NO306303B1 - Kondensert benzazepinderivat og farmasöytisk preparat derav - Google Patents

Kondensert benzazepinderivat og farmasöytisk preparat derav

Info

Publication number
NO306303B1
NO306303B1 NO960231A NO960231A NO306303B1 NO 306303 B1 NO306303 B1 NO 306303B1 NO 960231 A NO960231 A NO 960231A NO 960231 A NO960231 A NO 960231A NO 306303 B1 NO306303 B1 NO 306303B1
Authority
NO
Norway
Prior art keywords
pharmaceutical preparation
benzazepine derivative
condensed benzazepine
condensed
derivative
Prior art date
Application number
NO960231A
Other languages
English (en)
Norwegian (no)
Other versions
NO960231L (no
NO960231D0 (no
Inventor
Akihiro Tanaka
Hiroyuki Koshio
Nobuaki Taniguchi
Akira Matsuhisa
Ken-Ichiro Sakamoto
Atsuki Yamazaki
Takeyuki Yatsu
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Publication of NO960231D0 publication Critical patent/NO960231D0/no
Publication of NO960231L publication Critical patent/NO960231L/no
Publication of NO306303B1 publication Critical patent/NO306303B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Output Control And Ontrol Of Special Type Engine (AREA)
NO960231A 1993-07-21 1996-01-19 Kondensert benzazepinderivat og farmasöytisk preparat derav NO306303B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP18043593 1993-07-21
PCT/JP1994/001183 WO1995003305A1 (fr) 1993-07-21 1994-07-19 Derive de benzazepine de fusion et composition pharmaceutique renfermant ce derive

Publications (3)

Publication Number Publication Date
NO960231D0 NO960231D0 (no) 1996-01-19
NO960231L NO960231L (no) 1996-03-21
NO306303B1 true NO306303B1 (no) 1999-10-18

Family

ID=16083198

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960231A NO306303B1 (no) 1993-07-21 1996-01-19 Kondensert benzazepinderivat og farmasöytisk preparat derav

Country Status (18)

