MX361728B - Ácido nucleico que comprende o codifica un tallo-bucle de histona y una secuencia poli(a) o una señal de poliadenilación para incrementar la expresión de un antígeno tumoral codificado. - Google Patents
Ácido nucleico que comprende o codifica un tallo-bucle de histona y una secuencia poli(a) o una señal de poliadenilación para incrementar la expresión de un antígeno tumoral codificado.Info
- Publication number
- MX361728B MX361728B MX2014009909A MX2014009909A MX361728B MX 361728 B MX361728 B MX 361728B MX 2014009909 A MX2014009909 A MX 2014009909A MX 2014009909 A MX2014009909 A MX 2014009909A MX 361728 B MX361728 B MX 361728B
- Authority
- MX
- Mexico
- Prior art keywords
- nucleic acid
- sequence
- coding
- poly
- expression
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 5
- 150000007523 nucleic acids Chemical class 0.000 title abstract 4
- 108010033040 Histones Proteins 0.000 title abstract 3
- 108091034057 RNA (poly(A)) Proteins 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 108091007433 antigens Proteins 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 230000008488 polyadenylation Effects 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 239000012634 fragment Substances 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 108700026244 Open Reading Frames Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
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Abstract
La presente invención se refiere a una secuencia de ácidos nucleicos, que comprende o codifica una región de codificación, que codifica por lo menos un péptido o proteína que comprende un antígeno tumoral o un fragmento, variante o derivado del mismo, por lo menos un tallo-bucle de histona y una secuencia de poli(A) o una señal de poliadenilación. Adicionalmente, la presente invención proporciona el uso del ácido nucleico para incrementar la expresión del péptido o proteína codificada. También se describe su uso para la preparación de una composición farmacéutica, especialmente una vacuna, por ejemplo para el uso en el tratamiento de enfermedades cancerosas o tumorales. La presente invención describe además un método para incrementar la expresión de un péptido o proteína que comprende un antígeno tumoral o un fragmento, variante o derivado del mismo, utilizando el ácido nucleico que comprende o que codifica un tallo-bucle de histona y una secuencia poli(A) o una señal de poliadenilación.
Applications Claiming Priority (2)
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PCT/EP2012/000674 WO2013120500A1 (en) | 2012-02-15 | 2012-02-15 | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen |
PCT/EP2013/000459 WO2013120627A1 (en) | 2012-02-15 | 2013-02-15 | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen |
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MX2014009909A MX2014009909A (es) | 2015-10-12 |
MX361728B true MX361728B (es) | 2018-12-14 |
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MX2014009909A MX361728B (es) | 2012-02-15 | 2013-02-15 | Ácido nucleico que comprende o codifica un tallo-bucle de histona y una secuencia poli(a) o una señal de poliadenilación para incrementar la expresión de un antígeno tumoral codificado. |
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KR (2) | KR102020086B1 (es) |
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AU (2) | AU2013220747B2 (es) |
BR (1) | BR112014017384A2 (es) |
CA (1) | CA2857560C (es) |
DK (1) | DK2814961T3 (es) |
ES (4) | ES2671393T3 (es) |
HR (1) | HRP20191033T1 (es) |
HU (1) | HUE044366T2 (es) |
LT (1) | LT3178488T (es) |
ME (1) | ME03484B (es) |
MX (1) | MX361728B (es) |
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RU (2) | RU2718577C2 (es) |
SG (3) | SG10201907775QA (es) |
SI (1) | SI3178488T1 (es) |
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