NO20081970L - Sulfonamidderivat med PGD2-reseptorantagonistaktivitet - Google Patents

Sulfonamidderivat med PGD2-reseptorantagonistaktivitet

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Publication number
NO20081970L
NO20081970L NO20081970A NO20081970A NO20081970L NO 20081970 L NO20081970 L NO 20081970L NO 20081970 A NO20081970 A NO 20081970A NO 20081970 A NO20081970 A NO 20081970A NO 20081970 L NO20081970 L NO 20081970L
Authority
NO
Norway
Prior art keywords
ring
receptor antagonist
antagonist activity
sulfonamide derivatives
nitrogen
Prior art date
Application number
NO20081970A
Other languages
English (en)
Norwegian (no)
Inventor
Akira Kugimiya
Masahiko Fujioka
Yuki Tachibana
Takami Murashi
Naohiro Onodera
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of NO20081970L publication Critical patent/NO20081970L/no

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Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5114202B2 (ja) * 2005-09-27 2013-01-09 塩野義製薬株式会社 Pgd2受容体アンタゴニスト活性を有するスルホンアミド誘導体
WO2007134457A1 (fr) * 2006-05-22 2007-11-29 Merck Frosst Canada Ltd. Dérivés d'amines cycliques en tant qu'inhibiteurs de la stéaroyl-coenzyme a delta-9-désaturase
WO2008123349A1 (fr) * 2007-03-27 2008-10-16 Shionogi & Co., Ltd. Procédé de fabrication d'un dérivé de n-phényl-n'-phénylsulfonylpipérazine
MY148657A (en) 2007-04-27 2013-05-15 Purdue Pharma Lp Trpv1 antagonists and uses thereof
RU2491279C2 (ru) * 2007-09-25 2013-08-27 Актимис Фармасьютикалз, Инк. 2-s-бензилзамещенные пиримидины в качестве антагонистов crth2
RU2488591C2 (ru) 2007-09-26 2013-07-27 Маунт Синай Скул Оф Медсин Аналоги азацитидина и их применение
CN101952244B (zh) 2008-02-01 2014-11-05 潘米拉制药公司 ***素d2受体的n,n-二取代氨基烷基联苯拮抗剂
US8242145B2 (en) 2008-02-14 2012-08-14 Panmira Pharmaceuticals, Llc Cyclic diaryl ether compounds as antagonists of prostaglandin D2 receptors
US8497381B2 (en) 2008-02-25 2013-07-30 Panmira Pharmaceuticals, Llc Antagonists of prostaglandin D2 receptors
EP2268611A2 (fr) 2008-04-02 2011-01-05 Amira Pharmaceuticals, Inc. Antagonistes d aminoalkylphényle de récepteurs de prostaglandine d<sb>2</sb>
UA103319C2 (en) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
US8071807B2 (en) 2008-07-03 2011-12-06 Panmira Pharmaceuticals, Llc Antagonists of prostaglandin D2 receptors
WO2010009166A1 (fr) 2008-07-14 2010-01-21 Gilead Colorado, Inc. Composés inhibiteurs de l’oxindolyle
NZ602832A (en) 2008-07-14 2014-04-30 Gilead Sciences Inc Fused heterocyclic hdac inhibitor compounds
US8134000B2 (en) 2008-07-14 2012-03-13 Gilead Sciences, Inc. Imidazolyl pyrimidine inhibitor compounds
JP5394487B2 (ja) * 2008-07-15 2014-01-22 エフ.ホフマン−ラ ロシュ アーゲー アミノテトラヒドロインダゾロ酢酸
EP2307383B1 (fr) * 2008-07-15 2012-05-16 F. Hoffmann-La Roche AG Acides aminotétrahydroindazoloacétiques
WO2010014611A1 (fr) 2008-07-28 2010-02-04 Gilead Colorado, Inc. Composés inhibiteurs de cycloalkylidène et d'hétérocycloalkylidène d'histone désacétylase
GB2463788B (en) 2008-09-29 2010-12-15 Amira Pharmaceuticals Inc Heteroaryl antagonists of prostaglandin D2 receptors
US8378107B2 (en) 2008-10-01 2013-02-19 Panmira Pharmaceuticals, Llc Heteroaryl antagonists of prostaglandin D2 receptors
WO2010042652A2 (fr) 2008-10-08 2010-04-15 Amira Pharmaceuticals, Inc. Antagonistes hétéroalkyl biphényle des récepteurs de la prostaglandine d2
