NO20091766L - Spiro-piperidinderivater - Google Patents

Spiro-piperidinderivater

Info

Publication number
NO20091766L
NO20091766L NO20091766A NO20091766A NO20091766L NO 20091766 L NO20091766 L NO 20091766L NO 20091766 A NO20091766 A NO 20091766A NO 20091766 A NO20091766 A NO 20091766A NO 20091766 L NO20091766 L NO 20091766L
Authority
NO
Norway
Prior art keywords
present
spiro
piperidine
compounds
anxiety
Prior art date
Application number
NO20091766A
Other languages
English (en)
Inventor
Patrick Schnider
Hasane Ratni
Caterina Bissantz
Christophe Grundschober
Mark Rogers-Evans
Rafaello Masciadri
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20091766L publication Critical patent/NO20091766L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Foreliggende oppfinnelse angår nye indol-2-yl-karbonyl-spiro-piperidin-derivater som V1a-reseptorantagonister, fremstilling av dem, farmasøytiske preparater inneholdende dem og anvendelse av dem som medikamenter. De aktive forbindelser ifølge foreliggende oppfinnelse er anvendelige for forebygging og/eller behandling av angst og depressive lidelser og andre sykdommer. Forbindelsene ifølge foreliggende oppfinnelse har den generelle formel (I) hvor R1 til R11 og X er som definert i beskrivelsen.
NO20091766A 2006-12-07 2009-05-05 Spiro-piperidinderivater NO20091766L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125645 2006-12-07
PCT/EP2007/062857 WO2008068159A1 (en) 2006-12-07 2007-11-27 Spiro-piperidine derivatives

Publications (1)

Publication Number Publication Date
NO20091766L true NO20091766L (no) 2009-07-06

Family

ID=39201604

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20091766A NO20091766L (no) 2006-12-07 2009-05-05 Spiro-piperidinderivater

Country Status (21)

Country Link
US (2) US7432259B2 (no)
EP (1) EP2099799B1 (no)
JP (1) JP2010511654A (no)
KR (1) KR101111022B1 (no)
CN (1) CN101541797A (no)
AR (1) AR064136A1 (no)
AT (1) ATE469899T1 (no)
AU (1) AU2007329066B2 (no)
BR (1) BRPI0720246A2 (no)
CA (1) CA2670671A1 (no)
CL (1) CL2007003483A1 (no)
DE (1) DE602007006989D1 (no)
ES (1) ES2343286T3 (no)
IL (1) IL198549A0 (no)
MX (1) MX2009005507A (no)
NO (1) NO20091766L (no)
PE (1) PE20081489A1 (no)
RU (1) RU2009119393A (no)
TW (1) TW200843758A (no)
WO (1) WO2008068159A1 (no)
ZA (1) ZA200903175B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2418801C2 (ru) * 2005-09-28 2011-05-20 Ф. Хоффманн-Ля Рош Аг Индол-3-ил-карбонил-азаспиропроизводные в качестве антагонистов рецептора вазопрессина
JP5399518B2 (ja) * 2009-01-30 2014-01-29 エフ．ホフマン−ラ ロシュ アーゲー Ｎｋ３レセプターアンタゴニストとしてのピペリジン誘導体
US8324250B2 (en) * 2009-03-19 2012-12-04 Hoffmann-La Roche Inc. Piperidine derivatives as NK3 receptor antagonists
RS56791B1 (sr) * 2013-12-19 2018-04-30 Hoffmann La Roche Spiro-oksazoloni
ES2951874T3 (es) * 2017-09-05 2023-10-25 Neumora Therapeutics Inc Antagonistas del receptor de vasopresina y productos y métodos relacionados con los mismos
WO2020048828A1 (en) 2018-09-03 2020-03-12 Bayer Pharma Aktiengesellschaft 5-heteroaryl-3,9-diazaspiro[5.5]undecane compounds
WO2020048826A1 (en) 2018-09-03 2020-03-12 Bayer Aktiengesellschaft 5-substituted 1-oxa-3,9-diazaspiro[5.5]undecan-2-one compounds
WO2020048830A1 (en) 2018-09-03 2020-03-12 Bayer Aktiengesellschaft 5-aryl-3,9-diazaspiro[5.5]undecan-2-one compounds
TW202024083A (zh) 2018-09-03 2020-07-01 德商拜耳廠股份有限公司 3,9-二氮雜螺[5.5]十一烷化合物
WO2020048831A1 (en) 2018-09-03 2020-03-12 Bayer Aktiengesellschaft 5-aryl-3,9-diazaspiro[5.5]undecan-2-one compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO5150201A1 (es) 1998-09-07 2002-04-29 Hoffmann La Roche Derivados de piperidina
ATE255578T1 (de) 2000-05-12 2003-12-15 Solvay Pharm Bv Piperazin- und piperidinverbindungen
MXPA05003948A (es) 2002-10-17 2005-06-17 Amgen Inc Derivados de bencimidazol y su uso como ligandos de receptor vaniloide.
EP1701959A1 (en) * 2003-12-22 2006-09-20 Pfizer Limited Triazole derivatives as vasopressin antagonists
US7351706B2 (en) * 2006-01-05 2008-04-01 Hoffmann-La Roche Inc. Indol-3-yl-carbonyl-spiro-piperidine derivatives

Also Published As

Publication number Publication date
RU2009119393A (ru) 2011-01-20
PE20081489A1 (es) 2008-10-30
CL2007003483A1 (es) 2008-07-04
EP2099799A1 (en) 2009-09-16
ATE469899T1 (de) 2010-06-15
AR064136A1 (es) 2009-03-18
JP2010511654A (ja) 2010-04-15
AU2007329066B2 (en) 2012-04-12
CN101541797A (zh) 2009-09-23
US7432259B2 (en) 2008-10-07
US8022213B2 (en) 2011-09-20
WO2008068159A1 (en) 2008-06-12
AU2007329066A1 (en) 2008-06-12
IL198549A0 (en) 2010-02-17
BRPI0720246A2 (pt) 2013-12-31
EP2099799B1 (en) 2010-06-02
KR101111022B1 (ko) 2012-03-14
US20080161298A1 (en) 2008-07-03
MX2009005507A (es) 2009-06-03
ZA200903175B (en) 2010-03-31
TW200843758A (en) 2008-11-16
ES2343286T3 (es) 2010-07-27
KR20090080112A (ko) 2009-07-23
US20080161299A1 (en) 2008-07-03
DE602007006989D1 (en) 2010-07-15
CA2670671A1 (en) 2008-06-12

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