NO20073332L - Pyridinforbindelser for behandling av prostaglandinmedierte sykdommer - Google Patents
Pyridinforbindelser for behandling av prostaglandinmedierte sykdommerInfo
- Publication number
- NO20073332L NO20073332L NO20073332A NO20073332A NO20073332L NO 20073332 L NO20073332 L NO 20073332L NO 20073332 A NO20073332 A NO 20073332A NO 20073332 A NO20073332 A NO 20073332A NO 20073332 L NO20073332 L NO 20073332L
- Authority
- NO
- Norway
- Prior art keywords
- prostaglandin
- treatment
- mediated diseases
- pyridine compounds
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Forbindelser med formel (I) eller et farmasøytisk akseptabelt derivat derav; hvori X, Y, Z, R2a, R2b,R3a, R3b, R8, R9 og Rx er som definert i beskrivelsen, en fremgangsmåte for fremstilling av slike forbindelser, farmasøytiske sammensetninger som innbefatter slike forbindelser og anvendelsen av slike forbindelser innen medisin (EP,- reseptorantagonister).
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0428263A GB0428263D0 (en) | 2004-12-23 | 2004-12-23 | Compounds |
GB0508458A GB0508458D0 (en) | 2005-04-26 | 2005-04-26 | Compounds |
GB0524675A GB0524675D0 (en) | 2005-12-02 | 2005-12-02 | Compounds |
PCT/EP2005/014061 WO2006066968A1 (en) | 2004-12-23 | 2005-12-21 | Pyridine compounds for the treatment of prostaglandin mediated diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20073332L true NO20073332L (no) | 2007-09-17 |
Family
ID=35735391
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20073332A NO20073332L (no) | 2004-12-23 | 2007-06-28 | Pyridinforbindelser for behandling av prostaglandinmedierte sykdommer |
Country Status (20)
Country | Link |
---|---|
US (2) | US20100137378A1 (no) |
EP (2) | EP1833795B1 (no) |
JP (1) | JP2008525363A (no) |
KR (1) | KR20070091301A (no) |
AR (1) | AR052429A1 (no) |
AT (1) | ATE424386T1 (no) |
AU (1) | AU2005318372A1 (no) |
BR (1) | BRPI0519398A2 (no) |
CA (1) | CA2592442A1 (no) |
DE (1) | DE602005013116D1 (no) |
EA (2) | EA200701324A1 (no) |
ES (1) | ES2321535T3 (no) |
IL (1) | IL183781A0 (no) |
MA (1) | MA29082B1 (no) |
MX (1) | MX2007007830A (no) |
NO (1) | NO20073332L (no) |
PE (2) | PE20060838A1 (no) |
TW (1) | TW200640865A (no) |
UY (1) | UY29298A1 (no) |
WO (1) | WO2006066968A1 (no) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0608825D0 (en) * | 2006-05-04 | 2006-06-14 | Glaxo Group Ltd | Compounds |
NZ581309A (en) * | 2007-05-25 | 2012-02-24 | Vertex Pharma | Ion channel modulators and methods of use |
FR2921062A1 (fr) * | 2007-09-17 | 2009-03-20 | Commissariat Energie Atomique | Composes utiles comme ligands et notamment comme chromophores organiques de complexation des lanthanides et leurs applications |
UY32571A (es) | 2009-04-24 | 2010-11-30 | Glaxo Group Ltd | Compuestos derivados de pirazol amida |
CN102596199A (zh) | 2009-07-31 | 2012-07-18 | 潘米拉制药公司 | Dp2受体拮抗剂的眼用医药组合物 |
KR20120047273A (ko) | 2009-08-05 | 2012-05-11 | 판미라 파마슈티칼스, 엘엘씨 | Dp2 길항제 및 이의 용도 |
EP2630127A1 (en) | 2010-10-21 | 2013-08-28 | Glaxo Group Limited | Pyrazole compounds acting against allergic, inflammatory and immune disorders |
EP2570125A1 (en) * | 2011-09-16 | 2013-03-20 | Almirall, S.A. | Ep1 receptor ligands |
