NI201000107A - Derivados de tiazol utilizados como inhibidores de pi 3 - cinasa. - Google Patents
Derivados de tiazol utilizados como inhibidores de pi 3 - cinasa.Info
- Publication number
- NI201000107A NI201000107A NI201000107A NI201000107A NI201000107A NI 201000107 A NI201000107 A NI 201000107A NI 201000107 A NI201000107 A NI 201000107A NI 201000107 A NI201000107 A NI 201000107A NI 201000107 A NI201000107 A NI 201000107A
- Authority
- NI
- Nicaragua
- Prior art keywords
- kinase
- inhibitors
- derivatives used
- thiazol derivatives
- thiazol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
La presente invención se refiere a compuestos de la Fórmula (I); y sus sales, en donde los sustituyentes son como los definidos en la descripción; a composiciones y uso de los compuestos en el tratamiento de enfermedades; mejoradas por la inhibición de la fosfaditilinositol 3-cinasa.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07150228 | 2007-12-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
NI201000107A true NI201000107A (es) | 2011-03-15 |
Family
ID=39273277
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NI201000107A NI201000107A (es) | 2007-12-20 | 2010-06-18 | Derivados de tiazol utilizados como inhibidores de pi 3 - cinasa. |
Country Status (28)
Country | Link |
---|---|
US (1) | US8940771B2 (es) |
EP (1) | EP2240475B1 (es) |
JP (1) | JP2011506560A (es) |
KR (1) | KR20100093129A (es) |
CN (1) | CN101952282A (es) |
AR (1) | AR069798A1 (es) |
AU (1) | AU2008340053A1 (es) |
BR (1) | BRPI0820722A2 (es) |
CA (1) | CA2710122A1 (es) |
CL (1) | CL2008003822A1 (es) |
CO (1) | CO6321276A2 (es) |
CR (1) | CR11491A (es) |
DO (1) | DOP2010000183A (es) |
EA (1) | EA201000947A1 (es) |
EC (1) | ECSP10010271A (es) |
ES (1) | ES2437595T3 (es) |
IL (1) | IL206286A0 (es) |
MA (1) | MA31903B1 (es) |
NI (1) | NI201000107A (es) |
PA (1) | PA8809001A1 (es) |
PE (1) | PE20091523A1 (es) |
SM (1) | SMP201000096B (es) |
SV (1) | SV2010003598A (es) |
TN (1) | TN2010000293A1 (es) |
TW (1) | TW200930364A (es) |
UY (1) | UY31545A1 (es) |
WO (1) | WO2009080694A1 (es) |
ZA (1) | ZA201003928B (es) |
Families Citing this family (26)
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TW200519106A (en) * | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
KR20100049068A (ko) | 2007-07-17 | 2010-05-11 | 리겔 파마슈티칼스, 인크. | Pkc 억제제로서의 시클릭 아민 치환된 피리미딘디아민 |
UA104147C2 (uk) | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
UY32748A (es) * | 2009-07-02 | 2011-01-31 | Novartis Ag | 2-carboxamida-cicloamino-ureas |
US8293753B2 (en) * | 2009-07-02 | 2012-10-23 | Novartis Ag | Substituted 2-carboxamide cycloamino ureas |
CN102596963A (zh) | 2009-09-10 | 2012-07-18 | 诺瓦提斯公司 | 二环杂芳基的醚衍生物 |
JP2013512215A (ja) | 2009-11-25 | 2013-04-11 | ノバルティス アーゲー | 二環式ヘテロアリールのベンゼン縮合6員酸素含有ヘテロ環誘導体 |
US20130085161A1 (en) | 2010-06-17 | 2013-04-04 | Novartis Ag | Piperidinyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives |
WO2011157787A1 (en) | 2010-06-17 | 2011-12-22 | Novartis Ag | Biphenyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives |
WO2012062694A1 (en) * | 2010-11-08 | 2012-05-18 | Novartis Ag | Use of 2-carboxamide cycloamino urea derivatives in the treatment of egfr dependent diseases or diseases that have acquired resistance to agents that target egfr family members |
UA112539C2 (uk) | 2011-03-03 | 2016-09-26 | Новартіс Аг | Спосіб одержання похідних 2-карбоксамідциклоаміносечовини |
EP2683722A1 (en) | 2011-03-08 | 2014-01-15 | Novartis AG | Fluorophenyl bicyclic heteroaryl compounds |
US9926309B2 (en) | 2011-10-05 | 2018-03-27 | The Board Of Trustees Of The Leland Stanford Junior University | Pi-kinase inhibitors with anti-infective activity |
EP2763532B1 (en) | 2011-10-05 | 2018-09-19 | The Board of Trustees of the Leland Stanford Junior University | Pi-kinase inhibitors with broad spectrum anti-infective activity |
JP2015512416A (ja) * | 2012-03-30 | 2015-04-27 | ノバルティス アーゲー | 神経芽細胞腫、ユーイング肉腫または横紋筋肉腫の治療に使用するための化合物 |
KR20160027219A (ko) | 2012-05-23 | 2016-03-09 | 에프. 호프만-라 로슈 아게 | 내배엽 및 간세포를 수득하고 사용하는 조성물 및 방법 |
PT2897644T (pt) * | 2012-09-20 | 2018-10-16 | Novartis Ag | Associação farmacêutica compreendendo um inibidor de fosfatidilinositol 3-quinase e um inibidor da aromatase |