GB2465062B (en) 2008-11-06 2011-04-13 Amira Pharmaceuticals Inc Cycloalkane(B)azaindole antagonists of prostaglandin D2 receptors
EP2358677B1 (fr) 2008-11-17 2014-01-08 F. Hoffmann-La Roche AG Acides naphtylacétiques employés en tant qu'antagonistes ou agonistes partiels de crth2
CN102216249A (zh) 2008-11-17 2011-10-12 霍夫曼-拉罗奇有限公司 萘乙酸
WO2010057118A2 (fr) 2008-11-17 2010-05-20 Amira Pharmaceuticals, Inc. Antagonistes hétérocycliques des récepteurs de la prostaglandine d2
CA2740863A1 (fr) 2008-11-17 2010-05-20 F. Hoffmann-La Roche Ag Acides naphtylacetiques
US8673920B2 (en) 2009-05-06 2014-03-18 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
KR20120031170A (ko) 2009-06-08 2012-03-30 길리애드 사이언시즈, 인코포레이티드 알카노일아미노 벤즈아미드 아닐린 hdac 저해제 화합물
US8283357B2 (en) 2009-06-08 2012-10-09 Gilead Sciences, Inc. Cycloalkylcarbamate benzamide aniline HDAC inhibitor compounds
US8785393B2 (en) 2009-07-31 2014-07-22 Panmira Pharmaceuticals, Llc Ophthalmic pharmaceutical compositions of DP2 receptor antagonists
CN102596902A (zh) 2009-08-05 2012-07-18 潘米拉制药公司 Dp2拮抗剂及其用途
CN102812000A (zh) 2010-01-06 2012-12-05 潘米拉制药公司 Dp2拮抗剂及其用途
CA2805452C (fr) 2010-07-05 2018-07-31 Actelion Pharmaceuticals Ltd Derives d'heterocyclyle substitues par un 1-phenyle et leur utilisation en tant que modulateurs des recepteurs de la prostaglandine d2
US9073882B2 (en) 2010-10-27 2015-07-07 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2012058134A1 (fr) 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. Inhibiteurs du canal à potassium de la medulla externe du rein
JP5951625B2 (ja) 2010-11-24 2016-07-13 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨークThe Trustees Of Columbia University In The City Of New York 加齢性黄斑変性症およびシュタルガルト病の処置のための非レチノイドrbp4アンタゴニスト
MY185061A (en) 2011-06-22 2021-04-30 Shionogi & Co Trpv1 antagonists including dihydroxy substituent and uses thereof
AU2012284184B2 (en) * 2011-07-18 2017-03-09 Merck Patent Gmbh Benzamides
CA2844310A1 (fr) 2011-08-19 2013-02-28 Merck Sharp & Dohme Corp. Inhibiteurs du canal potassique medullaire externe renal
TW201317213A (zh) 2011-09-16 2013-05-01 Merck Sharp & Dohme 腎外髓質鉀通道抑制劑
US20140243351A1 (en) 2011-09-29 2014-08-28 Shionogi & Co., Ltd. Drug for the treatment of allergic rhinitis comprising pgd2 antagonist and histamine antagonist
US8999991B2 (en) 2011-10-25 2015-04-07 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2771005B1 (fr) 2011-10-25 2016-05-18 Merck Sharp & Dohme Corp. Inhibiteurs du canal potassique médullaire extérieur rénal
US9725442B2 (en) 2011-10-25 2017-08-08 Shionogi & Co., Ltd. Heterocyclic derivative having PGD2 receptor antagonist activity
EP2773199B1 (fr) 2011-10-31 2019-04-10 Merck Sharp & Dohme Corp. Inhibiteurs du canal potassique médullaire externe rénal
US9108947B2 (en) 2011-10-31 2015-08-18 Merck Sharp & Dohme Corp. Inhibitors of the Renal Outer Medullary Potassium channel
EP2773351B1 (fr) 2011-10-31 2017-08-23 Merck Sharp & Dohme Corp. Inhibiteurs du canal potassique médullaire externe rénal
US8470884B2 (en) 2011-11-09 2013-06-25 Hoffmann-La Roche Inc. Alkenyl naphthylacetic acids
US8691993B2 (en) * 2011-12-12 2014-04-08 Hoffmann-La Roche Inc. Piperidinyl naphthylacetic acids
EP2790511B1 (fr) 2011-12-16 2016-09-14 Merck Sharp & Dohme Corp. Inhibiteurs du canal à potassium de la medulla externe du rein
