MXPA03007563A - Recuperacion incrementada de proteinas activas. - Google Patents
Recuperacion incrementada de proteinas activas.Info
- Publication number
- MXPA03007563A MXPA03007563A MXPA03007563A MXPA03007563A MXPA03007563A MX PA03007563 A MXPA03007563 A MX PA03007563A MX PA03007563 A MXPA03007563 A MX PA03007563A MX PA03007563 A MXPA03007563 A MX PA03007563A MX PA03007563 A MXPA03007563 A MX PA03007563A
- Authority
- MX
- Mexico
- Prior art keywords
- active proteins
- increased recovery
- proteins
- preparations
- reduction
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Measurement Of Radiation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27103301P | 2001-02-23 | 2001-02-23 | |
| PCT/US2002/005645 WO2002068455A2 (en) | 2001-02-23 | 2002-02-22 | Efficient recovery of correctly refolded proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03007563A true MXPA03007563A (es) | 2003-12-11 |
Family
ID=23033913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03007563A MXPA03007563A (es) | 2001-02-23 | 2002-02-22 | Recuperacion incrementada de proteinas activas. |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7157557B2 (es) |
| EP (1) | EP1366062B1 (es) |
| JP (1) | JP2005505494A (es) |
| KR (1) | KR20040052481A (es) |
| CN (1) | CN1547586A (es) |
| AT (1) | ATE517909T1 (es) |
| AU (1) | AU2002255600B2 (es) |
| BG (1) | BG108087A (es) |
| CA (1) | CA2438094C (es) |
| CZ (1) | CZ20032208A3 (es) |
| EE (1) | EE200300408A (es) |
| ES (1) | ES2370235T3 (es) |
| HK (1) | HK1059267A1 (es) |
| HU (1) | HUP0303246A2 (es) |
| IL (1) | IL157446A0 (es) |
| MX (1) | MXPA03007563A (es) |
| PL (1) | PL374045A1 (es) |
| RU (1) | RU2316563C2 (es) |
| SK (1) | SK10472003A3 (es) |
| WO (1) | WO2002068455A2 (es) |
| ZA (1) | ZA200305909B (es) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA03007563A (es) * | 2001-02-23 | 2003-12-11 | Immunex Corp | Recuperacion incrementada de proteinas activas. |
| EP1660094A4 (en) | 2003-08-26 | 2009-09-16 | Univ Colorado | INHIBITORS OF SERINE PROTEASE ACTIVITY AND USES THEREOF IN METHODS AND PREPARATIONS FOR TREATING BACTERIAL INFECTIONS |
| WO2006060083A1 (en) * | 2004-10-22 | 2006-06-08 | Amgen Inc. | Methods for refolding polypeptides |
| EA012162B1 (ru) * | 2004-10-22 | 2009-08-28 | Эмджен Инк. | Способ рефолдинга рекомбинантных антител |
| EP1844069A4 (en) * | 2005-01-28 | 2009-05-20 | Apollo Life Sciences Ltd | MOLECULES AND CHIMESE MOLECULES THEREOF |
| JP5053264B2 (ja) | 2005-05-19 | 2012-10-17 | アムジェン インコーポレイテッド | 抗体の安定性を増加させるための組成物および方法 |
| EA012801B1 (ru) | 2005-06-14 | 2009-12-30 | Эмджен Инк. | Самобуферирующиеся композиции белков |
| JP5335422B2 (ja) * | 2005-06-17 | 2013-11-06 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 少なくとも１つの非天然のシステインを含んでいる操作されたタンパク質の選択的な還元および誘導体化 |
| KR101067525B1 (ko) | 2005-12-22 | 2011-09-27 | 제넨테크, 인크. | 헤파린 결합 단백질의 재조합 생산 |
| WO2007102946A2 (en) | 2006-01-23 | 2007-09-13 | Amgen Inc. | Crystalline polypeptides |
| AU2007272412B2 (en) | 2006-07-14 | 2013-11-07 | Genentech, Inc. | Refolding of recombinant proteins |
| CL2007002881A1 (es) | 2006-10-20 | 2008-05-09 | Amgen Inc | Formulacion estable que comprende un tampon con un ph de aproximadamente 4 y menos de 6, un cation divalente de 5-150 mm, un excipiente que comprende un azucar o un poliol, y un anticuerpo anti-receptor del factor de crecimiento epidermico; y metodo |
| KR102262298B1 (ko) | 2007-07-09 | 2021-06-07 | 제넨테크, 인크. | 폴리펩티드의 재조합 생산 동안의 디술피드 결합 환원의 방지 |
| MX2010002683A (es) * | 2007-09-14 | 2010-03-26 | Amgen Inc | Poblaciones de anticuerpos homogeneos. |
