE (2) | DE69528000T2 (no) |
DK (2) | DK0676398T3 (no) |
ES (2) | ES2165895T3 (no) |
FI (1) | FI951731A (no) |
HK (2) | HK1029338A1 (no) |
HU (1) | HU219887B (no) |
ID (1) | ID20564A (no) |
IL (1) | IL113313A (no) |
NO (2) | NO305987B1 (no) |
NZ (1) | NZ270917A (no) |
PT (2) | PT676398E (no) |
RU (2) | RU2114844C1 (no) |
TW (2) | TW503237B (no) |
ZA (1) | ZA952990B (no) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ289317B6 (cs) * | 1994-04-11 | 2002-01-16 | Sankyo Company Limited | Heterocyklická sloučenina, farmaceutický prostředek ji obsahující a její pouľití |
TW403748B (en) * | 1994-11-02 | 2000-09-01 | Takeda Chemical Industries Ltd | An oxazolidinedione derivative, its production and a pharmaceutical composition for lowering blood sugar and lipid in blood comprising the same |
US5925656A (en) * | 1995-04-10 | 1999-07-20 | Dr. Reddy's Research Foundation | Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
IL118474A (en) * | 1995-06-01 | 2001-08-08 | Sankyo Co | Benzimideol derivatives and pharmaceutical preparations containing them |
NO318765B1 (no) * | 1995-07-03 | 2005-05-02 | Sankyo Co | Anvendelse av en HMG-CoA reduktaseinhibitor og en insulinsensibilisator til fremstilling av et medikament for forebyggelse eller behandling av arteriosklerose eller xantom, samt pakket farmasoytisk preparat som omfatter de to midlene i separate porsjoner. |
EP0783888A1 (en) * | 1995-12-26 | 1997-07-16 | Sankyo Company Limited | Use of troglitazone and related thiazolidinediones in the manufacture of a medicament for the treatment and prophylaxis of osteoporosis |
NZ314406A (en) * | 1996-03-18 | 2000-12-22 | Sankyo Co | Treatment or prophylaxis of pancreatitis with a medicament containing an insulin sensitiser including oxazoles and thiazoles |
US5889032A (en) * | 1996-05-06 | 1999-03-30 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
US5919782A (en) * | 1996-05-06 | 1999-07-06 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
US5889025A (en) * | 1996-05-06 | 1999-03-30 | Reddy's Research Foundation | Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
CA2257284C (en) * | 1996-05-31 | 2005-10-04 | Sankyo Company Limited | Remedy for autoimmune diseases |
US5885997A (en) * | 1996-07-01 | 1999-03-23 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
BR9711098B1 (pt) * | 1996-07-01 | 2011-10-04 | compostos heterocìclicos, processo para sua preparação e composições farmacêuticas contendo os mesmos e seu uso no tratamento de diabetes e doenças relacionadas. | |
US6372750B2 (en) | 1996-07-01 | 2002-04-16 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases |
USRE39266E1 (en) * | 1996-07-01 | 2006-09-05 | Dr. Reddy's Laboratories, Limited | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
US6114526A (en) * | 1996-07-01 | 2000-09-05 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
US6313113B1 (en) | 1997-04-15 | 2001-11-06 | Reddy-Cheminor, Inc. | Heterocyclic compounds having antidiabetic, hypolipidemic and antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
AU2823797A (en) * | 1997-05-02 | 1997-11-19 | Dr. Reddy's Research Foundation | Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
HU228193B1 (en) | 1997-10-08 | 2013-01-28 | Sankyo Co | Imidazole fused heterocyclic compounds, process for their preparation, pharmaceutical compositions containing the same and their use |
