NI201200132A - Derivados de arilmetoxi isoindolina y composiciones que los comprenden y metodos para utilizar los mismos - Google Patents

Derivados de arilmetoxi isoindolina y composiciones que los comprenden y metodos para utilizar los mismos

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Publication number
NI201200132A
NI201200132A NI201200132A NI201200132A NI201200132A NI 201200132 A NI201200132 A NI 201200132A NI 201200132 A NI201200132 A NI 201200132A NI 201200132 A NI201200132 A NI 201200132A NI 201200132 A NI201200132 A NI 201200132A
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NI
Nicaragua
Prior art keywords
methods
compositions
arylmetoxy
isoindoline derivatives
compounds
Prior art date
Application number
NI201200132A
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English (en)
Inventor
- Wah Man Hon
W Muller George
Ruchelman Alexander
M Khalil Ehab
Shen-Chu Chen Roger
Zhang Weihong
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Celgene Corp
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Application filed by Celgene Corp filed Critical Celgene Corp
Publication of NI201200132A publication Critical patent/NI201200132A/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/10—Spiro-condensed systems
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    • C07D498/08—Bridged systems

Abstract

Se proporcionan compuestos de 4' - arilmetoxi isoindolina, y sales, solvatos, clatratos, estereoisómeros y profármacos farmacéuticamente aceptables de los mismos. Se describen los métodos de uso, y las composiciones farmacéuticas de estos compuestos. Los compuestos son derivados de hidroxi talidomida activa contra el cáncer.
NI201200132A 2010-02-11 2012-08-09 Derivados de arilmetoxi isoindolina y composiciones que los comprenden y metodos para utilizar los mismos NI201200132A (es)

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US30361810P 2010-02-11 2010-02-11

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NI201200132A true NI201200132A (es) 2013-04-22

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US (8) US8518972B2 (es)
EP (6) EP4289838A3 (es)
JP (5) JP2013519675A (es)
KR (2) KR101931468B1 (es)
CN (2) CN102822165B (es)
AR (1) AR081058A1 (es)
AU (1) AU2011215877C1 (es)
CA (1) CA2787823C (es)
CO (1) CO6571916A2 (es)
CR (1) CR20120414A (es)
CY (3) CY1119177T1 (es)
DK (3) DK2536706T3 (es)
EC (1) ECSP12012098A (es)
ES (5) ES2713482T3 (es)
HR (3) HRP20171078T1 (es)
HU (3) HUE044652T2 (es)
IL (2) IL220992A (es)
LT (3) LT3202460T (es)
ME (2) ME03441B (es)
MX (3) MX2012009237A (es)
NI (1) NI201200132A (es)
NZ (3) NZ717149A (es)
PH (1) PH12014501082B1 (es)
PL (3) PL2536706T3 (es)
PT (3) PT3202460T (es)
RS (3) RS58523B1 (es)
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SG (3) SG183257A1 (es)
SI (3) SI2536706T1 (es)
TR (1) TR201903027T4 (es)
UA (2) UA114856C2 (es)
WO (1) WO2011100380A1 (es)

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