NO20092729L - Lipasevarianter for farmasoytisk anvendelse - Google Patents
Lipasevarianter for farmasoytisk anvendelseInfo
- Publication number
- NO20092729L NO20092729L NO20092729A NO20092729A NO20092729L NO 20092729 L NO20092729 L NO 20092729L NO 20092729 A NO20092729 A NO 20092729A NO 20092729 A NO20092729 A NO 20092729A NO 20092729 L NO20092729 L NO 20092729L
- Authority
- NO
- Norway
- Prior art keywords
- lipases
- digestive
- improved
- pharmaceutical use
- diabetes
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Nutrition Science (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Detergent Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Sammendrag Den farmasøytiske anvendelsen av lipaser som er beslektet med lipasen fra Thermomyces lanuginosus (Humicola lanuginosa) som omfatter aminosyrene 1-269 ifølge SEQ ID NO:2, alternativt i kombinasjon med en protease og/eller en amylase. Eksempler på medisinske indikasjoner er: behandling av fordøyelsesforstyrrelser, pankreatisk eksokrin mangel (PEI), pankreaitt, cystisk fibrose, diabetes type I og/eller diabetes type II. Lipasene ifølge oppfinnelsen har for eksempel en forbedret fordøyelseseffektivitet in vitro, en forbedret aktivitet ved en pH i det nøytrale området, en forbedret stabilitet ved lav pH, og er stabile mot proteasedegradering og/eller er stabile i nærvær av pepsin eller gallesalter. Oppfinnelsen vedrører også fremgangsmåter for bestemmelse av fordøyelsesaktivitet in vitro av lipaser, så vel som visse nye varianter av lipasen fra T. lanuginosus.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87119606P | 2006-12-21 | 2006-12-21 | |
PCT/US2007/087168 WO2008079685A2 (en) | 2006-12-21 | 2007-12-12 | Lipase variants for pharmaceutical use |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20092729L true NO20092729L (no) | 2009-09-18 |
Family
ID=38043020
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20092729A NO20092729L (no) | 2006-12-21 | 2009-07-20 | Lipasevarianter for farmasoytisk anvendelse |
Country Status (16)
Country | Link |
---|---|
US (3) | US8273348B2 (no) |
EP (6) | EP2455462B1 (no) |
JP (1) | JP5406040B2 (no) |
KR (1) | KR20090101930A (no) |
CN (2) | CN105112386A (no) |
AR (1) | AR064494A1 (no) |
AU (1) | AU2007337150A1 (no) |
BR (1) | BRPI0721103A2 (no) |
CA (3) | CA2961041C (no) |
IL (1) | IL198893A0 (no) |
MX (1) | MX2009006597A (no) |
NO (1) | NO20092729L (no) |
RU (1) | RU2009128067A (no) |
TW (1) | TW200829698A (no) |
WO (1) | WO2008079685A2 (no) |
ZA (1) | ZA200903598B (no) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2314646T3 (es) | 2004-03-22 | 2009-03-16 | Solvay Pharmaceuticals Gmbh | Composiciones farmaceuticas por via de productos que contienen lipasa , en particular de pancreatina, que contienen tensioactivos. |
RU2413532C2 (ru) | 2005-07-29 | 2011-03-10 | Зольвай Фармасьютиклз Гмбх | Способ получения стерилизованного порошкообразного панкреатина |
US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
CN105112386A (zh) | 2006-12-21 | 2015-12-02 | 诺维信公司 | 用于药物用途的脂肪酶变体 |
MX2010009457A (es) * | 2008-02-29 | 2010-09-24 | Procter & Gamble | Composicion detergente que comprende lipasa. |
CN102016015B (zh) | 2008-02-29 | 2014-09-03 | 帝斯曼知识产权资产管理有限公司 | 对短链脂肪酸具有高度特异性的脂肪酶及其用途 |
