NO20020348D0 - Peptid acceptor ligeringsmetoder - Google Patents

Peptid acceptor ligeringsmetoder

Info

Publication number
NO20020348D0
NO20020348D0 NO20020348A NO20020348A NO20020348D0 NO 20020348 D0 NO20020348 D0 NO 20020348D0 NO 20020348 A NO20020348 A NO 20020348A NO 20020348 A NO20020348 A NO 20020348A NO 20020348 D0 NO20020348 D0 NO 20020348D0
Authority
NO
Norway
Prior art keywords
peptide acceptor
ligation methods
acceptor ligation
methods
peptide
Prior art date
Application number
NO20020348A
Other languages
English (en)
Other versions
NO20020348L (no
Inventor
Markus Kurz
Peter Lohse
Richard Wagner
Original Assignee
Phylos Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phylos Inc filed Critical Phylos Inc
Publication of NO20020348D0 publication Critical patent/NO20020348D0/no
Publication of NO20020348L publication Critical patent/NO20020348L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NO20020348A 1999-07-27 2002-01-23 Peptid acceptor ligeringsmetoder NO20020348L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14583499P 1999-07-27 1999-07-27
PCT/US2000/019653 WO2001007657A1 (en) 1999-07-27 2000-07-19 Peptide acceptor ligation methods

Publications (2)

Publication Number Publication Date
NO20020348D0 true NO20020348D0 (no) 2002-01-23
NO20020348L NO20020348L (no) 2002-01-23

Family

ID=22514769

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20020348A NO20020348L (no) 1999-07-27 2002-01-23 Peptid acceptor ligeringsmetoder

Country Status (16)

