NO20092729L - Lipasevarianter for farmasoytisk anvendelse - Google Patents

Lipasevarianter for farmasoytisk anvendelse

Info

Publication number
NO20092729L
NO20092729L NO20092729A NO20092729A NO20092729L NO 20092729 L NO20092729 L NO 20092729L NO 20092729 A NO20092729 A NO 20092729A NO 20092729 A NO20092729 A NO 20092729A NO 20092729 L NO20092729 L NO 20092729L
Authority
NO
Norway
Prior art keywords
lipases
digestive
improved
pharmaceutical use
diabetes
Prior art date
Application number
NO20092729A
Other languages
English (en)
Norwegian (no)
Inventor
Peter-Colin Gregory
Allan Svendsen
Michael Skjot
Debbie Yaver
Lars Lehmann Hylling Christensen
Signe Eskildsen Larsen
Nina Lundin
Michael Lamsa
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Publication of NO20092729L publication Critical patent/NO20092729L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Detergent Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
NO20092729A 2006-12-21 2009-07-20 Lipasevarianter for farmasoytisk anvendelse NO20092729L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87119606P 2006-12-21 2006-12-21
PCT/US2007/087168 WO2008079685A2 (fr) 2006-12-21 2007-12-12 Variantes lipasiques pour une utilisation pharmaceutique

Publications (1)

Publication Number Publication Date
NO20092729L true NO20092729L (no) 2009-09-18

Family

ID=38043020

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20092729A NO20092729L (no) 2006-12-21 2009-07-20 Lipasevarianter for farmasoytisk anvendelse

Country Status (16)

Country Link
US (3) US8273348B2 (fr)
EP (6) EP2455462B1 (fr)
JP (1) JP5406040B2 (fr)
KR (1) KR20090101930A (fr)
CN (2) CN105112386A (fr)
AR (1) AR064494A1 (fr)
AU (1) AU2007337150A1 (fr)
BR (1) BRPI0721103A2 (fr)
CA (3) CA2961041C (fr)
IL (1) IL198893A0 (fr)
MX (1) MX2009006597A (fr)
NO (1) NO20092729L (fr)
RU (1) RU2009128067A (fr)
TW (1) TW200829698A (fr)
WO (1) WO2008079685A2 (fr)
ZA (1) ZA200903598B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2314646T3 (es) 2004-03-22 2009-03-16 Solvay Pharmaceuticals Gmbh Composiciones farmaceuticas por via de productos que contienen lipasa , en particular de pancreatina, que contienen tensioactivos.
RU2413532C2 (ru) 2005-07-29 2011-03-10 Зольвай Фармасьютиклз Гмбх Способ получения стерилизованного порошкообразного панкреатина
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
US10072256B2 (en) 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
CN105112386A (zh) 2006-12-21 2015-12-02 诺维信公司 用于药物用途的脂肪酶变体
MX2010009457A (es) * 2008-02-29 2010-09-24 Procter & Gamble Composicion detergente que comprende lipasa.
CN102016015B (zh) 2008-02-29 2014-09-03 帝斯曼知识产权资产管理有限公司 对短链脂肪酸具有高度特异性的脂肪酶及其用途
JP2011514805A (ja) * 2008-02-29 2011-05-12 ノボザイムス アクティーゼルスカブ 向上した安定性を有する脂肪分解酵素変異体、及びこれをコードするポリヌクレオチド
DK2734633T3 (da) 2011-07-22 2019-06-11 Novozymes North America Inc Fremgangsmåder til forbehandling af celluloseholdigt materiale og forbedring af hydrolyse deraf
US8268305B1 (en) 2011-09-23 2012-09-18 Bio-Cat, Inc. Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase
EP2798053B1 (fr) 2011-12-29 2018-05-16 Novozymes A/S Compositions de détergent avec variants de lipases
ES2794644T3 (es) * 2012-02-03 2020-11-18 Novozymes As Variantes de lipasa y polinucleótidos que las codifican
US9909109B2 (en) 2012-04-02 2018-03-06 Novozymes A/S Lipase variants and polynucleotides encoding same
WO2014059360A1 (fr) * 2012-10-12 2014-04-17 Danisco Us Inc. Compositions comprenant un variant d'enzyme lipolytique et procédés associés
MY192746A (en) * 2013-05-14 2022-09-06 Novozymes As Detergent compositions
MX371497B (es) * 2013-07-19 2020-01-31 Danisco Us Inc Composiciones y metodos que comprenden una variante de enzima lipolitica.
US10287562B2 (en) * 2014-11-20 2019-05-14 Novoszymes A/S Alicyclobacillus variants and polynucleotides encoding same
EP4067485A3 (fr) * 2014-12-05 2023-01-04 Novozymes A/S Variantes de la lipase et polynucléotides les codant
US11268076B2 (en) 2014-12-09 2022-03-08 Novozymes A/S Lipase variants and polynucleotides encoding same
CN107864658A (zh) 2015-04-07 2018-03-30 诺维信公司 用于选择具有脂肪酶活性的酶的方法
WO2017005640A1 (fr) * 2015-07-03 2017-01-12 Novozymes A/S Compositions détergentes présentant une stabilité accrue en présence de sulfites
US11028131B2 (en) * 2017-01-30 2021-06-08 Nippon Medical School Foundation Mutant of adeno-associated virus (AAV) capsid protein
US11286443B2 (en) * 2017-09-27 2022-03-29 The Procter & Gamble Company Detergent compositions comprising lipases
CA3073362A1 (fr) * 2017-09-27 2019-04-04 Novozymes A/S Variants de lipase et compositions de microcapsules comprenant de tels variants de lipase
EP3749760A1 (fr) * 2018-02-08 2020-12-16 Novozymes A/S Variants de lipase et compositions en comprenant
CN111334369B (zh) * 2020-03-11 2022-10-21 陕西科技大学 一种酶法制备卵磷脂型pufa的方法
EP4237552A2 (fr) * 2020-10-29 2023-09-06 Novozymes A/S Variants de lipase et compositions comprenant de tels variants de lipase
CN113846074B (zh) * 2021-10-20 2022-10-21 南京林业大学 一种疏棉状嗜热丝孢菌脂肪酶突变体g91c及其应用
WO2023225459A2 (fr) 2022-05-14 2023-11-23 Novozymes A/S Compositions et procédés de prévention, de traitement, de suppression et/ou d'élimination d'infestations et d'infections phytopathogènes