Country Link
US (2) US5723606A (de)
EP (2) EP0709386B1 (de)
KR (1) KR100304331B1 (de)
CN (1) CN1040210C (de)
AT (2) ATE277003T1 (de)
AU (2) AU683483B2 (de)
CA (1) CA2167673C (de)
DE (2) DE69432632T2 (de)
ES (2) ES2228405T3 (de)
FI (1) FI113178B (de)
HU (1) HUT74582A (de)
NO (1) NO306303B1 (de)
NZ (1) NZ268671A (de)
PL (1) PL177738B1 (de)
RU (1) RU2129123C1 (de)
TW (1) TW279163B (de)
UA (1) UA64690C2 (de)
WO (1) WO1995003305A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693635A (en) * 1993-07-29 1997-12-02 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5760031A (en) * 1993-07-29 1998-06-02 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
AR002459A1 (es) * 1995-01-17 1998-03-25 American Cyanamid Co Antagonistas de vasopresina de benzacepina triciclicos, una composicion farmaceutica que los contiene, un metodo para tratar enfermedades y unprocedimiento para su preparacion.
KR20010034461A (ko) * 1998-01-28 2001-04-25 요시다 쇼지 시기능 장해의 예방 또는 치료제
AR018818A1 (es) * 1998-04-03 2001-12-12 Yamano Masaki Una composicion farmaceutica para la terapia de un edema.
WO1999065525A1 (fr) * 1998-06-19 1999-12-23 Wakamoto Pharmaceutical Co., Ltd. Agents permettant d'abaisser la tension oculaire et derives d'ester phosphorique
US7015212B1 (en) 1999-05-12 2006-03-21 The United States Of America As Represented By The Department Of Health And Human Services Thiazepine inhibitors of HIV-1 integrase
US6765004B1 (en) * 1999-06-17 2004-07-20 Ortho-Mcneil Pharmaceutical, Inc. Indoloazepines as vasopressin receptor antagonists
US6437006B1 (en) 1999-09-27 2002-08-20 American Cyanamid Company Pharmaceutical carrier formulation
US20030103983A1 (en) * 2002-05-09 2003-06-05 Pressler Milton Lethan Ace inhibitor-vasopressin antagonist combinations
AU2001218083A1 (en) * 2000-01-26 2001-08-07 Warner Lambert Company Ace inhibitor-vasopressin antagonist combinations
WO2001054698A1 (en) * 2000-01-26 2001-08-02 Warner-Lambert Company Method for preventing or treating postoperative ileus
US20030008860A1 (en) * 2002-05-09 2003-01-09 Bakker-Arkema Rebecca Guggemos Treatment of congestive heart failure
AU779929B2 (en) * 2000-10-04 2005-02-17 Warner-Lambert Company Treatment of pulmonary hypertension
IL145684A (en) * 2000-10-04 2007-06-17 Warner Lambert Co Medications for the treatment of pulmonary hypertension
US7056910B2 (en) * 2000-11-28 2006-06-06 Astellas Pharma Inc. 1,4,5.6-tetrahydroimidazo[4,5-d]diazepine derivatives or salts thereof
WO2007087066A2 (en) * 2005-12-28 2007-08-02 Vertex Pharmaceuticals Incorporated 1-(benzo [d] [1,3] di0x0l-5-yl) -n- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of atp-binding cassette transporters for the treatment of cystic fibrosis
US7671221B2 (en) * 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
US20080221084A1 (en) * 2006-10-30 2008-09-11 Otsuka Pharmaceutical Co., Ltd. Method for reducing infarction using vasopressin antagonist compounds, and compositions and combinations therefor
US20090069295A1 (en) * 2007-09-09 2009-03-12 Protia, Llc Deuterium-enriched conivaptan
JP2011509261A (ja) * 2008-01-07 2011-03-24 シンタ ファーマシューティカルズ コーポレーション 炎症および免疫関連用途向けの化合物
WO2009102761A1 (en) * 2008-02-12 2009-08-20 Bristol-Myers Squibb Company 1,2,3-triazoles as 11-beta hydroxysteroid dehydrogenase type i inhibitors
CA2728767A1 (en) * 2008-06-26 2009-12-30 Amgen Inc. Alkynyl alcohols as kinase inhibitors
JP5717645B2 (ja) * 2009-10-26 2015-05-13 大塚製薬株式会社 ベンズアゼピン化合物
WO2014062888A1 (en) 2012-10-18 2014-04-24 University Of South Florida Compositions and methods for treating stroke
CN103497195B (zh) * 2013-10-21 2016-01-27 北京科莱博医药开发有限责任公司 盐酸考尼伐坦新晶型及其制备方法
CN105310978A (zh) * 2014-08-04 2016-02-10 李峰 一种含有活性成分盐酸考尼伐坦的药物组合物及其制剂
CN105884778A (zh) * 2014-09-24 2016-08-24 李峰 一种化合物和制备方法
CN105153168A (zh) * 2015-09-29 2015-12-16 上海天慈国际药业有限公司 N-[4-(2-甲基-4,5-二氢-3H-咪唑并[4,5-d][1]苯并氮杂卓-6-甲酰基)苯基]-2-苯基苯甲酰胺盐酸盐的制备方法
CN106317060B (zh) * 2016-08-22 2019-02-15 山东罗欣药业集团恒欣药业有限公司 一种盐酸考尼伐坦的制备方法
US11498903B2 (en) 2017-08-17 2022-11-15 Bristol-Myers Squibb Company 2-(1,1′-biphenyl)-1H-benzodimidazole derivatives and related compounds as apelin and APJ agonists for treating cardiovascular diseases
TW201938171A (zh) 2017-12-15 2019-10-01 匈牙利商羅特格登公司 作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物
HU231206B1 (hu) 2017-12-15 2021-10-28 Richter Gedeon Nyrt. Triazolobenzazepinek
WO2022111581A1 (zh) * 2020-11-26 2022-06-02 上海济煜医药科技有限公司 新型苯并氮杂卓螺环衍生物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011628A (en) * 1988-06-15 1991-04-30 Givaudan Corporation N,N'-diarylbenzamidines useful as ultraviolet light absorbers
ATE80610T1 (de) * 1988-06-15 1992-10-15 Givaudan & Cie Sa Benzamidine, verwendbar als uv-lichtabsorptionsmittel.
US5225402A (en) * 1989-02-10 1993-07-06 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
US5258510A (en) * 1989-10-20 1993-11-02 Otsuka Pharma Co Ltd Benzoheterocyclic compounds
KR0167349B1 (ko) * 1989-10-20 1999-02-18 오스카 아끼히꼬 벤조헤테로 고리 화합물
JP2905909B2 (ja) * 1991-04-19 1999-06-14 大塚製薬株式会社 バソプレシン拮抗剤
JPH03255077A (ja) * 1990-03-01 1991-11-13 Taiji Nakayama ピリミジン誘導体およびそれを有効成分とする血小板凝集阻止剤
TW198715B (de) * 1991-04-19 1993-01-21 Dtsuka Seiyaku Kk
US5512563A (en) * 1993-07-29 1996-04-30 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
JP3255077B2 (ja) * 1997-04-23 2002-02-12 日本電気株式会社 電話機

