NI201600129A - Inhibidores de diacilglicerol aciltransferasa 2 - Google Patents

Inhibidores de diacilglicerol aciltransferasa 2

Info

Publication number
NI201600129A
NI201600129A NI201600129A NI201600129A NI201600129A NI 201600129 A NI201600129 A NI 201600129A NI 201600129 A NI201600129 A NI 201600129A NI 201600129 A NI201600129 A NI 201600129A NI 201600129 A NI201600129 A NI 201600129A
Authority
NI
Nicaragua
Prior art keywords
diacilglicerol
aciltransferase
inhibitors
dgat2
animals
Prior art date
Application number
NI201600129A
Other languages
English (en)
Inventor
Cabral Shawn
Futatsugi Kentaro
Hepworth David
Huard Kim
Wei-Shung Kung Daniel
Tuula Marjukka Orr Suvi
Song Kun
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NI201600129A publication Critical patent/NI201600129A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
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Abstract

En la presente se decriben compuestos de la Fórmula Ique inhiben la actividad de la diacilglicerol aciltransferasa 2 (DGAT2) y sus usos en el tratamiento de enfermedades relacionadas con estos en animales.
NI201600129A 2014-03-17 2016-09-05 Inhibidores de diacilglicerol aciltransferasa 2 NI201600129A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461954351P 2014-03-17 2014-03-17

Publications (1)

Publication Number Publication Date
NI201600129A true NI201600129A (es) 2016-11-18

Family

ID=52682788

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201600129A NI201600129A (es) 2014-03-17 2016-09-05 Inhibidores de diacilglicerol aciltransferasa 2

Country Status (39)

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US (3) US9440949B2 (es)
EP (1) EP3119757B1 (es)
JP (1) JP6152229B2 (es)
KR (1) KR101772836B1 (es)
CN (1) CN106103425A (es)
AP (1) AP2016009407A0 (es)
AR (1) AR099768A1 (es)
AU (1) AU2015233094B2 (es)
CA (1) CA2942759C (es)
CL (1) CL2016002169A1 (es)
CR (1) CR20160405A (es)
CU (1) CU24395B1 (es)
CY (1) CY1120354T1 (es)
DK (1) DK3119757T3 (es)
DO (1) DOP2016000248A (es)
EA (1) EA032356B1 (es)
EC (1) ECSP16072034A (es)
ES (1) ES2674240T3 (es)
GE (1) GEP20186864B (es)
HR (1) HRP20180992T1 (es)
HU (1) HUE039446T2 (es)
IL (1) IL247809A0 (es)
LT (1) LT3119757T (es)
MA (1) MA39753B1 (es)
MD (1) MD20160099A2 (es)
MX (1) MX2016012008A (es)
NI (1) NI201600129A (es)
PE (1) PE20161368A1 (es)
PH (1) PH12016501654A1 (es)
PL (1) PL3119757T3 (es)
PT (1) PT3119757T (es)
RS (1) RS57384B1 (es)
SG (1) SG11201606779RA (es)
SI (1) SI3119757T1 (es)
SV (1) SV2016005279A (es)
TR (1) TR201809388T4 (es)
TW (1) TWI551596B (es)
UY (1) UY36033A (es)
WO (1) WO2015140658A1 (es)

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AR109179A1 (es) * 2016-08-19 2018-11-07 Pfizer Inhibidores de diacilglicerol aciltransferasa 2
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KR20240036703A (ko) * 2016-11-11 2024-03-20 새지메트 바이오사이언시스, 인코포레이티드 지질 합성의 헤테로사이클릭 조절인자
GB201815018D0 (en) * 2018-09-14 2018-10-31 Univ Oxford Innovation Ltd Enantiomeric compounds
CN110305966B (zh) * 2019-06-18 2023-03-28 广西壮族自治区水产科学研究院 一种罗非鱼肝脏dgat2基因表达的调控方法
TWI771766B (zh) 2019-10-04 2022-07-21 美商輝瑞股份有限公司 二醯基甘油醯基轉移酶２ 抑制劑
BR112022012352A2 (pt) 2019-12-23 2022-09-06 Lg Chemical Ltd Novo derivado de amida útil como inibidor de diacilglicerol aciltransferase 2 e uso do mesmo
JOP20220158A1 (ar) * 2019-12-23 2023-01-30 Lg Chemical Ltd مشتق أمينو أريل جديد مفيد كمثبط لثنائي أسيل غليسيرول أسيل ترانسفيراز 2 diacylglycerol acyltransferase 2 واستخدامه
WO2021161222A1 (en) * 2020-02-11 2021-08-19 Inorbit Therapeutics Ab Compounds useful in inhibiting diacylglycerol o-acyltransferase and methods of making and using the same
JP2022058085A (ja) 2020-02-24 2022-04-11 ファイザー・インク ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ
US11478533B2 (en) 2020-04-27 2022-10-25 Novo Nordisk A/S Semaglutide for use in medicine
EP4153596A1 (en) 2020-05-18 2023-03-29 Merck Sharp & Dohme LLC Novel diacylglyceride o-acyltransferase 2 inhibitors
TWI817191B (zh) * 2020-09-04 2023-10-01 南韓商Ｌｇ化學股份有限公司 新穎聯芳基衍生物及其作為針對二醯基甘油醯基轉移酶２之抑制劑之用途
MX2023003842A (es) 2020-10-08 2023-04-14 Merck Sharp & Dohme Llc Preparacion de derivados de benzoimidazolona como nuevos inhibidores de la diacilglicerol o-aciltransferasa 2.
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