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK173590D0 (da) * 1990-06-06 1990-07-19 Novo Nordisk As Rekombinante terapeutiske lipaser
US5869438A (en) 1990-09-13 1999-02-09 Novo Nordisk A/S Lipase variants
DE69129988T2 (de) * 1990-09-13 1999-03-18 Novo Nordisk As Lipase-varianten
DK46693D0 (fr) * 1993-04-23 1993-04-23 Novo Nordisk As
DE69130113T2 (de) 1990-12-05 1999-05-12 Novo Nordisk As Proteine mit geänderten epitopen und verfahren zur deren herstellung
US5914306A (en) 1991-05-01 1999-06-22 Novo Nordisk A/S Stabilized enzymes
DK39693D0 (da) 1993-04-02 1993-04-02 Novo Nordisk As Enzym
AU7807394A (en) 1993-10-04 1995-05-01 Novo Nordisk A/S An enzyme preparation comprising a modified enzyme
AU1806795A (en) 1994-02-22 1995-09-04 Novo Nordisk A/S A method of preparing a variant of a lipolytic enzyme
AU3924095A (en) 1994-11-24 1996-06-17 Novo Nordisk A/S A process for producing polypeptides with reduced allergenicity
WO1996017929A1 (fr) 1994-12-07 1996-06-13 Novo Nordisk A/S Polypeptide a allergenicite reduite
CN1165614C (zh) 1995-01-26 2004-09-08 诺沃奇梅兹有限公司 含有木聚糖酶的动物饲料添加剂
JP4307549B2 (ja) 1995-07-14 2009-08-05 ノボザイムス アクティーゼルスカブ 脂肪分解活性を有する修飾された酵素
US6495357B1 (en) 1995-07-14 2002-12-17 Novozyme A/S Lipolytic enzymes
ES2221934T3 (es) 1995-08-11 2005-01-16 Novozymes A/S Nuevas enzimas lipoliticas.
EP0954572A1 (fr) 1997-01-10 1999-11-10 Novo Nordisk A/S Enzyme couplee a des molecules polymeres pour les soins de la peau
JP2001511162A (ja) 1997-02-06 2001-08-07 ノボ ノルディスク アクティーゼルスカブ 付加され、そして／又は除去された付着基を有するポリペプチド−ポリマー結合体
CA2294567A1 (fr) 1997-06-25 1999-01-07 Novo Nordisk A/S Polypeptide modifie
AU3247699A (en) 1998-02-17 1999-09-06 Novo Nordisk A/S Lipase variant
ATE328070T1 (de) * 1998-02-17 2006-06-15 Novozymes As Lipasevariante
JP2002527059A (ja) 1998-10-13 2002-08-27 ノボザイムス アクティーゼルスカブ 低められた免疫応答を有する修飾されたポリペプチド
NZ511291A (en) 1998-10-30 2003-08-29 Novozymes As A method for selecting a protein variant that has reduced immunogenicity as compared with the parent or wild-type protein
DE69936351T2 (de) 1998-10-30 2008-02-21 Novozymes A/S Glykosylierte proteine mit reduzierter allergenität
US7312062B2 (en) * 1998-11-27 2007-12-25 Novozymes A/S Lipolytic enzyme variants
EP1131416B1 (fr) 1998-11-27 2009-09-02 Novozymes A/S Variants d'enzyme lipolytique
CZ20013345A3 (cs) * 1999-03-17 2002-01-16 Solvay Pharmaceuticals Gmbh Léčivo k léčení diabetu
AU3420100A (en) 1999-03-31 2000-10-23 Novozymes A/S Lipase variant
CA2366843A1 (fr) * 1999-03-31 2000-10-12 Jesper Vind Variante genetique de lipase
CA2395343C (fr) 2000-02-08 2009-06-30 F. Hoffmann-La Roche Ag Utilisation de proteases a acidite stable dans l'alimentation animale
AU2001254622A1 (en) * 2000-04-28 2001-11-12 Novozymes A/S Laccase mutants
AU2002219020B2 (en) 2001-01-10 2007-05-24 Novozymes A/S Thermostable lipolytic enzyme variant
AR032392A1 (es) 2001-01-19 2003-11-05 Solvay Pharm Gmbh Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado.
JP4287149B2 (ja) 2001-02-07 2009-07-01 ノボザイムス アクティーゼルスカブ リパーゼ変異体
US20050255544A1 (en) * 2002-01-16 2005-11-17 Novozymes A/S Lipolytic enzyme variants and method for their production
JP2007506405A (ja) 2003-02-06 2007-03-22 ノボザイムス アクティーゼルスカブ 糸状菌におけるヒトｈ鎖抗体の発現
DK2270140T3 (en) 2003-05-09 2016-03-14 Novozymes As Lipolytic enzyme variants
EP1639102A2 (fr) 2003-06-19 2006-03-29 Novozymes A/S Variantes genetiques de la phospholipase
EP1639107B1 (fr) 2003-06-19 2013-08-14 Novozymes A/S Proteases ameliorees et procedes de production de ces dernieres
EP1711529A1 (fr) 2004-01-21 2006-10-18 Novozymes A/S Production d'un anticorps monoclonal dans un champignon heterocaryon ou dans une cellule hote fongique
ES2314646T3 (es) 2004-03-22 2009-03-16 Solvay Pharmaceuticals Gmbh Composiciones farmaceuticas por via de productos que contienen lipasa , en particular de pancreatina, que contienen tensioactivos.
EP1809320B1 (fr) 2004-10-14 2010-07-21 Altus Pharmaceuticals Inc. Compositions contenant de la lipase, de la protease et de l'amylase pour le traitement de l'insuffisance pancreatique
US20080138856A1 (en) 2005-02-10 2008-06-12 Novozymes A/S Enzymatic Enantioselective Ester or Amide Hydrolysis or Synthesis
AU2006261442A1 (en) * 2005-06-24 2006-12-28 Novozymes A/S Lipases for pharmaceutical use
BRPI0611932A2 (pt) 2005-06-24 2011-01-04 Novozymes As amilase, uso da mesma, composição farmacêutica, e, método para o tratamento de uma doença
CA2612806A1 (fr) 2005-06-24 2006-12-28 Solvay Pharmaceuticals Gmbh Proteases a usage pharmaceutique
WO2007080197A2 (fr) * 2006-01-16 2007-07-19 Novozymes A/S Enzymes immobilisees
EP1979456A2 (fr) 2006-01-23 2008-10-15 The Procter & Gamble Company Composition comprenant une lipase et un catalyseur de blanchiment
EP1979477B1 (fr) * 2006-01-23 2017-04-19 Novozymes A/S Variantes de lipase
CN105112386A (zh) * 2006-12-21 2015-12-02 诺维信公司 用于药物用途的脂肪酶变体