| AU2010270986B2 (en) | 2009-06-22 | 2014-05-22 | Amgen Inc. | Refolding proteins using a chemically controlled redox state |
| EP2445924B2 (en) | 2009-06-25 | 2023-12-13 | Amgen Inc. | Capture purification processes for proteins expressed in a non-mammalian system |
| DK2483289T3 (da) | 2009-10-02 | 2019-06-11 | Biogen Ma Inc | Fremgangsmåder til forebyggelse og fjernelse af trisulfidbindinger |
| CA2782320A1 (en) * | 2009-12-02 | 2011-06-09 | Acceleron Pharma Inc. | Compositions and methods for increasing serum half-life of fc fusion proteins |
| CN107337728B (zh) | 2011-02-07 | 2023-05-23 | 塞勒尼斯医疗控股公司 | 脂蛋白复合物及其制备和用途 |
| WO2012170938A1 (en) | 2011-06-08 | 2012-12-13 | Acceleron Pharma Inc. | Compositions and methods for increasing serum half-life |
| WO2012178102A2 (en) | 2011-06-24 | 2012-12-27 | The Regents Of The Unversity Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
| WO2013106589A1 (en) | 2012-01-10 | 2013-07-18 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
| US9353165B2 (en) * | 2012-07-25 | 2016-05-31 | Grifols, S.A. | Purification of cell culture derived alpha1 protease inhibitor |
| CN104508133B (zh) | 2012-08-02 | 2018-04-20 | 弗·哈夫曼-拉罗切有限公司 | 用于产生单体和多聚体分子的方法及其用途 |
| AU2013315750B9 (en) | 2012-09-11 | 2018-11-15 | Coherus Biosciences, Inc. | Correctly folded etanercept in high purity and excellent yield |
| US9650412B2 (en) | 2013-03-08 | 2017-05-16 | Genzyme Corporation | Integrated continuous manufacturing of therapeutic protein drug substances |
| TWI709569B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析樹脂及其用於製造方法的用途 |
| TWI671312B (zh) | 2014-01-17 | 2019-09-11 | 美商健臻公司 | 無菌層析法及製法 |
| AR103172A1 (es) | 2014-12-22 | 2017-04-19 | Novartis Ag | Reducción selectiva de residuos de cisteina en anticuerpos il-17 |
| MX2019004580A (es) | 2016-10-21 | 2019-08-12 | Amgen Inc | Formulaciones farmaceuticas y metodos para prepararlas. |
| KR20210049155A (ko) | 2018-08-31 | 2021-05-04 | 젠자임 코포레이션 | 멸균 크로마토그래피 수지 및 제조 공정에서 이의 용도 |
| MX2021003976A (es) | 2018-10-11 | 2021-05-27 | Amgen Inc | Procesamiento posterior de constructos de anticuerpos biespecificos. |
| US20240083972A1 (en) | 2020-12-22 | 2024-03-14 | Amgen Inc. | Cell culture method |
| CN118047854A (zh) * | 2024-02-26 | 2024-05-17 | 武汉鹰达生物科技有限公司 | 一种人载脂蛋白a-i的分离纯化方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5453363A (en) * | 1985-10-23 | 1995-09-26 | Boehringer Mannheim Gmbh | Process for the activation of t-PA or Ing after genetic expression in prokaryotes |
| US4766205A (en) * | 1985-11-13 | 1988-08-23 | Beatrice Companies, Inc. | Method for isolation of recombinant polypeptides in biologically active forms |
| AU626524B2 (en) * | 1987-05-29 | 1992-08-06 | Bristol-Myers Squibb Company | Cloning and expression of simian transforming growth factor- beta 1 |
| US4970067A (en) * | 1988-12-12 | 1990-11-13 | Helene Curtis, Inc. | Method and composition to condition hair and impart semi-permanent hair set retention properties |
| GB8927546D0 (en) * | 1989-12-06 | 1990-02-07 | Ciba Geigy | Process for the production of biologically active tgf-beta |
| AU648214B2 (en) * | 1991-12-31 | 1994-04-14 | Lucky Limited | Recombinant gene coding for human alpha interferon and expression vector thereof, etc. |
| US5447851B1 (en) * | 1992-04-02 | 1999-07-06 | Univ Texas System Board Of | Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells |
| AU685835B2 (en) * | 1993-08-04 | 1998-01-29 | Novartis Ag | High molecular weight desulphatohirudin |