TR201816624T4 (tr) | 2014-06-03 | 2018-11-21 | Idorsia Pharmaceuticals Ltd | Pirazol bileşikleri ve t tipi kalsiyum kanalı bloke edicileri olarak kullanımları. |
NZ768373A (en) | 2014-10-06 | 2024-03-22 | Vertex Pharma | Modulators of cystic fibrosis transmembrane conductance regulator |
WO2017173274A1 (en) | 2016-03-31 | 2017-10-05 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
US10570115B2 (en) | 2016-09-30 | 2020-02-25 | Vertex Pharmaceuticals Incorporated | Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
AU2017371200B2 (en) | 2016-12-09 | 2021-05-06 | Vertex Pharmaceuticals Incorporated | Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
BR112019011208A2 (pt) | 2016-12-16 | 2019-10-15 | Idorsia Pharmaceuticals Ltd | combinação farmacêutica, composição farmacêutica, e, kit de partes. |
CN110234622B (zh) | 2017-02-06 | 2023-07-04 | 爱杜西亚药品有限公司 | 用于合成1-芳基-1-三氟甲基环丙烷的新颖方法 |
AU2018279646B2 (en) | 2017-06-08 | 2023-04-06 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
BR112020000941A2 (pt) | 2017-07-17 | 2020-07-21 | Vertex Pharmaceuticals Incorporated | métodos de tratamento para fibrose cística |
ES2912657T3 (es) | 2017-08-02 | 2022-05-26 | Vertex Pharma | Procesos para preparar compuestos de pirrolidina |
US10654829B2 (en) | 2017-10-19 | 2020-05-19 | Vertex Pharmaceuticals Incorporated | Crystalline forms and compositions of CFTR modulators |
KR20200097293A (ko) | 2017-12-08 | 2020-08-18 | 버텍스 파마슈티칼스 인코포레이티드 | 낭포성 섬유증 막횡단 전도 조절자의 조정제의 제조 방법 |
TWI810243B (zh) | 2018-02-05 | 2023-08-01 | 美商維泰克斯製藥公司 | 用於治療囊腫纖化症之醫藥組合物 |
EP3774825A1 (en) | 2018-04-13 | 2021-02-17 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
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EP0388682A1 (de) | 1989-03-15 | 1990-09-26 | Bayer Ag | Substituierte Heteroarylphenylether, Verfahren zu ihrer Herstellung und ihre Verwendung als Insektizide |
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UA57002C2 (uk) | 1995-10-13 | 2003-06-16 | Мерк Фросст Кенада Енд Ко./Мерк Фросст Кенада Енд Сі. | Похідне (метилсульфоніл)феніл-2-(5н)-фуранону, фармацевтична композиція та спосіб лікування |
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DK0912518T3 (da) | 1996-07-18 | 2003-12-08 | Merck Frosst Canada Inc | Substituerede pyridiner som selektive cyclooxygenase-2 inhibitorer |
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AUPP873799A0 (en) | 1999-02-17 | 1999-03-11 | Fujisawa Pharmaceutical Co., Ltd. | Pyridine compounds |
DE69915519T2 (de) | 1999-02-27 | 2005-02-03 | Glaxo Group Ltd., Greenford | Pyrazolopyridine |
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JP2001089452A (ja) | 1999-09-22 | 2001-04-03 | Sankyo Co Ltd | ピリミジン誘導体 |
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GB0003224D0 (en) | 2000-02-11 | 2000-04-05 | Glaxo Group Ltd | Chemical compounds |
GB0021494D0 (en) | 2000-09-01 | 2000-10-18 | Glaxo Group Ltd | Chemical comkpounds |
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GB0212785D0 (en) | 2002-05-31 | 2002-07-10 | Glaxo Group Ltd | Compounds |
CA2503767C (en) | 2002-10-30 | 2009-09-22 | Merck Frosst Canada & Co./Merck Frosst Canada & Cie | Pyridopyrrolizine and pyridoindolizine derivatives |
GB0225548D0 (en) * | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Compounds |
GB0306329D0 (en) | 2003-03-19 | 2003-04-23 | Glaxo Group Ltd | Compounds |
GB0323581D0 (en) | 2003-10-08 | 2003-11-12 | Glaxo Group Ltd | Novel compounds |
GB0323585D0 (en) | 2003-10-08 | 2003-11-12 | Glaxo Group Ltd | Compounds |
GB0323584D0 (en) | 2003-10-08 | 2003-11-12 | Glaxo Group Ltd | Compounds |
US20070060596A1 (en) | 2003-10-24 | 2007-03-15 | Giblin Gerard M P | Heterocyclyl compounds |
GB0328024D0 (en) | 2003-12-03 | 2004-01-07 | Glaxo Group Ltd | Compounds |
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-
2005
- 2005-12-21 WO PCT/EP2005/014061 patent/WO2006066968A1/en active Application Filing
- 2005-12-21 DE DE602005013116T patent/DE602005013116D1/de active Active
- 2005-12-21 BR BRPI0519398-2A patent/BRPI0519398A2/pt not_active IP Right Cessation
- 2005-12-21 US US11/722,402 patent/US20100137378A1/en not_active Abandoned
- 2005-12-21 EA EA200701324A patent/EA200701324A1/ru unknown
- 2005-12-21 AR ARP050105412A patent/AR052429A1/es unknown
- 2005-12-21 TW TW094145424A patent/TW200640865A/zh unknown
- 2005-12-21 AU AU2005318372A patent/AU2005318372A1/en not_active Abandoned
- 2005-12-21 EP EP05817767A patent/EP1833795B1/en active Active
- 2005-12-21 CA CA002592442A patent/CA2592442A1/en not_active Abandoned
- 2005-12-21 JP JP2007547393A patent/JP2008525363A/ja not_active Withdrawn
- 2005-12-21 UY UY29298A patent/UY29298A1/es unknown
- 2005-12-21 EA EA200801909A patent/EA200801909A1/ru unknown
- 2005-12-21 MX MX2007007830A patent/MX2007007830A/es not_active Application Discontinuation
- 2005-12-21 EP EP09150218A patent/EP2053042A1/en not_active Withdrawn
- 2005-12-21 AT AT05817767T patent/ATE424386T1/de not_active IP Right Cessation
- 2005-12-21 ES ES05817767T patent/ES2321535T3/es active Active
- 2005-12-21 KR KR1020077014271A patent/KR20070091301A/ko not_active Application Discontinuation
-
2006
- 2006-01-03 PE PE2006000025A patent/PE20060838A1/es not_active Application Discontinuation
- 2006-01-30 PE PE2008001431A patent/PE20081440A1/es not_active Application Discontinuation
-
2007
- 2007-06-06 MA MA29966A patent/MA29082B1/fr unknown
- 2007-06-07 IL IL183781A patent/IL183781A0/en unknown
- 2007-06-21 US US11/766,418 patent/US7759369B2/en not_active Expired - Fee Related
- 2007-06-28 NO NO20073332A patent/NO20073332L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PE20081440A1 (es) | 2008-12-31 |
MX2007007830A (es) | 2007-07-25 |
BRPI0519398A2 (pt) | 2009-01-20 |
UY29298A1 (es) | 2006-05-31 |
EP2053042A1 (en) | 2009-04-29 |
AU2005318372A1 (en) | 2006-06-29 |
US20080249138A1 (en) | 2008-10-09 |
EA200701324A1 (ru) | 2007-10-26 |
KR20070091301A (ko) | 2007-09-10 |
EP1833795B1 (en) | 2009-03-04 |
DE602005013116D1 (de) | 2009-04-16 |
EP1833795A1 (en) | 2007-09-19 |
ES2321535T3 (es) | 2009-06-08 |
TW200640865A (en) | 2006-12-01 |
IL183781A0 (en) | 2007-09-20 |
US20100137378A1 (en) | 2010-06-03 |
AR052429A1 (es) | 2007-03-21 |
CA2592442A1 (en) | 2006-06-29 |
PE20060838A1 (es) | 2006-10-12 |
EA200801909A1 (ru) | 2009-06-30 |
ATE424386T1 (de) | 2009-03-15 |
US7759369B2 (en) | 2010-07-20 |
WO2006066968A1 (en) | 2006-06-29 |
JP2008525363A (ja) | 2008-07-17 |
MA29082B1 (fr) | 2007-12-03 |
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