FI960260A0 - Kondensoitunut bentsatsepiinijohdannainen ja sen farmaseuttinen seos - Google Patents

Kondensoitunut bentsatsepiinijohdannainen ja sen farmaseuttinen seos

Info

Publication number
FI960260A0
FI960260A0 FI960260A FI960260A FI960260A0 FI 960260 A0 FI960260 A0 FI 960260A0 FI 960260 A FI960260 A FI 960260A FI 960260 A FI960260 A FI 960260A FI 960260 A0 FI960260 A0 FI 960260A0
Authority
FI
Finland
Prior art keywords
pharmaceutical mixture
benzazepine derivative
condensed benzazepine
condensed
derivative
Prior art date
Application number
FI960260A
Other languages
English (en)
Swedish (sv)
Other versions
FI113178B (fi
FI960260A (fi
Inventor
Akihiro Tanaka
Hiroyuki Koshio
Nobuaki Taniguchi
Akira Matsuhisa
Ken-Ichiro Sakamoto
Atsuki Yamazaki
Takeyuki Yatsu
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Publication of FI960260A0 publication Critical patent/FI960260A0/fi
Publication of FI960260A publication Critical patent/FI960260A/fi
Application granted granted Critical
Publication of FI113178B publication Critical patent/FI113178B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Output Control And Ontrol Of Special Type Engine (AREA)
FI960260A 1993-07-21 1996-01-19 Menetelmä valmistaa terapeuttisesti arvokas 5,6-dihydro-4H-tiatsolo[5,4-d]-, -oksatsolo[4,5-d]- tai - imidatso[4,5-d][1]-bentsatsepiini-6-fenyylikarbonyylijohdannainen FI113178B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP18043593 1993-07-21
JP18043593 1993-07-21
PCT/JP1994/001183 WO1995003305A1 (fr) 1993-07-21 1994-07-19 Derive de benzazepine de fusion et composition pharmaceutique renfermant ce derive
JP9401183 1994-07-19

Publications (3)

Publication Number Publication Date
FI960260A0 true FI960260A0 (fi) 1996-01-19
FI960260A FI960260A (fi) 1996-01-19
FI113178B FI113178B (fi) 2004-03-15

Family

ID=16083198

Family Applications (1)

Application Number Title Priority Date Filing Date
FI960260A FI113178B (fi) 1993-07-21 1996-01-19 Menetelmä valmistaa terapeuttisesti arvokas 5,6-dihydro-4H-tiatsolo[5,4-d]-, -oksatsolo[4,5-d]- tai - imidatso[4,5-d][1]-bentsatsepiini-6-fenyylikarbonyylijohdannainen

Country Status (18)

Country Link
US (2) US5723606A (fi)
EP (2) EP0709386B1 (fi)
KR (1) KR100304331B1 (fi)
CN (1) CN1040210C (fi)
AT (2) ATE277003T1 (fi)
AU (2) AU683483B2 (fi)
CA (1) CA2167673C (fi)
DE (2) DE69432632T2 (fi)
ES (2) ES2198418T3 (fi)
FI (1) FI113178B (fi)
HU (1) HUT74582A (fi)
NO (1) NO306303B1 (fi)
NZ (1) NZ268671A (fi)
PL (1) PL177738B1 (fi)
RU (1) RU2129123C1 (fi)
TW (1) TW279163B (fi)
UA (1) UA64690C2 (fi)
WO (1) WO1995003305A1 (fi)

Families Citing this family (34)