HUP9902721A2 (hu) | 1997-11-25 | 1999-12-28 | The Procter & Gamble Co. | Tömény textillágyító készítmény és ehhez alkalmazható magas telítetlenségű textillágyító vegyület |
JP2002510283A (ja) * | 1997-12-02 | 2002-04-02 | ドクター・レディーズ・リサーチ・ファウンデーション | 抗糖尿病性、低脂質性及び抗高血圧性を有する置換チアゾリンジオンとオキサゾリジンジオン |
US7105552B2 (en) * | 1998-05-08 | 2006-09-12 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
US7407978B2 (en) * | 1999-04-06 | 2008-08-05 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
AU757729B2 (en) * | 1999-04-07 | 2003-03-06 | Sankyo Company Limited | Amine derivatives |
AU3670900A (en) * | 1999-04-08 | 2000-11-14 | Sankyo Company Limited | Substituted fused imidazole derivatives |
IL130169A (en) | 1999-05-27 | 2006-08-20 | Neurim Pharma 1991 | Indole derivatives, and pharmaceutical preparations, skin protection preparations, and cosmetics containing them |
DE60032898T2 (de) * | 1999-06-18 | 2007-10-25 | Merck & Co., Inc. | Arylthiazolidindion- und aryloxazolidinderivate |
AU2001241168B2 (en) * | 2000-03-17 | 2005-06-16 | Ajinomoto Co., Inc. | Drugs for complications of diabetes and neuropathy and utilization thereof |
US6921762B2 (en) * | 2001-11-16 | 2005-07-26 | Amgen Inc. | Substituted indolizine-like compounds and methods of use |
ITRM20020016A1 (it) * | 2002-01-15 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Derivati di acidi fenil(alchil)carbossilici e derivati fenilalchileterociclici dionici, loro uso come medicamenti ad attivita' ipoglicemizza |
US7232828B2 (en) * | 2002-08-10 | 2007-06-19 | Bethesda Pharmaceuticals, Inc. | PPAR Ligands that do not cause fluid retention, edema or congestive heart failure |
CN101076334A (zh) * | 2004-05-28 | 2007-11-21 | 默克公司 | 具有抗糖尿病活性的苯并脲类化合物 |
WO2006080524A1 (ja) * | 2005-01-31 | 2006-08-03 | Ajinomoto Co., Inc. | 血糖降下剤を含有する、耐糖能異常、境界型糖尿病、インスリン抵抗性及び高インスリン血症の改善ないし治療用医薬組成物 |
WO2006138328A1 (en) * | 2005-06-14 | 2006-12-28 | Merck & Co., Inc. | Process for the production of antidiabetic oxazolidinediones |
EP1909789A4 (en) * | 2005-07-20 | 2009-10-21 | Merck & Co Inc | OXAZOLIDINEDIONES AND ANTIDIABETIC THIAZOLIDINEDIONES |
KR101331768B1 (ko) | 2005-11-08 | 2013-11-22 | 버텍스 파마슈티칼스 인코포레이티드 | Atp 결합 카세트 수송체의 헤테로사이클릭 조정제 |
WO2008141119A2 (en) | 2007-05-09 | 2008-11-20 | Vertex Pharmaceuticals Incorporated | Modulators of cftr |
KR101537830B1 (ko) * | 2007-09-14 | 2015-07-17 | 메타볼릭 솔루션스 디벨롭먼트 컴퍼니, 엘엘씨 | 고혈압 치료용 티아졸리딘디온 유사체 |
US8143280B2 (en) * | 2007-09-27 | 2012-03-27 | Hoffmann-La Roche Inc. | Glucocorticoid receptor antagonists |
KR20150066608A (ko) | 2007-12-07 | 2015-06-16 | 버텍스 파마슈티칼스 인코포레이티드 | 사이클로알킬카복시아미도-피리딘 벤조산의 제조 방법 |
SG186638A1 (en) | 2007-12-07 | 2013-01-30 | Vertex Pharma | Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid |
CN101463031B (zh) * | 2007-12-20 | 2014-02-12 | 中国医学科学院药物研究所 | 吲唑及四氢吲唑类化合物及其制法和其药物组合物与用途 |
CA2716109C (en) | 2008-02-28 | 2016-07-19 | Vertex Pharmaceuticals Incorporated | Heteroaryl derivatives as cftr modulators |
TWI461423B (zh) * | 2008-07-02 | 2014-11-21 | Astrazeneca Ab | 用於治療Pim激酶相關病狀及疾病之噻唑啶二酮化合物 |
RU2592368C2 (ru) | 2010-04-07 | 2016-07-20 | Вертекс Фармасьютикалз Инкорпорейтед | ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, ВКЛЮЧАЮЩИЕ 3-(2, 2-ДИФТОРБЕНЗО[d][1, 3]ДИОКСОЛ-5-ИЛ)ЦИКЛОПРОПАНКАРБОКСАМИДО)-3-МЕТИЛПИРИДИН-2-ИЛ)БЕНЗОЙНУЮ КИСЛОТУ, И ИХ ВВЕДЕНИЕ |
