MX9304595A - Derivados de 1,2,4-triazola substituidos en 4 - Google Patents

Derivados de 1,2,4-triazola substituidos en 4

Info

Publication number
MX9304595A
MX9304595A MX9304595A MX9304595A MX9304595A MX 9304595 A MX9304595 A MX 9304595A MX 9304595 A MX9304595 A MX 9304595A MX 9304595 A MX9304595 A MX 9304595A MX 9304595 A MX9304595 A MX 9304595A
Authority
MX
Mexico
Prior art keywords
triazola
derivatives
substituted
selective
receptors
Prior art date
Application number
MX9304595A
Other languages
English (en)
Inventor
Victor Giulio Matassa
Francine Sternfeld
Raymond Baker
Austin John Reeve
Leslie Joseph Street
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929216264A external-priority patent/GB9216264D0/en
Priority claimed from GB929216192A external-priority patent/GB9216192D0/en
Priority claimed from GB929222261A external-priority patent/GB9222261D0/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MX9304595A publication Critical patent/MX9304595A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Una clase discreta de derivados de 1,2,4-triazola substituídos en 4 son agonistas selectivos de los receptores tipo 5-HT1 y por lo tanto son útiles en el tratamiento de condiciones clínicas, en particular migraña y enfermedades asociadas, para los cuales se indica un agonista selectivo de esos receptores.
MX9304595A 1992-07-30 1993-07-29 Derivados de 1,2,4-triazola substituidos en 4 MX9304595A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB929216264A GB9216264D0 (en) 1992-07-30 1992-07-30 Therapeutic agents
GB929216192A GB9216192D0 (en) 1992-07-30 1992-07-30 Therapeutic agents
GB929222261A GB9222261D0 (en) 1992-10-23 1992-10-23 Therapeutic agents

Publications (1)

Publication Number Publication Date
MX9304595A true MX9304595A (es) 1994-02-28

Family

ID=27266308

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9304595A MX9304595A (es) 1992-07-30 1993-07-29 Derivados de 1,2,4-triazola substituidos en 4

Country Status (12)

Country Link
US (1) US5554629A (es)
EP (1) EP0581538B1 (es)
JP (1) JP2599557B2 (es)
CN (1) CN1037101C (es)
AT (1) ATE177096T1 (es)
AU (1) AU664102B2 (es)
CA (1) CA2101219A1 (es)
DE (1) DE69323667T2 (es)
ES (1) ES2127789T3 (es)
IL (1) IL106445A (es)
MX (1) MX9304595A (es)
WO (1) WO1994003446A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9402011D0 (en) * 1994-02-02 1994-03-30 Merck Sharp & Dohme Therapeutic agents
GB9402016D0 (en) * 1994-02-02 1994-03-30 Merck Sharp & Dohme Therapeutic agents
US5552402A (en) * 1994-05-19 1996-09-03 Merck, Sharp & Dohme Ltd. Five-membered heteroaromatic compounds as 5-HT receptor agonists
GB9410031D0 (en) * 1994-05-19 1994-07-06 Merck Sharp & Dohme Therapeutic agents
CA2195107A1 (en) * 1994-08-02 1996-02-15 Richard Alexander Jelley Azetidine, pyrrolidine and piperidine derivatives
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine
GB9423460D0 (en) * 1994-11-21 1995-01-11 Merck Sharp & Dohme Therapeutic agents
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
JPH11502816A (ja) * 1995-03-20 1999-03-09 イーライ・リリー・アンド・カンパニー ５−置換−３−（１，２，３，６−テトラヒドロピリジン−４−イル）−および３−（ピペリジン−４−イル）−１ｈ−インドール類：新規５−ｈｔ▲下１ｆ▼アゴニスト
JPH11513666A (ja) * 1995-10-10 1999-11-24 イーライ・リリー・アンド・カンパニー Ｎ−［２−置換−３−（２−アミノエチル）−１ｈ−インドール−５−イル］−アミド：新規５−ｈｔ▲下１ｆ▼作動剤
US5998438A (en) * 1996-11-26 1999-12-07 Allelix Biopharmaceuticals, Inc. 5-cyclo indole compounds
EP1003738B1 (en) 1997-08-09 2003-11-19 SmithKline Beecham plc Bicyclic compounds as ligands for 5-ht1 receptors
FR2767827A1 (fr) * 1997-09-03 1999-02-26 Adir Nouveaux derives de l'indole et de l'indazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6602889B1 (en) * 1998-03-09 2003-08-05 H. Lundbeck A.S. 5-heteroaryl substituted indoles
KR20130136010A (ko) 2005-04-13 2013-12-11 네우렉슨 인코포레이티드 Ｎｏｓ 저해 활성을 갖는 치환된 인돌 화합물
EP2010527B1 (en) 2006-04-13 2013-08-14 Neuraxon Inc. 1,5 and 3,6- substituted indole compounds having nos inhibitory activity
WO2009062319A1 (en) 2007-11-16 2009-05-22 Neuraxon, Inc. Indole compounds and methods for treating visceral pain
WO2010084507A2 (en) * 2008-07-15 2010-07-29 Sun Pharmaceutical Industries Ltd. Process for the preparation of n-methyl-2-[3-(1-methyl-4-piperidyl)-1h-indol-5-yl]-ethanesulfonamide and its acid addition salts

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3475437A (en) * 1964-06-05 1969-10-28 Boehringer Sohn Ingelheim 3-tertiary amino lower alkylpseudoindoles
GB1237008A (en) * 1968-12-18 1971-06-30 Pfizer Ltd Novel indoline derivatives
US3686213A (en) * 1970-08-28 1972-08-22 American Cyanamid Co Substituted aminoethyl indoles
DE2520816C3 (de) * 1975-05-09 1979-02-15 Bayer Ag, 5090 Leverkusen Methinfarbstoffe
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
ZA815541B (en) * 1980-08-12 1983-03-30 Glaxo Group Ltd Heterocyclic compounds
GB2083463B (en) * 1980-08-12 1984-05-10 Glaxo Group Ltd Heterocyclic compounds
US4453001A (en) * 1982-02-22 1984-06-05 Sandoz, Inc. Isoxazolyl indolamines as intermediates
JPS58150576A (ja) * 1982-03-03 1983-09-07 Sumitomo Chem Co Ltd 新規な１，２，４−オキサジアゾ−ル誘導体
US4692531A (en) * 1984-06-22 1987-09-08 Bristol-Myers Company Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
DE3430284A1 (de) * 1984-08-17 1986-02-27 Troponwerke GmbH & Co KG, 5000 Köln Neue tryptamin-derivate, ein verfahren zu ihrer herstellung und ihre verwendung
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
DE3531658A1 (de) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
NZ227841A (en) * 1988-02-12 1991-08-27 Merck Sharp & Dohme Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions
SI21560B (sl) * 1990-06-07 2005-04-30 Astrazeneca Ab 3,5-disubstituirani indolni derivati kot "5-HT1-podobni" receptorski agonisti
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi

Also Published As

Publication number Publication date
US5554629A (en) 1996-09-10
DE69323667D1 (de) 1999-04-08
EP0581538B1 (en) 1999-03-03
ATE177096T1 (de) 1999-03-15
CN1037101C (zh) 1998-01-21
AU4215593A (en) 1994-02-03
DE69323667T2 (de) 1999-09-30
AU664102B2 (en) 1995-11-02
JPH06184139A (ja) 1994-07-05
EP0581538A1 (en) 1994-02-02
IL106445A (en) 1998-01-04
IL106445A0 (en) 1993-11-15
CN1089262A (zh) 1994-07-13
JP2599557B2 (ja) 1997-04-09
WO1994003446A1 (en) 1994-02-17
CA2101219A1 (en) 1994-01-31
ES2127789T3 (es) 1999-05-01

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Legal Events

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FG Grant or registration
MM Annulment or lapse due to non-payment of fees