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US5760031A (en) * 1993-07-29 1998-06-02 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5693635A (en) * 1993-07-29 1997-12-02 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
AR002459A1 (es) * 1995-01-17 1998-03-25 American Cyanamid Co Antagonistas de vasopresina de benzacepina triciclicos, una composicion farmaceutica que los contiene, un metodo para tratar enfermedades y unprocedimiento para su preparacion.
US6268359B1 (en) 1998-01-28 2001-07-31 Senju Pharmaceutical Co., Ltd. Preventives or remedies for vision disorders
AR018818A1 (es) * 1998-04-03 2001-12-12 Yamano Masaki Una composicion farmaceutica para la terapia de un edema.
WO1999065525A1 (fr) * 1998-06-19 1999-12-23 Wakamoto Pharmaceutical Co., Ltd. Agents permettant d'abaisser la tension oculaire et derives d'ester phosphorique
US7015212B1 (en) 1999-05-12 2006-03-21 The United States Of America As Represented By The Department Of Health And Human Services Thiazepine inhibitors of HIV-1 integrase
US6765004B1 (en) * 1999-06-17 2004-07-20 Ortho-Mcneil Pharmaceutical, Inc. Indoloazepines as vasopressin receptor antagonists
US6437006B1 (en) 1999-09-27 2002-08-20 American Cyanamid Company Pharmaceutical carrier formulation
ATE341342T1 (de) * 2000-01-26 2006-10-15 Astellas Pharma Inc Ace inhibitor-vasopressin antagonist kombinationen
US20030103983A1 (en) * 2002-05-09 2003-06-05 Pressler Milton Lethan Ace inhibitor-vasopressin antagonist combinations
US6645959B1 (en) 2000-01-26 2003-11-11 Warner-Lambert Company Method for treating postoperative ileus
US20030008860A1 (en) * 2002-05-09 2003-01-09 Bakker-Arkema Rebecca Guggemos Treatment of congestive heart failure
AU779929B2 (en) * 2000-10-04 2005-02-17 Warner-Lambert Company Treatment of pulmonary hypertension
ATE367815T1 (de) * 2000-10-04 2007-08-15 Astellas Pharma Inc Verwendung von einem vasopressin-antagonisten wie conivaptan zur herstellung eines medikaments für die behandlung der pulmonalen hypertension
US7056910B2 (en) * 2000-11-28 2006-06-06 Astellas Pharma Inc. 1,4,5.6-tetrahydroimidazo[4,5-d]diazepine derivatives or salts thereof
JP5165586B2 (ja) * 2005-12-28 2013-03-21 バーテックス ファーマシューティカルズ インコーポレイテッド 嚢胞性線維症の処置のためのＡＴＰ結合カセットトランスポーターのモジュレーターとしての、１−（ベンゾ［ｄ］［１，３］ジオキソール−５−イル）−Ｎ−（フェニル）シクロプロパン−カルボキサミド誘導体および関連化合物
US7671221B2 (en) * 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
US20080221084A1 (en) * 2006-10-30 2008-09-11 Otsuka Pharmaceutical Co., Ltd. Method for reducing infarction using vasopressin antagonist compounds, and compositions and combinations therefor
US20090069295A1 (en) * 2007-09-09 2009-03-12 Protia, Llc Deuterium-enriched conivaptan
CA2711644A1 (en) * 2008-01-07 2009-07-16 Synta Pharmaceuticals Corp. Compounds for inflammation and immune-related uses
US8263630B2 (en) * 2008-02-12 2012-09-11 Bristol-Myers Squibb Company 1,2,3-triazoles as 11-beta hydroxysteroid dehydrogenase type I inhibitors
US20110086834A1 (en) * 2008-06-26 2011-04-14 Amgen Inc. Alkynyl alcohols as kinase inhibitors
US8940727B2 (en) * 2009-10-26 2015-01-27 Otsuka Pharmaceutical Co., Ltd. Benzazepine compound
WO2014062888A1 (en) 2012-10-18 2014-04-24 University Of South Florida Compositions and methods for treating stroke
CN103497195B (zh) * 2013-10-21 2016-01-27 北京科莱博医药开发有限责任公司 盐酸考尼伐坦新晶型及其制备方法
CN105310978A (zh) * 2014-08-04 2016-02-10 李峰 一种含有活性成分盐酸考尼伐坦的药物组合物及其制剂
CN105884778A (zh) * 2014-09-24 2016-08-24 李峰 一种化合物和制备方法
CN105153168A (zh) * 2015-09-29 2015-12-16 上海天慈国际药业有限公司 N-[4-(2-甲基-4,5-二氢-3H-咪唑并[4,5-d][1]苯并氮杂卓-6-甲酰基)苯基]-2-苯基苯甲酰胺盐酸盐的制备方法
CN106317060B (zh) * 2016-08-22 2019-02-15 山东罗欣药业集团恒欣药业有限公司 一种盐酸考尼伐坦的制备方法
US11498903B2 (en) 2017-08-17 2022-11-15 Bristol-Myers Squibb Company 2-(1,1′-biphenyl)-1H-benzodimidazole derivatives and related compounds as apelin and APJ agonists for treating cardiovascular diseases
TW201938171A (zh) 2017-12-15 2019-10-01 匈牙利商羅特格登公司 作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物
HU231206B1 (hu) 2017-12-15 2021-10-28 Richter Gedeon Nyrt. Triazolobenzazepinek
WO2022111581A1 (zh) * 2020-11-26 2022-06-02 上海济煜医药科技有限公司 新型苯并氮杂卓螺环衍生物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011628A (en) * 1988-06-15 1991-04-30 Givaudan Corporation N,N'-diarylbenzamidines useful as ultraviolet light absorbers
ATE80610T1 (de) * 1988-06-15 1992-10-15 Givaudan & Cie Sa Benzamidine, verwendbar als uv-lichtabsorptionsmittel.
US5225402A (en) * 1989-02-10 1993-07-06 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
JP2905909B2 (ja) * 1991-04-19 1999-06-14 大塚製薬株式会社 バソプレシン拮抗剤
US5258510A (en) * 1989-10-20 1993-11-02 Otsuka Pharma Co Ltd Benzoheterocyclic compounds
DK0450097T3 (da) * 1989-10-20 1996-05-20 Otsuka Pharma Co Ltd Benzoheterocykliske forbindelser
JPH03255077A (ja) * 1990-03-01 1991-11-13 Taiji Nakayama ピリミジン誘導体およびそれを有効成分とする血小板凝集阻止剤
CA2066104C (en) * 1991-04-19 2003-05-27 Hidenori Ogawa Benzazepine derivatives as vasopressin antagonists
US5512563A (en) * 1993-07-29 1996-04-30 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
JP3255077B2 (ja) * 1997-04-23 2002-02-12 日本電気株式会社 電話機

