MX355623B - Hidrazino-1h-imidazoquinolin-4-aminas y conjugados elaborados a partir de las mismas. - Google Patents
Hidrazino-1h-imidazoquinolin-4-aminas y conjugados elaborados a partir de las mismas.Info
- Publication number
- MX355623B MX355623B MX2013014145A MX2013014145A MX355623B MX 355623 B MX355623 B MX 355623B MX 2013014145 A MX2013014145 A MX 2013014145A MX 2013014145 A MX2013014145 A MX 2013014145A MX 355623 B MX355623 B MX 355623B
- Authority
- MX
- Mexico
- Prior art keywords
- amines
- imidazoquinolin
- hydrazino
- made therefrom
- conjugates made
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A—HUMAN NECESSITIES
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- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
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- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
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- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
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- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Zoology (AREA)
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- General Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Abstract
Se describen las 1H-imidazo[4,5-c]quinolin-4-aminas sustituidas en la posición 1 con un sustituyente que posee una hidrazinobenzamida o hidrazino nicotinamida, una sal del mismo, o una hidrazinobenzamida o hidrazinonicotinamida protegida, y conjugados elaborados a partir de tales compuestos. Se describen también las composiciones farmacéuticas que contienen el compuesto o el conjugado, los métodos de elaboración de un conjugado, y los métodos de uso de los compuestos o conjugados como inmunomoduladores para inducir la biosíntesis de citocina en un animal, y para vacunar a un animal.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161493143P | 2011-06-03 | 2011-06-03 | |
US201161493051P | 2011-06-03 | 2011-06-03 | |
PCT/US2012/040461 WO2012167081A1 (en) | 2011-06-03 | 2012-06-01 | Hydrazino 1h-imidazoquinolin-4-amines and conjugates made therefrom |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013014145A MX2013014145A (es) | 2014-01-31 |
MX355623B true MX355623B (es) | 2018-04-25 |
Family
ID=47259897
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013014145A MX355623B (es) | 2011-06-03 | 2012-06-01 | Hidrazino-1h-imidazoquinolin-4-aminas y conjugados elaborados a partir de las mismas. |
Country Status (10)
Country | Link |
---|---|
US (3) | US9107958B2 (es) |
EP (3) | EP3153180A1 (es) |
JP (3) | JP6415979B2 (es) |
CN (1) | CN103582640B (es) |
AU (1) | AU2012261959B2 (es) |
BR (1) | BR112013031039B1 (es) |
CA (1) | CA2838023C (es) |
MX (1) | MX355623B (es) |
WO (1) | WO2012167081A1 (es) |
ZA (1) | ZA201309687B (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5043435B2 (ja) | 2003-10-03 | 2012-10-10 | スリーエム イノベイティブ プロパティズ カンパニー | アルコキシ置換イミダゾキノリン |
US8541438B2 (en) | 2004-06-18 | 2013-09-24 | 3M Innovative Properties Company | Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines |
WO2012024284A1 (en) | 2010-08-17 | 2012-02-23 | 3M Innovative Properties Company | Lipidated immune response modifier compound compositions, formulations, and methods |
BR112013031039B1 (pt) * | 2011-06-03 | 2020-04-28 | 3M Innovative Properties Co | compostos de hidrazino 1h-imidazoquinolina-4-aminas, conjugados feitos destes compostos, composição e composição farmacêutica compreendendo ditos compostos e conjugados, usos dos mesmos e método de fabricação do conjugado |
CN103582496B (zh) * | 2011-06-03 | 2016-05-11 | 3M创新有限公司 | 具有聚乙二醇链段的异双官能连接基以及由其制成的免疫应答调节剂缀合物 |
ES2727293T3 (es) | 2013-03-14 | 2019-10-15 | Univ Massachusetts | Métodos de inhibición de cataratas y presbicia |
CN105491982B (zh) | 2013-08-12 | 2019-09-10 | 3M创新有限公司 | 用于增强透皮递送的肽 |
WO2015069535A1 (en) | 2013-11-05 | 2015-05-14 | 3M Innovative Properties Company | Sesame oil based injection formulations |
AR100137A1 (es) | 2014-04-22 | 2016-09-14 | Hoffmann La Roche | Compuestos 4-amino-imidazoquinolina |
LT3265458T (lt) | 2015-03-06 | 2019-03-12 | F. Hoffmann-La Roche Ag | Benzazepino dikarboksamido junginiai |
WO2016183371A1 (en) | 2015-05-13 | 2016-11-17 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for the treatment or prevention of ischemic tissue damage |
EP3350168B1 (en) | 2015-09-17 | 2019-12-18 | H. Hoffnabb-La Roche Ag | Sulfinylphenyl or sulfonimidoylphenyl benzazepines |
CN108770357B (zh) * | 2015-09-29 | 2022-10-28 | 芝加哥大学 | 聚合物结合疫苗 |
EA035402B1 (ru) * | 2015-11-13 | 2020-06-08 | Зе Юниверсити Оф Массачусеттс | Бифункциональные молекулы, содержащие полиэтиленгликоль, для подавления катаракт и пресбиопии |
JP7022702B2 (ja) | 2016-05-23 | 2022-02-18 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 第二級アミド基を有するベンズアゼピンジカルボキサミド化合物 |
JP6918838B2 (ja) | 2016-05-23 | 2021-08-11 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 第三級アミド基を有するベンズアゼピンジカルボキサミド化合物 |
JP7012668B2 (ja) | 2016-06-12 | 2022-02-14 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | ジヒドロピリミジニルベンズアゼピンジカルボキサミド化合物 |
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CN103582640A (zh) | 2014-02-12 |
CA2838023C (en) | 2019-08-13 |
JP2017160220A (ja) | 2017-09-14 |
BR112013031039A2 (pt) | 2016-11-29 |
US9585968B2 (en) | 2017-03-07 |
JP6415979B2 (ja) | 2018-10-31 |
US20150352218A1 (en) | 2015-12-10 |
EP3366311A1 (en) | 2018-08-29 |
EP3366311B1 (en) | 2020-02-26 |
US10406142B2 (en) | 2019-09-10 |
CN103582640B (zh) | 2015-11-25 |
EP3153180A1 (en) | 2017-04-12 |
WO2012167081A1 (en) | 2012-12-06 |
CA2838023A1 (en) | 2012-12-06 |
JP2014515406A (ja) | 2014-06-30 |
ZA201309687B (en) | 2015-05-27 |
JP6430574B2 (ja) | 2018-11-28 |
US20140286988A1 (en) | 2014-09-25 |
US20170173164A1 (en) | 2017-06-22 |
JP2017160219A (ja) | 2017-09-14 |
MX2013014145A (es) | 2014-01-31 |
EP2718292B1 (en) | 2018-03-14 |
EP2718292A4 (en) | 2014-10-15 |
AU2012261959A1 (en) | 2013-12-19 |
AU2012261959B2 (en) | 2015-12-03 |
EP2718292A1 (en) | 2014-04-16 |
US9107958B2 (en) | 2015-08-18 |
BR112013031039B1 (pt) | 2020-04-28 |
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