MXPA03004435A - Procedimiento de traba extendida para identificacion rapida de ligandos. - Google Patents

Procedimiento de traba extendida para identificacion rapida de ligandos.

Info

Publication number
MXPA03004435A
MXPA03004435A MXPA03004435A MXPA03004435A MXPA03004435A MX PA03004435 A MXPA03004435 A MX PA03004435A MX PA03004435 A MXPA03004435 A MX PA03004435A MX PA03004435 A MXPA03004435 A MX PA03004435A MX PA03004435 A MXPA03004435 A MX PA03004435A
Authority
MX
Mexico
Prior art keywords
tbm
library
sws
molecule
group
Prior art date
Application number
MXPA03004435A
Other languages
English (en)
Spanish (es)
Inventor
John Prescott
Original Assignee
Sunesis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunesis Pharmaceuticals Inc filed Critical Sunesis Pharmaceuticals Inc
Publication of MXPA03004435A publication Critical patent/MXPA03004435A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Structural Engineering (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Peptides Or Proteins (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Control And Safety Of Cranes (AREA)
MXPA03004435A 2000-11-21 2001-11-20 Procedimiento de traba extendida para identificacion rapida de ligandos. MXPA03004435A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25229400P 2000-11-21 2000-11-21
PCT/US2001/044036 WO2002042773A2 (en) 2000-11-21 2001-11-20 An extended tethering approach for rapid identification of ligands

Publications (1)

Publication Number Publication Date
MXPA03004435A true MXPA03004435A (es) 2005-01-25

Family

ID=22955415

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03004435A MXPA03004435A (es) 2000-11-21 2001-11-20 Procedimiento de traba extendida para identificacion rapida de ligandos.

Country Status (14)

Country Link
EP (2) EP1441228B1 (ja)
JP (2) JP3836791B2 (ja)
AT (1) ATE420366T1 (ja)
AU (2) AU2002225731B2 (ja)
CA (1) CA2430234C (ja)
DE (1) DE60137356D1 (ja)
DK (1) DK1337853T3 (ja)
ES (1) ES2322796T3 (ja)
HK (1) HK1063844A1 (ja)
IL (2) IL155926A0 (ja)
MX (1) MXPA03004435A (ja)
NZ (1) NZ525861A (ja)
WO (1) WO2002042773A2 (ja)
ZA (1) ZA200303772B (ja)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6998233B2 (en) 1998-06-26 2006-02-14 Sunesis Pharmaceuticals, Inc. Methods for ligand discovery
US7214487B2 (en) * 1998-06-26 2007-05-08 Sunesis Pharmaceuticals, Inc. Methods for identifying compounds that modulate enzymatic activities by employing covalently bonded target-extender complexes with ligand candidates
JP2004537594A (ja) * 2001-08-07 2004-12-16 サネシス ファーマシューティカルズ， インコーポレイテッド ジスルフィドリガンドおよびチオスルホネートリガンド、ならびにこれらのリガンドを含むライブラリー
IL161409A0 (en) * 2001-11-21 2004-09-27 Sunesis Pharmaceuticals Inc Methods for ligand discovery
CA2478981A1 (en) 2002-03-21 2003-10-02 Sunesis Pharmaceuticals, Inc. Identification of kinase inhibitors
CA2493461C (en) 2002-07-24 2013-01-08 Dror Ofer Drug discovery method
WO2004057340A1 (en) 2002-12-23 2004-07-08 Astex Technology Limited Synthesis and screening of ligands using x-ray crystallography
AU2003270848A1 (en) * 2003-09-17 2005-04-27 Sunesis Pharmaceuticals, Inc. Identification of kinase inhibitors
US7179923B2 (en) * 2003-11-14 2007-02-20 3M Innovative Properties Company N-sulfonylaminocarbonyl containing compounds
WO2005101019A2 (en) * 2004-04-12 2005-10-27 University Of Vermont And State Agricultural College Detection of nitrosylated proteins
US20060234299A1 (en) * 2004-11-16 2006-10-19 Avidia Research Institute Protein scaffolds and uses thereof
US20080070802A1 (en) * 2006-08-23 2008-03-20 Moerschell Richard P Directed heterobifunctional linkers
JP5946822B2 (ja) 2010-04-21 2016-07-06 ノヴォ ノルディスク アー／エス タンパク質の選択的改変
CN103140474A (zh) 2010-07-02 2013-06-05 吉里德科学公司 治疗aids的萘-2-基乙酸衍生物
CN103209963A (zh) 2010-07-02 2013-07-17 吉里德科学公司 作为hiv抗病毒化合物的2-喹啉基-乙酸衍生物
BR112013027096A2 (pt) 2011-04-21 2016-12-27 Gilead Sciences Inc compostos de benzotiazol e seu uso farmacêutico
WO2013103738A1 (en) 2012-01-04 2013-07-11 Gilead Sciences, Inc. Napthalene acetic acid derivatives against hiv infection
US9376392B2 (en) 2012-01-04 2016-06-28 Gilead Sciences, Inc. 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS
MD20140063A2 (ro) 2012-04-20 2014-12-31 Gilead Sciences, Inc. Derivaţi de acid benzotiazol-6-il acetic şi utilizarea acestora pentru tratarea unei infecţii HIV
US10782295B2 (en) 2013-08-13 2020-09-22 The Scripps Research Institute Cysteine-reactive ligand discovery in proteomes
KR20160111964A (ko) * 2014-01-29 2016-09-27 샹하이 헨그루이 파마수티컬 컴퍼니 리미티드 리간드-세포독성 약물 접합체, 이의 제조방법 및 이의 용도
RU2708461C2 (ru) * 2015-02-15 2019-12-09 Цзянсу Хэнжуй Медсин Ко., Лтд. Конъюгат лиганда с цитотоксическим лекарственным средством, способ его получения и применение
JP6953400B2 (ja) * 2015-10-22 2021-10-27 ザ スクリプス リサーチ インスティテュート システイン反応性プローブとその使用
GB201614152D0 (en) * 2016-08-18 2016-10-05 Imp Innovations Ltd Assay
IL268101B1 (en) 2017-01-18 2024-04-01 Scripps Research Inst Photoreactive ligands and their uses
US20180372751A1 (en) * 2017-06-23 2018-12-27 The Scripps Research Institute Lysine reactive probes and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998011436A1 (en) * 1996-09-13 1998-03-19 Whitehead Institute For Biomedical Research Non-specific affinity enhancement to identify combinatorial library members
US6344330B1 (en) * 1998-03-27 2002-02-05 The Regents Of The University Of California Pharmacophore recombination for the identification of small molecule drug lead compounds
US6335155B1 (en) * 1998-06-26 2002-01-01 Sunesis Pharmaceuticals, Inc. Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules

Also Published As

Publication number Publication date
WO2002042773A2 (en) 2002-05-30
EP1441228A1 (en) 2004-07-28
EP1337853A2 (en) 2003-08-27
CA2430234A1 (en) 2002-05-30
AU2002225731B2 (en) 2005-04-14
ES2322796T3 (es) 2009-06-29
ATE420366T1 (de) 2009-01-15
DK1337853T3 (da) 2009-05-04
JP2004514891A (ja) 2004-05-20
WO2002042773A3 (en) 2002-11-14
NZ525861A (en) 2004-09-24
AU2573102A (en) 2002-06-03
DE60137356D1 (de) 2009-02-26
EP1441228B1 (en) 2006-06-28
WO2002042773B1 (en) 2002-12-12
JP2006113077A (ja) 2006-04-27
EP1337853B1 (en) 2009-01-07
IL155926A (en) 2009-06-15
CA2430234C (en) 2008-02-12
ZA200303772B (en) 2004-05-17
HK1063844A1 (en) 2005-01-14
JP3836791B2 (ja) 2006-10-25
IL155926A0 (en) 2003-12-23

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