Also Published As

Publication number Publication date
DE69434032T2 (de) 2005-09-22
NO960231L (no) 1996-03-21
ES2228405T3 (es) 2005-04-16
NZ268671A (en) 1997-09-22
US5723606A (en) 1998-03-03
RU2129123C1 (ru) 1999-04-20
US5856564A (en) 1999-01-05
ATE239726T1 (de) 2003-05-15
AU7195794A (en) 1995-02-20
AU3990697A (en) 1997-12-18
CN1040210C (zh) 1998-10-14
EP0709386A4 (en) 1997-06-25
NO306303B1 (no) 1999-10-18
DE69432632D1 (de) 2003-06-12
KR100304331B1 (ko) 2001-11-22
KR960703917A (ko) 1996-08-31
EP0709386B1 (en) 2003-05-07
WO1995003305A1 (fr) 1995-02-02
FI113178B (fi) 2004-03-15
HUT74582A (en) 1997-01-28
EP1097920B1 (en) 2004-09-22
EP0709386A1 (en) 1996-05-01
DE69434032D1 (de) 2004-10-28
DE69432632T2 (de) 2004-02-19
HU9600102D0 (en) 1996-03-28
CA2167673A1 (en) 1995-02-02
CN1127508A (zh) 1996-07-24
TW279163B (fi) 1996-06-21
UA64690C2 (en) 2004-03-15
PL312654A1 (en) 1996-04-29
AU683483B2 (en) 1997-11-13
CA2167673C (en) 2004-09-21
NO960231D0 (no) 1996-01-19
ES2198418T3 (es) 2004-02-01
EP1097920A1 (en) 2001-05-09
ATE277003T1 (de) 2004-10-15
PL177738B1 (pl) 2000-01-31
FI960260A (fi) 1996-01-19

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Legal Events

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Owner name: ASTELLAS PHARMA INC.

Free format text: ASTELLAS PHARMA INC.