MX368107B - Explicacion de la optimizacion de entrada de la cromatografia de intercambio ionico. - Google Patents

Explicacion de la optimizacion de entrada de la cromatografia de intercambio ionico.

Info

Publication number
MX368107B
MX368107B MX2016000181A MX2016000181A MX368107B MX 368107 B MX368107 B MX 368107B MX 2016000181 A MX2016000181 A MX 2016000181A MX 2016000181 A MX2016000181 A MX 2016000181A MX 368107 B MX368107 B MX 368107B
Authority
MX
Mexico
Prior art keywords
elucidation
ion exchange
exchange chromatography
input optimization
chromatography input
Prior art date
Application number
MX2016000181A
Other languages
English (en)
Other versions
MX2016000181A (es
Inventor
Yajun Wang
Thomas Patapoff
Mcdonald Daniel
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2016000181A publication Critical patent/MX2016000181A/es
Publication of MX368107B publication Critical patent/MX368107B/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8658—Optimising operation parameters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3847—Multimodal interactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins

Abstract

La presente invención se refiere a métodos para determinar las condiciones de separación por cromatografía; por ejemplo, la separación de un polipéptido y sus variantes de carga. La invención también proporciona métodos para determinar una condición de amortiguador para las condiciones de separación por cromatografía. La invención también proporciona un método fuerte para analizar múltiples productos de polipéptido.
MX2016000181A 2013-07-12 2014-07-11 Explicacion de la optimizacion de entrada de la cromatografia de intercambio ionico. MX368107B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361845890P 2013-07-12 2013-07-12
PCT/US2014/046338 WO2015006686A1 (en) 2013-07-12 2014-07-11 Elucidation of ion exchange chromatography input optimization

Publications (2)

Publication Number Publication Date
MX2016000181A MX2016000181A (es) 2016-03-09
MX368107B true MX368107B (es) 2019-09-18

Family

ID=51257626

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016000181A MX368107B (es) 2013-07-12 2014-07-11 Explicacion de la optimizacion de entrada de la cromatografia de intercambio ionico.

Country Status (19)

Country Link
US (2) US10274466B2 (es)
EP (2) EP3019516B1 (es)
JP (2) JP6462681B2 (es)
KR (1) KR102251127B1 (es)
CN (1) CN105377873B (es)
AU (1) AU2014287044B2 (es)
BR (1) BR112016000231A8 (es)
CA (1) CA2918052A1 (es)
ES (1) ES2705700T3 (es)
HK (1) HK1222183A1 (es)
HR (1) HRP20190071T1 (es)
IL (1) IL243305B (es)
MX (1) MX368107B (es)
PL (1) PL3019516T3 (es)
RU (1) RU2016104542A (es)
SG (1) SG11201600221YA (es)
SI (1) SI3019516T1 (es)
TR (1) TR201818966T4 (es)
WO (1) WO2015006686A1 (es)

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SI3019516T1 (sl) 2013-07-12 2019-02-28 F. Hoffmann-La Roche Ag Določitev optimalnih vhodnih parametrov za ionsko izmenjevalno kromatografijo
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Also Published As

Publication number Publication date
TR201818966T4 (tr) 2019-01-21
AU2014287044A1 (en) 2016-02-11
MX2016000181A (es) 2016-03-09
CA2918052A1 (en) 2015-01-15
US20160161455A1 (en) 2016-06-09
US10921297B2 (en) 2021-02-16
SG11201600221YA (en) 2016-02-26
EP3019516B1 (en) 2018-11-14
CN105377873B (zh) 2021-03-30
JP2016529489A (ja) 2016-09-23
CN105377873A (zh) 2016-03-02
WO2015006686A8 (en) 2018-10-04
BR112016000231A8 (pt) 2019-12-31
SI3019516T1 (sl) 2019-02-28
IL243305B (en) 2019-09-26
JP2019090818A (ja) 2019-06-13
EP3019516A1 (en) 2016-05-18
KR102251127B1 (ko) 2021-05-11
RU2016104542A (ru) 2017-08-17
US10274466B2 (en) 2019-04-30
JP6462681B2 (ja) 2019-01-30
EP3536699A1 (en) 2019-09-11
IL243305A0 (en) 2016-03-31
PL3019516T3 (pl) 2019-04-30
AU2014287044B2 (en) 2020-02-06
US20190310234A1 (en) 2019-10-10
ES2705700T3 (es) 2019-03-26
HK1222183A1 (zh) 2017-06-23
HRP20190071T1 (hr) 2019-02-22
KR20160030251A (ko) 2016-03-16
WO2015006686A1 (en) 2015-01-15

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