NO302755B1 - Morfinan-derivater - Google Patents

Morfinan-derivater

Info

Publication number
NO302755B1
NO302755B1 NO933376A NO933376A NO302755B1 NO 302755 B1 NO302755 B1 NO 302755B1 NO 933376 A NO933376 A NO 933376A NO 933376 A NO933376 A NO 933376A NO 302755 B1 NO302755 B1 NO 302755B1
Authority
NO
Norway
Prior art keywords
nch3
morphinan derivatives
xso2
alkylene
chem
Prior art date
Application number
NO933376A
Other languages
English (en)
Other versions
NO933376L (no
NO933376D0 (no
Inventor
Hiroshi Nagase
Koji Kawai
Kuniaki Kawamura
Jun Hayakawa
Takashi Endoh
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Publication of NO933376D0 publication Critical patent/NO933376D0/no
Publication of NO933376L publication Critical patent/NO933376L/no
Publication of NO302755B1 publication Critical patent/NO302755B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Fertilizers (AREA)
  • Saccharide Compounds (AREA)
NO933376A 1992-01-23 1993-09-22 Morfinan-derivater NO302755B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP1011592 1992-01-23
JP29430892 1992-11-02
PCT/JP1993/000080 WO1993015081A1 (fr) 1992-01-23 1993-01-22 Derive de morphinane et utilisation en medicine

Publications (3)

Publication Number Publication Date
NO933376D0 NO933376D0 (no) 1993-09-22
NO933376L NO933376L (no) 1993-09-23
NO302755B1 true NO302755B1 (no) 1998-04-20

Family

ID=26345314

Family Applications (1)

Application Number Title Priority Date Filing Date
NO933376A NO302755B1 (no) 1992-01-23 1993-09-22 Morfinan-derivater

Country Status (15)

Country Link
US (2) US6323212B1 (no)
EP (2) EP0846694A1 (no)
JP (1) JP2525552B2 (no)
KR (1) KR970011390B1 (no)
AT (1) ATE172201T1 (no)
AU (2) AU666702B2 (no)
CA (1) CA2105072C (no)
DE (1) DE69321525T2 (no)
DK (1) DK0577847T3 (no)
ES (1) ES2121988T3 (no)
FI (1) FI106126B (no)
NO (1) NO302755B1 (no)
NZ (1) NZ246687A (no)
TW (1) TW332814B (no)
WO (1) WO1993015081A1 (no)

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US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
EP0829481A1 (en) * 1996-09-16 1998-03-18 Pfizer Inc. Morphinan hydroxamic acid compounds
EP1312361A1 (en) * 1996-11-25 2003-05-21 Toray Industries, Inc. Antipruritic agent
ATE377602T1 (de) 1997-03-27 2007-11-15 Toray Industries Morphinanderivate und ihre medizinische anwendung
EP0948965B1 (en) * 1997-07-11 2004-06-02 Toray Industries, Inc. Stable medicinal compositions containing 4,5-epoxymorphinane derivatives
WO1999003459A1 (en) * 1997-07-14 1999-01-28 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
AU6117298A (en) * 1997-07-25 1999-02-16 Toray Industries, Inc. Hyponatremia remedies
WO1999011289A1 (fr) * 1997-09-02 1999-03-11 Toray Industries, Inc. Remedes contre la toxicomanie
US6083944A (en) * 1997-10-07 2000-07-04 Cephalon, Inc. Quinoline-containing α-ketoamide cysteine and serine protease inhibitors
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ES2308990T3 (es) * 1999-08-24 2008-12-16 Toray Industries, Inc. Remedios para el dolor neuropatico y modelos animales de dolor neuropatico.
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US7923454B2 (en) 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US7501433B2 (en) * 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
JP4016986B2 (ja) * 2002-10-09 2007-12-05 東レ株式会社 頻尿もしくは尿失禁の治療または予防剤および含窒素環状置換基を有するモルヒナン誘導体
US8017622B2 (en) 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
AU2004245057B2 (en) * 2003-06-04 2008-07-31 Alkermes Pharma Ireland Limited Polymorphic forms of naltrexone
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AR053098A1 (es) * 2004-11-04 2007-04-25 Toray Industries Analgesico derivado de morfinano
CN101155814B (zh) 2005-04-06 2010-06-16 东丽株式会社 ***喃衍生物的晶体及其制备方法
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WO2008133297A1 (ja) 2007-04-24 2008-11-06 Toray Industries, Inc. ジスキネジアの治療または予防剤
CN101686976B (zh) 2007-04-26 2013-04-24 东丽株式会社 含有4,5-环氧基***喃衍生物的稳定的固体制剂
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CN102196811B (zh) 2008-10-24 2014-03-19 东丽株式会社 含有4,5-环氧基***烷衍生物的稳定片剂
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CN102325776A (zh) * 2009-02-23 2012-01-18 马林克罗特公司 (+)-***喃*季盐及其制备方法
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CN102325775A (zh) * 2009-02-23 2012-01-18 马林克罗特公司 (+)-6-羟基-***喃或(+)-6-氨基-***喃衍生物
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US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
US10363251B2 (en) 2009-07-16 2019-07-30 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
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AU2011317183B2 (en) * 2010-10-19 2016-10-20 Memorial Sloan-Kettering Cancer Center 6-amido derivatives of 4,5a-epoxymorphinans for treatment of pain
CN103327977B (zh) 2011-01-31 2016-05-04 东丽株式会社 恶液质的治疗或预防剂
PL2718294T3 (pl) 2011-06-09 2019-04-30 SpecGx LLC Redukcyjne aminowanie 6-keto morfinanów przez katalityczne przeniesienie wodoru
KR20140063763A (ko) 2011-09-08 2014-05-27 말린크로트 엘엘씨 중간체를 단리하지 않는 알칼로이드의 제조 방법
EP2884978B1 (en) * 2012-08-16 2019-07-17 The Scripps Research Institute Novel kappa opioid ligands
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US9969746B2 (en) 2013-12-05 2018-05-15 The University Of Bath Opioid compounds and their uses
JP2015166331A (ja) * 2014-05-14 2015-09-24 遼東化学工業株式会社 ナルフラフィンの結晶およびその製造方法
WO2016152953A1 (ja) * 2015-03-24 2016-09-29 東レ株式会社 モルヒナン誘導体及びその医薬用途
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US11529340B2 (en) 2016-03-22 2022-12-20 Regents Of The University Of Minnesota Combination for treating pain
EP3458061B1 (en) * 2016-05-19 2023-01-18 Virginia Commonwealth University Potent and selective mu opioid receptor modulators
JP6814470B2 (ja) 2017-02-10 2021-01-20 国立大学法人 筑波大学 モルヒナン誘導体
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Also Published As

Publication number Publication date
KR970011390B1 (ko) 1997-07-10
FI934144A0 (fi) 1993-09-22
EP0577847A1 (en) 1994-01-12
AU3367193A (en) 1993-09-01
DE69321525T2 (de) 1999-03-04
AU4067195A (en) 1996-03-07
ES2121988T3 (es) 1998-12-16
TW332814B (en) 1998-06-01
CA2105072A1 (en) 1993-07-24
EP0577847A4 (en) 1994-12-07
NO933376L (no) 1993-09-23
DK0577847T3 (da) 1999-06-23
NO933376D0 (no) 1993-09-22
CA2105072C (en) 1998-07-28
US6277859B1 (en) 2001-08-21
JPH08502275A (ja) 1996-03-12
NZ246687A (en) 1996-12-20
AU686483B2 (en) 1998-02-05
FI934144A (fi) 1993-09-22
US6323212B1 (en) 2001-11-27
ATE172201T1 (de) 1998-10-15
FI106126B (fi) 2000-11-30
DE69321525D1 (de) 1998-11-19
JP2525552B2 (ja) 1996-08-21
EP0846694A1 (en) 1998-06-10
AU666702B2 (en) 1996-02-22
WO1993015081A1 (fr) 1993-08-05
EP0577847B1 (en) 1998-10-14

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