MX2019002732A - Conjugados anticuerpo-farmaco de antigeno de membrana especifico de prostata. - Google Patents
Conjugados anticuerpo-farmaco de antigeno de membrana especifico de prostata.Info
- Publication number
- MX2019002732A MX2019002732A MX2019002732A MX2019002732A MX2019002732A MX 2019002732 A MX2019002732 A MX 2019002732A MX 2019002732 A MX2019002732 A MX 2019002732A MX 2019002732 A MX2019002732 A MX 2019002732A MX 2019002732 A MX2019002732 A MX 2019002732A
- Authority
- MX
- Mexico
- Prior art keywords
- drug conjugates
- antibody drug
- amino acid
- dolastatin analogs
- prostate
- Prior art date
Links
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 title abstract 5
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 title abstract 5
- 239000000611 antibody drug conjugate Substances 0.000 title abstract 4
- 229940049595 antibody-drug conjugate Drugs 0.000 title abstract 4
- -1 amino acid dolastatin analogs Chemical class 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 3
- AMRJKAQTDDKMCE-UHFFFAOYSA-N dolastatin Chemical class CC(C)C(N(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(C(C)C)C(OC)CC(=O)N1CCCC1C(OC)C(C)C(=O)NC(C=1SC=CN=1)CC1=CC=CC=C1 AMRJKAQTDDKMCE-UHFFFAOYSA-N 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000004989 dicarbonyl group Chemical group 0.000 abstract 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N hydroxylamine group Chemical group NO AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 150000002923 oximes Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- 108700012359 toxins Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6869—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of the reproductive system: ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Toxicology (AREA)
- Gynecology & Obstetrics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Esta invención se refiere a anticuerpos y conjugados anticuerpo-fármaco de antígeno de membrana específico de próstata (PSMA) que comprenden al menos un aminoácido no naturalmente codificado. Se describen en la presente anticuerpos aPSMA con uno o más aminoácidos no naturalmente codificados y se describen además conjugados anticuerpo-fármaco en donde los anticuerpos aPSMA de la invención se conjugan a una o más toxinas. También se describen en la presente análogos de dolastatina de aminoácidos no naturales que se modifican adicionalmente de manera post-traduccional, métodos para efectuar tales modificaciones y métodos para purificar tales análogos de dolastatina. Típicamente, los análogos de dolastatina modificados incluyen al menos un grupo oxima, carbonilo, dicarbonilo y/o hidroxilamina. Además se describen métodos para utilizar tales conjugados anticuerpo fármaco de aminoácidos no naturales, análogos de dolastatina y análogos de dolastatina de aminoácidos no naturales modificados, incluyendo los usos terapéuticos, de diagnóstico y otros biotecnológicos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261656883P | 2012-06-07 | 2012-06-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019002732A true MX2019002732A (es) | 2023-02-23 |
Family
ID=48699944
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014015029A MX363116B (es) | 2012-06-07 | 2013-06-07 | Conjugados anticuerpo-farmaco de antigeno de membrana especifico de prostata. |
MX2019002732A MX2019002732A (es) | 2012-06-07 | 2014-12-05 | Conjugados anticuerpo-farmaco de antigeno de membrana especifico de prostata. |
MX2023010485A MX2023010485A (es) | 2012-06-07 | 2014-12-05 | Conjugados anticuerpo-farmaco de antigeno de membrana especifico de prostata. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014015029A MX363116B (es) | 2012-06-07 | 2013-06-07 | Conjugados anticuerpo-farmaco de antigeno de membrana especifico de prostata. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023010485A MX2023010485A (es) | 2012-06-07 | 2014-12-05 | Conjugados anticuerpo-farmaco de antigeno de membrana especifico de prostata. |
Country Status (14)
Country | Link |
---|---|
US (2) | US10800856B2 (es) |
EP (2) | EP2858676B1 (es) |
JP (1) | JP6425650B2 (es) |
KR (1) | KR102143664B1 (es) |
CN (3) | CN104619349B (es) |
AU (2) | AU2013270686B2 (es) |
CA (1) | CA2874854C (es) |
DK (1) | DK2858676T3 (es) |
ES (1) | ES2725329T3 (es) |
IL (3) | IL235895B (es) |
MX (3) | MX363116B (es) |
NZ (2) | NZ703298A (es) |
SG (2) | SG11201408153YA (es) |
WO (1) | WO2013185117A1 (es) |
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ES2916722T3 (es) | 2013-12-27 | 2022-07-05 | Zymeworks Inc | Sistemas de enlace que contienen sulfonamida para conjugados de fármacos |
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CN107206101B (zh) * | 2014-12-03 | 2021-06-25 | 基因泰克公司 | 季铵化合物及其抗体-药物缀合物 |
JP6871858B2 (ja) | 2015-01-28 | 2021-05-19 | ソレント・セラピューティクス・インコーポレイテッドSorrento Therapeutics, Inc. | 抗体薬物コンジュゲート |
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US10233212B2 (en) | 2015-11-03 | 2019-03-19 | Industrial Technology Research Institute | Compounds, linker-drugs and ligand-drug conjugates |
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CN110099682B (zh) * | 2016-11-14 | 2023-03-31 | 杭州多禧生物科技有限公司 | 偶联连接体,含有此连接体的细胞结合分子-药物偶联物及其制备和应用 |
US10266578B2 (en) | 2017-02-08 | 2019-04-23 | Bristol-Myers Squibb Company | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
EP3630977B1 (en) | 2017-06-02 | 2024-02-21 | Ambrx, Inc. | Methods and compositions for promoting non-natural amino acid-containing protein production |
JP2021519076A (ja) | 2018-03-29 | 2021-08-10 | アンブルックス, インコーポレイテッドAmbrx, Inc. | ヒト化抗前立腺特異的膜抗原(psma)抗体薬物複合体 |
CN109232712B (zh) * | 2018-08-21 | 2021-08-03 | 联宁(苏州)生物制药有限公司 | 一种用于抗体药物偶联物的中间体的制备方法 |
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2013
- 2013-06-07 NZ NZ703298A patent/NZ703298A/en unknown
- 2013-06-07 EP EP13732008.1A patent/EP2858676B1/en active Active
- 2013-06-07 JP JP2015516268A patent/JP6425650B2/ja active Active
- 2013-06-07 SG SG11201408153YA patent/SG11201408153YA/en unknown
- 2013-06-07 US US14/406,190 patent/US10800856B2/en active Active
- 2013-06-07 CN CN201380040218.3A patent/CN104619349B/zh active Active
- 2013-06-07 MX MX2014015029A patent/MX363116B/es unknown
- 2013-06-07 KR KR1020147037084A patent/KR102143664B1/ko active IP Right Grant
- 2013-06-07 NZ NZ713941A patent/NZ713941A/en unknown
- 2013-06-07 CN CN202310351927.9A patent/CN116514899A/zh active Pending
- 2013-06-07 ES ES13732008T patent/ES2725329T3/es active Active
- 2013-06-07 CN CN201810564663.4A patent/CN108727466B/zh active Active
- 2013-06-07 SG SG10201702176XA patent/SG10201702176XA/en unknown
- 2013-06-07 EP EP19156167.9A patent/EP3536700A1/en active Pending
- 2013-06-07 WO PCT/US2013/044850 patent/WO2013185117A1/en active Application Filing
- 2013-06-07 DK DK13732008.1T patent/DK2858676T3/da active
- 2013-06-07 CA CA2874854A patent/CA2874854C/en active Active
- 2013-06-07 AU AU2013270686A patent/AU2013270686B2/en active Active
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