JP2011514805A (ja) * | 2008-02-29 | 2011-05-12 | ノボザイムス アクティーゼルスカブ | 向上した安定性を有する脂肪分解酵素変異体、及びこれをコードするポリヌクレオチド |
DK2734633T3 (da) | 2011-07-22 | 2019-06-11 | Novozymes North America Inc | Fremgangsmåder til forbehandling af celluloseholdigt materiale og forbedring af hydrolyse deraf |
US8268305B1 (en) | 2011-09-23 | 2012-09-18 | Bio-Cat, Inc. | Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase |
EP2798053B1 (en) | 2011-12-29 | 2018-05-16 | Novozymes A/S | Detergent compositions with lipase variants |
ES2794644T3 (es) * | 2012-02-03 | 2020-11-18 | Novozymes As | Variantes de lipasa y polinucleótidos que las codifican |
US9909109B2 (en) | 2012-04-02 | 2018-03-06 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
WO2014059360A1 (en) * | 2012-10-12 | 2014-04-17 | Danisco Us Inc. | Compositions and methods comprising a lipolytic enzyme variant |
MY192746A (en) * | 2013-05-14 | 2022-09-06 | Novozymes As | Detergent compositions |
MX371497B (es) * | 2013-07-19 | 2020-01-31 | Danisco Us Inc | Composiciones y metodos que comprenden una variante de enzima lipolitica. |
US10287562B2 (en) * | 2014-11-20 | 2019-05-14 | Novoszymes A/S | Alicyclobacillus variants and polynucleotides encoding same |
EP4067485A3 (en) * | 2014-12-05 | 2023-01-04 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
US11268076B2 (en) | 2014-12-09 | 2022-03-08 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
CN107864658A (zh) | 2015-04-07 | 2018-03-30 | 诺维信公司 | 用于选择具有脂肪酶活性的酶的方法 |
WO2017005640A1 (en) * | 2015-07-03 | 2017-01-12 | Novozymes A/S | Detergent compositions with improved stability in the presence of sulfites |
US11028131B2 (en) * | 2017-01-30 | 2021-06-08 | Nippon Medical School Foundation | Mutant of adeno-associated virus (AAV) capsid protein |
US11286443B2 (en) * | 2017-09-27 | 2022-03-29 | The Procter & Gamble Company | Detergent compositions comprising lipases |
CA3073362A1 (en) * | 2017-09-27 | 2019-04-04 | Novozymes A/S | Lipase variants and microcapsule compositions comprising such lipase variants |
EP3749760A1 (en) * | 2018-02-08 | 2020-12-16 | Novozymes A/S | Lipase variants and compositions thereof |
CN111334369B (zh) * | 2020-03-11 | 2022-10-21 | 陕西科技大学 | 一种酶法制备卵磷脂型pufa的方法 |
EP4237552A2 (en) * | 2020-10-29 | 2023-09-06 | Novozymes A/S | Lipase variants and compositions comprising such lipase variants |
CN113846074B (zh) * | 2021-10-20 | 2022-10-21 | 南京林业大学 | 一种疏棉状嗜热丝孢菌脂肪酶突变体g91c及其应用 |
WO2023225459A2 (en) | 2022-05-14 | 2023-11-23 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK173590D0 (da) * | 1990-06-06 | 1990-07-19 | Novo Nordisk As | Rekombinante terapeutiske lipaser |
US5869438A (en) | 1990-09-13 | 1999-02-09 | Novo Nordisk A/S | Lipase variants |
DE69129988T2 (de) * | 1990-09-13 | 1999-03-18 | Novo Nordisk As | Lipase-varianten |
DK46693D0 (no) * | 1993-04-23 | 1993-04-23 | Novo Nordisk As | |
DE69130113T2 (de) | 1990-12-05 | 1999-05-12 | Novo Nordisk As | Proteine mit geänderten epitopen und verfahren zur deren herstellung |
US5914306A (en) | 1991-05-01 | 1999-06-22 | Novo Nordisk A/S | Stabilized enzymes |
DK39693D0 (da) | 1993-04-02 | 1993-04-02 | Novo Nordisk As | Enzym |