CN103232406B (zh) * | 2013-04-26 | 2015-07-29 | 北京大学 | 一种1,3-噻唑衍生物 |
GB201308278D0 (en) * | 2013-05-08 | 2013-06-12 | Imp Innovations Ltd | Labelled Carboxylic Acids and Their Uses in Molecular Imaging |
WO2017004383A1 (en) * | 2015-06-30 | 2017-01-05 | Dana-Farber Cancer Institute, Inc. | Inhibitors of egfr and methods of use thereof |
CN105294546B (zh) * | 2015-10-29 | 2017-12-08 | 天津市斯芬克司药物研发有限公司 | 一种吡啶化合物及其制备方法 |
EP3419980A4 (en) | 2016-02-26 | 2019-07-03 | The Board of Trustees of the Leland Stanford Junior University | INHIBITORS OF PI-KINASE WITH ANTI-INFECTIOUS ACTIVITY |
CN109111439B (zh) * | 2017-06-26 | 2020-09-18 | 深圳市塔吉瑞生物医药有限公司 | 一种酰胺类化合物及包含该化合物的组合物及其用途 |
CA3115103A1 (en) * | 2018-10-05 | 2020-04-09 | Sloan-Kettering Institute For Cancer Research | Pi3k inhibitors and uses thereof |
CN110759900B (zh) * | 2019-10-25 | 2021-07-30 | 沈阳药科大学 | 噻吩类化合物的制备方法和用途 |
WO2021142006A1 (en) * | 2020-01-07 | 2021-07-15 | Disarm Therapeutics, Inc. | Inhibitors of sarm1 |
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-
2008
- 2008-12-18 CN CN200880127267XA patent/CN101952282A/zh active Pending
- 2008-12-18 AU AU2008340053A patent/AU2008340053A1/en not_active Abandoned
- 2008-12-18 AR ARP080105519A patent/AR069798A1/es unknown
- 2008-12-18 WO PCT/EP2008/067859 patent/WO2009080694A1/en active Application Filing
- 2008-12-18 UY UY31545A patent/UY31545A1/es not_active Application Discontinuation
- 2008-12-18 ES ES08865012.2T patent/ES2437595T3/es active Active
- 2008-12-18 EP EP08865012.2A patent/EP2240475B1/en active Active
- 2008-12-18 JP JP2010538723A patent/JP2011506560A/ja not_active Ceased
- 2008-12-18 CA CA2710122A patent/CA2710122A1/en not_active Abandoned
- 2008-12-18 EA EA201000947A patent/EA201000947A1/ru unknown
- 2008-12-18 PE PE2008002131A patent/PE20091523A1/es not_active Application Discontinuation
- 2008-12-18 KR KR1020107015995A patent/KR20100093129A/ko not_active Application Discontinuation
- 2008-12-18 BR BRPI0820722-4A patent/BRPI0820722A2/pt not_active IP Right Cessation
- 2008-12-18 US US12/338,432 patent/US8940771B2/en active Active
- 2008-12-18 PA PA20088809001A patent/PA8809001A1/es unknown
- 2008-12-19 TW TW097149899A patent/TW200930364A/zh unknown
- 2008-12-19 CL CL2008003822A patent/CL2008003822A1/es unknown
-
2010
- 2010-06-02 ZA ZA2010/03928A patent/ZA201003928B/en unknown
- 2010-06-08 MA MA32896A patent/MA31903B1/fr unknown
- 2010-06-10 IL IL206286A patent/IL206286A0/en unknown
- 2010-06-10 CR CR11491A patent/CR11491A/es not_active Application Discontinuation
- 2010-06-17 DO DO2010000183A patent/DOP2010000183A/es unknown
- 2010-06-18 TN TN2010000293A patent/TN2010000293A1/fr unknown
- 2010-06-18 EC EC2010010271A patent/ECSP10010271A/es unknown
- 2010-06-18 NI NI201000107A patent/NI201000107A/es unknown
- 2010-06-18 SV SV2010003598A patent/SV2010003598A/es not_active Application Discontinuation
- 2010-06-21 CO CO10074465A patent/CO6321276A2/es not_active Application Discontinuation
- 2010-07-20 SM SM201000096T patent/SMP201000096B/it unknown
Also Published As
Publication number | Publication date |
---|---|
PE20091523A1 (es) | 2009-10-29 |
ECSP10010271A (es) | 2010-07-30 |
KR20100093129A (ko) | 2010-08-24 |
MA31903B1 (fr) | 2010-12-01 |
PA8809001A1 (es) | 2009-07-23 |
AU2008340053A1 (en) | 2009-07-02 |
CR11491A (es) | 2010-08-05 |
SMP201000096B (it) | 2011-09-09 |
IL206286A0 (en) | 2010-12-30 |
TW200930364A (en) | 2009-07-16 |
US20090163469A1 (en) | 2009-06-25 |
BRPI0820722A2 (pt) | 2015-06-16 |
CN101952282A (zh) | 2011-01-19 |
AR069798A1 (es) | 2010-02-17 |
EP2240475A1 (en) | 2010-10-20 |
SMAP201000096A (it) | 2010-09-10 |
CO6321276A2 (es) | 2011-09-20 |
TN2010000293A1 (en) | 2011-11-11 |
EA201000947A1 (ru) | 2011-02-28 |
CA2710122A1 (en) | 2009-07-02 |
DOP2010000183A (es) | 2010-07-31 |
ZA201003928B (en) | 2011-04-28 |
SV2010003598A (es) | 2011-03-23 |
WO2009080694A1 (en) | 2009-07-02 |
JP2011506560A (ja) | 2011-03-03 |
CL2008003822A1 (es) | 2009-06-26 |
US8940771B2 (en) | 2015-01-27 |
ES2437595T3 (es) | 2014-01-13 |
UY31545A1 (es) | 2009-08-03 |
EP2240475B1 (en) | 2013-09-25 |
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