AU2012356076A1 (en) 2011-12-21 2014-08-14 Actelion Pharmaceuticals Ltd Heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators
ES2663972T3 (es) * 2012-01-10 2018-04-17 Merck Patent Gmbh Derivados de benzamida como moduladores de la hormona folículo estimulante
JPWO2013147118A1 (ja) * 2012-03-29 2015-12-14 塩野義製薬株式会社 N−フェニル−n’−フェニルスルホニルピペラジン誘導体およびその中間体の製造方法
US9333202B2 (en) 2012-05-01 2016-05-10 The Trustees Of Columbia University In The City Of New York Non-retinoid antagonists for treatment of age-related macular degeneration and stargardt disease
AU2013277154A1 (en) 2012-06-20 2014-12-18 Jonathan E. Grob Complement pathway modulators and uses thereof
JP6127135B2 (ja) 2012-07-05 2017-05-10 アクテリオン ファーマシューティカルズ リミテッドActelion Pharmaceuticals Ltd 1−フェニル置換ヘテロシクリル誘導体及びプロスタグランジンd2受容体調節剤としてのそれらの使用
AR092031A1 (es) 2012-07-26 2015-03-18 Merck Sharp & Dohme Inhibidores del canal de potasio medular externo renal
PT2925757T (pt) 2012-11-19 2018-01-09 Novartis Ag Compostos e composições para o tratamento de doenças parasitárias
WO2014085210A1 (fr) 2012-11-29 2014-06-05 Merck Sharp & Dohme Corp. Inhibiteurs du canal potassique médullaire extérieur rénal
WO2014099633A2 (fr) 2012-12-19 2014-06-26 Merck Sharp & Dohme Corp. Inhibiteurs du canal potassique médullaire externe rénal
EP2956142B1 (fr) 2013-02-18 2017-09-20 Merck Sharp & Dohme Corp. Inhibiteurs du canal potassique médullaire extérieur rénal
ES2705247T3 (es) 2013-03-14 2019-03-22 Univ Columbia 4-fenilpiperidinas, su preparación y uso
WO2014151959A1 (fr) 2013-03-14 2014-09-25 The Trustees Of Columbia University In The City Of New York N-alkyl-2-phénoxyéthanamines, leurs préparation et utilisation
US9944644B2 (en) 2013-03-14 2018-04-17 The Trustees Of Columbia University In The City Of New York Octahydropyrrolopyrroles their preparation and use
EP2968303B1 (fr) 2013-03-14 2018-07-04 The Trustees of Columbia University in the City of New York Octahydrocyclopentapyrroles, leur préparation et leur utilisation
US9765074B2 (en) 2013-03-15 2017-09-19 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2982670B1 (fr) 2013-04-04 2018-11-07 Takeda Pharmaceutical Company Limited Composé hétérocyclique
JP6304877B2 (ja) * 2013-04-22 2018-04-04 塩野義製薬株式会社 へテロ環誘導体を含有する、アレルギー性疾患の治療および/または予防用医薬組成物
EP3027625B1 (fr) 2013-07-31 2018-05-30 Merck Sharp & Dohme Corp. Derives spiro-fusionnes de piperidine utiles dans le traitement, entre autres, de l'hypertension et de l' insuffisance cardiaque aiguë ou chronique
BR112016025356B1 (pt) 2014-04-30 2023-04-18 The Trustees Of Columbia University In The City Of New York Compostos de 4-fenilpiperidinas substituídas, composições e seus usos
EP3140298A1 (fr) 2014-05-07 2017-03-15 Pfizer Inc. Inhibiteurs de kinases apparentées à la tropomyosine
TW201625253A (zh) * 2014-07-09 2016-07-16 Shionogi & Co 包含pgd2拮抗劑之伴隨過敏性疾病之症狀之治療用醫藥
SI3209655T1 (sl) 2014-10-24 2020-11-30 Landos Biopharma, Inc. Terapevtiki na osnovi C-podobne lantionin sintetaze 2
WO2016127358A1 (fr) 2015-02-12 2016-08-18 Merck Sharp & Dohme Corp. Inhibiteurs du canal potassique médullaire externe rénal
MX2022001915A (es) 2019-12-20 2022-03-17 Landos Biopharma Inc Ligandos de proteina 2 tipo lantionina c, celulas preparadas con los mismos y terapias que usan los mismos.
WO2022040604A1 (fr) 2020-08-21 2022-02-24 BioAge Labs, Inc. Utilisation d'antagonistes du récepteur dp1 pour le traitement d'infections virales des voies respiratoires et de la réponse immunitaire dérégulée chez des patients âgés et vieillissants
JP2024054429A (ja) * 2020-12-28 2024-04-17 塩野義製薬株式会社 Dp1アンタゴニストおよびノイラミニダーゼ阻害剤からなるウイルス性気道感染症治療用医薬
JP2024054430A (ja) * 2020-12-28 2024-04-17 塩野義製薬株式会社 Dp1アンタゴニストおよびキャップ依存性エンドヌクレアーゼ阻害剤からなるウイルス性気道感染症治療用医薬

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5777676A (en) 1980-10-31 1982-05-15 Otsuka Pharmaceut Co Ltd Carbostyril derivative
DE3139970A1 (de) 1981-10-08 1983-04-28 Boehringer Mannheim Gmbh, 6800 Mannheim Neue carbonsaeurederivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
JPH01117865A (ja) 1981-11-11 1989-05-10 Otsuka Pharmaceut Co Ltd カルボン酸誘導体
JPS5883678A (ja) 1981-11-11 1983-05-19 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体の製造法
JPS5883141A (ja) 1981-11-11 1983-05-18 Hitachi Ltd 空調機駆動装置
JPS5888314A (ja) 1981-11-20 1983-05-26 Otsuka Pharmaceut Co Ltd 強心剤
JPS6144817A (ja) 1984-08-08 1986-03-04 Otsuka Pharmaceut Co Ltd 強心剤
JPH0784462B2 (ja) 1986-07-25 1995-09-13 日清製粉株式会社 ベンゾイミダゾ−ル誘導体
JP2544939B2 (ja) * 1987-09-01 1996-10-16 大塚製薬株式会社 ベンゾヘテロ環誘導体
JPH03141258A (ja) 1989-10-25 1991-06-17 Kowa Co 新規なピペラジン誘導体
JPH03275679A (ja) * 1990-03-26 1991-12-06 Taisho Pharmaceut Co Ltd 2―置換アラルキルチアゾリジン誘導体
JPH03275678A (ja) * 1990-03-26 1991-12-06 Taisho Pharmaceut Co Ltd チアゾリジン誘導体
WO1993012086A1 (fr) 1991-12-11 1993-06-24 Ss Pharmaceutical Co., Ltd. Derive d'arylamide
JP3141258B2 (ja) 1992-08-11 2001-03-05 鐘淵化学工業株式会社 難燃性ポリエステル樹脂組成物
ES2156120T3 (es) * 1992-12-08 2001-06-16 Ss Pharmaceutical Co Derivados arilamidicos.
CA2114981A1 (fr) 1993-02-09 1994-08-10 Kazumi Ogata Derives de l'acide quinolonecarboxylique
JPH072784A (ja) * 1993-02-09 1995-01-06 Senju Pharmaceut Co Ltd キノロンカルボン酸誘導体
JPH07219168A (ja) 1994-02-02 1995-08-18 Konica Corp ハロゲン化銀カラー写真感光材料
US6696449B2 (en) * 1997-03-04 2004-02-24 Pharmacia Corporation Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors
PH11998001072B1 (en) 1997-05-07 2006-11-21 Univ Pittsburgh Inhibitors of protein isoprenyl transferases
JP3729374B2 (ja) 1997-07-31 2005-12-21 富士写真フイルム株式会社 脱泡方法
JP4676613B2 (ja) 1998-01-27 2011-04-27 アベンティス・ファーマスーティカルズ・インコーポレイテツド 置換オキソアザヘテロシクリルXa因子阻害剤
GB9805520D0 (en) 1998-03-17 1998-05-13 Zeneca Ltd Chemical compounds
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
CN1420882A (zh) 1999-07-28 2003-05-28 阿温蒂斯药物公司 取代的氧代氮杂杂环基化合物
EP1741428A3 (fr) 1999-08-13 2007-05-09 Biogen Idec MA, Inc. inhibiteurs d'adhésion cellulaire
US6518285B2 (en) 1999-12-21 2003-02-11 Ortho Mcneil Pharmaceutical, Inc. Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials
WO2001078697A2 (fr) 2000-04-12 2001-10-25 Merck Frosst Canada & Co. Procede et compositions destines au traitement d'etats allergiques faisant appel a des antagonistes du recepteur pgd2
US20010051624A1 (en) 2000-04-12 2001-12-13 Jones Thomas R. Method and compositions for the treatment of allergic conditions using PGD2 receptor antagonists
US6506901B2 (en) * 2000-07-17 2003-01-14 Wyeth Substituted 2-(S)-hydroxy-3-(piperidin-4-yl-methylamino)-propyl ethers and substituted 2-aryl-2-(R)-hydroxy-1-(piperidin-4-yl-methyl)-ethylamine β-3 adrenergic receptor agonists
US6498170B2 (en) * 2000-07-17 2002-12-24 Wyeth Cyclamine sulfonamides as β-3 adrenergic receptor agonists
AU2001288432A1 (en) 2000-09-01 2002-03-22 Icos Corporation Materials and methods to potentiate cancer treatment
ES2306859T3 (es) * 2002-03-13 2008-11-16 Janssen Pharmaceutica Nv Derivados de sulfonil como nuevos inhibidores de histona deacetilasa.
KR20040095302A (ko) * 2002-03-19 2004-11-12 오노 야꾸힝 고교 가부시키가이샤 카르복실산 화합물 및 그 화합물을 유효 성분으로서함유하는 약제
JP4484108B2 (ja) * 2002-05-16 2010-06-16 塩野義製薬株式会社 Pgd2受容体拮抗作用を有する化合物
ATE382043T1 (de) 2003-02-14 2008-01-15 Lilly Co Eli Sulfonamid-derivate als ppar-modulatoren
US20060258683A1 (en) * 2003-04-07 2006-11-16 Liu Kevin Para-sulfonyl substituted phenyl compounds as modulators of ppars
SE0301009D0 (sv) 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
SE0301010D0 (sv) 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
SE0301569D0 (sv) 2003-05-27 2003-05-27 Astrazeneca Ab Novel compounds
CN1860320A (zh) 2004-04-14 2006-11-08 贝克休斯公司 低压阀杆气密封件
EP1776357A1 (fr) 2004-08-09 2007-04-25 Astellas Pharma Inc. Composés d'hydroxyamide présentant une activité en tant qu'inhibiteurs d'histone désacétylase (hdac)
US8273740B2 (en) * 2004-08-26 2012-09-25 Actelion Pharmaceuticals, Ltd. 2-sulfanyl-benzoimidazol-1-yi-acetic acid derivatives as CRTH2 antagonists
SI1817282T1 (sl) * 2004-11-23 2011-10-28 Astrazeneca Ab Derivati fenoksiocetne kisline, uporabni za zdravljenje respiratornih bolezni
CN102127023B (zh) * 2004-12-02 2013-02-06 第一三共株式会社 7-元环化合物及其制备方法和用途
WO2006095822A1 (fr) 2005-03-11 2006-09-14 Ono Pharmaceutical Co., Ltd. Compose sulfonamide et produit pharmaceutique le contenant
JP5140577B2 (ja) 2005-03-31 2013-02-06 タケダ カリフォルニア インコーポレイテッド ヒドロキシステロイドデヒドロゲナーゼ阻害剤
US20060276464A1 (en) * 2005-05-13 2006-12-07 Wyeth Diarylsulfone sulfonamides and use thereof
JP5114202B2 (ja) * 2005-09-27 2013-01-09 塩野義製薬株式会社 Pgd2受容体アンタゴニスト活性を有するスルホンアミド誘導体
JP4982297B2 (ja) 2007-08-27 2012-07-25 シャープ株式会社 特定小電力無線テレメータシステム
JP2009055295A (ja) 2007-08-27 2009-03-12 Nikon Corp 撮像装置

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US8993763B2 (en) 2015-03-31
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