AU7807394A (en) | 1993-10-04 | 1995-05-01 | Novo Nordisk A/S | An enzyme preparation comprising a modified enzyme |
AU1806795A (en) | 1994-02-22 | 1995-09-04 | Novo Nordisk A/S | A method of preparing a variant of a lipolytic enzyme |
AU3924095A (en) | 1994-11-24 | 1996-06-17 | Novo Nordisk A/S | A process for producing polypeptides with reduced allergenicity |
WO1996017929A1 (en) | 1994-12-07 | 1996-06-13 | Novo Nordisk A/S | Polypeptide with reduced allergenicity |
CN1165614C (zh) | 1995-01-26 | 2004-09-08 | 诺沃奇梅兹有限公司 | 含有木聚糖酶的动物饲料添加剂 |
JP4307549B2 (ja) | 1995-07-14 | 2009-08-05 | ノボザイムス アクティーゼルスカブ | 脂肪分解活性を有する修飾された酵素 |
US6495357B1 (en) | 1995-07-14 | 2002-12-17 | Novozyme A/S | Lipolytic enzymes |
ES2221934T3 (es) | 1995-08-11 | 2005-01-16 | Novozymes A/S | Nuevas enzimas lipoliticas. |
EP0954572A1 (en) | 1997-01-10 | 1999-11-10 | Novo Nordisk A/S | Enzyme coupled with polymeric molecules for skin care |
JP2001511162A (ja) | 1997-02-06 | 2001-08-07 | ノボ ノルディスク アクティーゼルスカブ | 付加され、そして/又は除去された付着基を有するポリペプチド−ポリマー結合体 |
CA2294567A1 (en) | 1997-06-25 | 1999-01-07 | Novo Nordisk A/S | A modified polypeptide |
AU3247699A (en) | 1998-02-17 | 1999-09-06 | Novo Nordisk A/S | Lipase variant |
ATE328070T1 (de) * | 1998-02-17 | 2006-06-15 | Novozymes As | Lipasevariante |
JP2002527059A (ja) | 1998-10-13 | 2002-08-27 | ノボザイムス アクティーゼルスカブ | 低められた免疫応答を有する修飾されたポリペプチド |
NZ511291A (en) | 1998-10-30 | 2003-08-29 | Novozymes As | A method for selecting a protein variant that has reduced immunogenicity as compared with the parent or wild-type protein |
DE69936351T2 (de) | 1998-10-30 | 2008-02-21 | Novozymes A/S | Glykosylierte proteine mit reduzierter allergenität |
US7312062B2 (en) * | 1998-11-27 | 2007-12-25 | Novozymes A/S | Lipolytic enzyme variants |
EP1131416B1 (en) | 1998-11-27 | 2009-09-02 | Novozymes A/S | Lipolytic enzyme variants |
CZ20013345A3 (cs) * | 1999-03-17 | 2002-01-16 | Solvay Pharmaceuticals Gmbh | Léčivo k léčení diabetu |
AU3420100A (en) | 1999-03-31 | 2000-10-23 | Novozymes A/S | Lipase variant |
CA2366843A1 (en) * | 1999-03-31 | 2000-10-12 | Jesper Vind | Lipase variant |
CA2395343C (en) | 2000-02-08 | 2009-06-30 | F. Hoffmann-La Roche Ag | Use of acid-stable proteases in animal feed |
AU2001254622A1 (en) * | 2000-04-28 | 2001-11-12 | Novozymes A/S | Laccase mutants |
AU2002219020B2 (en) | 2001-01-10 | 2007-05-24 | Novozymes A/S | Thermostable lipolytic enzyme variant |
AR032392A1 (es) | 2001-01-19 | 2003-11-05 | Solvay Pharm Gmbh | Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado. |
JP4287149B2 (ja) | 2001-02-07 | 2009-07-01 | ノボザイムス アクティーゼルスカブ | リパーゼ変異体 |
US20050255544A1 (en) * | 2002-01-16 | 2005-11-17 | Novozymes A/S | Lipolytic enzyme variants and method for their production |
JP2007506405A (ja) | 2003-02-06 | 2007-03-22 | ノボザイムス アクティーゼルスカブ | 糸状菌におけるヒトh鎖抗体の発現 |
DK2270140T3 (en) | 2003-05-09 | 2016-03-14 | Novozymes As | Lipolytic enzyme variants |
EP1639102A2 (en) | 2003-06-19 | 2006-03-29 | Novozymes A/S | Phospholipase variants |
EP1639107B1 (en) | 2003-06-19 | 2013-08-14 | Novozymes A/S | Improved proteases and methods for producing them |
EP1711529A1 (en) | 2004-01-21 | 2006-10-18 | Novozymes A/S | Production of a monoclonal antibody in a heterokaryon fungus or in a fungal host cell |