AU2014349010C1 (en) | 2013-11-12 | 2020-08-06 | Vertex Pharmaceuticals Incorporated | Process of preparing pharmaceutical compositions for the treatment of CFTR mediated diseases |
JP6494757B2 (ja) | 2014-11-18 | 2019-04-03 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | ハイスループット試験高速液体クロマトグラフィーを行うプロセス |
CN111883832A (zh) * | 2020-07-24 | 2020-11-03 | 香河昆仑化学制品有限公司 | 一种锂离子电池电解液以及电池负极和电化学储能器件 |
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US4097594A (en) * | 1977-03-30 | 1978-06-27 | Fmc Corporation | Mono-5-substituted-3-chloro-4H-1,2,6-thiadiazin-4-one antifungal agents |
JPS5522636A (en) * | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
JPS6051189A (ja) * | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
JPS60226873A (ja) * | 1984-03-28 | 1985-11-12 | Sankyo Co Ltd | 1,3−ベンゾオキサチオ−ル誘導体及びその製法 |
CN1003445B (zh) * | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物,其制备方法和用途 |
DK173350B1 (da) * | 1985-02-26 | 2000-08-07 | Sankyo Co | Thiazolidinderivater, deres fremstilling og farmaceutisk paæparat indeholdende dem |
JPH06779B2 (ja) * | 1985-06-10 | 1994-01-05 | 武田薬品工業株式会社 | チアゾリジオン誘導体およびそれを含んでなる医薬組成物 |
US4681940A (en) * | 1985-11-19 | 1987-07-21 | American Home Products Corporation | 5-[3-[[2-quinolyl]methoxy]phenyl]-1,3-oxazoles |
US4873255A (en) * | 1987-02-04 | 1989-10-10 | Sankyo Company Limited | Thiazolidinone derivatives, their preparation and their use |
JPH0764866B2 (ja) * | 1987-02-24 | 1995-07-12 | 財団法人微生物化学研究会 | 1−n−(4−アミノ−3−フルオロ−2−ヒドロキシブチリル)カナマイシン類 |
DE3856378T2 (de) * | 1987-09-04 | 2000-05-11 | Beecham Group Plc | Substituierte Thiazolidindionderivate |
GB8820389D0 (en) * | 1988-08-26 | 1988-09-28 | Beecham Group Plc | Novel compounds |
WO1991007107A1 (en) * | 1989-11-13 | 1991-05-30 | Pfizer Inc. | Oxazolidinedione hypoglycemic agents |
US5143930A (en) * | 1990-02-07 | 1992-09-01 | Sankyo Company, Limited | Thiazolidine derivatives with anti-diabetic activity, their preparation and their use |
DE69132713D1 (de) * | 1990-04-27 | 2001-10-11 | Sankyo Co | Benzylidenthiazolidinderivate, ihre Herstellung und ihre Anwendung als Lipidperoxid-Inhibitoren |
GB9017218D0 (en) * | 1990-08-06 | 1990-09-19 | Beecham Group Plc | Novel compounds |
US5334604A (en) * | 1990-08-23 | 1994-08-02 | Pfizer Inc. | Hypoglycemic hydroxyurea derivatives |
GB9023585D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
GB9023584D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
CZ196693A3 (en) * | 1991-04-11 | 1994-05-18 | Upjohn Co | Thiazolidinedione derivatives, and process for preparing thereof |
FR2680512B1 (fr) * | 1991-08-20 | 1995-01-20 | Adir | Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
NO179246C (no) * | 1991-11-20 | 1996-09-04 | Sankyo Co | Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav |
NO302519B1 (no) * | 1991-12-26 | 1998-03-16 | Sankyo Co | Tiazolidinforbindelser som inneholder en kinongruppe, og farmasöytisk preparat |
EP0590793B1 (en) * | 1992-08-31 | 1999-10-13 | Sankyo Company Limited | Oxazolidine derivatives having anti-diabetic and anti-obesity properties, their preparation and their therapeutic uses |
US5614544A (en) * | 1993-09-14 | 1997-03-25 | Takeda Chemical Industries, Ltd. | Oxazolidinedione derivatives and their use |
CZ289317B6 (cs) * | 1994-04-11 | 2002-01-16 | Sankyo Company Limited | Heterocyklická sloučenina, farmaceutický prostředek ji obsahující a její pouľití |
-
1995
- 1995-04-10 CZ CZ1995910A patent/CZ289317B6/cs not_active IP Right Cessation
- 1995-04-10 RU RU95105423/04A patent/RU2114844C1/ru not_active IP Right Cessation
- 1995-04-10 CA CA002146701A patent/CA2146701A1/en not_active Abandoned
- 1995-04-10 NO NO951398A patent/NO305987B1/no not_active IP Right Cessation
- 1995-04-10 IL IL11331395A patent/IL113313A/xx not_active IP Right Cessation
- 1995-04-10 RU RU95118736/04A patent/RU2151145C1/ru not_active IP Right Cessation
- 1995-04-11 FI FI951731A patent/FI951731A/fi unknown
- 1995-04-11 AT AT95302409T patent/ATE207488T1/de not_active IP Right Cessation
- 1995-04-11 ID IDP981611A patent/ID20564A/id unknown
- 1995-04-11 ZA ZA952990A patent/ZA952990B/xx unknown
- 1995-04-11 US US08/419,919 patent/US5624935A/en not_active Expired - Fee Related
- 1995-04-11 PT PT95302409T patent/PT676398E/pt unknown
- 1995-04-11 ES ES95302409T patent/ES2165895T3/es not_active Expired - Lifetime
- 1995-04-11 KR KR1019950008429A patent/KR950032188A/ko active IP Right Grant
- 1995-04-11 DK DK95302409T patent/DK0676398T3/da active
- 1995-04-11 PT PT00102313T patent/PT1022274E/pt unknown
- 1995-04-11 AT AT00102313T patent/ATE222895T1/de not_active IP Right Cessation
- 1995-04-11 AU AU16383/95A patent/AU683348B2/en not_active Ceased
- 1995-04-11 TW TW087114283A patent/TW503237B/zh not_active IP Right Cessation
- 1995-04-11 DK DK00102313T patent/DK1022274T3/da active
- 1995-04-11 CN CN95105765A patent/CN1060173C/zh not_active Expired - Fee Related
- 1995-04-11 HU HU9501040A patent/HU219887B/hu not_active IP Right Cessation
- 1995-04-11 DE DE69528000T patent/DE69528000T2/de not_active Expired - Fee Related
- 1995-04-11 ES ES00102313T patent/ES2180477T3/es not_active Expired - Lifetime
- 1995-04-11 EP EP00102313A patent/EP1022274B1/en not_active Expired - Lifetime
- 1995-04-11 TW TW084103469A patent/TW407156B/zh not_active IP Right Cessation
- 1995-04-11 EP EP95302409A patent/EP0676398B1/en not_active Expired - Lifetime
- 1995-04-11 DE DE69523358T patent/DE69523358T2/de not_active Expired - Fee Related
- 1995-04-11 NZ NZ270917A patent/NZ270917A/en unknown
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1996
- 1996-09-13 US US08/713,543 patent/US5834501A/en not_active Expired - Fee Related
- 1996-11-08 US US08/745,377 patent/US5739345A/en not_active Expired - Fee Related
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1997
- 1997-12-30 US US09/001,093 patent/US5962470A/en not_active Expired - Fee Related
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1998
- 1998-07-07 US US09/110,693 patent/US5977365A/en not_active Expired - Fee Related
- 1998-08-25 NO NO983900A patent/NO307299B1/no not_active IP Right Cessation
- 1998-11-30 HK HK00108123A patent/HK1029338A1/xx not_active IP Right Cessation
- 1998-11-30 HK HK98112512A patent/HK1011365A1/xx not_active IP Right Cessation
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1999
- 1999-03-03 US US09/261,645 patent/US6117893A/en not_active Expired - Fee Related
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