MX2009007411A - Derivados de espiropiperidina-glicinamida. - Google Patents

Derivados de espiropiperidina-glicinamida.

Info

Publication number
MX2009007411A
MX2009007411A MX2009007411A MX2009007411A MX2009007411A MX 2009007411 A MX2009007411 A MX 2009007411A MX 2009007411 A MX2009007411 A MX 2009007411A MX 2009007411 A MX2009007411 A MX 2009007411A MX 2009007411 A MX2009007411 A MX 2009007411A
Authority
MX
Mexico
Prior art keywords
present
glycinamide derivatives
concerned
spiropiperidine
spiropiperidine glycinamide
Prior art date
Application number
MX2009007411A
Other languages
English (en)
Inventor
Mark Rogers-Evans
Raffaello Masciadri
Patrick Schnider
Erwin Goetschi
Hasane Ratni
Caterina Bissantz
Christophe Grundschober
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009007411A publication Critical patent/MX2009007411A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invención se refiere a nuevos derivados de espiropiperidina-glicinamida como antagonistas del receptor de la V1a, con su obtención, con composiciones farmacéuticas que los contienen y con su utilización como medicamentos. Los compuestos activos de la presente invención son útiles para la prevención y/o tratamiento de la ansiedad, trastornos depresivos y otras enfermedades. En particular, la presente invención se refiere a compuestos de la fórmula general (I) (ver fórmula (I)) en donde X, Y, y R1 a R10 tienen los significados definidos en la presente.
MX2009007411A 2007-01-12 2008-01-03 Derivados de espiropiperidina-glicinamida. MX2009007411A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07100486 2007-01-12
PCT/EP2008/050028 WO2008084005A1 (en) 2007-01-12 2008-01-03 Spiropiperidine glycinamide derivatives

Publications (1)

Publication Number Publication Date
MX2009007411A true MX2009007411A (es) 2009-07-17

Family

ID=39201768

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009007411A MX2009007411A (es) 2007-01-12 2008-01-03 Derivados de espiropiperidina-glicinamida.

Country Status (17)

Country Link
US (3) US7498339B2 (es)
EP (1) EP2104677B1 (es)
JP (1) JP2010515700A (es)
KR (1) KR101129791B1 (es)
CN (1) CN101583615B (es)
AR (1) AR064831A1 (es)
AT (1) ATE536356T1 (es)
AU (1) AU2008204491B2 (es)
BR (1) BRPI0806538A2 (es)
CA (1) CA2674958A1 (es)
CL (1) CL2008000059A1 (es)
ES (1) ES2376378T3 (es)
IL (1) IL199583A0 (es)
MX (1) MX2009007411A (es)
PE (1) PE20081851A1 (es)
TW (1) TW200836728A (es)
WO (1) WO2008084005A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101547923A (zh) * 2006-12-07 2009-09-30 弗·哈夫曼-拉罗切有限公司 作为via受体拮抗剂的螺环-哌啶衍生物
US20080153863A1 (en) * 2006-12-22 2008-06-26 Caterina Bissantz Spiropiperidine derivatives
KR101129791B1 (ko) * 2007-01-12 2012-03-23 에프. 호프만-라 로슈 아게 스파이로피페리딘 글리신아마이드 유도체
JP5567027B2 (ja) 2008-11-13 2014-08-06 エフ．ホフマン−ラ ロシュ アーゲー スピロ−５，６−ジヒドロ−４Ｈ−２，３，５，１０ｂ−テトラアザ−ベンゾ［ｅ］アズレン
PL2358714T3 (pl) 2008-11-18 2012-12-31 Hoffmann La Roche Etery alkilocykloheksylowe dihydrotetraazabenzoazulenu
NZ592076A (en) 2008-11-28 2012-06-29 Hoffmann La Roche Arylcyclohexylethers of dihydrotetraazabenzoazulenes for use as vasopressin via receptor antagonists
US8420633B2 (en) 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en) 2010-04-13 2013-06-11 Hoffmann-La Roche Inc. Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en) 2010-04-21 2013-07-23 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8481528B2 (en) 2010-04-26 2013-07-09 Hoffmann-La Roche Inc. Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8513238B2 (en) 2010-05-10 2013-08-20 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes
MX370663B (es) * 2013-12-19 2019-12-19 Hoffmann La Roche Espiro-oxazolonas.
TW201600522A (zh) 2014-02-20 2016-01-01 赫孚孟拉羅股份公司 螺－唑酮
WO2016075181A1 (en) * 2014-11-14 2016-05-19 F. Hoffmann-La Roche Ag Spiro-thiazolones

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3370091A (en) * 1964-06-15 1968-02-20 Hoffmann La Roche 2 aminobenzhydrylhalides
US3531467A (en) * 1966-12-23 1970-09-29 Hoffmann La Roche Process for the preparation of 2,3,4,5-tetrahydro - 5 - aryl - 1h - 1,4 - benzodiazepine derivatives
DK78692D0 (da) 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
IT1271026B (it) 1994-10-21 1997-05-26 Isagro Ricerca Srl Derivati dell'acido b-amminopropionico ad attivita' fungicida
GB9601724D0 (en) * 1996-01-29 1996-03-27 Merck Sharp & Dohme Therapeutic agents
US20040152741A1 (en) 2002-09-09 2004-08-05 Nps Allelix Corporation Arylglycine derivatives and their use as glycine transport inhibitors
AU2003263155A1 (en) 2002-09-20 2004-04-08 H. Lundbeck A/S Method for manufacture of dihydroisobenzofuran derivatives
WO2004069809A1 (en) 2003-02-03 2004-08-19 Janssen Pharmaceutica N.V. Mercaptoimidazoles as ccr2 receptor antagonists
US7244852B2 (en) * 2003-02-27 2007-07-17 Abbott Laboratories Process for preparing 2-methylpyrrolidine and specific enantiomers thereof
CA2544602A1 (en) * 2003-11-04 2005-05-26 Elixir Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
CA2615726C (en) * 2005-07-14 2014-05-27 Caterina Bissantz Indol-3-yl-carbonyl-spiro-piperidine derivatives as v1a receptor antagonists
US8193208B2 (en) * 2005-09-09 2012-06-05 Purdue Pharma L.P. Fused and spirocycle compounds and the use thereof
KR101129791B1 (ko) * 2007-01-12 2012-03-23 에프. 호프만-라 로슈 아게 스파이로피페리딘 글리신아마이드 유도체

Also Published As

Publication number Publication date
KR20090097217A (ko) 2009-09-15
PE20081851A1 (es) 2009-01-09
JP2010515700A (ja) 2010-05-13
TW200836728A (en) 2008-09-16
EP2104677B1 (en) 2011-12-07
US20080194610A1 (en) 2008-08-14
ES2376378T3 (es) 2012-03-13
CN101583615A (zh) 2009-11-18
US20080171760A1 (en) 2008-07-17
WO2008084005A1 (en) 2008-07-17
AR064831A1 (es) 2009-04-29
EP2104677A1 (en) 2009-09-30
AU2008204491B2 (en) 2012-05-03
US20080171759A1 (en) 2008-07-17
IL199583A0 (en) 2010-03-28
CL2008000059A1 (es) 2008-07-18
US7498339B2 (en) 2009-03-03
CN101583615B (zh) 2012-07-04
KR101129791B1 (ko) 2012-03-23
BRPI0806538A2 (pt) 2014-04-22
AU2008204491A1 (en) 2008-07-17
CA2674958A1 (en) 2008-07-17
ATE536356T1 (de) 2011-12-15

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Legal Events

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HH Correction or change in general
FA Abandonment or withdrawal