| US6310185B1 (en) * | 1994-03-08 | 2001-10-30 | Memorial Sloan Kettering Cancer Center | Recombinant human anti-Lewis Y antibodies |
| WO1995032216A1 (en) | 1994-05-25 | 1995-11-30 | University Of Nebraska Board Of Regents | Biologically active glycoprotein hormones produced in procaryotic cells |
| CZ283219B6 (cs) | 1994-07-22 | 1998-02-18 | F. Hoffmann-La Roche Ag | Použití chimerního proteinu vázajícího TNF pro výrobu farmaceutického prostředku k ošetřování autoimunních nemocí |
| US5879673A (en) * | 1996-01-25 | 1999-03-09 | Genentech, Inc. | Administration of thrombopoietin on a single day only |
| US5935824A (en) * | 1996-01-31 | 1999-08-10 | Technologene, Inc. | Protein expression system |
| US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
| FR2803303B1 (fr) | 2000-01-04 | 2002-05-10 | Aventis Pasteur | Glycoproteine d'enveloppe du vih modifiee chimiquement |
| MXPA03007563A (es) * | 2001-02-23 | 2003-12-11 | Immunex Corp | Recuperacion incrementada de proteinas activas. |
-
2002
- 2002-02-22 MX MXPA03007563A patent/MXPA03007563A/es active IP Right Grant
- 2002-02-22 PL PL02374045A patent/PL374045A1/xx unknown
- 2002-02-22 CA CA2438094A patent/CA2438094C/en not_active Expired - Fee Related
- 2002-02-22 ES ES02725004T patent/ES2370235T3/es not_active Expired - Lifetime
- 2002-02-22 SK SK1047-2003A patent/SK10472003A3/sk not_active Application Discontinuation
- 2002-02-22 KR KR10-2003-7010687A patent/KR20040052481A/ko not_active Application Discontinuation
- 2002-02-22 EE EEP200300408A patent/EE200300408A/xx unknown
- 2002-02-22 CN CNA02805444XA patent/CN1547586A/zh active Pending
- 2002-02-22 JP JP2002567965A patent/JP2005505494A/ja active Pending
- 2002-02-22 IL IL15744602A patent/IL157446A0/xx unknown
- 2002-02-22 HU HU0303246A patent/HUP0303246A2/hu unknown
- 2002-02-22 US US10/080,471 patent/US7157557B2/en not_active Expired - Lifetime
- 2002-02-22 EP EP02725004A patent/EP1366062B1/en not_active Expired - Lifetime
- 2002-02-22 WO PCT/US2002/005645 patent/WO2002068455A2/en active Application Filing
- 2002-02-22 AU AU2002255600A patent/AU2002255600B2/en not_active Expired
- 2002-02-22 CZ CZ20032208A patent/CZ20032208A3/cs unknown
- 2002-02-22 AT AT02725004T patent/ATE517909T1/de not_active IP Right Cessation
- 2002-02-22 RU RU2003127830/13A patent/RU2316563C2/ru active
-
2003
- 2003-07-31 ZA ZA200305909A patent/ZA200305909B/en unknown
- 2003-08-13 BG BG108087A patent/BG108087A/bg unknown
-
2004
- 2004-01-30 HK HK04100666.9A patent/HK1059267A1/xx not_active IP Right Cessation
-
2006
- 2006-11-22 US US11/603,544 patent/US7544784B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2370235T3 (es) | 2011-12-13 |
| RU2316563C2 (ru) | 2008-02-10 |
| IL157446A0 (en) | 2004-03-28 |
| HK1059267A1 (en) | 2004-06-25 |
| AU2002255600B2 (en) | 2008-01-24 |
| KR20040052481A (ko) | 2004-06-23 |
| BG108087A (bg) | 2005-04-30 |
| JP2005505494A (ja) | 2005-02-24 |
| ZA200305909B (en) | 2004-06-04 |
| RU2003127830A (ru) | 2005-04-10 |
| US20020182665A1 (en) | 2002-12-05 |
| US7157557B2 (en) | 2007-01-02 |
| ATE517909T1 (de) | 2011-08-15 |
| WO2002068455A3 (en) | 2003-09-18 |
| WO2002068455A2 (en) | 2002-09-06 |
| US20070270577A1 (en) | 2007-11-22 |
| US7544784B2 (en) | 2009-06-09 |
| CA2438094C (en) | 2011-10-11 |
| HUP0303246A2 (hu) | 2003-12-29 |
| EP1366062B1 (en) | 2011-07-27 |
| SK10472003A3 (sk) | 2004-03-02 |
| CZ20032208A3 (cs) | 2004-01-14 |
| PL374045A1 (en) | 2005-09-19 |
| CN1547586A (zh) | 2004-11-17 |
| EP1366062A2 (en) | 2003-12-03 |
| CA2438094A1 (en) | 2002-09-06 |
| EE200300408A (et) | 2003-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |