NO20076052L - Nye oksabispidinforbindelser for behandling av forstyrrelser i hjerterytmen - Google Patents
Nye oksabispidinforbindelser for behandling av forstyrrelser i hjerterytmenInfo
- Publication number
- NO20076052L NO20076052L NO20076052A NO20076052A NO20076052L NO 20076052 L NO20076052 L NO 20076052L NO 20076052 A NO20076052 A NO 20076052A NO 20076052 A NO20076052 A NO 20076052A NO 20076052 L NO20076052 L NO 20076052L
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- treatment
- oxabispidin
- new
- cardiac arrhythmias
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Det tilveiebringes forbindelser med formel I, hvor R1, R2, R3, R41 til R46, X, Y og Z har betydningene som er angitt i beskrivelsen, som er anvendelige ved forebygging og behandling av arytmier, spesielt atriale og ventrikulære arytmier.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/SE2005/000891 WO2005123748A1 (en) | 2004-06-15 | 2005-06-13 | Novel oxabispidine compounds and their use in the treatment of cardiac arrhythmias |
SE0502775 | 2005-12-15 | ||
PCT/SE2006/000688 WO2006135316A1 (en) | 2005-06-13 | 2006-06-12 | New oxabispidine compounds for the treatment of cardiac arrhythmias |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20076052L true NO20076052L (no) | 2008-03-11 |
Family
ID=37532579
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20076052A NO20076052L (no) | 2005-06-13 | 2007-11-26 | Nye oksabispidinforbindelser for behandling av forstyrrelser i hjerterytmen |
Country Status (12)
Country | Link |
---|---|
US (1) | US7928225B2 (no) |
EP (1) | EP1893619A1 (no) |
JP (1) | JP2008543750A (no) |
KR (1) | KR20080021114A (no) |
CN (1) | CN101243093A (no) |
AR (1) | AR057064A1 (no) |
AU (1) | AU2006258293B2 (no) |
CA (1) | CA2609938A1 (no) |
EC (1) | ECSP078025A (no) |
MX (1) | MX2007015800A (no) |
NO (1) | NO20076052L (no) |
WO (1) | WO2006135316A1 (no) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2538254T3 (es) | 2006-04-18 | 2015-06-18 | Emisphere Technologies, Inc. | Agentes de administración de dialquil éter |
TW200940110A (en) * | 2008-02-22 | 2009-10-01 | Astrazeneca Ab | Pharmaceutical formulation comprising oxabispidines |
TW201004963A (en) * | 2008-07-03 | 2010-02-01 | Targacept Inc | Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands |
WO2010059119A1 (en) * | 2008-11-21 | 2010-05-27 | Astrazeneca Ab | A combination of tert -butyl (2-{7- [2- (4-cyano-2- f luorophenoxy) ethyl] -9-oxa-3, 7-diazabicyclo [3.3.1] non-3- yl } ethyl) carbamate and certain antiarrhythmic benzofurans |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3196154A (en) | 1962-05-17 | 1965-07-20 | Sterling Drug Inc | 3-substituted-9-methyl-3, 9-diazabicyclo [3.3.1] nonanes |
US3503939A (en) | 1967-03-29 | 1970-03-31 | Du Pont | Polyamides from heterocyclic diamines |
CH488048A (de) | 1969-06-12 | 1970-03-31 | Inventa Ag | Verfahren zur Herstellung von Polyesterfasern mit verbesserter Gummihaftung |
DE2428792A1 (de) | 1974-06-14 | 1976-01-02 | Knoll Ag | Neue antiarrhythmika |
JPS5772977A (en) | 1980-10-23 | 1982-05-07 | Dainippon Ink & Chem Inc | Fluorine-containing diepoxy compound and its preparation |
DE3112055A1 (de) | 1981-03-27 | 1982-10-07 | Basf Ag, 6700 Ludwigshafen | Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel |
DE3234697A1 (de) | 1982-09-18 | 1984-03-22 | Kali-Chemie Pharma Gmbh, 3000 Hannover | Neue diazabicyclo-(3,3,1)-nonane |
US4533713A (en) | 1983-05-06 | 1985-08-06 | Minnesota Mining And Manufacturing Company | Fluoroaliphaticsulfonamides containing oxirane groups and/or N-β-hydroxyalkylene groups |
PT88381B (pt) | 1987-09-09 | 1995-07-06 | Kali Chemie Pharma Gmbh | Processo para a preparacao de novos compostos 3,7-diazabiciclo{3,3,1} nonano, e de composicoes farmaceuticas que contem estes compostos |
