NO20021367D0 - Indolyl-3-glyoxylic acid derivatives having therapeutically valuable properties - Google Patents

Indolyl-3-glyoxylic acid derivatives having therapeutically valuable properties

Info

Publication number
NO20021367D0
NO20021367D0 NO20021367A NO20021367A NO20021367D0 NO 20021367 D0 NO20021367 D0 NO 20021367D0 NO 20021367 A NO20021367 A NO 20021367A NO 20021367 A NO20021367 A NO 20021367A NO 20021367 D0 NO20021367 D0 NO 20021367D0
Authority
NO
Norway
Prior art keywords
indolyl
acid derivatives
glyoxylic acid
therapeutically valuable
valuable properties
Prior art date
Application number
NO20021367A
Other languages
Norwegian (no)
Other versions
NO322614B1 (en
NO20021367L (en
Inventor
Bernd Nickel
Thomas Klenner
Gerald Bacher
Thomas Beckers
Peter Emig
Juergen Engel
Erik Bruyneel
Guenter Kam
Kirsten Peters
Original Assignee
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19946301A external-priority patent/DE19946301A1/en
Application filed by Baxter Healthcare Sa filed Critical Baxter Healthcare Sa
Publication of NO20021367D0 publication Critical patent/NO20021367D0/en
Publication of NO20021367L publication Critical patent/NO20021367L/en
Publication of NO322614B1 publication Critical patent/NO322614B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention relates to the use of N-substituted indol-3- glyoxylamides of general formula 1 for treating tumors, in particular, in cases of drug resistance and metastatic carcinoma, and as angiogenesis inhibitors having distinctly fewer side effects, in particular, distinctly lower neurotoxicity. The invention also relates to medicaments containing the inventive compounds.
NO20021367A 1999-09-28 2002-03-19 Indolyl-3-glycosyl acid derivatives having therapeutically valuable properties NO322614B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19946301A DE19946301A1 (en) 1998-04-02 1999-09-28 Antitumor agents and angiogenesis inhibitors having low neurotoxicity, comprise indole-3-glyoxylamide derivatives, are effective against resistant and metastasis-forming carcinomas
PCT/EP2000/009390 WO2001022954A2 (en) 1999-09-28 2000-09-26 Indolyl-3-glyoxylic acid derivatives serving as antitumor agents

Publications (3)

Publication Number Publication Date
NO20021367D0 true NO20021367D0 (en) 2002-03-19
NO20021367L NO20021367L (en) 2002-05-22
NO322614B1 NO322614B1 (en) 2006-11-06

Family

ID=7923485

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021367A NO322614B1 (en) 1999-09-28 2002-03-19 Indolyl-3-glycosyl acid derivatives having therapeutically valuable properties

Country Status (32)

Country Link
EP (1) EP1218006B1 (en)
JP (1) JP2003510274A (en)
KR (1) KR100759242B1 (en)
CN (1) CN1301712C (en)
AR (1) AR025885A1 (en)
AT (1) ATE459356T1 (en)
AU (1) AU783436B2 (en)
BG (1) BG106639A (en)
BR (1) BR0014378A (en)
CA (1) CA2386069C (en)
CZ (1) CZ303246B6 (en)
DE (1) DE50015879D1 (en)
DZ (1) DZ3196A1 (en)
EE (1) EE200200169A (en)
ES (1) ES2342042T3 (en)
GE (1) GEP20043250B (en)
HK (1) HK1048941B (en)
HR (1) HRP20020369A2 (en)
HU (1) HUP0202788A3 (en)
IL (2) IL148670A0 (en)
IS (1) IS6319A (en)
MX (1) MXPA02002824A (en)
NO (1) NO322614B1 (en)
NZ (1) NZ517988A (en)
PL (1) PL199576B1 (en)
RS (1) RS51302B (en)
RU (1) RU2282444C2 (en)
SK (1) SK287533B6 (en)
TW (1) TWI269654B (en)
UA (1) UA75872C2 (en)
WO (1) WO2001022954A2 (en)
ZA (1) ZA200202556B (en)

Families Citing this family (24)