Country Link
US (3) US6429300B1 (no)
EP (2) EP1196637B1 (no)
JP (2) JP4766808B2 (no)
KR (1) KR20020033743A (no)
AT (2) ATE360706T1 (no)
AU (2) AU781783B2 (no)
CA (2) CA2377468C (no)
CY (1) CY1113185T1 (no)
DE (1) DE60034566T2 (no)
DK (2) DK1196637T3 (no)
ES (2) ES2284508T3 (no)
HK (2) HK1045334A1 (no)
IL (1) IL147037A0 (no)
NO (1) NO20020348L (no)
PT (2) PT1196637E (no)
WO (1) WO2001007657A1 (no)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2377468C (en) * 1999-07-27 2010-04-20 Phylos, Inc. Peptide acceptor ligation methods
WO2001051689A1 (en) 2000-01-11 2001-07-19 Nanogen Recognomics Gmbh Biomolecules having multiple attachment moieties for binding to a substrate surface
JP2003530094A (ja) * 2000-03-31 2003-10-14 メモレック シュトッフェル ゲゼルシャフト ミット ベシュレンクテル ハフツング メディツィニッシューモレクラー エントヴィクルンク，ケルン 核酸の抽出方法
WO2003044194A1 (en) * 2001-11-16 2003-05-30 Proteonova, Inc. Selection and evolution of nucleic acids and polypeptides
US20040229271A1 (en) 2000-05-19 2004-11-18 Williams Richard B. Compositions and methods for the identification and selection of nucleic acids and polypeptides
WO2005072087A2 (en) * 2003-12-12 2005-08-11 Proteonova, Inc. System and methods for nucleic acid and polypeptide selection
US7410761B2 (en) * 2000-05-19 2008-08-12 Proteonova, Inc. System for rapid identification and selection of nucleic acids and polypeptides, and method thereof
US6962781B1 (en) 2000-05-19 2005-11-08 Proteonova, Inc. In vitro evolution of nucleic acids and encoded polypeptide
US7129229B2 (en) 2000-08-11 2006-10-31 Nanogen Recognomics Gmbh Hydrazide building blocks and hydrazide modified biomolecules
WO2002014558A2 (en) * 2000-08-11 2002-02-21 Nanogen Recognomics Gmbh New hydrazide building blocks and hydrazide modified biomolecules
JP4963142B2 (ja) * 2000-12-14 2012-06-27 学校法人慶應義塾 遺伝子型と表現型の対応付け分子とその構成要素、および対応付け分子の製造方法と利用方法
EP1401850A1 (en) * 2001-06-20 2004-03-31 Nuevolution A/S Nucleoside derivatives for library preparation
US20060234231A1 (en) * 2001-06-20 2006-10-19 Nuevolution A/S Microarrays displaying encoded molecules
US6893822B2 (en) 2001-07-19 2005-05-17 Nanogen Recognomics Gmbh Enzymatic modification of a nucleic acid-synthetic binding unit conjugate
WO2003012146A1 (en) * 2001-07-31 2003-02-13 Phylos, Inc. Modular assembly of nucleic acid-protein fusion multimers
DE10147074A1 (de) * 2001-09-25 2003-05-08 Beru Ag Verfahren zum Betreiben einer aus mehreren Heizelementen bestehenden mehrstufigen elektrischen Heizung
WO2003045975A2 (en) * 2001-11-27 2003-06-05 Compound Therapeutics, Inc. Solid-phase immobilization of proteins and peptides
DE20200926U1 (de) * 2002-01-23 2002-04-18 Hegenscheidt Mfd Gmbh & Co Kg Festwalzgerät einer Festwalzmaschine für Kurbelwellen
DK1487978T3 (da) * 2002-03-15 2009-03-23 Nuevolution As Forbedret fremgangsmåde til syntese af templatemolekyler
US20050221318A1 (en) * 2002-03-15 2005-10-06 Gouliaev Alex H Building block forming a c-c bond upon reaction
AU2003218630A1 (en) * 2002-03-15 2003-09-29 Nuevolution A/S A building block capable of functional entity transfer to nucleophil
AU2003218629A1 (en) * 2002-03-15 2003-09-29 Nuevolution A/S A building block forming a c-c or a c-hetero atom bond uponreaction
EP1539980B1 (en) 2002-08-01 2016-02-17 Nuevolution A/S Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules
AU2003256857A1 (en) * 2002-08-08 2004-02-25 Dharmacon, Inc. Short interfering rnas having a hairpin structure containing a non-nucleotide loop
JP4895608B2 (ja) * 2002-10-30 2012-03-14 ヌエヴォリューション・アクティーゼルスカブ 二官能性複合体の合成方法
AU2003291964A1 (en) * 2002-12-19 2004-07-14 Nuevolution A/S Quasirandom structure and function guided synthesis methods
WO2004074429A2 (en) 2003-02-21 2004-09-02 Nuevolution A/S Method for producing second-generation library
EP1597394A2 (en) * 2003-02-21 2005-11-23 Nuevolution A/S A method for obtaining structural information about an encoded molecule
DE602004019764D1 (de) * 2003-03-20 2009-04-16 Nuevolution As Ligationsvermittelnde codierung von kleinen molekülen
WO2004110964A2 (en) * 2003-06-16 2004-12-23 Nuevolution A/S Encoded molecules by translation (emt)
WO2005074417A2 (en) * 2003-09-03 2005-08-18 Salk Institute For Biological Studies Multiple antigen detection assays and reagents
DE602004023960D1 (de) 2003-09-18 2009-12-17 Nuevolution As Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
US8299210B2 (en) * 2003-11-20 2012-10-30 Sanofi Pasteur Methods for purifying pertussis toxin and peptides useful therefor
KR20060129246A (ko) 2003-12-05 2006-12-15 컴파운드 쎄라퓨틱스, 인크. 타입 2 혈관 내피 성장 인자 수용체의 억제제
US20090239211A1 (en) * 2004-02-17 2009-09-24 Nuevolution A/S Method For Enrichment Involving Elimination By Mismatch Hybridisation
DK1730277T3 (da) * 2004-03-22 2010-03-01 Nuevolution As Kodning ved ligering under anvendelse af byggebloksoligonukleotider
CA2467321A1 (en) * 2004-05-14 2005-11-14 Paul J. Santerre Polymeric coupling agents and pharmaceutically-active polymers made therefrom
JP4318721B2 (ja) * 2004-10-15 2009-08-26 独立行政法人科学技術振興機構 ｍＲＮＡ−ピューロマイシン−タンパク質連結体作製用リンカー
US10206998B2 (en) 2005-01-12 2019-02-19 Proteonova, Inc. Modular targeted therapeutic agents and methods of making same
US20080199499A1 (en) 2005-01-12 2008-08-21 Proteonova, Inc. Method for Making Targeted Therapeutic Agents
KR20080079643A (ko) 2005-11-16 2008-09-01 암브룩스, 인코포레이티드 비-천연 아미노산을 포함하는 방법 및 조성물
US9574189B2 (en) 2005-12-01 2017-02-21 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries
US7749957B2 (en) 2006-04-06 2010-07-06 E.I. Du Pont De Nemours And Company Clay-binding peptides and methods of use
CA2670471A1 (en) 2006-11-22 2008-06-05 Adnexus, A Bristol-Myers Squibb R&D Company (A Delaware Corporation) Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including igf-ir
JP2010517583A (ja) 2007-02-12 2010-05-27 プロテオノヴァ、 インコーポレイテッド ｍＲＮＡに連結された可溶性ランダムポリペプチドのライブラリーの生成
US7678883B2 (en) * 2007-07-25 2010-03-16 E.I. Du Pont De Nemours And Company Solubility tags for the expression and purification of bioactive peptides