Also Published As

Publication number Publication date
EP2455462A2 (fr) 2012-05-23
CA3081308C (fr) 2024-02-20
EP2455459A3 (fr) 2013-04-24
EP2261328B1 (fr) 2013-11-20
EP2455460A2 (fr) 2012-05-23
CA3081308A1 (fr) 2008-07-03
CN101743308B (zh) 2015-09-16
EP2455459A2 (fr) 2012-05-23
US8273348B2 (en) 2012-09-25
AR064494A1 (es) 2009-04-08
EP2261328A1 (fr) 2010-12-15
EP2455462B1 (fr) 2016-03-16
CA2961041C (fr) 2020-07-14
US20150209414A1 (en) 2015-07-30
CN101743308A (zh) 2010-06-16
CA2670643C (fr) 2017-04-25
US20120308543A1 (en) 2012-12-06
EP2455461A2 (fr) 2012-05-23
ZA200903598B (en) 2010-04-28
EP2455461A3 (fr) 2013-05-29
CN105112386A (zh) 2015-12-02
JP2010512795A (ja) 2010-04-30
EP2455461B1 (fr) 2016-03-16
AU2007337150A1 (en) 2008-07-03
TW200829698A (en) 2008-07-16
BRPI0721103A2 (pt) 2014-03-04
KR20090101930A (ko) 2009-09-29
WO2008079685A2 (fr) 2008-07-03
EP2455462A3 (fr) 2013-05-29
US20100034797A1 (en) 2010-02-11
CA2670643A1 (fr) 2008-07-03
JP5406040B2 (ja) 2014-02-05
IL198893A0 (en) 2010-02-17
MX2009006597A (es) 2009-07-02
EP2455459B1 (fr) 2016-03-16
US9539311B2 (en) 2017-01-10
EP2455460A3 (fr) 2012-12-26
WO2008079685A3 (fr) 2008-11-06
US9029115B2 (en) 2015-05-12
EP2099907A2 (fr) 2009-09-16
RU2009128067A (ru) 2011-01-27
CA2961041A1 (fr) 2008-07-03

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