ES2314646T3 (es) | 2004-03-22 | 2009-03-16 | Solvay Pharmaceuticals Gmbh | Composiciones farmaceuticas por via de productos que contienen lipasa , en particular de pancreatina, que contienen tensioactivos. |
EP1809320B1 (en) | 2004-10-14 | 2010-07-21 | Altus Pharmaceuticals Inc. | Compositions containing lipase; protease and amylase for treating pancreatic insufficiency |
US20080138856A1 (en) | 2005-02-10 | 2008-06-12 | Novozymes A/S | Enzymatic Enantioselective Ester or Amide Hydrolysis or Synthesis |
AU2006261442A1 (en) * | 2005-06-24 | 2006-12-28 | Novozymes A/S | Lipases for pharmaceutical use |
BRPI0611932A2 (pt) | 2005-06-24 | 2011-01-04 | Novozymes As | amilase, uso da mesma, composição farmacêutica, e, método para o tratamento de uma doença |
CA2612806A1 (en) | 2005-06-24 | 2006-12-28 | Solvay Pharmaceuticals Gmbh | Proteases for pharmaceutical use |
WO2007080197A2 (en) * | 2006-01-16 | 2007-07-19 | Novozymes A/S | Immobilised enzymes |
EP1979456A2 (en) | 2006-01-23 | 2008-10-15 | The Procter & Gamble Company | A composition comprising a lipase and a bleach catalyst |
EP1979477B1 (en) * | 2006-01-23 | 2017-04-19 | Novozymes A/S | Lipase variants |
CN105112386A (zh) * | 2006-12-21 | 2015-12-02 | 诺维信公司 | 用于药物用途的脂肪酶变体 |
-
2007
- 2007-12-12 CN CN201510504893.8A patent/CN105112386A/zh active Pending
- 2007-12-12 EP EP12155319.2A patent/EP2455462B1/en active Active
- 2007-12-12 CA CA2961041A patent/CA2961041C/en active Active
- 2007-12-12 CA CA3081308A patent/CA3081308C/en active Active
- 2007-12-12 EP EP12155315A patent/EP2455460A3/en not_active Withdrawn
- 2007-12-12 EP EP07869130A patent/EP2099907A2/en not_active Withdrawn
- 2007-12-12 EP EP10172609.9A patent/EP2261328B1/en active Active
- 2007-12-12 WO PCT/US2007/087168 patent/WO2008079685A2/en active Application Filing
- 2007-12-12 MX MX2009006597A patent/MX2009006597A/es not_active Application Discontinuation
- 2007-12-12 RU RU2009128067/10A patent/RU2009128067A/ru not_active Application Discontinuation
- 2007-12-12 CA CA2670643A patent/CA2670643C/en active Active
- 2007-12-12 JP JP2009543078A patent/JP5406040B2/ja active Active
- 2007-12-12 KR KR1020097014850A patent/KR20090101930A/ko not_active Application Discontinuation
- 2007-12-12 EP EP12155294.7A patent/EP2455459B1/en active Active
- 2007-12-12 CN CN200780051638.6A patent/CN101743308B/zh active Active
- 2007-12-12 US US12/519,868 patent/US8273348B2/en active Active
- 2007-12-12 EP EP12155317.6A patent/EP2455461B1/en active Active
- 2007-12-12 AU AU2007337150A patent/AU2007337150A1/en not_active Abandoned
- 2007-12-12 BR BRPI0721103-1A patent/BRPI0721103A2/pt not_active IP Right Cessation
- 2007-12-18 TW TW096148377A patent/TW200829698A/zh unknown
- 2007-12-21 AR ARP070105859A patent/AR064494A1/es not_active Application Discontinuation
-
2009
- 2009-05-21 IL IL198893A patent/IL198893A0/en unknown
- 2009-05-25 ZA ZA200903598A patent/ZA200903598B/xx unknown
- 2009-07-20 NO NO20092729A patent/NO20092729L/no not_active Application Discontinuation
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2012
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2015
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