US7829311B2 (en) 2007-07-25 2010-11-09 E.I. Du Pont De Nemours And Company Ketosteroid isomerase inclusion body tag engineered to be acid-resistant by replacing aspartates with glutamate
US7951559B2 (en) * 2007-07-25 2011-05-31 E.I. Du Pont De Nemours And Company Recombinant peptide production using a cross-linkable solubility tag
US7794963B2 (en) 2007-11-02 2010-09-14 E.I. Du Pont De Nemours And Company Use of tetracysteine tags in fluorescence-activated cell sorting analysis of prokaryotic cells producing peptides or proteins
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
CA2707483A1 (en) 2007-11-30 2009-06-11 Wolfgang Fraunhofer Protein formulations and methods of making same
KR20100128291A (ko) 2008-02-14 2010-12-07 브리스톨-마이어스 스큅 컴퍼니 Ｅｇｆｒ에 결합하는 조작된 단백질을 기초로 하는 표적화된 치료제
CA2723265C (en) * 2008-05-02 2015-11-24 Epicentre Technologies Corporation Selective 5' ligation tagging of rna
BRPI0913007A2 (pt) 2008-05-02 2019-09-24 Novartis Ag moléculas de ligação aprimoradas à base de fibronectina e usos das mesmas
EP2799448A1 (en) 2008-05-22 2014-11-05 Bristol-Myers Squibb Company Multivalent fibronectin based scaffold domain proteins
KR20110036638A (ko) 2008-07-25 2011-04-07 리차드 더블유. 와그너 단백질 스크리닝 방법
NZ591544A (en) * 2008-09-30 2013-01-25 Abbott Lab Improved method of rna display
TWI496582B (zh) 2008-11-24 2015-08-21 必治妥美雅史谷比公司 雙重專一性之ｅｇｆｒ／ｉｇｆｉｒ結合分子
US20100158822A1 (en) 2008-12-18 2010-06-24 E .I. Du Pont De Nemours And Company Peptides that bind to silica-coated particles
US8287845B2 (en) * 2008-12-18 2012-10-16 E I Du Pont De Nemours And Company Hair-binding peptides
US20100158846A1 (en) * 2008-12-18 2010-06-24 E. I. Du Pont De Nemours And Company Hair-binding peptides
US20100158837A1 (en) 2008-12-18 2010-06-24 E. I. Du Pont De Nemours And Company Iron oxide-binding peptides
EP2414045A2 (en) * 2009-03-30 2012-02-08 Johnson & Johnson Peptide-based systems for delivery of costmetic agents
WO2010114638A1 (en) 2009-03-30 2010-10-07 E. I. Du Pont De Nemours And Company Peptide-based tooth whitening reagents
JP5733784B2 (ja) * 2009-09-24 2015-06-10 国立大学法人埼玉大学 ｃＤＮＡ／ｍＲＮＡ−タンパク質連結体の効率的合成法
WO2011051327A2 (en) 2009-10-30 2011-05-05 Novartis Ag Small antibody-like single chain proteins
WO2011051466A1 (en) 2009-11-02 2011-05-05 Novartis Ag Anti-idiotypic fibronectin-based binding molecules and uses thereof
WO2011092233A1 (en) 2010-01-29 2011-08-04 Novartis Ag Yeast mating to produce high-affinity combinations of fibronectin-based binders
JP2013519869A (ja) 2010-02-10 2013-05-30 ノバルティス アーゲー 筋肉成長のための方法および化合物
ES2588708T3 (es) * 2010-04-09 2016-11-04 Universiteit Utrecht Holding B.V. Proteínas de la gripe multiméricas recombinantes
EP2558577B1 (en) 2010-04-16 2018-12-12 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
TW201138808A (en) 2010-05-03 2011-11-16 Bristol Myers Squibb Co Serum albumin binding molecules
ES2573108T3 (es) 2010-05-26 2016-06-06 Bristol-Myers Squibb Company Proteínas de armazón a base de fibronectina que tienen estabilidad mejorada
AU2011283646B2 (en) 2010-07-30 2015-07-09 Novartis Ag Fibronectin cradle molecules and libraries thereof
DE102010056289A1 (de) 2010-12-24 2012-06-28 Geneart Ag Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken
US9880160B2 (en) 2011-03-15 2018-01-30 X-Body, Inc. Antibody screening methods
EP2702146B1 (en) 2011-04-28 2018-11-28 The Board of Trustees of The Leland Stanford Junior University Identification of polynucleotides associated with a sample
US9422550B2 (en) 2011-08-01 2016-08-23 The General Hospital Corporation Protein and peptide libraries
MX367013B (es) 2011-10-11 2019-08-02 Medimmune Llc Matrices de soporte derivadas de tn3 especificas para cd40l y sus metodos de empleo.
CA2857721C (en) 2011-12-05 2022-05-31 X-Body, Inc. Pdgf receptor beta binding polypeptides
WO2014142020A1 (ja) 2013-03-13 2014-09-18 国立大学法人東京大学 核酸リンカー
KR102309517B1 (ko) 2013-06-28 2021-10-07 엑스-바디 인코포레이티드 표적 항원 발견, 표현형 선별 및 표적 세포 특이성 표적 에피토프를 규명하기 위한 그의 용도
CN103382579B (zh) * 2013-07-06 2015-10-21 中国科学院成都生物研究所 一种体外筛选多肽的方法
ES2827281T3 (es) 2013-09-23 2021-05-20 X Body Inc Métodos y composiciones para la generación de agentes de unión contra antígenos de superficie celular
US20150184214A1 (en) * 2013-12-31 2015-07-02 Roche Nimblegen, Inc. Enrichment of full length oligonucleotides via transcription/translation mediated purification
CA2937524A1 (en) 2014-02-05 2015-08-13 Molecular Templates, Inc. Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity
CN113150117A (zh) 2014-03-20 2021-07-23 百时美施贵宝公司 新的结合血清白蛋白的纤连蛋白iii型结构域
JP6478392B2 (ja) * 2014-12-26 2019-03-06 国立研究開発法人産業技術総合研究所 核酸リンカー
JP6862348B2 (ja) 2015-03-12 2021-04-21 メディミューン，エルエルシー アルブミン融合タンパク質を精製する方法
EP3708580B1 (en) 2015-09-23 2023-11-01 Bristol-Myers Squibb Company Fast-off rate serum albumin binding fibronectin type iii domains
CN110199019A (zh) 2016-05-02 2019-09-03 Encodia有限公司 采用核酸编码的大分子分析
EP3472355A4 (en) 2016-06-15 2020-07-29 Genecapture, Inc. COMPOSITIONS, METHODS AND DEVICES INCLUDING ROD LOOP MOLECULES-SENSORS
MA45491A (fr) 2016-06-27 2019-05-01 Juno Therapeutics Inc Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés
CN110291402B (zh) 2016-06-27 2023-09-01 朱诺治疗学股份有限公司 鉴定肽表位的方法、结合此类表位的分子和相关用途
CA3057419A1 (en) 2017-03-21 2018-09-27 Fujifilm Corporation Peptide compound and method for producing same, composition for screening use, and method for selecting peptide compound
KR102556494B1 (ko) * 2017-10-31 2023-07-18 엔코디아, 인코포레이티드 핵산 암호화 및/또는 표지를 이용한 분석용 키트
CA3078540A1 (en) 2017-11-30 2019-06-06 Arrakis Therapeutics, Inc. Nucleic acid-binding photoprobes and uses thereof
KR20200121816A (ko) 2018-02-02 2020-10-26 리플 테라퓨틱스 코포레이션 스테로이드 이량체를 포함하는 유리 제제 및 이의 용도
TWI830718B (zh) * 2018-02-09 2024-02-01 日商住友化學股份有限公司 核酸分子之製造方法
CN111971396A (zh) * 2018-03-30 2020-11-20 住友化学株式会社 单链rna的制造方法
WO2019236644A1 (en) * 2018-06-05 2019-12-12 Arrakis Therapeutics, Inc. Encoded libraries and methods of use for screening nucleic acid targets
EP4146664A2 (en) 2020-05-01 2023-03-15 Ripple Therapeutics Corporation Heterodimer compositions and methods for the treatment of ocular disorders