Also Published As

Publication number Publication date
TW279163B (de) 1996-06-21
CN1040210C (zh) 1998-10-14
EP0709386A4 (de) 1997-06-25
CN1127508A (zh) 1996-07-24
FI113178B (fi) 2004-03-15
RU2129123C1 (ru) 1999-04-20
EP0709386A1 (de) 1996-05-01
PL177738B1 (pl) 2000-01-31
FI960260A (fi) 1996-01-19
CA2167673A1 (en) 1995-02-02
FI960260A0 (fi) 1996-01-19
NZ268671A (en) 1997-09-22
ES2198418T3 (es) 2004-02-01
AU7195794A (en) 1995-02-20
AU3990697A (en) 1997-12-18
WO1995003305A1 (fr) 1995-02-02
ES2228405T3 (es) 2005-04-16
DE69434032T2 (de) 2005-09-22
HUT74582A (en) 1997-01-28
NO960231L (no) 1996-03-21
DE69432632T2 (de) 2004-02-19
KR960703917A (ko) 1996-08-31
EP1097920B1 (de) 2004-09-22
NO960231D0 (no) 1996-01-19
AU683483B2 (en) 1997-11-13
CA2167673C (en) 2004-09-21
ATE239726T1 (de) 2003-05-15
PL312654A1 (en) 1996-04-29
HU9600102D0 (en) 1996-03-28
KR100304331B1 (ko) 2001-11-22
DE69434032D1 (de) 2004-10-28
UA64690C2 (en) 2004-03-15
EP1097920A1 (de) 2001-05-09
ATE277003T1 (de) 2004-10-15
EP0709386B1 (de) 2003-05-07
US5723606A (en) 1998-03-03
US5856564A (en) 1999-01-05
DE69432632D1 (de) 2003-06-12

Similar Documents

Publication Publication Date Title
NO960231L (no) Kondensert benzazepinderivat og farmasöytisk preparat derav
NO302366B1 (no) 4-merkaptoacetylamino-£2|benzazepinon(3)-derivater, og farmasöytisk preparat
NO940789D0 (no) Quinolinkarboksylsyrederivater, deres fremstilling og anvendelse
IS6348A (is) (1a,3a,5a)(3-amínómetýl bísýkló[3.2.0]hept-3-ýl)-ediksýra, lyfjasamsetningar og notkun efnasambandsins til framleiðslu á lyfjum
NZ234327A (en) Quinazoline derivatives and pharmaceutical compositions
FI944217A (fi) Substituoidut pipekoliinihappojohdannaiset HIV-proteaasin estäjinä
ES2167720T3 (es) Compuestos de 1-fenilpirazol y aplicaciones medicinales de los mismos.
DE69021618D1 (de) Antagonisten von exzitatorischen Aminosäuren.
NO984331L (no) Karboksylsyrederivater med kondensert ring
ATE255117T1 (de) Aminophosphonsäure-derivate als arzneimittel
MX9204342A (es) Indoles.
ES2111871T3 (es) Nuevos derivados de aminoacidos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
FI941149A0 (fi) 2,4-diamino-3-hydroksikarboksyylihapon johdannaisia
NO934032D0 (no) Fremgangsmaate for fjerning av allergeniske forbindelser fra en proteinblanding, et saaledes erholdt produkt, og anvendelse derav
MA23133A1 (fr) Derives d'acide d'acyloxyhexanoique .
FI953361A (fi) Menetelmä substituoitujen indolonijohdannaisten valmistamiseksi
NO923266L (no) Heksahydrobenzo(f)quinolinoner
FI941380A0 (fi) Heterosyklisesti substituoitujen fenyylietikkahappojohdannnaisten fenyyliglysiiniamidit
KR950702115A (ko) 디히드로피리딘 유도체의 신규 의약 용도(novel medicinal use of dihydropyridine derivative)
NO912167L (no) Fremgangsmaate for fremstilling av ftalsyreanhydrid-derivater.
ES2080445T3 (es) Derivados de ursano, su preparacion y formulaciones farmaceuticas de los mismos.
CA2453123A1 (en) Intermediate for condensed benzazepine derivatives
NO307738B1 (no) Farmasøytisk preparat av retrovirale inhibitorer
TH33723A (de)
BR1101036A (pt) Derivados de n-(pirrolo(2,3-d)pirimidin-3-ilacil)-ácido glutâmico

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees