NL7701398A - Werkwijze ter bereiding van nieuwe chinoline- carbonzuur-3 derivaten, werkwijze ter vervaar- diging van farmaceutische preparaten hiermede, alsmede de aldus gevormde preparaten. - Google Patents

Werkwijze ter bereiding van nieuwe chinoline- carbonzuur-3 derivaten, werkwijze ter vervaar- diging van farmaceutische preparaten hiermede, alsmede de aldus gevormde preparaten.

Info

Publication number: NL7701398A
Authority: NL; Netherlands
Prior art keywords: preparations; hereby; derivatives; manufacture; preparation
Prior art date: 1976-02-11

Application number

NL7701398A

Other languages

English (en)

Dutch (nl)

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-02-11

Filing date

1977-02-10

Publication date

1977-08-15

1977-02-10 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1977-08-15 Publication of NL7701398A publication Critical patent/NL7701398A/xx

Links

238000000034 method Methods 0.000 title 2
238000002360 preparation method Methods 0.000 title 2
238000004519 manufacturing process Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/02—Magnesium compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Pain & Pain Management (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)

NL7701398A 1976-02-11 1977-02-10 Werkwijze ter bereiding van nieuwe chinoline- carbonzuur-3 derivaten, werkwijze ter vervaar- diging van farmaceutische preparaten hiermede, alsmede de aldus gevormde preparaten. NL7701398A (nl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR7603754A FR2340735A1 (fr)	1976-02-11	1976-02-11	Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament

Publications (1)

Publication Number	Publication Date
NL7701398A true NL7701398A (nl)	1977-08-15

Family

ID=9168994

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL7701398A NL7701398A (nl)	1976-02-11	1977-02-10	Werkwijze ter bereiding van nieuwe chinoline- carbonzuur-3 derivaten, werkwijze ter vervaar- diging van farmaceutische preparaten hiermede, alsmede de aldus gevormde preparaten.

Country Status (19)

Country	Link
US (1)	US4107310A (xx)
JP (1)	JPS52116479A (xx)
AU (1)	AU508345B2 (xx)
BE (1)	BE851306A (xx)
CA (1)	CA1089464A (xx)
CH (1)	CH620437A5 (xx)
DD (1)	DD129552A5 (xx)
DE (1)	DE2705446A1 (xx)
DK (1)	DK150512C (xx)
ES (1)	ES455804A1 (xx)
FR (1)	FR2340735A1 (xx)
GB (1)	GB1572482A (xx)
IE (1)	IE44879B1 (xx)
IL (1)	IL51413A (xx)
LU (1)	LU76742A1 (xx)
NL (1)	NL7701398A (xx)
SE (1)	SE441528B (xx)
SU (1)	SU867299A3 (xx)
ZA (1)	ZA77787B (xx)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4190659A (en) *	1973-08-27	1980-02-26	Sandoz, Inc.	Pharmaceutical preparation and use of 4-hydroxy-2-quinolinone-3-carboxylic acid esters
US4281131A (en)	1977-06-20	1981-07-28	Sandoz, Inc.	4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof
US4187309A (en) *	1977-06-20	1980-02-05	Sandoz, Inc.	4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof
US4273930A (en) *	1977-06-20	1981-06-16	Sandoz, Inc.	4-Hydroxy-2-quinolinone-3-carboxylic acid esters
US4221797A (en) *	1978-08-14	1980-09-09	Sandoz, Inc.	Dihydroquinoline-one derivatives
FR2443467A1 (fr) *	1978-12-08	1980-07-04	Roussel Uclaf	Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2482596A1 (fr) *	1980-05-19	1981-11-20	Roussel Uclaf	Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur procede de preparation et leur application comme medicament
US4266050A (en) *	1980-07-02	1981-05-05	American Home Products Corporation	1,2-Dihydro-4-hydroxy-2-imino-N-substituted-3-quinolinecarboxamide derivatives
IE52670B1 (en) *	1981-03-03	1988-01-20	Leo Ab	Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation
FR2523130A1 (fr) *	1982-03-15	1983-09-16	Roussel Uclaf	Nouveaux derives de la n-dihydrothiazolyl-3-quinoleine carboxamide, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
FR2507602A1 (fr) *	1981-06-12	1982-12-17	Roussel Uclaf	Nouveau derive dihydrothiazole de la quinoleine, ses sels, procede de preparation, application a titre de medicaments et compositions les renfermant
HU190796B (en) *	1981-06-12	1986-11-28	Roussel Uclaf,Fr	Process for producing n-dihydrothiazolyl-3-quinoline-carboxamide derivatives
FR2509728A1 (fr) *	1981-07-17	1983-01-21	Roussel Uclaf	Nouveaux derives de la quinoleine, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
FR2537139B2 (fr) *	1982-03-15	1985-09-20	Roussel Uclaf	Nouveau derive de la n-dihydrothiazolyl 3-quinoleine carboxamide, procede de preparation, application a titre de medicament et compositions le renfermant
FR2551437B2 (fr) *	1982-06-03	1985-10-25	Roussel Uclaf	Nouveaux derives de l'acide 4-oh 3-quinoleine carboxylique substitues en 2, nouveau procede de preparation, leur application comme medicament et les compositions les renfermant et produits necessaires a leur preparation
FR2530633A1 (fr) *	1982-06-03	1984-01-27	Roussel Uclaf	Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, et les compositions les renfermant
FR2532939A1 (fr) *	1982-09-13	1984-03-16	Roussel Uclaf	Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, les compositions les renfermant et les nouveaux intermediaires obtenus
FR2537140B1 (fr) *	1982-12-07	1986-07-18	Roussel Uclaf	Nouveaux derives de la 4-hydroxy-3-quinoleine carboxamide, leur sels, procede de preparation, application a titre de medicaments, et compositions les renfermant
SE452170B (sv) *	1983-10-03	1987-11-16	Boliden Ab	Forfarande for utvinning av metall ur koppar och/eller edelmetall innehallande material som innehaller antimon och vismut
FR2566405B1 (fr) *	1984-06-25	1986-09-26	Roussel Uclaf	Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus
US4602014A (en) *	1984-07-09	1986-07-22	Ciba-Geigy Corporation	Ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives as benzodiazepine receptor modulators
JPH0358559A (ja) *	1989-07-26	1991-03-13	Sekisui Chem Co Ltd	電話システム
US5175151A (en) *	1990-09-07	1992-12-29	Schering Corporation	Antiviral compounds and antihypertensive compounds
US5412104A (en) *	1990-09-07	1995-05-02	Schering Corporation	Ester and alkoxy substituted benzopyrans
US5179093A (en) *	1991-05-10	1993-01-12	Schering Corporation	Quinoline-diones
DE4138820A1 (de) *	1991-11-26	1993-05-27	Basf Ag	Chinolin-3-carbonsaeureamide, deren herstellung und verwendung
SE9201076L (sv) *	1992-04-06	1993-10-07	Shimon Slavin	Användningen av gamla läkemedel för behandling av diabetes
SE9400810D0 (sv) *	1994-03-10	1994-03-10	Pharmacia Ab	New use of Quinoline-3-carboxamide compounds
SE9400809D0 (sv) *	1994-03-10	1994-03-10	Pharmacia Ab	New use of quinoline-3-carboxamide compounds
US20100074949A1 (en)	2008-08-13	2010-03-25	William Rowe	Pharmaceutical composition and administration thereof
US8314124B2 (en)	2004-02-06	2012-11-20	Active Biotech Ab	Crystalline salts of quinoline compounds and methods for preparing them
SE0400235D0 (sv) *	2004-02-06	2004-02-06	Active Biotech Ab	New composition containing quinoline compounds
US8354427B2 (en)	2004-06-24	2013-01-15	Vertex Pharmaceutical Incorporated	Modulators of ATP-binding cassette transporters
RU2528046C2 (ru) *	2004-06-24	2014-09-10	Вертекс Фармасьютикалз Инкорпорейтед	Модуляторы транспортеров атф-связывающей кассеты
PL1773816T3 (pl)	2004-06-24	2015-06-30	Vertex Pharma	Modulatory transporterów posiadających kasetę wiążącą ATP
WO2006087830A1 (ja) *	2005-02-18	2006-08-24	Kanebo, Ltd.	帯状織物構造体およびその製法
RS53666B1 (en) *	2005-10-19	2015-04-30	Teva Pharmaceutical Industries Ltd	CRYSTALS OF SODIUM LAKVINIMOD AND THE PROCESS FOR OBTAINING THEM
JP2009521468A (ja) *	2005-12-24	2009-06-04	バーテックスファーマシューティカルズインコーポレイテッド	Ａｂｃ輸送体の調節因子としてのキノリン−４−オン誘導体
HUE049976T2 (hu) *	2005-12-28	2020-11-30	Vertex Pharma	N-[2,4-bisz(1,1-dimetil-etil)-5-hidroxi-fenil]-1,4-dihidro-4-oxo-kinolin-3-karboxamid amorf alakjának gyógyászati kompozíciói
DK2035001T3 (da)	2006-06-12	2012-02-27	Teva Pharma	Stabile laquinimod-tilberedninger
WO2008097976A1 (en) *	2007-02-09	2008-08-14	Kalypsys, Inc.	Heterocyclic modulators of tgr5 for treatment of disease
SI2234485T1 (sl) *	2007-12-20	2014-03-31	Teva Pharmaceutical Industries Ltd.	Stabilni lakvinimodni pripravki
WO2010028015A2 (en) *	2008-09-03	2010-03-11	Auspex Pharmaceuticals, Inc	2-oxo-1,2-dihydro-quinoline modulators of immune function
KR101852173B1 (ko)	2009-03-20	2018-04-27	버텍스 파마슈티칼스 인코포레이티드	낭성 섬유증 막횡단 전도도 조절자의 조정자의 제조 방법
JP5882208B2 (ja) *	2009-07-30	2016-03-09	テバファーマシューティカルインダストリーズリミティド	ラキニモドによるクローン病の治療
AU2010282948C1 (en) *	2009-08-10	2017-03-02	Active Biotech, Ab	Treatment of BDNF-related disorders using laquinimod
SG183513A1 (en) *	2010-03-03	2012-09-27	Teva Pharma	Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate
ES2601819T3 (es) *	2010-03-03	2017-02-16	Teva Pharmaceutical Industries Ltd.	Tratamiento de la artritis lúpica usando laquinimod
MX337614B (es) *	2010-03-03	2016-03-10	Teva Pharma	Tratamiento de lupus nefritis usando laquinimod.
CN102267984B (zh) *	2010-06-04	2014-07-30	中国人民解放军军事医学科学院毒物药物研究所	4-羟基喹啉-3-酰胺衍生物及其制备方法和用途
BR112013007850A2 (pt)	2010-10-14	2016-06-07	Immunahr Ab	1,2-diidro-4-hidróxi-2-oxo-quinolina-3-carboxanilidas como ativadores de ahr
US8802700B2 (en)	2010-12-10	2014-08-12	Vertex Pharmaceuticals Incorporated	Modulators of ATP-Binding Cassette transporters
EP2537517A1 (en) *	2011-06-22	2012-12-26	Active Biotech AB	Deuterium-enriched 4-hydroxy-5-methoxy-n,1-dimethyl-2-oxo-n-[(4-trifluoro-methyl)phenyl]-1,2-dihydroquinoline-3-carboxamide
EP2766020A4 (en)	2011-10-12	2015-04-01	Teva Pharma	TREATMENT OF MULTIPLE SCLEROSIS BY COMBINING LAQUINIMOD AND FINGOLIMOD
SG11201404214QA (en)	2012-02-03	2014-08-28	Teva Pharma	USE OF LAQUINIMOD FOR TREATING CROHN'S DISEASE PATIENTS WHO FAILED FIRST-LINE ANTI-TNFα THERAPY
BR112014021090B1 (pt)	2012-02-27	2023-01-24	Vertex Pharmaceuticals Incorporated	Composição farmacêutica e uso de n-[2,4-bis(1,1-dimetiletil)-5-hidróxifenil]-1,4-di-hidro-4-oxoquinolina3-carboxamida na preparação da mesma
TW201400117A (zh)	2012-06-05	2014-01-01	Teva Pharma	使用拉喹莫德治療眼發炎疾病
CA2890194A1 (en)	2012-11-07	2014-05-15	Teva Pharmaceutical Industries Ltd.	Amine salts of laquinimod
EP2951168B1 (en)	2013-01-31	2017-01-04	Vertex Pharmaceuticals Incorporated	Quinoline and quinoxaline amides as modulators of sodium channels
US20160046582A1 (en)	2013-03-14	2016-02-18	Teva Pharmaceutical Industries Ltd.	Crystals of laquinimod sodium and improved process for the manufacture thereof
SG11201608674UA (en)	2014-04-29	2016-11-29	Teva Pharma	Laquinimod for the treatment of relapsing-remitting multiple sclerosis (rrms) patients with a high disability status
KR20170063954A (ko)	2014-10-07	2017-06-08	버텍스 파마슈티칼스 인코포레이티드	낭성 섬유증 막횡단 전도도 조절자의 조정제의 공-결정

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL289475A (xx) *	1962-03-01
US3749731A (en) *	1971-07-08	1973-07-31	Warner Lambert Co	2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide
FR2281761A1 (fr) *	1974-08-13	1976-03-12	Roussel Uclaf	Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament

1976
- 1976-02-11 FR FR7603754A patent/FR2340735A1/fr active Granted
1977
- 1977-01-26 SE SE7700804A patent/SE441528B/xx not_active IP Right Cessation
- 1977-02-07 US US05/766,487 patent/US4107310A/en not_active Expired - Lifetime
- 1977-02-09 CA CA271,429A patent/CA1089464A/fr not_active Expired
- 1977-02-09 DD DD7700197299A patent/DD129552A5/xx not_active IP Right Cessation
- 1977-02-09 DE DE19772705446 patent/DE2705446A1/de active Granted
- 1977-02-10 IE IE289/77A patent/IE44879B1/en unknown
- 1977-02-10 JP JP1313977A patent/JPS52116479A/ja active Granted
- 1977-02-10 IL IL51413A patent/IL51413A/xx unknown
- 1977-02-10 ES ES455804A patent/ES455804A1/es not_active Expired
- 1977-02-10 NL NL7701398A patent/NL7701398A/xx not_active Application Discontinuation
- 1977-02-10 GB GB5556/77A patent/GB1572482A/en not_active Expired
- 1977-02-10 DK DK056077A patent/DK150512C/da not_active IP Right Cessation
- 1977-02-10 SU SU772450451A patent/SU867299A3/ru active
- 1977-02-10 BE BE174832A patent/BE851306A/xx not_active IP Right Cessation
- 1977-02-10 LU LU76742A patent/LU76742A1/xx unknown
- 1977-02-10 ZA ZA00770787A patent/ZA77787B/xx unknown
- 1977-02-11 AU AU22218/77A patent/AU508345B2/en not_active Expired
- 1977-02-11 CH CH172177A patent/CH620437A5/fr not_active IP Right Cessation

Also Published As

Publication number	Publication date
BE851306A (fr)	1977-08-10
CH620437A5 (xx)	1980-11-28
ZA77787B (en)	1978-03-29
SU867299A3 (ru)	1981-09-23
DE2705446C2 (xx)	1989-10-12
JPS52116479A (en)	1977-09-29
GB1572482A (en)	1980-07-30
AU2221877A (en)	1978-08-17
IL51413A (en)	1980-09-16
IE44879B1 (en)	1982-05-05
DE2705446A1 (de)	1977-08-18
SE441528B (sv)	1985-10-14
DK150512C (da)	1987-11-16
FR2340735A1 (fr)	1977-09-09
IL51413A0 (en)	1977-04-29
JPS623152B2 (xx)	1987-01-23
AU508345B2 (en)	1980-03-20
CA1089464A (fr)	1980-11-11
DK56077A (da)	1977-08-12
ES455804A1 (es)	1978-01-16
SE7700804L (sv)	1977-08-12
DK150512B (da)	1987-03-16
IE44879L (en)	1977-08-11
FR2340735B1 (xx)	1978-11-03
LU76742A1 (xx)	1977-08-19
US4107310A (en)	1978-08-15
DD129552A5 (de)	1978-01-25

Legal Events

Date	Code	Title
1983-06-01	BV	The patent application has lapsed
1984-01-02	BA	A request for search or an international-type search has been filed
1984-02-01	BB	A search report has been drawn up
1984-06-01	BC	A request for examination has been filed
1985-01-01	A85	Still pending on 85-01-01
1990-10-01	BV	The patent application has lapsed

Publication	Publication Date	Title
NL7701398A (nl)	1977-08-15	Werkwijze ter bereiding van nieuwe chinoline- carbonzuur-3 derivaten, werkwijze ter vervaar- diging van farmaceutische preparaten hiermede, alsmede de aldus gevormde preparaten.
NL7704057A (nl)	1977-10-18	Werkwijze ter bereiding van nieuwe cefolosporine- derivaten, werkwijze ter bereiding van farmaceu- tische preparaten en gevormde farmaceutische preparaten.
NL7503696A (nl)	1975-09-30	Werkwijze ter vervaardiging van farmaceutische preparaten, alsmede de aldus gevormde voort- brengselen.
NL7707129A (nl)	1978-03-10	Werkwijze ter bereiding van nieuwe cefalospori- nederivaten, werkwijze ter bereiding van far- maceutische preparaten en aldus verkregen ge- vormde preparaten.
NL7506675A (nl)	1975-12-09	Werkwijze ter bereiding van alkanolaminederivaten, werkwijze ter vervaardiging van farmaceutische pre- paraten hiermede, alsmede de aldus vervaardigde voortbrengselen.
NL7611975A (nl)	1977-05-02	Werkwijze ter bereiding van farmaceutische pre- paraten, aldus verkregen gevormde preparaten en werkwijze ter bereiding van nieuwe 2-fenyl 3-aroyl- benzothiofeenderivaten.
NL7611394A (nl)	1977-04-18	Werkwijze ter bereiding van nieuwe pyridinederi- vaten en farmaceutische preparaten.
NL7603569A (nl)	1976-10-11	Werkwijze ter bereiding van nieuwe erythromycine- derivaten, werkwijze ter vervaardiging van farma- ceutische preparaten hiermede, alsmede de aldus gevormde voortbrengselen.
NL7510535A (nl)	1976-03-09	Werkwijze ter bereiding van nieuwe arylpiperi- dinen, alsmede werkwijze ter bereiding van farmaceutische preparaten.
NL7705738A (nl)	1977-11-29	Werkwijze voor de bereiding van nieuwe farma- ceutische preparaten.
NL7710502A (nl)	1978-03-29	Werkwijze ter bereiding van farmaceutische pre- paraten alsmede werkwijze ter bereiding van nieuwe, analgetisch werkzame verbindingen.
NL7704566A (nl)	1977-11-01	Werkwijze ter bereiding van nieuwe 1,2-dihydro- naftaleenderivaten, alsmede werkwijze ter bereiding van farmaceutische preparaten.
NL7702446A (nl)	1977-09-13	Werkwijze ter bereiding van nieuwe 2.3-dihydro- -imidazo(2.1-b)thiazolen, werkwijze ter berei- ding van farmaceutische preparaten en aldus verkregen gevormde preparaten.
NL7415174A (nl)	1975-05-23	Werkwijze ter bereiding van nieuwe verbindingen, werkwijze ter vervaardiging van farmaceutische preparaten hiermede, alsmede de aldus gevormde voortbrengselen.
NL7607254A (nl)	1977-02-08	Werkwijze ter bereiding van nieuwe thienopy- ridinederivaten en werkwijze ter bereiding van farmaceutische preparaten.
NL7606612A (nl)	1976-12-27	Werkwijze ter bereiding van nieuwe farmaceutische preparaten.
NL7505140A (nl)	1975-11-11	Werkwijze ter bereiding van morfolinederivaten, werkwijze ter vervaardiging van farmaceutische preparaten hiermede, alsmede de aldus gevormde voortbrengselen.
NL7604209A (nl)	1976-10-26	Werkwijze ter bereiding van nieuwe piperi- dinoverbindingen, werkwijze ter vervaardiging van anticaries en antiperiodontitispreparaten hiermede, alsmede de aldus gevormde voort- brengselen.
NL7601411A (nl)	1976-08-16	Werkwijze ter bereiding van nieuwe o-aminooxi- men, alsmede werkwijze ter bereiding van far- maceutische preparaten en aldus verkregen ge- vormde farmaceutische preparaten.
NL7514177A (nl)	1976-06-09	Werkwijze ter bereiding van nieuwe ergolinederi- vaten, alsmede werkwijze ter bereiding van farma- ceutische preparaten die deze ergolinederivaten bevatten.
NL7700203A (nl)	1977-08-09	Werkwijze ter bereiding van farmaceutische pre- paraten, alsmede aldus verkregen gevormde pre- paraten.
NL7508706A (nl)	1976-01-26	Werkwijze ter bereiding van pyrazofurinederivaten, alsmede werkwijze ter bereiding van farmaceutische preparaten.
NL7706742A (nl)	1977-12-23	Werkwijze ter bereiding van farmaceutische preparaten en werkwijze ter bereiding van nieuwe cefalosplrinederivaten.
NL7506011A (nl)	1975-12-05	Werkwijze ter bereiding van nieuwe derivaten van benzodiazepinen en van farmaceutische preparaten, die deze nieuwe derivaten bevatten.
NL7514113A (nl)	1976-06-09	Werkwijze ter bereiding van farmaceutische prepa- raten, gevormde farmaceutische preparaten, alsme- de werkwijze ter bereiding van nieuwe cefemverbin- dingen.