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5391723A (en) * 1989-05-31 1995-02-21 Neorx Corporation Oligonucleotide conjugates
US5843701A (en) 1990-08-02 1998-12-01 Nexstar Pharmaceticals, Inc. Systematic polypeptide evolution by reverse translation
AU8124694A (en) * 1993-10-29 1995-05-22 Affymax Technologies N.V. In vitro peptide and antibody display libraries
DE19646372C1 (de) * 1995-11-11 1997-06-19 Evotec Biosystems Gmbh Genotyp und Phänotyp koppelnde Verbindung
WO1997019193A2 (en) * 1995-11-21 1997-05-29 Yale University Unimolecular segment amplification and detection
US6117635A (en) * 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US5842701A (en) * 1996-10-08 1998-12-01 Smith International, Inc. Dual functioning seal for rock bits
AU729690B2 (en) 1996-10-10 2001-02-08 Henrik Garoff Alphavirus-retrovirus vectors
EP0962527B1 (en) * 1996-10-17 2004-08-04 Mitsubishi Chemical Corporation Molecule that homologizes genotype and phenotype and utilization thereof
US6261804B1 (en) * 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
EP1712623B1 (en) * 1997-01-21 2011-10-19 The General Hospital Corporation Selection of proteins using RNA-protein fusions
US5935791A (en) * 1997-09-23 1999-08-10 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
ATE197817T1 (de) * 1997-12-22 2000-12-15 Genset Sa Prostatakrebs-gen
US5985575A (en) 1998-05-20 1999-11-16 Wisconsin Alumni Research Foundation Tethered function assay for protein function
CA2377468C (en) * 1999-07-27 2010-04-20 Phylos, Inc. Peptide acceptor ligation methods
WO2001016352A1 (en) * 1999-08-27 2001-03-08 Phylos, Inc. Methods for encoding and sorting in vitro translated proteins

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PT1870417E (pt) 2012-06-01
ES2383332T3 (es) 2012-06-20
WO2001007657A1 (en) 2001-02-01
ATE551352T1 (de) 2012-04-15
US20020182687A1 (en) 2002-12-05
JP2010284172A (ja) 2010-12-24
JP2003505094A (ja) 2003-02-12
US20060246549A1 (en) 2006-11-02
CA2377468A1 (en) 2001-02-01
AU781783B2 (en) 2005-06-16
IL147037A0 (en) 2002-08-14
JP5512463B2 (ja) 2014-06-04
EP1870417B1 (en) 2012-03-28
EP1196637A4 (en) 2003-11-12
CY1113185T1 (el) 2016-04-13
PT1196637E (pt) 2007-07-04
US7790421B2 (en) 2010-09-07
AU6111200A (en) 2001-02-13
US6429300B1 (en) 2002-08-06
US7078197B2 (en) 2006-07-18
ATE360706T1 (de) 2007-05-15
AU2005211548B2 (en) 2007-11-29
JP4766808B2 (ja) 2011-09-07
EP1870417B9 (en) 2012-08-01
HK1112007A1 (en) 2008-08-22
EP1196637A1 (en) 2002-04-17
AU2005211548A1 (en) 2005-10-13
HK1045334A1 (zh) 2002-11-22
ES2284508T3 (es) 2007-11-16
DE60034566D1 (de) 2007-06-06
DK1196637T3 (da) 2007-07-30
DK1870417T3 (da) 2012-07-16
EP1196637B1 (en) 2007-04-25
KR20020033743A (ko) 2002-05-07
NO20020348L (no) 2002-01-23
DE60034566T2 (de) 2008-01-03
CA2377468C (en) 2010-04-20
CA2693274A1 (en) 2001-02-01
CA2693274C (en) 2013-05-28
EP1870417A2 (en) 2007-12-26
EP1870417A3 (en) 2008-06-11

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