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Publication number Priority date Publication date Assignee Title
DE19962300A1 (en) * 1999-12-23 2001-06-28 Asta Medica Ag New N-benzylindolyl glyoxylic acid derivatives are useful as antitumor agents
MXPA02011770A (en) 2000-05-31 2003-04-10 Astrazeneca Ab Indole derivatives with vascular damaging activity.
DE10037310A1 (en) 2000-07-28 2002-02-07 Asta Medica Ag New indole derivatives and their use as medicines
EP1484329A1 (en) * 2003-06-06 2004-12-08 Zentaris GmbH Indole derivatives with apoptosis inducing activity
BRPI0410998A (en) * 2003-06-05 2006-07-04 Zentaris Gmbh indole derivatives with apoptosis inducing effect
EP1595878A1 (en) * 2004-05-15 2005-11-16 Zentaris GmbH Indole derivatives with apoptosis inducing activity
US20050124623A1 (en) 2003-11-26 2005-06-09 Bender John A. Diazaindole-dicarbonyl-piperazinyl antiviral agents
CN103356636A (en) * 2004-05-23 2013-10-23 杰勒德·M·豪斯 Theramutein modulators
MX2007005434A (en) * 2004-11-08 2007-07-10 Baxter Int Nanoparticulate compositions of tubulin inhibitor.
US20060100432A1 (en) 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
CA2605214C (en) 2004-12-31 2016-07-12 Reddy Us Therapeutics, Inc. Benzylamine derivatives as cetp inhibitors
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
US7851476B2 (en) 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
AU2007325797B2 (en) * 2006-11-28 2014-03-13 Ziopharm Oncology, Inc. Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer
EP2744803A2 (en) 2011-08-18 2014-06-25 Dr. Reddy's Laboratories Ltd. Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (cetp) inhibitors
JP6140168B2 (en) 2011-09-27 2017-05-31 ドクター レディズ ラボラトリーズ リミテッド 5-Benzylaminomethyl-6-aminopyrazolo [3,4-B] pyridine derivatives as cholesteryl ester transfer protein (CETP) inhibitors useful for the treatment of atherosclerosis
US9353150B2 (en) 2012-12-04 2016-05-31 Massachusetts Institute Of Technology Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
US10201623B2 (en) 2013-03-15 2019-02-12 Memorial Sloan Kettering Cancer Center HSP90-targeted cardiac imaging and therapy
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
US11932650B2 (en) 2017-05-11 2024-03-19 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
CN109111501B (en) * 2017-06-23 2022-04-22 首都医科大学 Fatty amino acid modified indole ethanol derivative, and synthesis, activity and application thereof
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
WO2020247054A1 (en) 2019-06-05 2020-12-10 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4128089A (en) 1988-09-15 1990-03-22 Rorer International (Overseas) Inc. Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same
WO1994008581A1 (en) * 1992-10-20 1994-04-28 Toray Industries, Inc. Eosinophil infiltration inhibitor
DE19636150A1 (en) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituted indole-3-glyoxylamides with antiasthmatic, antiallergic and immunosuppressive / immunomodulating effects
AU6523598A (en) 1997-04-08 1998-10-30 Banyu Pharmaceutical Co., Ltd. Cancerous metastasis-associated gene
PL343007A1 (en) * 1998-02-25 2001-07-30 Genetics Inst Inhibitors of phospholipase enzymes
WO1999046237A1 (en) * 1998-03-12 1999-09-16 Novo Nordisk A/S Modulators of protein tyrosine phosphatases
DE19814838C2 (en) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylic acid derivatives with anti-tumor effects
EP1475377B1 (en) * 1998-04-28 2006-06-21 elbion AG Derivatives of indole and their use as phosphodiesterase 4 inhibitors
JP2000239252A (en) * 1999-02-16 2000-09-05 Mitsubishi Chemicals Corp Indole derivative
AU4834200A (en) * 1999-05-10 2000-11-21 Protarga, Inc. Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof

Also Published As

Publication number Publication date
NO322614B1 (en) 2006-11-06
BG106639A (en) 2002-12-29
RS51302B (en) 2010-12-31
HK1048941A1 (en) 2003-04-25
CA2386069A1 (en) 2001-04-05
EP1218006B1 (en) 2010-03-03
GEP20043250B (en) 2004-06-25
HUP0202788A3 (en) 2003-02-28
PL199576B1 (en) 2008-10-31
SK4072002A3 (en) 2003-11-04
UA75872C2 (en) 2006-06-15
HK1048941B (en) 2007-09-21
DZ3196A1 (en) 2001-04-05
PL364811A1 (en) 2004-12-13
CN1376064A (en) 2002-10-23
AU783436B2 (en) 2005-10-27
YU22702A (en) 2004-12-31
CA2386069C (en) 2012-08-14
RU2282444C2 (en) 2006-08-27
EE200200169A (en) 2003-04-15
IS6319A (en) 2002-03-21
ATE459356T1 (en) 2010-03-15
HUP0202788A2 (en) 2003-01-28
ZA200202556B (en) 2003-08-27
EP1218006A2 (en) 2002-07-03
CZ303246B6 (en) 2012-06-20
AU7782900A (en) 2001-04-30
ES2342042T3 (en) 2010-07-01
KR100759242B1 (en) 2007-09-18
HRP20020369A2 (en) 2004-12-31
KR20030019295A (en) 2003-03-06
DE50015879D1 (en) 2010-04-15
MXPA02002824A (en) 2003-07-21
IL148670A0 (en) 2002-09-12
NO20021367L (en) 2002-05-22
AR025885A1 (en) 2002-12-18
JP2003510274A (en) 2003-03-18
NZ517988A (en) 2004-10-29
IL148670A (en) 2009-09-01
CN1301712C (en) 2007-02-28
SK287533B6 (en) 2011-01-04
WO2001022954A2 (en) 2001-04-05
WO2001022954A3 (en) 2002-03-28
CZ20021005A3 (en) 2004-01-14
TWI269654B (en) 2007-01-01
BR0014378A (en) 2003-07-29

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Legal Events

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