IL157446A0 - Increased recovery of active proteins - Google Patents

Increased recovery of active proteins

Info

Publication number
IL157446A0
IL157446A0 IL15744602A IL15744602A IL157446A0 IL 157446 A0 IL157446 A0 IL 157446A0 IL 15744602 A IL15744602 A IL 15744602A IL 15744602 A IL15744602 A IL 15744602A IL 157446 A0 IL157446 A0 IL 157446A0
Authority
IL
Israel
Prior art keywords
active proteins
increased recovery
proteins
preparations
reduction
Prior art date
Application number
IL15744602A
Other languages
English (en)
Original Assignee
Immunex Corp Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunex Corp Immunex Corp filed Critical Immunex Corp Immunex Corp
Publication of IL157446A0 publication Critical patent/IL157446A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Measurement Of Radiation (AREA)
IL15744602A 2001-02-23 2002-02-22 Increased recovery of active proteins IL157446A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27103301P 2001-02-23 2001-02-23
PCT/US2002/005645 WO2002068455A2 (en) 2001-02-23 2002-02-22 Efficient recovery of correctly refolded proteins

Publications (1)

Publication Number Publication Date
IL157446A0 true IL157446A0 (en) 2004-03-28

Family

ID=23033913

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15744602A IL157446A0 (en) 2001-02-23 2002-02-22 Increased recovery of active proteins

Country Status (21)

Country Link
US (2) US7157557B2 (xx)
EP (1) EP1366062B1 (xx)
JP (1) JP2005505494A (xx)
KR (1) KR20040052481A (xx)
CN (1) CN1547586A (xx)
AT (1) ATE517909T1 (xx)
AU (1) AU2002255600B2 (xx)
BG (1) BG108087A (xx)
CA (1) CA2438094C (xx)
CZ (1) CZ20032208A3 (xx)
EE (1) EE200300408A (xx)
ES (1) ES2370235T3 (xx)
HK (1) HK1059267A1 (xx)
HU (1) HUP0303246A2 (xx)
IL (1) IL157446A0 (xx)
MX (1) MXPA03007563A (xx)
PL (1) PL374045A1 (xx)
RU (1) RU2316563C2 (xx)
SK (1) SK10472003A3 (xx)
WO (1) WO2002068455A2 (xx)
ZA (1) ZA200305909B (xx)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040052481A (ko) * 2001-02-23 2004-06-23 임뮤넥스 코포레이션 재조합 단백질의 수득률을 증가시키는 방법
EP2520654B8 (en) 2003-08-26 2017-04-19 The Regents of the University of Colorado, a body corporate Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections
WO2006060083A1 (en) * 2004-10-22 2006-06-08 Amgen Inc. Methods for refolding polypeptides
NZ554520A (en) * 2004-10-22 2010-03-26 Amgen Inc Methods for refolding of recombinant antibodies
JP2008528006A (ja) * 2005-01-28 2008-07-31 アポロ ライフ サイエンシズ リミテッド 分子およびそのキメラ分子
JP5053264B2 (ja) 2005-05-19 2012-10-17 アムジェン インコーポレイテッド 抗体の安定性を増加させるための組成物および方法
US20080311078A1 (en) 2005-06-14 2008-12-18 Gokarn Yatin R Self-Buffering Protein Formulations
EP1893632B1 (en) * 2005-06-17 2015-08-12 Novo Nordisk Health Care AG Selective reduction and derivatization of engineered factor vii proteins comprising at least one non-native cysteine
ATE497973T1 (de) 2005-12-22 2011-02-15 Genentech Inc Rekombinante produktion heparinbindender proteine
WO2007102946A2 (en) 2006-01-23 2007-09-13 Amgen Inc. Crystalline polypeptides
SG162834A1 (en) 2006-07-14 2010-07-29 Genentech Inc Refolding of recombinant proteins
MX2009003982A (es) 2006-10-20 2009-04-27 Amgen Inc Formulaciones de polipeptido estables.
LT3597659T (lt) 2007-07-09 2023-05-10 Genentech, Inc. Disulfidinės jungties redukcijos prevencijos būdas gaminant polipeptidą rekombinantiniu būdu
EP2197911A2 (en) * 2007-09-14 2010-06-23 Amgen Inc. Homogeneous antibody populations
EA020621B1 (ru) 2009-06-22 2014-12-30 Амген Инк. Рефолдинг белков с использованием химически контролируемого окислительно-восстановительного состояния
EP3660032A1 (en) 2009-06-25 2020-06-03 Amgen, Inc Capture purification processes for proteins expressed in a non-mammalian system
EP2483289B1 (en) 2009-10-02 2019-03-20 Biogen MA Inc. Methods of preventing and removing trisulfide bonds
BR112012013330A2 (pt) * 2009-12-02 2017-03-28 Acceleron Pharma Inc composições e métodos para aumentar meia vida do soro de proteínas de fusão fc
HUE042314T2 (hu) 2011-02-07 2019-06-28 Cerenis Therapeutics Holding Sa Lipoprotein komplexek és azok gyártása és alkalmazásai
US8883982B2 (en) 2011-06-08 2014-11-11 Acceleron Pharma, Inc. Compositions and methods for increasing serum half-life
KR20200044138A (ko) 2011-06-24 2020-04-28 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도
KR20140137347A (ko) 2012-01-10 2014-12-02 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도
US9353165B2 (en) * 2012-07-25 2016-05-31 Grifols, S.A. Purification of cell culture derived alpha1 protease inhibitor
EP2880169B1 (en) 2012-08-02 2017-05-17 F. Hoffmann-La Roche AG Method for producing monomeric and multimeric molecules and uses thereof
EA031324B1 (ru) 2012-09-11 2018-12-28 Кохерус Байосайенсис, Инк. Правильно свернутый этанерцепт с высокой чистотой и высоким уровнем выхода
AU2014226126B2 (en) 2013-03-08 2019-02-14 Genzyme Corporation Continuous purification of therapeutic proteins
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
AR103172A1 (es) 2014-12-22 2017-04-19 Novartis Ag Reducción selectiva de residuos de cisteina en anticuerpos il-17
EA201990998A1 (ru) 2016-10-21 2019-11-29 Фармацевтические составы и способы их получения
EP3843869A1 (en) 2018-08-31 2021-07-07 Genzyme Corporation Sterile chromatography resin and use thereof in manufacturing processes
AU2019356564A1 (en) 2018-10-11 2021-04-29 Amgen Inc. Downstream processing of bispecific antibody constructs
US20240083972A1 (en) 2020-12-22 2024-03-14 Amgen Inc. Cell culture method

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453363A (en) * 1985-10-23 1995-09-26 Boehringer Mannheim Gmbh Process for the activation of t-PA or Ing after genetic expression in prokaryotes
US4766205A (en) 1985-11-13 1988-08-23 Beatrice Companies, Inc. Method for isolation of recombinant polypeptides in biologically active forms
EP0293785A3 (en) * 1987-05-29 1990-05-02 Oncogen Limited Partnership Cloning and expression of simian transforming growth factor-ss1
US4970067A (en) * 1988-12-12 1990-11-13 Helene Curtis, Inc. Method and composition to condition hair and impart semi-permanent hair set retention properties
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
AU648214B2 (en) 1991-12-31 1994-04-14 Lucky Limited Recombinant gene coding for human alpha interferon and expression vector thereof, etc.
US5447851B1 (en) * 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
HUT72926A (en) * 1993-08-04 1996-06-28 Ciba Geigy Ag High molecular weight desulphatohirudin
US6310185B1 (en) * 1994-03-08 2001-10-30 Memorial Sloan Kettering Cancer Center Recombinant human anti-Lewis Y antibodies
AU2603995A (en) 1994-05-25 1995-12-18 University Of Nebraska Board Of Regents Biologically active glycoprotein hormones produced in procaryotic cells
JPH09508140A (ja) 1994-07-22 1997-08-19 エフ・ホフマン−ラ ロシュ アーゲー キメラｔｎｆ結合タンパク質を含有する医薬組成物
US5879673A (en) * 1996-01-25 1999-03-09 Genentech, Inc. Administration of thrombopoietin on a single day only
US5935824A (en) * 1996-01-31 1999-08-10 Technologene, Inc. Protein expression system
US6808902B1 (en) 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
FR2803303B1 (fr) 2000-01-04 2002-05-10 Aventis Pasteur Glycoproteine d'enveloppe du vih modifiee chimiquement
KR20040052481A (ko) * 2001-02-23 2004-06-23 임뮤넥스 코포레이션 재조합 단백질의 수득률을 증가시키는 방법

Also Published As

Publication number Publication date
MXPA03007563A (es) 2003-12-11
HUP0303246A2 (hu) 2003-12-29
CA2438094C (en) 2011-10-11
WO2002068455A2 (en) 2002-09-06
CA2438094A1 (en) 2002-09-06
PL374045A1 (en) 2005-09-19
WO2002068455A3 (en) 2003-09-18
ATE517909T1 (de) 2011-08-15
CZ20032208A3 (cs) 2004-01-14
US7157557B2 (en) 2007-01-02
AU2002255600B2 (en) 2008-01-24
US20070270577A1 (en) 2007-11-22
US7544784B2 (en) 2009-06-09
KR20040052481A (ko) 2004-06-23
HK1059267A1 (en) 2004-06-25
EE200300408A (et) 2003-12-15
EP1366062A2 (en) 2003-12-03
JP2005505494A (ja) 2005-02-24
CN1547586A (zh) 2004-11-17
SK10472003A3 (sk) 2004-03-02
US20020182665A1 (en) 2002-12-05
RU2003127830A (ru) 2005-04-10
ZA200305909B (en) 2004-06-04
RU2316563C2 (ru) 2008-02-10
EP1366062B1 (en) 2011-07-27
BG108087A (bg) 2005-04-30
ES2370235T3 (es) 2011-12-13

Similar Documents

Publication Publication Date Title
IL157446A0 (en) Increased recovery of active proteins
BE2016C015I2 (xx)
EP2298331A3 (en) Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
PT1641483E (pt) Proteínas de fusão
WO2005021579A3 (en) Epo mimetic peptides and fusion proteins
ATE408631T1 (de) Chimäres protein welches eine intramolekulare chaperon-ähnliche sequenz enthält und dessen anwendung zur insulinproduktion
DK1368372T3 (da) Peptid med affinitet til det virale gp120-protein samt anvendelse deraf
EA200400392A1 (ru) Связывающий каспазу-8 белок, его получение и применение
WO2003022883A3 (de) Verwendung eines proteins zur herstellung eines medikaments zur stimulierung des angeborenen unspezifischen immunsystems
WO2004035733A3 (en) Isolated human hepsin/46 proteins, nucleic acid molecules encoding human hepsin/46 proteins, and uses thereof
EA200500624A1 (ru) Промотор для il-18bp, его получение и применение
WO2002038765A3 (en) Dna encoding bovine immunoglobulin a inducing protein and uses therefor
AU2013245463B2 (en) Immunoglobulin Chimeric Monomer-Dimer Hybrids
WO2003048320A3 (en) Novel motor protein of p. falciparum and methods for its use