MX363116B - Conjugados anticuerpo-farmaco de antigeno de membrana especifico de prostata. - Google Patents
Conjugados anticuerpo-farmaco de antigeno de membrana especifico de prostata.Info
- Publication number
- MX363116B MX363116B MX2014015029A MX2014015029A MX363116B MX 363116 B MX363116 B MX 363116B MX 2014015029 A MX2014015029 A MX 2014015029A MX 2014015029 A MX2014015029 A MX 2014015029A MX 363116 B MX363116 B MX 363116B
- Authority
- MX
- Mexico
- Prior art keywords
- drug conjugates
- antibody drug
- amino acid
- dolastatin analogs
- prostate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6869—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of the reproductive system: ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Toxicology (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a anticuerpos y conjugados anticuerpo-fármaco de antígeno de membrana específico de próstata (PSMA) que comprenden al menos un aminoácido no naturalmente codificado. Se describen en la presente anticuerpos aPSMA con uno o más aminoácidos no naturalmente codificados y se describen además conjugados anticuerpo-fármaco en donde los anticuerpos aPSMA de la invención se conjugan a una o más toxinas. También se describen en la presente análogos de dolastatina de aminoácidos no naturales que se modifican adicionalmente de manera post-traduccional, métodos para efectuar tales modificaciones y métodos para purificar tales análogos de dolastatina. Típicamente, los análogos de dolastatina modificados incluyen al menos un grupo oxima, carbonilo, dicarbonilo y/o hidroxilamina. Además se describen métodos para utilizar tales conjugados anticuerpo-fármaco de aminoácidos no naturales, análogos de dolastatina y análogos de dolastatina de aminoácidos no naturales modificados, incluyendo los usos terapéuticos, de diagnóstico y otros biotecnológicos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261656883P | 2012-06-07 | 2012-06-07 | |
PCT/US2013/044850 WO2013185117A1 (en) | 2012-06-07 | 2013-06-07 | Prostate-specific membrane antigen antibody drug conjugates |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014015029A MX2014015029A (es) | 2015-03-03 |
MX363116B true MX363116B (es) | 2019-03-11 |
Family
ID=48699944
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014015029A MX363116B (es) | 2012-06-07 | 2013-06-07 | Conjugados anticuerpo-farmaco de antigeno de membrana especifico de prostata. |
MX2023010485A MX2023010485A (es) | 2012-06-07 | 2014-12-05 | Conjugados anticuerpo-farmaco de antigeno de membrana especifico de prostata. |
MX2019002732A MX2019002732A (es) | 2012-06-07 | 2014-12-05 | Conjugados anticuerpo-farmaco de antigeno de membrana especifico de prostata. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023010485A MX2023010485A (es) | 2012-06-07 | 2014-12-05 | Conjugados anticuerpo-farmaco de antigeno de membrana especifico de prostata. |
MX2019002732A MX2019002732A (es) | 2012-06-07 | 2014-12-05 | Conjugados anticuerpo-farmaco de antigeno de membrana especifico de prostata. |
Country Status (14)
Country | Link |
---|---|
US (2) | US10800856B2 (es) |
EP (2) | EP2858676B1 (es) |
JP (1) | JP6425650B2 (es) |
KR (1) | KR102143664B1 (es) |
CN (3) | CN108727466B (es) |
AU (2) | AU2013270686B2 (es) |
CA (1) | CA2874854C (es) |
DK (1) | DK2858676T3 (es) |
ES (1) | ES2725329T3 (es) |
IL (3) | IL235895B (es) |
MX (3) | MX363116B (es) |
NZ (2) | NZ713941A (es) |
SG (2) | SG10201702176XA (es) |
WO (1) | WO2013185117A1 (es) |
Families Citing this family (26)
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US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
JP6239597B2 (ja) | 2012-05-15 | 2017-11-29 | ソレント・セラピューティクス・インコーポレイテッドSorrento Therapeutics, Inc. | 薬物コンジュゲート、コンジュゲーション方法およびその使用 |
KR102190832B1 (ko) | 2012-06-19 | 2020-12-15 | 암브룩스, 인코포레이티드 | 항cd70 항체 약물 컨쥬게이트 |
JP6431038B2 (ja) | 2013-03-15 | 2018-11-28 | ザイムワークス インコーポレイティド | 細胞毒性及び抗有糸***性化合物とその使用方法 |
FR3005051A1 (fr) * | 2013-04-25 | 2014-10-31 | Pf Medicament | Derives de la dolastatine 10 et d'auristatines |
EP3057610B1 (en) | 2013-10-15 | 2021-09-22 | Sorrento Therapeutics, Inc. | Drug-conjugates with a targeting molecule and two different drugs |
KR102384740B1 (ko) | 2013-12-27 | 2022-04-07 | 자임워크스 인코포레이티드 | 약물 접합체를 위한 설폰아마이드-함유 연결 시스템 |
KR20160125361A (ko) | 2013-12-27 | 2016-10-31 | 자임워크스 인코포레이티드 | Var2csa-약물 접합체 |
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WO2016090050A1 (en) * | 2014-12-03 | 2016-06-09 | Genentech, Inc. | Quaternary amine compounds and antibody-drug conjugates thereof |
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RU2708461C2 (ru) * | 2015-02-15 | 2019-12-09 | Цзянсу Хэнжуй Медсин Ко., Лтд. | Конъюгат лиганда с цитотоксическим лекарственным средством, способ его получения и применение |
TWI715611B (zh) | 2015-08-14 | 2021-01-11 | 美商Rc生物科技公司 | 抗體藥物偶聯物的共價鍵連接子及其製備方法與應用 |
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KR102459469B1 (ko) * | 2016-11-14 | 2022-10-26 | 항저우 디에이씨 바이오테크 씨오, 엘티디 | 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용 |
CN110637027A (zh) | 2017-02-08 | 2019-12-31 | 百时美施贵宝公司 | 包含药代动力学增强子的修饰的松弛素多肽及其用途 |
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2013
- 2013-06-07 EP EP13732008.1A patent/EP2858676B1/en active Active
- 2013-06-07 SG SG10201702176XA patent/SG10201702176XA/en unknown
- 2013-06-07 NZ NZ713941A patent/NZ713941A/en unknown
- 2013-06-07 AU AU2013270686A patent/AU2013270686B2/en active Active
- 2013-06-07 NZ NZ703298A patent/NZ703298A/en unknown
- 2013-06-07 ES ES13732008T patent/ES2725329T3/es active Active
- 2013-06-07 CA CA2874854A patent/CA2874854C/en active Active
- 2013-06-07 KR KR1020147037084A patent/KR102143664B1/ko active IP Right Grant
- 2013-06-07 SG SG11201408153YA patent/SG11201408153YA/en unknown
- 2013-06-07 CN CN201810564663.4A patent/CN108727466B/zh active Active
- 2013-06-07 WO PCT/US2013/044850 patent/WO2013185117A1/en active Application Filing
- 2013-06-07 DK DK13732008.1T patent/DK2858676T3/da active
- 2013-06-07 US US14/406,190 patent/US10800856B2/en active Active
- 2013-06-07 CN CN201380040218.3A patent/CN104619349B/zh active Active
- 2013-06-07 CN CN202310351927.9A patent/CN116514899A/zh active Pending
- 2013-06-07 EP EP19156167.9A patent/EP3536700A1/en active Pending
- 2013-06-07 MX MX2014015029A patent/MX363116B/es unknown
- 2013-06-07 JP JP2015516268A patent/JP6425650B2/ja active Active
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2014
- 2014-11-25 IL IL235895A patent/IL235895B/en active IP Right Grant
- 2014-12-05 MX MX2023010485A patent/MX2023010485A/es unknown
- 2014-12-05 MX MX2019002732A patent/MX2019002732A/es unknown
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2017
- 2017-02-09 AU AU2017200877A patent/AU2017200877B2/en active Active
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2018
- 2018-04-25 IL IL258937A patent/IL258937B/en active IP Right Grant
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2019
- 2019-08-06 IL IL268538A patent/IL268538B/en active IP Right Grant
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2020
- 2020-08-26 US US17/003,952 patent/US20220033518A1/en active Pending
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