DE3732094A1 (de) | 1987-09-24 | 1989-04-06 | Basf Ag | Bispidinderivate als klasse iii-antiarrhythmika |
US5140033A (en) | 1989-04-03 | 1992-08-18 | Bayer Aktiengesellschaft | Antibacterial 5-alkylquinolonecarboxylic acids |
US5110933A (en) | 1989-11-13 | 1992-05-05 | Board Of Regents Of Oklahoma State University | Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof |
FI100151B (fi) | 1992-09-04 | 1997-09-30 | Nokia Mobile Phones Ltd | Tehonsäästö matkaviestimessä |
JPH06284071A (ja) | 1993-01-27 | 1994-10-07 | Casio Comput Co Ltd | 無線受信機 |
US5468858A (en) | 1993-10-28 | 1995-11-21 | The Board Of Regents Of Oklahoma State University Physical Sciences | N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents |
FR2713081B1 (fr) | 1993-11-29 | 1996-01-12 | Celsa Lg | Filtre sanguin perfectionné à deux séries de pattes en pétales. |
US5831099A (en) | 1995-03-10 | 1998-11-03 | The United States Of America As Represented By The Secretary Of The Army | Compounds of 1,5-disubstituted-3,7 diaza bicyclo 3.3.0! octanes and products containing the same |
SE9704709D0 (sv) | 1997-12-17 | 1997-12-17 | Astra Ab | Pharmaceutically active compounds |
JP2002541249A (ja) | 1999-04-09 | 2002-12-03 | アストラゼネカ・アクチエボラーグ | アダマンタン誘導体 |
SE9903759D0 (sv) | 1999-10-18 | 1999-10-18 | Astra Ab | Pharmaceutically active compounds |
AR030756A1 (es) | 2000-10-02 | 2003-09-03 | Astrazeneca Ab | Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas |
SE0101323D0 (sv) | 2001-04-12 | 2001-04-12 | Astrazeneca Ab | New process |
SE0101324D0 (sv) | 2001-04-12 | 2001-04-12 | Astrazeneca Ab | New process |
SE0101327D0 (sv) * | 2001-04-12 | 2001-04-12 | Astrazeneca Ab | New crystalline forms |
TWI259836B (en) | 2001-04-12 | 2006-08-11 | Astrazeneca Ab | Modified release formulation suitable for antiarrhythmic compounds |
SE0201662D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Pharmaceutical combination |
CN1681495B (zh) * | 2002-08-19 | 2010-05-12 | 辉瑞产品公司 | 用于治疗过度增生性疾病的组合物 |
GB0223712D0 (en) | 2002-10-14 | 2002-11-20 | Astrazeneca Ab | Chemical intermediate |
SE0401540D0 (sv) | 2004-06-15 | 2004-06-15 | Astrazeneca Ab | New compounds |
SE0401539D0 (sv) * | 2004-06-15 | 2004-06-15 | Astrazeneca Ab | New compounds |
-
2006
- 2006-06-12 WO PCT/SE2006/000688 patent/WO2006135316A1/en active Application Filing
- 2006-06-12 CN CNA200680029416XA patent/CN101243093A/zh active Pending
- 2006-06-12 AR ARP060102458A patent/AR057064A1/es not_active Application Discontinuation
- 2006-06-12 KR KR1020087000158A patent/KR20080021114A/ko not_active Application Discontinuation
- 2006-06-12 JP JP2008515658A patent/JP2008543750A/ja active Pending
- 2006-06-12 CA CA002609938A patent/CA2609938A1/en not_active Abandoned
- 2006-06-12 MX MX2007015800A patent/MX2007015800A/es not_active Application Discontinuation
- 2006-06-12 EP EP06747881A patent/EP1893619A1/en not_active Withdrawn
- 2006-06-12 AU AU2006258293A patent/AU2006258293B2/en not_active Ceased
- 2006-06-12 US US11/917,195 patent/US7928225B2/en not_active Expired - Fee Related
-
2007
- 2007-11-26 NO NO20076052A patent/NO20076052L/no not_active Application Discontinuation
- 2007-12-17 EC EC2007008025A patent/ECSP078025A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CA2609938A1 (en) | 2006-12-21 |
MX2007015800A (es) | 2008-03-04 |
AU2006258293A1 (en) | 2006-12-21 |
AR057064A1 (es) | 2007-11-14 |
US20090054422A1 (en) | 2009-02-26 |
EP1893619A1 (en) | 2008-03-05 |
ECSP078025A (es) | 2008-01-23 |
WO2006135316A1 (en) | 2006-12-21 |
JP2008543750A (ja) | 2008-12-04 |
US7928225B2 (en) | 2011-04-19 |
KR20080021114A (ko) | 2008-03-06 |
AU2006258293B2 (en) | 2010-06-17 |
CN101243093A (zh) | 2008-08-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |