NO20060494L - Regioselektiv syntese av CCI-779 - Google Patents
Regioselektiv syntese av CCI-779Info
- Publication number
- NO20060494L NO20060494L NO20060494A NO20060494A NO20060494L NO 20060494 L NO20060494 L NO 20060494L NO 20060494 A NO20060494 A NO 20060494A NO 20060494 A NO20060494 A NO 20060494A NO 20060494 L NO20060494 L NO 20060494L
- Authority
- NO
- Norway
- Prior art keywords
- cci
- regioselective synthesis
- regioselective
- synthesis
- boronate
- Prior art date
Links
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 229960000235 temsirolimus Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 2
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49324903P | 2003-08-07 | 2003-08-07 | |
| PCT/US2004/022860 WO2005016935A2 (fr) | 2003-08-07 | 2004-07-15 | Synthese stereoselective de cci-779 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20060494L true NO20060494L (no) | 2006-03-06 |
Family
ID=34193170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20060494A NO20060494L (no) | 2003-08-07 | 2006-01-31 | Regioselektiv syntese av CCI-779 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7153957B2 (fr) |
| EP (1) | EP1658295B1 (fr) |
| JP (1) | JP4227649B2 (fr) |
| KR (1) | KR20060057605A (fr) |
| CN (1) | CN1829722B (fr) |
| AR (1) | AR045217A1 (fr) |
| AT (1) | ATE365169T1 (fr) |
| AU (1) | AU2004265267A1 (fr) |
| BR (1) | BRPI0412667A (fr) |
| CA (1) | CA2532988A1 (fr) |
| CO (1) | CO5650251A2 (fr) |
| CR (1) | CR8189A (fr) |
| DE (1) | DE602004007145T2 (fr) |
| DK (1) | DK1658295T3 (fr) |
| EC (1) | ECSP066413A (fr) |
| ES (1) | ES2287772T3 (fr) |
| HK (1) | HK1085482A1 (fr) |
| IL (1) | IL173134A0 (fr) |
| MX (1) | MXPA06000951A (fr) |
| NO (1) | NO20060494L (fr) |
| PL (1) | PL1658295T3 (fr) |
| PT (1) | PT1658295E (fr) |
| RU (1) | RU2339639C2 (fr) |
| TW (1) | TW200508241A (fr) |
| UA (1) | UA83245C2 (fr) |
| WO (1) | WO2005016935A2 (fr) |
| ZA (1) | ZA200601055B (fr) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60231868D1 (de) | 2001-04-24 | 2009-05-20 | Purdue Research Foundation | Folat-mimetika und deren folatrezeptorbindende konjugate |
| AU2003243226A1 (en) * | 2002-05-15 | 2003-12-02 | Endocyte, Inc. | Vitamin-mitomycin conjugates |
| CN100402031C (zh) | 2002-07-30 | 2008-07-16 | 惠氏公司 | 含有瑞帕霉素羟基酯的胃肠外制剂 |
| EP2529758A3 (fr) | 2003-01-27 | 2013-01-02 | Endocyte, Inc. | Conjugués d'administration de médicaments à liaison au récepteur de vitamines |
| BRPI0414066A (pt) * | 2003-09-03 | 2006-10-24 | Wyeth Corp | 42-éster de rapamicina amorfo com ácido 3-hidróxi-2-( hidroximetil )-2-metilproipiÈnico e composições farmacêuticas que o contenha |
| EP1701698B1 (fr) * | 2004-01-08 | 2008-01-16 | Wyeth a Corporation of the State of Delaware | Composition pharmaceutique directement compressible pour l'administration orale de cci-779 |
| US7202256B2 (en) | 2004-04-14 | 2007-04-10 | Wyeth | Proline CCI-779, production of and uses therefor, and two-step enzymatic synthesis of proline CCI-779 and CCI-779 |
| WO2005105811A1 (fr) | 2004-04-14 | 2005-11-10 | Wyeth | Synthese regiospecifique de derives de 42-esters de rapamycine |
| AU2005238432A1 (en) * | 2004-04-14 | 2005-11-10 | Wyeth | Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies |
| JP2007534337A (ja) * | 2004-04-27 | 2007-11-29 | ワイス | ラパマイシン特異的メチラーゼを用いるラパマイシンの標識 |
| WO2006012527A1 (fr) | 2004-07-23 | 2006-02-02 | Endocyte, Inc. | Groupes de liaison bivalents et conjugués de ceux-ci |
| WO2006038972A1 (fr) | 2004-08-10 | 2006-04-13 | Wyeth | Derives du cci-779 et procedes pour les fabriquer |
| CA2585840A1 (fr) | 2004-10-28 | 2006-05-11 | Wyeth | Utilisation d'un inhibiteur mtor dans le traitement de leiomyomes uterins |
| MX2007009590A (es) | 2005-02-09 | 2007-09-12 | Wyeth Corp | Polimorfo cci-779 y uso del mismo. |
| CA2599580A1 (fr) | 2005-03-02 | 2006-09-08 | Wyeth | Recuperation de cci-779 a partir de solutions meres |
| CN101133065A (zh) * | 2005-03-02 | 2008-02-27 | 惠氏公司 | 雷帕霉素的纯化 |
| US8044200B2 (en) | 2005-03-16 | 2011-10-25 | Endocyte, Inc. | Synthesis and purification of pteroic acid and conjugates thereof |
| CN103893779A (zh) | 2005-08-19 | 2014-07-02 | 恩多塞特公司 | 多药物配体缀合物 |
| EP2382995A3 (fr) * | 2005-08-19 | 2013-09-25 | Endocyte, Inc. | Conjugués de ligands d'alcaloïdes de Vinca, analogues et dérivés |
| US7538119B2 (en) * | 2005-11-04 | 2009-05-26 | Wyeth | 41-Methoxy isotope labeled rapamycin 42-ester |
| CN103110948A (zh) | 2005-11-04 | 2013-05-22 | 惠氏公司 | mTOR抑制剂、赫赛汀和/或HKI-272的抗肿瘤组合 |
| US7622578B2 (en) * | 2005-12-07 | 2009-11-24 | Wyeth | Scalable process for the preparation of a rapamycin 42-ester from a rapamycin 42-ester boronate |
| AR058283A1 (es) * | 2005-12-07 | 2008-01-30 | Wyeth Corp | Metodos para la preparacion de rapamicina cristalina y para la medicion de la cristalinidad de los compuestos de rapamicina utilizando calorimetria diferencial de barrido |
| EP1957500A1 (fr) * | 2005-12-07 | 2008-08-20 | Wyeth a Corporation of the State of Delaware | Procede de preparation de cci-779 cristallin purifie |
| AU2006331874A1 (en) * | 2005-12-20 | 2007-07-05 | Wyeth | Control of CCI-779 dosage form stability through control of drug substance impurities |
| US20070203169A1 (en) * | 2006-02-28 | 2007-08-30 | Zhao Jonathon Z | Isomers and 42-epimers of rapamycin ester analogs, methods of making and using the same |
| TW200824713A (en) | 2006-10-18 | 2008-06-16 | Wyeth Corp | Processes for the synthesis of individual isomers of mono-PEG CCI-779 |
| US20080175887A1 (en) | 2006-11-20 | 2008-07-24 | Lixiao Wang | Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs |
| US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
| US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
| US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
| US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| WO2008101231A2 (fr) | 2007-02-16 | 2008-08-21 | Endocyte, Inc. | Procédés et compositions de traitement et de diagnostic d'une maladie rénale |
| CA2680535C (fr) * | 2007-03-14 | 2016-09-20 | Endocyte, Inc. | Conjugues d'administration de medicament lies a un ligand de liaison de tubulysines |
| TW200845960A (en) * | 2007-04-05 | 2008-12-01 | Wyeth Corp | Wortmannin-rapalog conjugate and uses thereof |
| TW200901989A (en) | 2007-04-10 | 2009-01-16 | Wyeth Corp | Anti-tumor activity of CCI-779 in papillary renal cell cancer |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| WO2009002993A1 (fr) | 2007-06-25 | 2008-12-31 | Endocyte, Inc. | Conjugués contenant des lieurs espaceurs hydrophiles |
| AU2008316835B2 (en) | 2007-10-25 | 2015-07-16 | Endocyte, Inc. | Tubulysins and processes for preparing |
| WO2010024898A2 (fr) | 2008-08-29 | 2010-03-04 | Lutonix, Inc. | Procédés et appareils pour poser un revêtement sur des cathéters à ballonnet |
| US8754207B2 (en) | 2009-09-25 | 2014-06-17 | Cadila Healthcare Limited | Process for the preparation of rapamycin derivatives |
| WO2011092564A2 (fr) * | 2010-01-28 | 2011-08-04 | Fresenius Kabi Oncology Ltd | Procédé amélioré pour la préparation du temsirolimus et de ses intermédiaires |
| CN102020661B (zh) * | 2011-01-07 | 2013-02-13 | 天津市炜杰科技有限公司 | 一种驮瑞塞尔合成方法 |
| CN102020662B (zh) * | 2011-01-07 | 2013-02-13 | 天津市炜杰科技有限公司 | 一种驮瑞塞尔制备方法 |
| CA2828829A1 (fr) * | 2011-04-01 | 2012-10-04 | Sandoz Ag | Acylation regioselective de la rapamycine au niveau de la position c-42 |
| WO2013126797A1 (fr) | 2012-02-24 | 2013-08-29 | Purdue Research Foundation | Ciblage du récepteur de la cholécystokinine de type b pour imagerie et thérapie |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| WO2014062697A2 (fr) | 2012-10-16 | 2014-04-24 | Endocyte, Inc. | Conjugués d'administration de médicament contenant des acides aminés artificiels et procédés d'utilisation |
| CN104086564B (zh) * | 2014-07-30 | 2019-02-05 | 江苏奥赛康药业股份有限公司 | 一种高纯度坦罗莫司的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
| DE19857765A1 (de) * | 1998-12-15 | 2000-06-21 | Clariant Gmbh | Verfahren zur Herstellung von para-Oxadiazolyl-phenyl-boronsäuren |
| US6277983B1 (en) * | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
-
2004
- 2004-07-15 WO PCT/US2004/022860 patent/WO2005016935A2/fr active IP Right Grant
- 2004-07-15 CN CN2004800217944A patent/CN1829722B/zh not_active Expired - Fee Related
- 2004-07-15 ES ES04778398T patent/ES2287772T3/es not_active Expired - Lifetime
- 2004-07-15 PT PT04778398T patent/PT1658295E/pt unknown
- 2004-07-15 DK DK04778398T patent/DK1658295T3/da active
- 2004-07-15 KR KR1020067002610A patent/KR20060057605A/ko not_active Application Discontinuation
- 2004-07-15 AU AU2004265267A patent/AU2004265267A1/en not_active Abandoned
- 2004-07-15 PL PL04778398T patent/PL1658295T3/pl unknown
- 2004-07-15 MX MXPA06000951A patent/MXPA06000951A/es active IP Right Grant
- 2004-07-15 CA CA002532988A patent/CA2532988A1/fr not_active Abandoned
- 2004-07-15 EP EP04778398A patent/EP1658295B1/fr not_active Expired - Lifetime
- 2004-07-15 BR BRPI0412667-0A patent/BRPI0412667A/pt not_active IP Right Cessation
- 2004-07-15 UA UAA200602447A patent/UA83245C2/ru unknown
- 2004-07-15 JP JP2006522574A patent/JP4227649B2/ja not_active Expired - Fee Related
- 2004-07-15 RU RU2006106910/04A patent/RU2339639C2/ru not_active IP Right Cessation
- 2004-07-15 DE DE602004007145T patent/DE602004007145T2/de not_active Expired - Fee Related
- 2004-07-15 AT AT04778398T patent/ATE365169T1/de not_active IP Right Cessation
- 2004-07-30 US US10/903,062 patent/US7153957B2/en not_active Expired - Fee Related
- 2004-08-04 AR ARP040102778A patent/AR045217A1/es unknown
- 2004-08-05 TW TW093123422A patent/TW200508241A/zh unknown
-
2006
- 2006-01-12 IL IL173134A patent/IL173134A0/en unknown
- 2006-01-13 CR CR8189A patent/CR8189A/es not_active Application Discontinuation
- 2006-01-31 NO NO20060494A patent/NO20060494L/no not_active Application Discontinuation
- 2006-02-06 ZA ZA200601055A patent/ZA200601055B/en unknown
- 2006-02-28 CO CO06019898A patent/CO5650251A2/es unknown
- 2006-03-07 EC EC2006006413A patent/ECSP066413A/es unknown
- 2006-07-11 HK HK06107729A patent/HK1085482A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2339639C2 (ru) | 2008-11-27 |
| JP4227649B2 (ja) | 2009-02-18 |
| CA2532988A1 (fr) | 2005-02-24 |
| WO2005016935A2 (fr) | 2005-02-24 |
| AU2004265267A1 (en) | 2005-02-24 |
| EP1658295B1 (fr) | 2007-06-20 |
| CN1829722B (zh) | 2010-10-27 |
| RU2006106910A (ru) | 2007-09-20 |
| UA83245C2 (en) | 2008-06-25 |
| EP1658295A2 (fr) | 2006-05-24 |
| CO5650251A2 (es) | 2006-06-30 |
| DE602004007145D1 (de) | 2007-08-02 |
| ECSP066413A (es) | 2006-09-18 |
| TW200508241A (en) | 2005-03-01 |
| PT1658295E (pt) | 2007-09-25 |
| ZA200601055B (en) | 2008-07-30 |
| PL1658295T3 (pl) | 2007-11-30 |
| CN1829722A (zh) | 2006-09-06 |
| DK1658295T3 (da) | 2007-09-24 |
| MXPA06000951A (es) | 2006-03-30 |
| KR20060057605A (ko) | 2006-05-26 |
| ES2287772T3 (es) | 2007-12-16 |
| ATE365169T1 (de) | 2007-07-15 |
| JP2007501783A (ja) | 2007-02-01 |
| IL173134A0 (en) | 2006-06-11 |
| US20050033046A1 (en) | 2005-02-10 |
| WO2005016935A3 (fr) | 2005-04-07 |
| DE602004007145T2 (de) | 2008-02-28 |
| US7153957B2 (en) | 2006-12-26 |
| BRPI0412667A (pt) | 2006-09-26 |
| CR8189A (es) | 2006-10-04 |
| HK1085482A1 (en) | 2006-08-25 |
| AR045217A1 (es) | 2005-10-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |